Digital Commons Network^™

Stress-Induced Reinstatement Of Nicotine Preference Requires Dynorphin/Kappa Opioid Activity In The Basolateral Amygdala, Stephanie K. Nygard, Nicholas J. Hourguettes, Gabe G. Sobczak, William A. Carlezon, Michael R. Bruchas

Open Access Publications

UNLABELLED: The dynorphin (DYN)/kappa-opioid receptor (KOR) system plays a conserved role in stress-induced reinstatement of drug seeking for prototypical substances of abuse. Due to nicotine's high propensity for stress-induced relapse, we hypothesized that stress would induce reinstatement of nicotine seeking-like behavior in a KOR-dependent manner. Using a conditioned place preference (CPP) reinstatement procedure in mice, we show that both foot-shock stress and the pharmacological stressor yohimbine (2 mg/kg, i.p.) induce reinstatement of nicotine CPP in a norbinaltorphimine (norBNI, a KOR antagonist)-sensitive manner, indicating that KOR activity is necessary for stress-induced nicotine CPP reinstatement. After reinstatement testing, we visualized robust c-fos …

De Novo And Inherited Mutations In The X-Linked Gene Clcn4 Are Associated With Syndromic Intellectual Disability And Behavior And Seizure Disorders In Males And Females, E E Palmer, D K Grange, L Manwaring, Et Al

Open Access Publications

No abstract provided.

Adam17 Substrate Release In Proximal Tubule Drives Kidney Fibrosis, Eirini Kefaloyianni, Muthu Lakshmi Muthu, Jakob Kaeppler, Xiaoming Sun, Venkata Sabbisetti, Athena Chalaris, Stefan Rose-John, Eitan Wong, Irit Sagi, Sushrut S. Waikar, Helmut Rennke, Benjamin D. Humphreys, Joseph V. Bonventre, Andreas Herrlich

Open Access Publications

Kidney fibrosis following kidney injury is an unresolved health problem and causes significant morbidity and mortality worldwide. In a study into its molecular mechanism, we identified essential causative features. Acute or chronic kidney injury causes sustained elevation of a disintegrin and metalloprotease 17 (ADAM17); of its cleavage-activated proligand substrates, in particular of pro-TNFα and the EGFR ligand amphiregulin (pro-AREG); and of the substrates' receptors. As a consequence, EGFR is persistently activated and triggers the synthesis and release of proinflammatory and profibrotic factors, resulting in macrophage/neutrophil ingress and fibrosis. ADAM17 hypomorphic mice, specific ADAM17 inhibitor-treated WT mice, or mice with inducible …

Multiple Mechanisms For Processing Reward Uncertainty In The Primate Basal Forebrain, Noah M. Ledbetter, Charles D. Chen, Ilya E. Monosov

Open Access Publications

UNLABELLED: The ability to use information about the uncertainty of future outcomes is critical for adaptive behavior in an uncertain world. We show that the basal forebrain (BF) contains at least two distinct neural-coding strategies to support this capacity. The dorsal-lateral BF, including the ventral pallidum (VP), contains reward-sensitive neurons, some of which are selectively suppressed by uncertain-reward predictions (U(-)). In contrast, the medial BF (mBF) contains reward-sensitive neurons, some of which are selectively enhanced (U(+)) by uncertain-reward predictions. In a two-alternative choice-task, U(-) neurons were selectively suppressed while monkeys chose uncertain options over certain options. During the same choice-epoch, …

Using Diffusion Tractography To Predict Cortical Connection Strength And Distance: A Quantitative Comparison With Tracers In The Monkey, Chad J. Donahue, Stamatios N. Sotiropoulos, Saad Jbabdi, Moises Hernandez-Fernandez, Timothy E. Behrens, Tim B. Dyrby, Timothy Coalson, Henry Kennedy, Kenneth Knoblauch, David C. Van Essen, Matthew F. Glasser

Open Access Publications

UNLABELLED: Tractography based on diffusion MRI offers the promise of characterizing many aspects of long-distance connectivity in the brain, but requires quantitative validation to assess its strengths and limitations. Here, we evaluate tractography's ability to estimate the presence and strength of connections between areas of macaque neocortex by comparing its results with published data from retrograde tracer injections. Probabilistic tractography was performed on high-quality postmortem diffusion imaging scans from two Old World monkey brains. Tractography connection weights were estimated using a fractional scaling method based on normalized streamline density. We found a correlation between log-transformed tractography and tracer connection weights …

Tmem184b Promotes Axon Degeneration And Neuromuscular Junction Maintenance, Martha R.C. Bhattacharya, Stefanie Geisler, Sara K. Pittman, Ryan A. Doan, Conrad C. Weihl, Jeffrey Milbrandt, Aaron Diantonio

