Digital Commons Network^™

The Benefits And Barriers To Expanding Crna Programs In Michigan, Grace Van Zweden

Honors Theses

The demand for Certified Registered Nurse Anesthetists (CRNAs) and their delivery of safe, high-quality anesthesia care has increased significantly due to nationwide anesthesia provider shortages and the growing reliance on CRNAs to meet healthcare system needs. This demand underscores the importance of expanding nurse anesthesia programs in Michigan and across the United States to support nurses pursuing advanced education and to improve patient access to essential care within their communities. The CRNA profession has evolved over time to meet the changing needs of the healthcare system, and current CRNA programs require applicants to satisfy rigorous and highly specific admission criteria. …

A Treatise On Tool Development: The Arthroscope’S Cultural, Technological, And Metascientific Translation, Montgomery F. Waterer

Honors Theses

The arthroscope was a revolutionary development in the fields of medicine, engineering, and ethics. There are many valuable lessons to be learned from the story of its development and translation that are relevant to the future of medicine and society. Beginning with a brief description of the tool’s design, this paper will examine a period within the history of the arthroscope. This window contains multiple innovators and ends with the life and work of Dr. Robert Jackson. In examining the relevant historical facts of its development, this paper will then briefly address the importance of sports medicine in the development …

The Implications Of The Scientific Developments Behind Oxidative Stress, Heat-Shock Proteins, And Antioxidants On Neurodegenerative Pathology, Nolan Wilbourn

Honors Theses

Homeostasis is essential for the health and development of all organisms, serving as a universal defense mechanism that ensures the stability of physiological processes faced with external and internal stimuli in the form of health challenges (Archana et al., 2017). Maintaining homeostasis is crucial for our health, as it helps keep the body's internal balance. However, this delicate equilibrium is challenged by various environmental factors, such as diet, exposure to chemicals, and fluctuations in temperature (Collier et al., 2017). These disruptions can lead to dysfunction in cellular processes, particularly affecting the production and regulation of proteins vital for biological functions. …

Fd&C Red Dye No. 40 (Allura Red) Effects On Non-Human Animal Testing: A Systematic Review, Vilate Winfrey

Honors Theses

Artificial food dye is added to foods to enhance their color and appearance for consumers. This systematic review aims to review the literature on Red Dye No. 40 and its effects on non-human animals. Studies were included if (a) exposure to Red Dye No. 40 was the independent variable, (b) nonhuman animals were the subjects, and (c) at least one behavioral, neurological, or physiological dependent variable was reported. An article search was conducted with Scopus Elsevier. An abstract review was conducted to determine whether the articles met all inclusion criteria. The author conducted a multi-stage application of inclusion criteria to …

Perceptions And Attitudes Of Western Michigan University Students On Antibiotic Medications, Emily Boask

Honors Theses

On a global scale, antibiotic resistance is a threat to public health. The causes of antibiotic resistance are multifaceted, including healthcare providers overprescribing antibiotics, antibiotic overuse in farming and food production, and antibiotic misuse or malpractices. The public recognizes antibiotic resistance as a significant problem but there are serious knowledge gaps regarding antibiotic resistance and antibiotic stewardship.

University students are a particularly important subpopulation of the public to understand appropriate antibiotic use because many of these individuals are navigating their health concerns on their own for the first time. Many individuals believe that antibiotics can improve cold symptoms, upper respiratory …

Communication Research On Sign Language Telecommunication And Digital Modes Of Interpretation., Scooter Briody

Honors Theses

Since the invention and proliferation of the telephone in the late nineteenth century, our world has become increasingly dependent on technologically mediated communication. Nowadays we are just as likely to have our next human interaction through our smartphone or computer screen as we are to meet another person face to face. We do not even tend to think of these things as tools for telecommunication anymore, but rather as extensions of our own will. Despite the overwhelming convenience of this technology, it is also fundamentally created with the interests of certain people in mind. If you are able to use …

