Digital Commons Network^™

Methodological Variations In Environmental Justice Screening Tools And Their Impact On Disadvantaged Community Designations, Thomas Robbins, Qingran Li, Stephen Bird

Faculty Publications

Government agencies in the United States have developed environmental justice screening tools (EJSTs) and designations to promote equitable distribution of benefits from environmental policies to disadvantaged communities (DACs). However, the methodological choices embedded in these tools, including the selection, weighting, and aggregation of environmental justice indicators, vary across EJSTs, and their implications for DAC designation outcomes are poorly understood. Here we systematically compare four EJSTs at the federal and state levels and show that these tools produce substantial variation in the DAC census tracts, with some tools emphasizing socioeconomic burdens while others prioritize environmental risks. Using quantitative regression models, we …

The Hope College Department Of Biology: The First 50+ Years, Christopher C. Barney

Faculty Publications

The Hope College Department of Biology was founded in 1899 with the appointment of the first Professor of Biology at Hope, Samuel Mast. During the first 50+ years of the Biology Department, there were eight total faculty members in the department, including Frances Koeman, the first female faculty member in the natural sciences. Four faculty members, Mast, Frank Patterson, Oscar Thompson, and Teunis Vergeer were primarily responsible for developing the department’s curriculum and programs, with Mast and Vergeer also carrying out published research. The department was housed primarily in Van Raalte Hall and the Science Building (now Lubbers Hall) for …

Don't Self-Opt Out Of Career Opportunities: Proceed With Confidence, Valerie Mendoza

Faculty Publications

While reflecting on your career in the past, have you ever stepped back from an opportunity that you wanted because you doubted yourself? In the workplace, confidence often gets mistaken for competence, and that means talented employees can be overlooked simply because they hesitate. The truth is that confidence isn’t something you’re born with. It’s a skill you can build. This session will get you started on building that skill.

We’ll explore practical strategies to strengthen your confidence starting today. We’ll also break down the key differences between how confident individuals act compared to those who aren’t, so you can …

Exploring Capacity For Future Sustainability Of Healthy Eating Policy, Systems, And Environmental Change Strategies Previously Implemented Through Snap-Ed Programming, Carrie L. Draper, Nicholas Younginer Ph.D.

Faculty Publications

Objective

Design

Setting

Participants

Phenomenon of Interest

Analysis

Results

Systematic Reviews Across Disciplines: Comparing Quality And Publication Practices, Megan Bresnahan, Eugenia Opuda

Faculty Publications

As the publication of systematic reviews has proliferated across the sciences in the past decade, librarians have a role in helping researchers select the appropriate type of review, providing best practice guidelines, and under-standing variations in disciplinary practices for evidence synthesis. Using a title-abstract search filtered by 10 research areas in the Web of Science, we collected a sample of 100 systematic reviews from a range of disciplines, including “Fisheries,” “Forestry,” “Health Care Sciences & Services,” and “Veterinary Sciences.” Our analysis of this data explores to what extent these articles include the basic components of a systematic review and adhere …

Wrky Transcription Factors: Integral Regulators Of Defence Responses To Biotic Stress In Crops, Dongjiao Wang, Ruize Zhang, Wenhui Zou, Yuanyuan Zhang, Wanying Zhao, Tingting Sun, Qibin Wu, Zheng Qing Fu, Youxiong Que

Faculty Publications

Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens and insect pests, which cause substantial yield and quality losses worldwide. WRKY transcription factors constitute a plant-specific and functionally diverse family that is central to immune regulation. Recent advances in genomic resources and multi-omics approaches have accelerated the identification and functional characterisation of WRKYs in crops. This review summarises the structural features and classification of WRKY genes and their genome-wide distribution across crop species. It also synthesises WRKY-centred regulatory modules that mediate resistance to major classes of biotic stress. In antifungal defence, WRKYs reinforce pattern- and effector-triggered …

Changes In Depression, Eating, Sleep, And Emotion Regulation In Air Force Rotc Cadets After The 12-Wk Star Training Program, Antonella V. Schwarz, Hunter Haynes, Sheena Puleali’I, Jacob Mota, Molly F. Johnson, Maria G. Kaylor, Andrew Addison, Robyn Braun-Trocchio, Austin J. Graybeal

Faculty Publications

Introduction: – Reserve Officer Training Corps (ROTC) cadets must balance collegiate demands with military preparation, leaving them vulnerable to psychological stressors. While structured strength and conditioning (S&C) programs enhance physical readiness, their impact on psychological health in cadet populations remains unclear. This study evaluated changes in depression, eating behaviors, sleep quality, and emotion regulation during a 12-wk S&C program. Methods: – Forty-nine U.S. Air Force ROTC cadets (21 female, 28 male; age: 20 ± 2 yr; body mass index: 24.2 ± 4.4 kg·m⁻²; body fat %: 27.1 ± 9.0%) completed the Supporting Tactical Athlete Readiness (STAR) program, a …