Open Access Publications

UNLABELLED: Complex nervous systems achieve proper connectivity during development and must maintain these connections throughout life. The processes of axon and synaptic maintenance and axon degeneration after injury are jointly controlled by a number of proteins within neurons, including ubiquitin ligases and mitogen activated protein kinases. However, our understanding of these molecular cascades is incomplete. Here we describe the phenotype resulting from mutation of TMEM184b, a protein identified in a screen for axon degeneration mediators. TMEM184b is highly expressed in the mouse nervous system and is found in recycling endosomes in neuronal cell bodies and axons. Disruption of TMEM184b expression …

Provisional Tic Disorder: What To Tell Parents When Their Child First Starts Ticcing, Kevin J. Black, Elizabeth Rose Black, Deanna J. Greene, Bradley L. Schlaggar

Open Access Publications

No abstract provided.

Oncomodulin, An Ef-Hand Ca2+ Buffer, Is Critical For Maintaining Cochlear Function In Mice, Benton Tong, Aubrey J. Hornak, Stéphane F. Maison, Kevin K. Ohlemiller, M Charles Liberman, Dwayne D. Simmons

Open Access Publications

UNLABELLED: Oncomodulin (Ocm), a member of the parvalbumin family of calcium binding proteins, is expressed predominantly by cochlear outer hair cells in subcellular regions associated with either mechanoelectric transduction or electromotility. Targeted deletion of Ocm caused progressive cochlear dysfunction. Although sound-evoked responses are normal at 1 month, by 4 months, mutants show only minimal distortion product otoacoustic emissions and 70-80 dB threshold shifts in auditory brainstem responses. Thus, Ocm is not critical for cochlear development but does play an essential role for cochlear function in the adult mouse.

SIGNIFICANCE STATEMENT: Numerous proteins act as buffers, sensors, or pumps to control …

Ability Of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, And S100b To Differentiate Normal And Abnormal Head Computer Tomography Findings In Patients With Suspected Mild Or Moderate Traumatic Brain Injury, Lawrence M. Lewis, Et Al

Open Access Publications

No abstract provided.

Conjugation To The Sigma-2 Ligand Sv119 Overcomes Uptake Blockade And Converts Dm-Erastin Into A Potent Pancreatic Cancer Therapeutic, Kerri A. Ohman, Yassar M. Hashim, Suwanna Vangveravong, Timothy M. Nywening, Darren R. Cullinan, S. Peter Goedegebuure, Jingxia Liu, Brian A. Van Tine, Herve Tiriac, David A. Tuveson, David G. Denardo, Dirk Spitzer, Robert H. Mach, William G. Hawkins

Open Access Publications

No abstract provided.

Full-Thickness Wound Healing Using 3d Bioprinted Gelatin-Alginate Scaffolds In Mice: A Histopathological Study, Jing Liu, Jinghua Chi, Kaixi Wang, Xiaoping Liu, Jie Liu, Fang Gu

Open Access Publications

No abstract provided.

Functional Variants Of Human Papillomavirus Type 16 Demonstrate Host Genome Integration And Transcriptional Alterations Corresponding To Their Unique Cancer Epidemiology, Robert Jackson, Bruce A. Rosa, Sonia Lameiras, Sean Cuninghame, Josee Bernard, Wely B. Floriano, Paul F. Lambert, Alain Nicolas, Ingeborg Zehbe

Open Access Publications

No abstract provided.

Pathogenic Mycobacteria Achieve Cellular Persistence By Inhibiting The Niemann-Pick Type C Disease Cellular Pathway [Version 1; Referees: 2 Approved, 2 Approved With Reservations], Daniel S. Ory, Et Al

Open Access Publications

No abstract provided.

Cancer Immunogenomics: Computational Neoantigen Identification And Vaccine Design, Jasreet Hundal, Christopher J. Miller, Malachi Griffith, Obi L. Griffith, Jason Walker, Susanna Kiwala, Aaron Graubert, Joshua Mcmichael, Adam Coffman, Elaine R. Mardis

Open Access Publications

No abstract provided.

Cancer Stem Cell Signaling During Repopulation In Head And Neck Cancer, George D. Wilson, Bryan J. Thibodeau, Laura E. Fortier, Barbara L. Pruetz, Sandra Galoforo, Brian Marples, Andrew M. Baschnagel, Jan Akervall, Jiayi Huang

Open Access Publications

No abstract provided.

Elevated Fibroblast Growth Factor Signaling Is Critical For The Pathogenesis Of The Dwarfism In Evc2/Limbin Mutant Mice, Honghao Zhang, Nobuhiro Kamiya, Takehito Tsuji, Haruko Takeda, Greg Scott, Sudha Rajderkar, Manas K. Ray, Yoshiyuki Mochida, Benjamin Allen, Veronique Lefebvre, Irene H. Hung, David M. Omitz, Tetsuo Kunieda, Yuji Mishina

Open Access Publications

No abstract provided.