Virtual Reality As An Adjunct To Behavior Therapy: A Systematic Literature Review, Alya Alharrasi

Honors Theses

The World Health Organization (WHO) projects that by 2030, mental disorders will become the primary source of global disease burden [1]. Anxiety-related disorders, including specific phobias, post-traumatic stress disorder (PTSD), and various forms of general or specific anxiety, are the most rapidly growing mental health disorders worldwide [2]. In the United States (US), over 1 in 10 American youths are experiencing depression, resulting in a severe impact on their personal, academic, or professional encounters and social engagements [3]. Similarly, anxiety disorders affect up to one-third of the US population during their lifetime [4].

Due to the growth of mental health …

Effects Of Cannabichromene On Pain And Neuroinflammation In Hiv-1 Tat Transgenic Mice, Sydney Wheeler

Honors Theses

HIV-1 TransActivator of Transcription (Tat) is a vital regulatory protein involved in HIV replication and implicated in development of HIV-associated pain and neurocognitive deficits. Tat is thought to contribute to these pathologies through proinflammatory pathways. Developing mechanisms to curb Tat-mediated inflammation is a key step in improving the quality of life of those living with HIV. Both recreational and medicinal cannabis use is prevalent among many people living with HIV; given this prevalence and the perceived anti-inflammatory benefits of cannabis use, it is important to investigate how chemical constituents of cannabis may impact HIV. In the present study, the effects …

Firefighter: 24/48 Versus 48/96; Sleep, Strain, And Recovery, Amy Sprague

Honors Theses

Firefighters provide important safety services for a 24-hour society. Sleep is very important to the human body. Without sleep a person can experience both short- and long-term side effects. These side effects not only put the sleep deprived person in danger but can also put the public in danger as well. There are many different shift schedules that fire departments can run on. While on duty firefighters must be ready to respond to any emergency call, they receive no matter the time. This can impact the amount of sleep they get while on duty. The current study used biometric straps …

The Effects Of Astrocytic Derived Insulin-Like Growth Factor (Igf-1) On Cognition And Astrocytes, Destiny Wilson

Honors Theses

Insulin-like growth factor 1 (IGF-1) is a neuroendocrine signaling hormone that plays a vital role in growth and development, as well as learning and memory. Inhibition of this hormone results in cognitive impairments like those seen with age-related decline. While a majority of research has focused on the role of IGF-1 on neurons, the role of astrocytes still needs to be explored. Our research investigates how astrocytes and cognition are affected as a result of direct regulation of localized IGF-1 production in early development and after puberty. Preliminary studies in our laboratory established a connection between IGF-1 and glial fibrillary …

Generation Of Baiap3 Expression Construct For Subcellular Localization And Phenotypic Rescue, Ireland Ann Little

Honors Theses

Mast cells secrete a variety of biological mediators crucial for innate and adaptive immunity. One such mediator is Tumor Necrosis Factor (TNF). TNF released from mast cells and other immune cells has been shown to elicit complex signaling pathways in target cells, resulting in the production of pro-inflammatory cytokines and/or immune cell recruitment. At the molecular level, TNF secretion/exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and other regulatory proteins that work together to promote the fusion between secretory granules and the plasma membrane. One regulatory protein, Munc13-4, which facilitates the priming of secretory granules, was recently …

The Role Of Free Radicals In The Activation Of Epidermal Growth Factor Receptors In Murine Microglial Cells, Eliana John

Honors Theses

Regulation of cellular processes is important for proper functioning. Environmental factors, including stress, can interfere with cellular regulation. One of the diseases caused by cellular regulation disturbance is cancer and mutations in EGF-related genes highly correlate with worse outcomes in cancer. The Epidermal Growth Factor (EGF) pathway is involved in the regulation of cell growth and differentiation. Phosphorylation of the receptors activates this pathway, leading to cell growth and regulation. This study examines the impact of oxidative stress on EGF pathway activation. Previous studies using breast cancer lines have indirectly shown a decrease in Epidermal Growth Factor Receptor (EGFR) activation …

