Digital Commons Network^™

Effects Of Flavonoids On Reducing Colon Cancer Risk Via Macrophage Polarization, Gracien Jules

Graduate Theses and Dissertations

Colorectal cancer is one of the most fatal diseases in the United States. Chronic tissue inflammation can cause cell proliferation, which leads to tumor formation and cancer development. Macrophages are responsible for maintaining tissue homeostasis and for inflammatory responses. M1 macrophages exhibit proinflammatory responses while M2 macrophages exhibit anti-inflammatory responses. Imbalance between M1 and M2 macrophages is closely related to inflammation-associated disease development. The anti-inflammatory effects of apiaceous vegetable constituents, specifically flavonoids, have been studied for their preventative effects towards reducing disease risk. However, sufficient evidence is lacking on the mechanisms by which flavonoids impact M1/M2 macrophage polarization. RAW 264.7 …

Student Perceptions And Academic Performance When Taught With Multiple Active Learning Methods In A High Enrollment Undergraduate Human Physiology Course, Kate Ireton Walker

Graduate Theses and Dissertations

When instructing very large groups of students in science, it can be difficult to engage all students in the content and measure their understanding. A major unaddressed challenge in science instruction is how specifically to design and implement strategies that engender active learning particularly in high-enrollment undergraduate courses. Active learning, which represents a diverse set of strategies, may include student engagement as part of instruction through discussions, active movement, and application (Bernstein, 2018; Cavanagh, et al. 2016; Michael, 2006 & Wilke, 2003). This study was designed to provide data addressing the gap in the literature regarding how the continual implementation …

Exploring The Effects Of N,N-Dimethylbiguanide And Ω-3 Pufas On Muscle Stem Cell Differentiation, Enayah Alhshim

Graduate Theses and Dissertations

The impacts of omega-3 (ω-3) fatty acid and metformin hydrochloride (Met-HCl) on muscle stem cells differentiation, mimicking the fetal muscle development under gestational diabetes mellitus (GDM), were investigated. ω-3 fatty acids have been known for their ability to regulate adipogenic transcription factors such as Sterol Regulatory Element-Binding Protien (SREBPs) and Peroxisome Proliferator-Activated Receptors (PPARs). This regulation resulted in gene expression modification for lipid metabolism and adipocyte differentiation, thus preventing excessive fat accumulation. Additionally, emerging evidence suggested that ω-3 fatty acids may also exert direct effects on myogenic processes that influence muscle stem cells proliferation, differentiation, and maturation. Meanwhile, Met-HCl, an …

Effects Of Cognitive Style On Food Perception And Eating Behavior, Thadeus Lyndon Beekman

Graduate Theses and Dissertations

Within the fields of psychology, notably cultural psychology, the analytic-holistic cognitive style theory has been introduced, developed, fine-tuned, and validated across a wide range of situations, stimuli, and populations. This research, combined with recent applications of the analytic-holistic theory, suggests that the differences in analytic or holistic tendencies of individuals in food, sensory, and consumer tests can impact food perception and associated behaviors. This dissertation aimed to investigate the impact of analytic-holistic cognitive styles of consumers in food situations. The first objective to accomplish this goal was to conduct exploratory research to identify if and where the analytic-holistic theory may …

Visualizing Interdisciplinary Collaborations Within Exercise Science: A Pilot Study, Elizabeth Bjornsen

Graduate Theses and Dissertations

Exercise science is a growing field with sub-disciplines exploring various aspects of physical activity. Diverse perspectives allow the field to answer complex research questions, but little is known about the collaborative nature of exercise science today. Research practices have implications on undergraduate curriculum, likely incorporating experiential knowledge into course subject matter and providing diverse experiences for students entering the workforce. Therefore, the purpose of the pilot study is to visualize and quantify interdisciplinary collaborations within exercise science. Journal citation analysis and an adaptation of social networking theory were utilized to examine collaborative practices of exercise science faculty at the University …

Characterization Of Avidin And Case9 Single Protein Molecules By A Solid-State Nanopore Device, Haopeng Li