A Critical Review Of Perfluorooctanoate And Perfluorooctanesulfonate Exposure And Immunological Health Conditions In Humans, Ellen T. Chang, Hans-Olov Adami, Paolo Boffetta, H. James Wedner, Jack S. Mandel

Open Access Publications

No abstract provided.

Human Metabolome-Derived Cofactors Are Required For The Antibacterial Activity Of Siderocalin In Urine, Robin R. Shields-Cutler, Jan R. Crowley, Connelly D. Miller, Ann E. Stapleton, Weidong Cui, Jeffery P. Henderson

Open Access Publications

No abstract provided.

Mdm2 Prevents Spontaneous Tubular Epithelial Cell Death And Acute Kidney Injury, Dana Thomasova, Martrez Ebrahim, Kristina Fleckinger, Moying Li, Jakob Molnar, Bastian Popper, Helen Liapis, Ahmed M. Kotb, Florian Siegerist, Nicole Endlich, Hans-Joachim Anders

Open Access Publications

No abstract provided.

Prognostic Value Of Lymph Node Ratio In Patients With Pathological N1 Non-Small Cell Lung Cancer: A Systematic Review With Meta-Analysis, Qian Li, Ping Zhan, Dongmei Yuan, Tangfeng Lv, Alexander Sasha Krupnick, Antonio Passaro, Alessandro Brunelli, Matthew P. Smeltzer, Raymond U. Osarogiagbon, Yong Song

Open Access Publications

No abstract provided.

Mice With Missense And Nonsense Nf1 Mutations Display Divergent Phenotypes Compared With Human Neurofibromatosis Type I, Kairong Li, Ashley N. Turner, Min Chen, Stephanie N. Brosius, Trenton R. Schoeb, Ludwine M. Messiaen, David M. Bedwell, Kurt R. Zinn, Corina Anastasaki, David H. Gutmann, Bruce R. Korf, Robert A. Kesterson

Open Access Publications

No abstract provided.

Socio-Demographic Differences In Toxic Release Inventory Siting And Emissions In Metro Atlanta, Ryan Johnson, Kim Ramsey-White, Christina H. Fuller

Open Access Publications

No abstract provided.

Cardiac Arrest-Induced Global Brain Hypoxia-Ischemia During Development Affects Spontaneous Activity Organization In Rat Sensory And Motor Thalamocortical Circuits During Adulthood, Michael Shoykhet, Jason W. Middleton

Open Access Publications

No abstract provided.

Regulation Of Monocyte Cell Fate By Blood Vessels Mediated By Notch Signalling, Carlos G. Briseño, Kenneth M. Murphy, Et Al

Open Access Publications

No abstract provided.

Transient Exposure To Calcium Ionophore Enables In Vitro Fertilization In Sterile Mouse Models, Felipe A. Navarrete, Antonio Alvau, Hoi Chang Lee, Lonny R. Levin, Jochen Buck, Patritica Martin-De Leon, Celia M. Santi, Dario Krapf, Jesse Mager, Rafael A. Fissore, Ana M. Salicioni, Alberto Darszon, Pablo E. Visconti

Open Access Publications

No abstract provided.

A Narnavirus-Like Element From The Trypanosomatid Protozoan Parasite Leptomonas Seymouri, Lon-Fye Lye, Natalia S. Akopyants, Deborah E. Dobson, Stephen M. Beverley

Open Access Publications

No abstract provided.

Two-Stage Association Study To Identify The Genetic Susceptibility Of A Novel Common Variant Of Rs2075290 In Zpr1 To Type 2 Diabetes, Fanglin Guan, Yu Niu, Tianxiao Zhang, Songfang Liu, Lei Ma, Ting Qi, Jia Feng, Hong Zuo, Guohong Li, Xufeng Liu, Shujin Wang

Open Access Publications

No abstract provided.

The Influence Of Temperament And Character Profiles On Specialty Choice And Well-Being In Medical Residents, Martin Sievert, Igor Zwir, Kevin M. Cloninger, Nigel Lester, Sandor Rozsa, C. Robert Cloninger

Open Access Publications

No abstract provided.

Ketamine: Nmda Receptors And Beyond, Charles F. Zorumski, Yukitoshi Izumi, Steven Mennerick

Open Access Publications

No abstract provided.

The Mechanism Of A Formaldehyde-Sensing Transcriptional Regulator, Katie J. Denby, Jeffrey Iwig, Claudine Bisson, Jodie Westwood, Matthew D. Rolfe, Svetlana E. Sedelnikova, Khadine Higgins, Michael J. Maroney, Patrick J. Baker, Peter T. Chivers, Jeffrey Green

Open Access Publications

No abstract provided.