Psychosocial Mediators Of A Physical Activity And Dietary Intervention In Pregnant Women With Overweight Or Obesity, Meghan Baruth, Sarah Wilcox, Jihong Liu, Rebecca Schlaff

Faculty Publications

Background

Mediation analyses provide insight into both ‘pieces’ of the mediation chain; they allow us to look into the ‘black box’ that is behavior change. They allow researchers to better understand the ‘how’ of an intervention’s effects and/or the ‘why’ behind why an intervention worked or did not work. The lack of publications in pregnant populations highlights the need for additional studies to be conducted and published. The purpose of this study is to examine the psychosocial mediators of physical activity and dietary outcomes in a sample of pregnant women with overweight or obesity participating in the Health in Pregnancy …

Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese Ph.D., Jiajia Zhang Ph.D., Elizabeth Angela Murphy, Susan E. Steck Phd, Mph, Rd

Faculty Publications

Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …

Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese, Jiajia Zhang, Elizabeth Angela Murphy, Susan E. Steck

Faculty Publications

Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …

A Livelihood Intervention Improved Nutritional, Mental Health And Sexual Health Outcomes Among Hiv-Affected Adolescents In Western Kenya: Results From The Shamba Maisha Randomised Controlled Trial, Sheri D. Weiser, Lila Aziz Sheira, Pauline Wekesa, Jennifer Monroe Zakaras, Edward A. Frongillo Jr. Ph.D., Elly Weke, Jason M. Nagata, Amy A. Conroy, Marguerita Lightfoot, Torsten B. Neilands, Lisa M. Butler, Elizabeth A. Bukusi, Craig R. Cohen, Maricianah Atieno Onono

Faculty Publications

Introduction Interventions that address household-level factors, including food insecurity (FI) and poverty, may reduce HIV risk and improve sexual and reproductive health (SRH) among adolescent girls and young women (AGYW).

Methods This cluster randomised controlled trial in Kenya assessed AGYW living in households of adults enrolled in Shamba Maisha (SM). SM was a multisectoral agricultural livelihood intervention designed to improve HIV health. At the trial end, we used linear and logistic regressions to compare differences between the intervention and control arms in FI, and mental health among AGYW-caregiver pairs and SRH outcomes among the AGYW, accounting for clusters with robust …

Predictors Of Employment Attrition In Lebanon During Multifaceted Crises: The Role Of Chronic Diseases – A National Cross-Sectional Study, Myriam Dagher, Ali Abboud, Ghada E. Saad, Rita Itani, Rindala Fayyad, Hala Ghattas Ph.D., Stephen J. Mccall, Jocelyn Dejong, Malak Ghezzawi, Nisreen Salti, Sasha Fahme, Serena Canaan

Faculty Publications

The COVID-19 pandemic and Lebanon’s ongoing economic crisis exacerbated existing workforce and health disparities. This study explored the predictors of employment attrition during Lebanon’s concurrent crises and examined the association between chronic conditions and employment attrition. This cross-sectional study recruited adults aged 19–64 years residing in Lebanon through random digit dialing (January – July 2024). Data collected included socio-demographics, household characteristics, employment history and characteristics, and self-reported chronic conditions. The outcome was loss of paid employment (employment attrition) during the crises. Predictors were identified through a Least Absolute Shrinkage and Selection Operator (LASSO) regression, and model discrimination and calibration were …

Dietary Inflammatory Index And Objective Disease Activity In Ibd: No Association Found, Rúbia Moresi Vianna De Oliveira, Ana Carolina Junqueira Vasques, Stefhani Andrioli Romero, Nitin Shivappa Mbbs, Mph, Ph.D., Michael David Wirth, James Hébert Scd, Glaucia Fernanda Soares Ruppert Reis, Cristiane Kibune Nagasako

Faculty Publications

Background

Inflammatory Bowel Disease (IBD) involves genetic and environmental factors, but the relationship between disease activity, adiposity, and diet remains unclear.

Objective

To investigate the association between endoscopic/radiological activity of IBD, body adiposity, and the Dietary Inflammatory Index with or without adjustment for energy density (E-DII or DII).