Graduate Theses and Dissertations

The shape and charge of a protein play significant roles in protein dynamics in the biological system of humans and animals. Characterizing and quantifying the shape and charge of a protein at the single-molecule level remains a challenge. Solid-state nanopores made of silicon nitride (SiNx) have emerged as novel platforms for biosensing such as diagnostics for single-molecule detection and DNA sequencing. SSN detection is based on measuring the variations in ionic conductance as charged biomolecules translocate through nanometer-sized channels driven by an external voltage applied across the membrane. In this paper, we observe the translocation of asymmetric cylindrical structure CRISPR-Cas9 …

Nutritional Supplementation And Skeletal Muscle Health In Chronic Diseases, Hexirui Wu

Graduate Theses and Dissertations

Prevalence of chronic diseases in the United States keeps increasing in recent years. There are approximately four in ten adults having chronic diseases in America. Chronic diseases include obesity, aging, heart diseases, cancer and many others. This thesis mainly focuses on obesity and aging. Skeletal muscle performance is impaired in obesity and aging conditions. One common reason causing this could be higher fat mass and lower muscle mass. However, there is no study showing what pathways are involved in the imbalance of body composition. Therefore, the first objective of the thesis is to determine gene expression of selected pathways in …

Gender In Apocalyptic California: The Ecological Frontier, Marykate Eileen Messimer

Graduate Theses and Dissertations

Climate change is the consequence of ideologies that promote human reproduction and resource consumption by sacrificing human justice, nonhuman species, and the land. Both biology and queer ecologies resist this notion of human separation and supremacy by showing that no body is a singular, impermeable entity, that all beings are biologically and inexorably connected. My dissertation demonstrates that fiction writers use this knowledge to locate a utopian vision that can counteract the dystopian impotence of living within climate change. This argument is founded on novels written by women and set in California, a state that uniquely inhabits a utopian and …

Characterization Of The Swine Gut Microbiome Dynamics, Culturomics And Probiotics, Xiaofan Wang

Graduate Theses and Dissertations

The gastrointestinal tract is a critical place where the immune system concentrates many of its protective functions. It exerts both physical and biochemical defenses against invading foodborne pathogens and other hazards. In pigs, the gut microbiota community assembled postnatal plays a very important role in the development of multiple physiologic aspects, such as development of the gastrointestinal tract, nutrient exchange, immune defense against foreign pathogens and growth performance. Microbiome-host communication changes with age. Despite recent advances in understanding the swine gut microbiome at different growth stages, a comprehensive longitudinal study of the lifelong dynamics of the swine gut microbiome is …

A Comparison Of The Curricula Of The Top-Ranked Prelicensure Baccalaureate Nursing Programs In The United States, Silvia Imanda

Graduate Theses and Dissertations

What constitutes an ideal prelicensure nursing curriculum is not well understood. Specifically, what are the strategic curricular sequencing and curricular themes or focus might be included to contribute to producing high quality graduates? The purpose of this qualitative multiple case study investigation was to look at successful programs and identify effective curricular sequencing and curricular themes or focus that might be inferred to have contributed to producing high quality graduates. Seven top-ranked prelicensure baccalaureate nursing programs were selected based on three national college rankings services. Based on data from interviews and publicly accessible documents, seven case studies were compared and …

Development Of A Methodology For Predicting Consumer Acceptance And Preference Toward Beverages, Shilpa Shailesh Samant

Graduate Theses and Dissertations

Consumer behavior toward food/beverages is influenced by multisensory attribute perceptions as well as emotional experiences. Traditional methods of sensory testing lack the ability to capture emotional responses and as a result, measuring food/beverage-evoked emotions remains a research challenge. There were three objectives of this dissertation study. Firstly, this study aimed to develop prediction models of acceptance of and preference for basic taste solutions using sensory attribute intensities and emotional responses. Secondly, this study aimed to extend the findings of the first objective to develop prediction models of commercially-available vegetable juice products in terms of (a) acceptance and preference under blind-tasting …

Effects Of Serving Temperature On Sensory Perception And Acceptance Of Brewed Coffee, Matthew James Chapko