Understanding The Role Of Race In American Medicine, Fariel C. A. Lamountain

Honors Theses

Long running inequity in health care and outcomes in the United States stem from failure to acknowledge the underlying role of the Transatlantic slave trade as it manifests in all facets of American society and commerce. This paper focuses specifically on the American medical system and its foundations to understand the precursors to generational trends in lack of access to healthcare and poor health for Black communities. This paper uses a three-pronged approach to understand the racist cycle of inequity, highlighting the history and origins of racism in American medicine, personal accounts and statistical evidence of inequity, and community and …

Coronary Artery Disease: An Analysis Of Its Biochemical, Physiological, And Sociological Causes And Effects, Alexander Velazquez

Honors Theses

Coronary Artery Disease (CAD) is a serious condition caused by a buildup of plaque in your coronary arteries, the blood vessels that bring oxygen-rich blood to your heart. It disproportionately affects millions of Americans and thousands of Mississippians. This study presents the results of an evaluation of causation factors of CAD, the physiological impact on the body, and the contributing determinants of CAD on Mississippi populations. Data on Mississippi populations were collected using the Center for Population Studies at the University of Mississippi. A multitude of individuals were evaluated when examining the causes and effects of CAD including men, women, …

Congenital Heart Defects And The Expression Of Ccdc141, Savanna Tillman

Honors Theses

Congenital heart defects (CHDs) are one of the most prevalent types of birth defects in the United States. Both environmental and genetic components are known to contribute to the development of CHDs. One of the ways toxins present in the environment cause CHDs is by disrupting the expression of genes known to be vital in normal cardiac morphogenesis. Thus, the identification of both toxins that cause birth defects in cardiac development and genes expressed during heart development is crucial in order to fully understand the relationship between environment and genetics as they relate to CHD. Due to their external development, …

Synthesis, Gari Eberly

Honors Theses

Synthesis is a scientifically-aware collection of poetry that explores how gender relations and race amalgamate to impact the maturation of an individual. Employing both sonnet and computer code, I reflect on my experiences as a mixed-raced girl growing up in central Pennsylvania, my growth through several romantic relationships, and how I currently navigate male-dominated spaces as a woman.

For the past four years, I have sought to bridge the gap between my two academic commitments: poetry and science. Both poetry and science exist as a means to ask and answer questions about the messy interactions that shape personalities and relations …

The Effect Of Pre-Workout Supplementation On Fitness Assessment Tests, Kassidy Davis

Honors Theses

Research regarding the benefits and detriments of Pre-workout supplement has gradually increased since its popularity arose in the early 1980’s. There have been a number of studies on its effects on human physiology during a workout; however, there are few studies regarding Preworkout supplement during fitness assessment tests. Therefore, further insights concerning Preworkout supplement and fitness testing is needed. Pre-workout supplement is taken prior to a training session and has been shown to enhance a workout by increasing aspects such as focus, reaction time, stamina, and power. This could be viewed as solely a psychological enhancement than an actual physical …

The Correlation Between The Microbiome And Neurodegenerative Disorders Such As Alzheimer Disease, Aurora Mokris

Honors Theses

Recent studies suggest that there are 1.3 times as many microbial cells as human cells in the body (Abbot, 2016). Another study claims that the combined genomes of this microbiota is 150 times that of the human genome (Zhuang & Shen, 2018). If you have ever had the feeling that you are not alone in an empty room you are most certainly correct. Your body is teeming with millions of organisms living in mutualistic symbiosis with you and surrounding microbes, but at times, this seemingly harmonious relationship can be disturbed, resulting in serious physical and psychological changes to the human …

Effects Of Age And Exercise On Density Of Sympathetic Innervation And Localization With Nerve Growth Factor And Glial Cell Line-Derived Neurotrophic Factor In Vascular Tissue, Kori Mecklenburg

