Digital Commons Network^™

Stimulated Hyposalivary Flow Rates In Healthcare Students In An Interprofessional Awareness Educational Program Curriculum, R Constance Wiener

Faculty & Staff Scholarship

Purpose. Hyposalivation influences quality of life and medication compliance. However, oral health knowledge (in general) and knowledge about hyposalivation (in particular) are often lacking in nondental healthcare professional’s curricula. Additionally, hyposalivation has not been adequately studied in young adults. The purpose for this study is twofold: to use an interprofessional educational curriculum to increase nondental healthcare students’ knowledge about oral health and salivary testing and determine whether hyposalivation is different between sexes in young adults. Method. First-year medical and pharmacy students () learned the process of saliva collection and provided samples in an interprofessional program. Results. There were 14.4% of …

Orthodontic Treatment Completion And Discontinuation In A Rural Sample From North Central Appalachia In The Usa, Chris A. Martin, Breana M. Dieringer, Daniel W. Mcneil

Faculty & Staff Scholarship

Background: Orthodontics has inherent demands, requiring regular appointments and active patient engagement, but relatively little is established in regard to rates of completion of treatment and possible factors affecting successful completion. These factors may be particularly important for cultural minority groups, such as those in rural Appalachia, given the environmental, social, and economic complexities affecting access to and utilization of treatment.

Design and methods: A naturalistic study design was employed, using retrospective data from a rural outpatient general dental office in July 2012. Chart abstraction yielded 219 (55.3% female) orthodontic patients (M age = 11.0 [3.7]). Chi-square tests for independence …

Researchmedical And Pharmacy Students’ Attitudes Towards Physician-Pharmacist Collaboration In Kuwait, Maram G. Katoue, Abdelmoneim I. Awad, Aishah Al-Jarallah, Ebaa Al-Oazairi, Terry L. Schwinghammer

Faculty & Staff Scholarship

Objective : To assess and compare the attitudes of medical and pharmacy students towards physician - pharmacist collaboration and explore their opinions about the barriers to collaborative practice in Kuwait. Methods : A cross - sectional survey of p harmacy and medical students (n=467) was conducted in Faculties of Medicine and Pharmacy, Kuwait University. Data were collected via self - administered questionnaire from first - year pharmacy and medical students and students in the last two professional yea rs of the pharmacy and medical programs. Descriptive and comparative analyses were performed using SPSS, version 22. Statistical significance was accepted at …

The Role Of Laminins In Cartilaginous Tissues: From Development To Regeneration, Y Sun, T L. Wang, W S. Toh, M Pei

Faculty & Staff Scholarship

As a key molecule of extracellular matrix, laminin provides a delicate microenvironment for cell functions. Recent findings suggest that laminins expressed by cartilage-forming cells (chondrocytes, progenitor cells and stem cells) could promote chondrogenesis. However, few papers outline the effect of laminins on providing a favorable matrix microenvironment for cartilage regeneration. In this review, we delineated the expression of laminins in hyaline cartilage, fibrocartilage and cartilage-like tissue (nucleus pulposus) throughout several developmental stages. We also examined the effect of laminins on the biological activities of chondrocytes, including adhesion, migration and survival. Furthermore, we scrutinized the potential influence of various laminin isoforms …

Genetic Association Of Mmp10, Mmp14, And Mmp16 With Dental Caries, D D. Lewis, J R. Shaffer, E Feingold, M Cooper, M M. Vanyukov, B S. Maher, R L. Slayton, M C. Willing, S E. Reis, D W. Mcneil, R J. Weyant, A R. Vieira, M L. Marazita

Faculty & Staff Scholarship

Matrix metalloproteinases (MMPs), which degrade extracellular proteins as part of a variety of physiological processes, and their inhibitors have been implicated in the dental caries process. Here we investigated 28 genetic variants spanning the MMP10, MMP14, and MMP16 genes to detect association with dental caries experience in 13 age- and race-stratified () samples from 6 parent studies. Analyses were performed separately for each sample, and results were combined across samples by meta-analysis. Two SNPs (rs2046315 and rs10429371) upstream of MMP16 were significantly associated with caries in an individual sample of white adults and via meta-analysis across 8 adult samples after …

A Preliminary Genome-Wide Association Study Of Pain-Related Fear: Implications For Orofacial Pain, Cameron L. Randall, Casey D. Wright, Jonathan M. Chernus, Daniel W. Mcneil, Eleanor Feingold, Richard J. Crout, Katherine Neiswanger, Robert J. Weyant, John R. Shaffer, Mary L. Marazita

Faculty & Staff Scholarship

Background. Acute and chronic orofacial pain can significantly impact overall health and functioning. Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive components of fear of pain have been elucidated. Little is known, however, regarding the specific genes contributing to fear of pain. Methods. A genome-wide association study (GWAS; ) was performed to identify plausible genes that may predispose individuals to various levels of fear of pain. The total score and three subscales (fear of minor, severe, and medical/dental pain) of the Fear of Pain Questionnaire-9 (FPQ-9) were modeled in a …

Periodontal Status And Quality Of Life: Impact Of Fear Of Pain And Dental Fear, Casey D. Wright, Daniel W. Mcneil, Cierra B. Edwards, Richard J. Crout, Katherine Neiswanger, John R. Shaffer, Mary L. Marzita

Faculty & Staff Scholarship

Background. Oral health-related quality of life (OHRQoL) is impacted by periodontal disease and orofacial pain. There is a limited research examining the impact of avoidance of care or physiological arousal related to the fear of pain response on periodontal-related OHRQoL. Methods. Data are from the Center for Oral Health Research in Appalachia family-based study focusing on 1,339 adults. Measures included a modified Periodontal Screening and Recording Index across sextants of dentition, dental fear survey, Fear of Pain Questionnaire-9, and Oral Health Impact Profile-14. Structural equation modeling was used to estimate the effects of periodontal disease screening indicators on OHRQoL including …

Influence Of Fear Of Pain And Coping Strategies On Health-Related Quality Of Life And Patient-Anticipated Outcomes In Patients With Chronic Pain: Cross-Sectional Study Protocol, Manasi M. Mittinty, David S. Brennan, Cameron L. Randall, Daniel W. Mcneil, Murthy N. Mittinty, Lisa Jameson

Faculty & Staff Scholarship

Background: Fear of pain and coping strategies are emotional-behavioral responses to pain and are known to play an important role in the development and maintenance of pain. It is highly likely that fear of pain and coping strategies influence each other, potentially affecting the course of chronic pain. To our knowledge, the relationship between pain, fear of pain and coping strategies, and how they influence patient-anticipated outcomes and health-related quality of life, have not been investigated.

Objective: The aims of this study are to test (1) if both fear of pain and/or coping strategies are sufficient causes for maintaining pain; …