Method

An observational, cross-sectional study was carried out. Endoscopic activity was defined by an endoscopic Mayo score >2, Crohn’s Disease Endoscopic Index of Severity (CDEIS) > 5, and/or the presence of a deep ulcer in any intestinal segment. Body adiposity was estimated using the body mass index, waist circumference, and waist-hip ratio (WHR). …

Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Of Multiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qin Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Et. Al.

Faculty Publications

No abstract provided.

Comprehensive, Multidisciplinary Care For Fragile X-Associated Tremor/Ataxia Syndrome, James A. Bourgeois, Andrea Schneider, Jessica Klusek Ph.D., Ccc-Slp, Thomas R. Christensen, Ellie Levin, Kendall Gardner, Ariel A. Jacobi, Randy J. Hagerman

Faculty Publications

Objective: 

The authors reviewed the pathophysiology, clinical genetics, phenotype, and comprehensive clinical management of Fragile X-associated Tremor/Ataxia Syndrome (FXTAS), a neurodegenerative disorder affecting FMR1 premutation carriers (55–200 CCG repeats).

Participants: 

A multispecialty and multidisciplinary team of authors with backgrounds in psychiatry, pediatrics, clinical psychology, speech and language pathology, and neurosciences.

Evidence: 

Review of English language sources on the clinical phenomenology, genetics, pathophysiology, and clinical management of FXTAS from 2001 (the original report) through 2025, with emphasis on the general medical, psychiatric, and neurological features of FXTAS and its multispecialty and multidisciplinary clinical management.

Consensus process:

All authors contributed to the …

Primary School Physical Activity Culture In The Uk: Findings From A Four-Month Rapid Ethnography In Three Schools, Robert Walker, Lydia Emm-Collison, Danielle House, Simoona Kent-Saisch, Ruth Salway, Alice Porter, Abi Howard, Tom Reid, Michael Beets Med, Mph, Phd, Frank De Vocht, Russell Jago

Faculty Publications

Introduction: Physical activity is fundamental for children’s health and well-being, yet most children are not active enough. School-based interventions aiming to increase children’s physical activity have largely been ineffective, perhaps due to a lack of consideration of the unique culture within each school. The aim of this paper is to understand the key aspects of physical activity culture in English primary schools using the organizational culture framework.

Methods: A four-month rapid ethnography study was conducted within three primary schools in Bristol, UK, between March and July 2024. The findings draw on observations, interviews, documentary data, photo elicitation, informal conversations and …

Text Messages To Improve Young Child Diets: Results From A Cluster-Randomized Controlled Trial In Kanchanpur, Nepal, Kenda Cunningham, Sidney Cech, Aman Sen Gupta, Pooja Pandey Rana, Debbie Humphries, Edward A. Frongillo Jr. Ph.D.

Faculty Publications

The objective of this study was to test whether adding a text message campaign about the importance of eating eggs and other nutrition-related behaviours to an on-going package of large-scale, diverse social and behaviour change interventions would improve four types of nutrition-related knowledge and behaviour outcomes: child diets (egg consumption as the primary outcome), maternal diets, maternal nutrition knowledge, and maternal participation in additional interventions. The cluster-randomized controlled trial involved a repeat cross-sectional design, recruiting families with children 12–23 months of age at baseline and endline in one plains district of Nepal. Throughout the 1000-day period, 51 text messages were …

Impact Of Suaahara, An At-Scale Multisectoral Nutrition Programme, On Health Workers’ Maternal And Child Health, And Nutrition Knowledge And Skills In Nepal, Deependra K. Thapa, Edward A. Frongillo Jr. Ph.D., Shalini Suresh, Ramesh P. Adhikari, Bhim Pun, Karuna L. Shakya, Raj Mandal, Subir K. Kole, Kenda Cunningham

Faculty Publications

Suaahara, an at-scale multisectoral nutrition programme in Nepal, aimed to advance knowledge and skills of frontline health workers to improve the quality of nutrition and health services at health facility and community levels. This study assessed the impact of Suaahara interventions on knowledge and skills of health facility workers and Female Community Health Volunteers (FCHVs). The study used a quasi-experimental design in which four Suaahara intervention districts were compared with pair-matched comparison districts. One health facility worker and three FCHVs from each survey cluster were included. Baseline survey consisted of 93 health facility workers (2015) and 118 FCHVs (2012), and …

Impact Of Suaahara, An Integrated Nutrition Programme, On Maternal And Child Nutrition At Scale In Nepal, Edward A. Frongillo Jr. Ph.D., Shalini Suresh, Deependra K. Thapa, Kenda Cunningham, Pooja Pandey Rana, Ramesh P. Adhikari, Subir Kole, Bhim Pun, Indra Kshetri, Debendra P. Adhikari, Rolf Klemm

