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Redefining The Endophenotype Concept To Accommodate Transdiagnostic Vulnerabilities And Etiological Complexity, Theodore P. Beauchaine, John N. Constantino
Redefining The Endophenotype Concept To Accommodate Transdiagnostic Vulnerabilities And Etiological Complexity, Theodore P. Beauchaine, John N. Constantino
Open Access Publications
In psychopathology research, endophenotypes are a subset of biomarkers that indicate genetic vulnerability independent of clinical state. To date, an explicit expectation is that endophenotypes be specific to single disorders. We evaluate this expectation considering recent advances in psychiatric genetics, recognition that transdiagnostic vulnerability traits are often more useful than clinical diagnoses in psychiatric genetics, and appreciation for etiological complexity across genetic, neural, hormonal and environmental levels of analysis. We suggest that the disorder-specificity requirement of endophenotypes be relaxed, that neural functions are preferable to behaviors as starting points in searches for endophenotypes, and that future research should focus on …
Incidental Angiosarcoma Of The Pancreas: A Case Report Of A Rare, Asymptomatic Tumor, Patrick J Worth, Michael Turner, Chet W Hammill
Incidental Angiosarcoma Of The Pancreas: A Case Report Of A Rare, Asymptomatic Tumor, Patrick J Worth, Michael Turner, Chet W Hammill
Open Access Publications
No abstract provided.
Downregulation Of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose–Induced Apoptosis, Dongjoon Kim, Robert P. Mecham, Philip C. Trackman, Sayon Roy
Downregulation Of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose–Induced Apoptosis, Dongjoon Kim, Robert P. Mecham, Philip C. Trackman, Sayon Roy
Open Access Publications
No abstract provided.
Isolation And Characterization Of Synovial Mesenchymal Stem Cell Derived From Hip Joints: A Comparative Analysis With A Matched Control Knee Group, Akihisa Hatakeyama, Soshi Uchida, Hajime Utsunomiya, Manabu Tsukamoto, Hirotaka Nakashima, Eiichiro Nakamura, Cecilia Pascual-Garrido, Ichiro Sekiya, Akinori Sakai
Isolation And Characterization Of Synovial Mesenchymal Stem Cell Derived From Hip Joints: A Comparative Analysis With A Matched Control Knee Group, Akihisa Hatakeyama, Soshi Uchida, Hajime Utsunomiya, Manabu Tsukamoto, Hirotaka Nakashima, Eiichiro Nakamura, Cecilia Pascual-Garrido, Ichiro Sekiya, Akinori Sakai
Open Access Publications
No abstract provided.
Alu Insertion Polymorphisms As Evidence For Population Structure In Baboons, Cody J. Steely, Jane Phillips-Conroy, Et Al
Alu Insertion Polymorphisms As Evidence For Population Structure In Baboons, Cody J. Steely, Jane Phillips-Conroy, Et Al
Open Access Publications
No abstract provided.
Genetic Metabolic Complementation Establishes A Requirement For Gdp-Fucose In Leishmania, Hongjie Guo, Natalia M. Novozhilova, Giulia Bandini, Salvatore J. Turco, Michael A. J. Ferguson, Stephen M. Beverly
Genetic Metabolic Complementation Establishes A Requirement For Gdp-Fucose In Leishmania, Hongjie Guo, Natalia M. Novozhilova, Giulia Bandini, Salvatore J. Turco, Michael A. J. Ferguson, Stephen M. Beverly
Open Access Publications
No abstract provided.
Deficiency Of Rgpg Causes Major Defects In Cell Division And Biofilm Formation, And Deficiency Of Lytr-Cpsapsr Family Proteins Leads To Accumulation Of Cell Wall Antigens In Culture Medium By Streptococcus Mutans, Arpan De, Sumei Liao, Jacob P. Bitoun, Randy Roth, Wandy L. Beatty, Hui Wu, Zezhang T. Wen
Deficiency Of Rgpg Causes Major Defects In Cell Division And Biofilm Formation, And Deficiency Of Lytr-Cpsapsr Family Proteins Leads To Accumulation Of Cell Wall Antigens In Culture Medium By Streptococcus Mutans, Arpan De, Sumei Liao, Jacob P. Bitoun, Randy Roth, Wandy L. Beatty, Hui Wu, Zezhang T. Wen
Open Access Publications
No abstract provided.
Correlates Of Bacterial Vaginosis Over Long-Term Follow-Up: Impact Of Hiv Infection, Leslie S. Massad, Charlesnika T. Evans, Raymond Kang, Anna Hotton, Ruth Greenblatt, Howard Minkoff, Kerry Murphy, Christine Colie, Kathleen M. Weber
Correlates Of Bacterial Vaginosis Over Long-Term Follow-Up: Impact Of Hiv Infection, Leslie S. Massad, Charlesnika T. Evans, Raymond Kang, Anna Hotton, Ruth Greenblatt, Howard Minkoff, Kerry Murphy, Christine Colie, Kathleen M. Weber
Open Access Publications
No abstract provided.
Genetic Correlation Between Amyotrophic Lateral Sclerosis And Schizophrenia, C. Robert Cloninger, Dragan M. Svrakic, Et Al
Genetic Correlation Between Amyotrophic Lateral Sclerosis And Schizophrenia, C. Robert Cloninger, Dragan M. Svrakic, Et Al
Open Access Publications
No abstract provided.
In Vivo Two-Photon Imaging Of Astrocytes In Gfap-Gfp Transgenic Mice, Dongjun Guo, Jia Zou, Nicholas Rensing, Michael Wong
In Vivo Two-Photon Imaging Of Astrocytes In Gfap-Gfp Transgenic Mice, Dongjun Guo, Jia Zou, Nicholas Rensing, Michael Wong
Open Access Publications
No abstract provided.