Graduate Theses and Dissertations

Coffee continues to be one of the most widely consumed beverages worldwide. How an individual perceives a cup of coffee is impacted by a plethora of factors including origin, growing climate, roasting level, and consumption habits. This thesis utilized both trained descriptive panelists and untrained consumer panelists to analyze how serving/consumption temperature modulates sensory perception of brewed coffee in regards to appearance, aroma, flavor, taste, and mouthfeel. Three varieties of coffee (Colombia, Ethiopia, and Kenya) were brewed and served to panelists at four temperatures: 70, 55, 40, and 25 °C. In one study (Study 1, Chapter 3), results from descriptive …

Determination Of The Effects Of Different Maillard Reaction Products On The Taxonomic Composition Of The Gut Microbiota, Nesreen Hamdan Aljahdali

Graduate Theses and Dissertations

The Maillard Reaction (MR) is a non-enzymatic chemical reaction which results in linkage between the amino group of amino acids and the carbonyl group of reduced sugars. This reaction generates Maillard reaction products (MRPs) which are not present naturally in foods, and are responsible for a range of colors, odors, flavors, and other sensory properties. Conflicting reports of MRPs impacts on human health are probably due to the fact that bioconversion of these digestible molecules by the gut microbiota has been marginally taken into account. This study aimed to determine the effects of different MRPs on rodent’s gut microbiota through16S …

Piglet Gut Microbiota Responses To Exposure To Outdoor Simulated Environment And Formula Feeding, Nguyen Vo

Graduate Theses and Dissertations

Several lines of evidence suggest that early-life gut microbiota composition is a crucial determinant of the susceptibility to diseases later in life. Understanding the evolution of early-life gut microbiota and critical factors that can modify this microbial community will espouse the prevention or reversion of health risk originating from dysbiosis of the gut microbiota in the early stage. In this research, we hypothesized that alterations in the environment (simulation of rural conditions by soil exposure) and feeding mode (breastmilk versus formula milk) will have significant impacts on the establishment of the gut microbiota in early life. At first, in literature …

The Effect Of Blinded Hydration State On Thermoregulation And Performance In Male Cyclists, Jon David Adams

Graduate Theses and Dissertations

Purpose: The purpose of these studies was to observe the effect of dehydration on exercise performance while subjects were blinded to their hydration status. Methods: Study 1: Seven male cyclists (weight: 71±8 kg, body fat: 14±6%, VO2peak: 59.4±6 ml∙kg-1·min-1) exercised for 2 hours on a cycle ergometer at 55% VO2peak, in a hot-dry environment (35°C, 30% rh), with a nasogastric (NG) tube under euhydrated (EUH-NT) and hypohydrated (DEH-NT) conditions. In both trials, thirst was matched by drinking 25 mL every 5 min. In the EUH-NT trial sweat losses were fully replaced via the NG tube. Following the 2 hours of …

A Numerical Study Of The Interaction Between One Dimensional Carbyne Chain And Single Stranded Dna, Zeina Salman

Graduate Theses and Dissertations

resolution at the single nucleotide level when developing DNA sequencers. The purpose of this research was to numerically study the electrical properties associated with the interaction between 1D carbon chain, known as carbyne, and ssDNA. First, the electrical properties of the carbyne chain were calculated. Second, the electrical properties of the carbyne chain were calculated in the presence of different ssDNA bases. Analyzing the differences between the two cases led to determining the effects of these different bases on the electrical properties. The numerical simulation approach conducted in this research was based on the first-principle simulation. The first-principle simulation was …

Gastrointestinal Health As A Stimulus For Native American Attraction To Medicinal Asteraceae And Further Implications For Human Evolution, Christopher David Stiegler

Graduate Theses and Dissertations

The Asteraceae, or the daisy family, is the largest family of flowering plants in the world, and its ethnobotanical, medical, and economic value is readily apparent cross-culturally. The aim of this thesis is to examine why constituent genera of the Aster family have remained such an integral part of human medicinal plant knowledge, and thereby to reveal any potential physiological, biological, or evolutionary mechanisms underlining human patterns of use regarding the Asteraceae. The present study focuses specifically on Native American plant knowledge made available by the expansive database in the works Daniel Moerman (Moerman 2003). Frequencies of plant use and …