Honors Theses

Hypertension is a condition that affects nearly 75 million people in the United States (Merai et al, 2017). To better understand this mostly idiopathic condition, the role of survival factors on arterial innervation must be understood. Nerve growth factor (NGF) and glial cell-line derived neurotrophic factor (GDNF) have been shown to support development and maintenance of the sympathetic nervous system. The aim of this study was to reveal how density of sympathetic innervation changes in mesenteric arteries over time and with six-months of exercise. Additionally, this study aimed to reveal the localization of GDNF and NGF alongside these changes in …

Propionate Enhances The Antimicrobial Defenses In Macrophages Against Listeria Monocytogenes, John Weis

Honors Theses

Propionate is a short chain fatty acid produced by the bacteria in the human gut. It has a wide range of nutritional functions in the human body. Several studies have also reported the effects of propionate on immune cell activation. In this study, we used Listeria monocytogenes as a model pathogen to determine how and what the effects of propionate on immune cells influence cell susceptibility to infections. Listeria is a dangerous intracellular pathogen that can replicate inside immune cells such as macrophages. Therefore, we can assess the impact of propionate on infection susceptibility by performing cell culture infections. We …

Towards A Pre-Processing Algorithm For Automated Arrhythmia Detection, Sarah Miller

Honors Theses

There are a variety of different wearable fitness/cardiac monitoring devices that are currently used in many people’s day to day life. The primary cardiac function of these devices is to monitor heart rate, however we believe that they could be utilized to detect different forms of arrhythmia. In order to categorize and identify different forms of arrhythmia, we are utilizing published EKG data sets from existing databases as a basis for machine learning. The challenge that comes from the existing data sets is that the format they present the data in does not lend itself to machine learning, which requires …

The Effect Of Remote Ischemic Preconditioning On Exercise Hyperemia In Multiple Sclerosis, Jane E. Rosmarin

Honors Theses

Remote ischemic preconditioning (RIPC) is a non-invasive technique in which blood flow is cut off to a limb for a short period of time which produces a protective effect throughout the whole body to subsequent low oxygen conditions. One of the prominent cardiovascular limitations to exercise in individuals with multiple sclerosis (MS) is fatigue, which may stem from the decreased delivery of oxygen to muscle tissue during exercise. The purpose of this study was to test the hypothesis that RIPC would increase forearm blood flow (FBF) and utilization of oxygen at the level of the muscle tissue in individuals with …

Bridging Act-R And Project Malmo, Developing Models Of Behavior In Complex Environments, David M. Schwartz

Honors Theses

Cognitive architectures such as ACT-R provide a system for simulating the mind and human behavior. On their own they model decision making of an isolated agent. However, applying a cognitive architecture to a complex environment yields more interesting results about how people make decisions in more realistic scenarios. Furthermore, cognitive architectures enable researchers to study human behavior in dangerous tasks which cannot be tested because they would harm participants. Nonetheless, these architectures aren’t commonly applied to such environments as they don’t come with one. It is left to the researcher to develop a task environment for their model. The difficulty …

Driving Anxiety In Young People With Autism Spectrum Disorder : A Driving Simulator Pilot Study, Rebecca Pasch

Honors Theses

The goal of this project was to investigate how driving anxiety changes overtime in young people with autism spectrum disorder (ASD) when using a driving simulator technology. Additional exploratory measures were collected on duration of participation,. stopping distance, and reaction time.

