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The Effects Of Preeclampsia On Signaling To Hematopoietic Progenitor Cells, Donna A. Santillan, Wendy S. Hamilton, Ashley Christensen, Katelyn M. Talcott, Lindsay K. Gravatt, Mark K. Santillan, Stephen K. Hunter
The Effects Of Preeclampsia On Signaling To Hematopoietic Progenitor Cells, Donna A. Santillan, Wendy S. Hamilton, Ashley Christensen, Katelyn M. Talcott, Lindsay K. Gravatt, Mark K. Santillan, Stephen K. Hunter
Mark K. Santillan
Background: The role of the microenvironment is important in cell differentiation. The effect of placental disease on the growth and differentiation and hematopoietic stem cells has not been well-studied.
Methods: Enzyme linked immunoassay was used to measure erythropoietin and osteopontin in plasma from umbilical cord blood of children born to normotensive and preeclamptic women. Additionally, CD34+ cells were isolated from umbilical cord blood and grown in complete methylcellulose media. Colony types were identified and enumerated.
Results: Differences in the concentration of erythropoietin in the cord blood between the controls and the preeclamptics approached significance (P = 0.067) using a Mann-Whitney …