Exploring The Production Of Extracellular Matrix By Astrocytes In Response To Mimetic Traumatic Brain Injury, Addison Walker

Graduate Theses and Dissertations

Following injury to the central nervous system, extracellular modulations are apparent at

the site of injury, often resulting in a glial scar. Astrocytes are mechanosensitive cells, which can create a neuroinhibitory extracellular environment in response to injury. The aim for this research was to gain a fundamental understanding of the affects a diffuse traumatic brain injury has on the astrocyte extracellular environment after injury. To accomplish this, a bioreactor culturing astrocytes in 3D constructs delivered 150G decelerations with 20% biaxial strain to mimic a traumatic brain injury. Experiments were designed to compare the potential effects of media type, number of …

The Influences Of Texture And Mastication Pattern On Flavor Perception Across The Lifespan, Curtis Robert Luckett

Graduate Theses and Dissertations

Texture is an often-overlooked food attribute and is known to influence other food characteristics. More specifically, texture has been repeatedly to influence how we perceive flavor. Several studies have linked this change in flavor perception to the altered mastication patterns that accompany texture changes. This dissertation is composed of four studies that were designed to address how American food consumers view texture and other food attributes as well as characterize how texture and mastication can influence temporal flavor dynamics. The first study was a survey that outlined consumer attitudes towards a variety of different foods. This study solidified that texture …

Cooling Effectiveness Of Modified Cold-Water Immersion Method Following Exercise-Induced Hyperthermia, Katherine Elizabeth Luhring

Graduate Theses and Dissertations

Context: Recommended treatment of exertional heat stroke (EHS) includes whole body cold-water immersion (CWI); however, remote locations, spatial or monetary restrictions challenge CWI feasibility. Thus, the development of a modified, portable CWI method would allow for optimal treatment of EHS when restrictions apply. Objective: Determine cooling efficacy of modified CWI (tarp assisted cooling with oscillation; TACO) following exertional hyperthermia. Design: Randomized, crossover controlled trial. Setting: Environmental chamber (33.4 ± 0.8°C, 55.7 ± 1.9% relative humidity). Patients or Other Participants: Sixteen (9 males, 7 females) volunteers (26 ± 4.7y, 1.76 ± 0.09m, 72.5 ± 9.0kg, 20.7 ± 7.1%body fat) with no …

Landscape Visibility And Prehistoric Artifact Distribution At Pea Ridge National Military Park, Jake Lee Mitchael

Graduate Theses and Dissertations

Pea Ridge National Military Park, in the north east corner of Benton County, Arkansas, is the 4,300 acre site of a crucial Civil War Battle. Human occupation of the Ozark Highland landscape, however, extends far into pre-history. A 2005 report to the National Park Service details the findings of a four year cultural resource survey of the park. The sampling strategy employed in the research design (random sample site selection and 2.5% park coverage) provides an excellent dataset to assess prehistoric land use. This dataset is not dependent on artificially defined sites, representing singular activity in a limited geographical space. …

Development Of A Heart Rate Variability Measurement System Using Embedded Electronics, Naresh Kumar Velmurugan

Graduate Theses and Dissertations

Recent advances in embedded electronics have a remarkable influence on the health care system. One of the most important applications is to monitor the health care of the patients at anytime and anyplace. In the last two decades, many researchers have focused mainly on heart rate variability (HRV) measurements. Patient's heart rate variability should be continuously monitored to help them in case of emergency. Under these circumstances, patients are required to have a HRV measuring kit for a constant observation.

The proposed project focuses on the development of a heart rate variability measurement system with the use of embedded electronics. …

Effects Of Breathing Cool Air During Cycling Exercise In The Heat, Christian B. Ridings

Graduate Theses and Dissertations

INTRODUCTION: The purpose of this study was to establish the ability of the Core Cooler device to prevent rises in physiological heat strain of trained male cyclists during cycling exercise in the heat. METHODS: 15 healthy male cyclists cycled at 50-70% VO2max for 75 minutes in a heat chamber of 31°C & 55% RH while breathing through the Core Cooler device under three different conditions: 1:4 ratio without ice termed control (CN), 1:4 ratio with ice termed low intermittent (LI), and at 1:1 ratio with ice termed high intermittent (HI). Data collected every 15 minutes assessing intestinal temperature (TGI), heart …