Exploration Of Thiol-Michael Addition Bioconjugation To Extend Polymers Of A Protein-Based Hydrogel, Elaine Wallin Smith

Honors Theses

Hydrogels have been explored for many biomedical applications, including targeted, in situ drug delivery to avoid the negative side effects associated with systemic delivery. In our work, we are exploiting the high affinity, calcium-dependent binding between calmodulin and its target peptides to create a biomaterial for in situ, extracellular drug delivery. Genes were engineered to make two protomers, Calmodulin Collagen-Like Protein (CCLP) and Peptide Collagen-Like Protein (PCLP), that will spontaneously self-assemble in situ due to the high Ca2+ concentration in the extracellular space and provide tunable, targeted drug delivery in a biocompatible hydrogel. One important factor that would dictate the …

Comparison Of Psychological States Of Runners Within Urban And Rural Environments, Christian Demastus

Honors Theses

With the research on persons health and well being increasing within the past years, new questions have emerged on if certain environments can also benefit along with exercise. This study looked at the different psychological states of endurance runners as they run in urban environments and transition into rural settings. The results of this study showed significant differences between urban and rural environments. Also showed increased focus going downhill in nature and greater inward attention while moving uphill in nature. With the findings from this study, it explains why runners choose to run or train where they do.

Inhibition Of Blood Coagulation Factor Xii: Evaluation Of Flavonoids As A Drug Candidate, Betsy Crosswhite

Honors Theses

This study investigated natural product inhibitors of blood coagulation Factor XII (FXII). FXII initiates the Kallikrein Kinin-System (KKS) within the intrinsic coagulation pathway. Increased expression of this system leads to proinflammatory and procoagulant activities. Inflammation occurs through downstream activation in the KKS. Following the activation of FXII-dependent pathway, bradykinin (BK) binds to the BK receptor 2 (B2) and produces inflammatory signaling. Abnormally increased BK can result in life threatening Hereditary Angioedema (HAE), characterized by severe reoccurring swelling. FXII is critical for pathogenic thrombosis, but is dispensable for hemostasis. This unique property of FXII makes it an attractive drug target. We …

Purification Protocol Development And Analysis Of Binding Properties Of Calmodulin Collagen-Like Protein, Patrick P. Boddie

Honors Theses

Calmodulin is an intensely studied, intracellular, calcium-binding protein that is involved in diverse physiological processes. When bound to calcium, calmodulin undergoes a conformational change that allows it to bind specific target peptides with high affinity, one being the calmodulin binding region of myosin light chain kinase, herein called M13. This high affinity, calcium dependent association has made it a desirable choice for use in a biomaterial for drug delivery for non-steroidal anti- inflammatory drugs (NSAIDs). Two artificial genes have been designed by our lab for use in the proposed biomaterial: calmodulin collagen-like protein (CCLP), a construct composed of two calmodulin …

Connecting The Mind And Body In Ancient Greek Medicine, Taylor Ferris

Honors Theses

I investigated Greek medicine and healing shrines in antiquity and focused on the issue of the mind-body connection and how this phenomenon was understood in antiquity. I researched the Athenian plague of 430-425 B.C., sleep and dreams, particularly in the Rites of Incubation, and Hippocratic medicine as well as religious medicine in order to understand more deeply the origins of Greek medicine and how the healing phenomena were practiced and understood. I have come to a greater understanding of this connection between the mind and the body and have come to redefine the placebo effect and argue that the mind …

Pravastatin™ Suppresses Venous Shear Stress Dependent Induction Of Aquaporin 1 Protein Expression In Human Umbilical Vein Endothelial Cells In Vitro, Raphael J. Crum

Honors Theses

Background: Aquaporins (AQPs) are transmembrane water channels that facilitate osmotically-driven transmembrane water flux. AQP1 is abundantly expressed in vascular endothelium, where it functions in endothelial cell migration, wound healing, and cell volume regulation in response to mechanical stimuli. AQP1 protein abundance is enhanced in cultured human umbilical vein endothelial cells (HUVECs) in response to fluid shear stress. Statins, a pharmacological class of HMG-CoA reductase inhibitors, suppress the early development of vein graft intimal hyperplasia by improving endothelial cell function, most likely by affecting endothelial response to arterial shear stress. Statins may also differentially regulate the expression of specific AQPs by …