Faculty Publications

Suaahara was an innovative, complex, multi-sectoral, large-scale, nutrition programme in Nepal to increase exposure to nutrition-related information and services, improve nutrition-related knowledge and practices among pregnant women and mothers of infants and young children, and improve their nutrition. This study evaluated the effectiveness of Suaahara to improve nutrition and nutrition-related practices by comparing changes over 10 years between intervention and comparison districts. The samples of households at baseline in 2012 and endline in 2022 were 2040 and 2480, respectively, from 120 old wards. The impact was estimated using intent-to-treat regression models in which survey year, arm and their interaction were …

Exposure To Suaahara Ii Interventions And Knowledge Of Maternal And Child Nutrition And Health Among Mothers, Grandmothers, And Male Household Heads: An Association Study In Nepal, Shalini Suresh, Edward A. Frongillo Jr. Ph.D., Deependra K. Thapa, Ramesh P. Adhikari, Subir K. Kole, Femila Sapkota, Manisha Laxmi Shrestha, Kristine Garn, Pooja Rana Pandey, Indra Kshetri, Dipak Sharma, Kenda Cunningham

Faculty Publications

Suaahara was a USAID-funded multi-sectoral integrated nutrition program that aimed to improve the nutritional status of children under the age of five and their mothers in Nepal. The program included multiple interventions targeted to mothers and children, as well as other caregivers. Caregiver knowledge of optimal nutrition and health practices among household members is an important driver of healthy child and maternal nutrition behaviors. This study investigates the associations between exposure to Suaahara interventions and knowledge of maternal and child nutrition and health practices among mothers (n =, grandmothers (n =, and male household heads (n =. Linear and logistic …

Using The Misinformation Exposure-Trust Framework For Audience Segmentation: Predicting Covid-19 Vaccine Hesitancy Among U.S., Jing Zeng, Jinxu Li, Nan Yu, Xi Cui, Anli Xiao Ph.D.

Faculty Publications

This study examines whether individuals’ exposure to and trust in COVID-19 vaccine misinformation can be used to segment audiences and explain variations in vaccine hesitancy and health beliefs. Using k-means clustering, a survey of 819 U.S. college students (March–May 2021) identifies four subgroups based on combinations of high or low misinformation exposure and trust: misinformation-shielded (low exposure, low trust), misinformation-vulnerable (low exposure, high trust), misinformation-resistant (high exposure, low trust), and misinformation-accepting (high exposure, high trust). These subgroups differ significantly in political ideology, vaccine hesitancy, and health beliefs. The misinformation-shielded subgroup reports more liberal views, lower hesitancy, and higher perceived efficacy, …

Exosome Engineering For Blocking Gut Dysbiosis And Inducing Cell Death Mechanisms In Glioblastoma Multiforme, Ahalya Muraleedharan, Karthik Rangavajhula, Swapan K. Ray

Faculty Publications

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor in adults. Emerging evidence endorses that gut dysbiosis contributes to GBM progression through the gut–brain axis (GBA), promoting inflammation and therapeutic resistance via abnormal short-chain fatty acid production and cytokine dysregulation. Exosomes, naturally occurring nanovesicles (30–150 nm), offer promising therapeutic potential due to their blood–brain barrier permeability, biocompatibility, and versatile cargo capacity. This review examines exosome engineering strategies for dual targeting: inhibiting alterations in gut microbiome and inducing regulated cell death mechanisms such as apoptosis and ferroptosis in GBM. We describe exosome engineering with detailed focus on cargo loading approaches …

Association Between Dietary Folate And Prostate Cancer Aggressiveness Among African Americans And European Americans, Lihchyun Joseph Su, Sarah O'Connor, Daniela Ramirez Aguilar, Minjae Lee, Harrison Wong, Hui-Yi Lin, Jeannette T. Bensen, James L. Mohler, Lenore Arab, Longgang Zhao, Ebonee N. Butler, Laura Farnan, Susan E. Steck Phd, Mph, Rd

Faculty Publications

Background: Despite the confirmed beneficial effects on preventing neural tube defects, concerns about high intakes of synthetic folate, or folic acid, in promoting cancer progression have been raised. This study evaluated the association between folate intake and prostate cancer (PCa) aggressiveness among African-American (AA) and European-American (EA) males. Methods: This study included 722 AA and 775 EA men with prostate cancer. Folate intake (dietary folate equivalent (DFE), synthetic folate, natural folate) was estimated using the National Cancer Institute Dietary History Questionnaire and detailed dietary supplement use questionnaire. Analyses included univariable comparisons of demographic and clinical characteristics of the two racial …