Stability Of Nano-Encapsulated Rice Bran Derived Bioactive Pentapeptide In Apple Juice, Fatima Mohammed Alessa

Graduate Theses and Dissertations

Cereal grains and their components derived Bioactive compounds such as rice bran can promote health and can be derived from Rice bran contains 12-20 % protein and could be a good source for extracting bioactive peptides. A pentapeptide with a secqunce of amino acids Glu-Gln-Arg-Pro-Arg (EQRPR) has been prepared from heat stablized defatted rice bran (HDRB) and has demonstrated anti-cancer proprerties in-vitro. This bioactive pentapeptide can thus be used as a nutraceutical by incorporating it into a suitable food system. Fruit juces can be vehicles to incorporate this pentapeptide. Fruit juices contribute to about 60% of the consumed beverages in …

Kirschner's Modal Ontological Argument, Andrew Kirschner

Graduate Theses and Dissertations

Ontological Arguments for the existence of God, first discovered by St. Anselm (1033-1109), attempt to deduce the existence of God from the concept of God. It is the aim of this thesis to champion a modal version of the Ontological Argument as philosophically sound by demonstrating it to be logically valid and by successfully defending the argument's premises as true. Kirschner's version of the Ontological Argument states:

P1 For every type of entity, instances of that type of entity either actually exist, merely possibly exist, or necessarily do not exist.

P2 If an entity can be conceived, then that entity …

Effects Of High-Velocity Versus Low-Velocity Resistance Training On Resting Metabolic Rate And Functional Performance In Older Adults, Laura Ashleigh Morgan

Graduate Theses and Dissertations

The purpose of this study was to compare the effects of a 12-week high-velocity resistance training (HVRT) protocol to a traditional low-velocity resistance training (LVRT) protocol on resting metabolic rate (RMR) and other selected measures of muscular and functional fitness in older adults. Nineteen adults between the ages of 65 and 82 participated: 8 HVRT, 7 LVRT, and 4 controls (CTRL). Initially, no differences existed between groups except for age (p = .016). HVRT (75.6 years) was older than LVRT (69.6 years) and CTRL (69.3 years). The exercise intervention consisted of 2 days/week sessions for 12 weeks at 3 sets …

Life History Variation Of Common Terns In The Gulf Of Maine, Jeffery Bryant Kimmons

Graduate Theses and Dissertations

Life history is the inheritable rules that determine energy and time allocation towards different competing functions in the energy budget of an organism. Reproductive effort varies as organisms make reproductive decisions based on available energy. Factors influencing life histories are those that change energy and time budgets such as diet, competition, and environmental conditions.

Common tern (Sterna hirundo) life history phenotypes vary between islands in the Gulf of Maine. Common terns on offshore islands (>10km from mainland) and nearshore islands (5 to 10km from mainland) lay smaller clutches, hatching chicks with slower growth rates than common terns …

A Reexamination Of The Eastern Collared Lizard (Crotaphytus Collaris Collaris) In Arkansas, Ashley A. Grimsley

Graduate Theses and Dissertations

Loss of suitable habitat is a threat to species worldwide. Habitat destruction, including loss, change, and fragmentation of habitat, is the leading cause of species extinction. Eastern collared lizards (Crotaphytus collaris collaris) are habitat specialists on glades. Both C. c. collaris and glade habitats are rare and of special concern in the state of Arkansas. Many glade populations have already been extirpated in the Ozarks of Arkansas and Missouri. Increasing knowledge of the distribution, habitat structure, and population dynamics of C. c. collaris is important to ensure the survival of this species in Arkansas.

A literature review of …

Molecular Genetic And Functional Analysis Of Aquaporins In Vitro And In Vivo, Sarah L. Zimmerman

Graduate Theses and Dissertations

No abstract provided.

Analysis Of Lung Protein Expression In Aqp5 Knockout And Il-13 Treated Asthmatic Mouse Models, Casey Alan Mcdonald

Graduate Theses and Dissertations

No abstract provided.