Examining The Impact Of Young Children’S Motor Development On Inhibitory Control And Social Skills, Ali S. Brian, Shea E. Ferguson, Angie Starrett, Emily Kallis, J. Ross Ramsey

Faculty Publications

Background/Objectives: Understanding how motor and cognitive development may contribute to prosocial behavior is essential for supporting whole-child development in early learning settings. Early childhood education settings are well-positioned to address these concerns through integrated approaches that support the whole child. Research exploring the mechanisms that link developmental domains remains limited, especially regarding how motor development may influence social outcomes through cognitive processes such as inhibitory control. Thus, the purpose of this study was to examine whether gains in motor skills were associated with prosocial behaviors indirectly through improvements in inhibitory control. Methods: Preschoolers (N = 238; Mage = 66.61, SD …

Examining The Impact Of Young Children’S Motor Development On Inhibitory Control And Social Skills, Ali S. Brian Ph.D., Shea E. Ferguson, Angie Starrett Ph.D., Emily Kallis, J. Ross Ramsey

Faculty Publications

Background/Objectives: Understanding how motor and cognitive development may contribute to prosocial behavior is essential for supporting whole-child development in early learning settings. Early childhood education settings are well-positioned to address these concerns through integrated approaches that support the whole child. Research exploring the mechanisms that link developmental domains remains limited, especially regarding how motor development may influence social outcomes through cognitive processes such as inhibitory control. Thus, the purpose of this study was to examine whether gains in motor skills were associated with prosocial behaviors indirectly through improvements in inhibitory control. Methods: Preschoolers (N = 238; Mage = 66.61, SD …

Supplementary Table 2. Colostrum Fatty Acid Content (%) For Cows Supplemented –40 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid Or –80 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid For 28 D Prepartum, Tess Stahl, J. Kraft, Sarah Allen, Peter S. Erickson

Faculty Publications

No abstract provided.

Supplementary Table 1. Fatty Acid Methyl Esters (% Of Colostrum) For Cows Supplemented –40 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid Or –80 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid For 28 D Prepartum, Tess Stahl, J. Kraft, Sarah Allen, Peter S. Erickson

Faculty Publications

No abstract provided.

Trends In Self-Reported Responses To Nutrition Facts Labels Before And After Nutrition Labeling Policy Implementation: A Comparison Of Adults In The United States And Mexico, Jim Thrasher Ph.D., Ma, Ms, Victor Vilalobos, Dai Fang, Alejandra Jáuregui, Alejandra Contreras-Manzano, Rachel Davis Ph.D., Lana Vanderlee, Christine M. White, Rachel B. Acton, James W. Hardin, Edward A. Frongillo Jr. Ph.D., Simón Barquera, David Hammond

Faculty Publications

Background

Objectives

Methods

Survival On Image Regression With Application To Partially Functional Distributional Representation Of Physical Activity, Rahul Ghosal, Sunwoo Emma Cho, Marcos Matabuena

Faculty Publications

Technological advancements in wearable devices and medical imaging often lead to high-dimensional physiological signals in the form of images or surfaces. To address these data structures, we develop a novel survival on image regression model with a specific focus on partially functional distributional representation of wearable data. The existing approaches for functional data and survival outcomes have been primarily developed for uni-dimensional functional predictors. Drawing on recent developments in distributional data analysis, we model temporally varying distributional patterns of physical activity (PA) as a partially functional distributional predictor within a semiparametric Cox model framework. We use tensor product splines to …

International Society Of Sports Nutrition Position Stand: Effects Of Dietary Antioxidants On Exercise And Sports Performance, Drew E. Gonzalez, Broderick L. Dickerson, Brandon M. Roberts, Jennifer A. Kurtz, Adam M. Gonzalez, Matthew J. Mcallister, Jeffrey L. Heileson, Richard J. Bloomer, Shawn M. Arent, Darren G. Candow, Jeffrey R. Stout, Karen A. Hecht, Bill Campbell, Chad M. Kerksick, Douglas Kalman, Jose Antoino, Richard B. Kreider

Faculty Publications

Following a comprehensive review, the International Society of Sports Nutrition (ISSN) has developed an official position on the role of dietary antioxidants in exercise and sport. Antioxidants play a complex, context-dependent role in vivo; they can facilitate recovery from exercise but may also hinder training adaptations when consumed at supraphysiological doses. While endogenous antioxidant systems can effectively maintain redox balance, dietary sources, particularly whole foods, can help mitigate excessive oxidative stress following intense/heavy training or inadequate recovery. The influence of dietary antioxidants depend on timing, dosage, type, and individual factors. The ISSN’s official position encompasses the following: (1) Redox balance …