Digital Commons Network^™

Weathering The Divide: Social Determinants, Neighborhood Context, And Systemic Lupus Erythematosus Among African American Women, Vanessa Cl Morman

Electronic Theses and Dissertations

Background: Systemic lupus erythematosus (SLE) disproportionately affects African American women and contributes to racial health disparities in the United States. Although genetic susceptibility influences disease risk, growing evidence suggests that social determinants of health (SDOH), including neighborhood conditions, structural racism, and socioeconomic disadvantage, contribute to disease development and progression. Epigenetic mechanisms may provide a biological pathway linking adverse social conditions to chronic disease disparities. This dissertation examined the influence of SDOH on SLE disparities through evidence synthesis and empirical investigation to inform public health practice and policy.

Methods: This integrated learning experience consisted of three complementary manuscripts. Aim 1 was …

Leveraging Mammal Mycophagy To Determine Environmental Drivers Of Truffle Diversity, Brittany Hartsock

Electronic Theses and Dissertations

Many mycorrhizal fungi are hypogeous (truffle-forming), producing underground fruiting bodies. Studying truffles is inherently challenging due to their hidden nature. However, mycophagous mammals provide a unique opportunity to study hypogeous fungi because they rely on truffles as a food source. Although several truffle species have recently been described in the southern Appalachian region, their fruiting patterns remain poorly understood. To address this, we quantified truffle richness and spore loads from 670 Peromyscus scat samples collected across 42 sites spanning an environmental gradient during 2024 in the Blue Ridge Mountains of East Tennessee. We found that truffle richness and spore abundance …

Enterococcus Abundance, Distribution, And Environmental Controls At A Sandy Shoreline, South Carolina, Usa, Helen Kehoe

Electronic Theses and Dissertations

Water quality monitoring crucially protects the health of beachgoers around the world. However, water-adjacent sediments, such as sandy beaches, are known to harbor harmful bacteria, yet are not monitored despite their intensive recreational use. This project monitored the abundance of fecal indicator bacteria (FIB), specifically Enterococci, in sandy beach sediments at beaches routinely monitored for water quality in Myrtle Beach and North Myrtle Beach, South Carolina. Surface sediment core sampling (0-5 cm) in the swash zone was conducted once per month for 4 months at 24 beaches in tandem with state-accredited surf-water FIB monitoring using IDEXX’s Enterolert test (Standard Method …

Spatial Variation In Resource Use And Species-Level Trophic Niches Of White And Brown Shrimp In North Inlet–Winyah Bay, South Carolina, Josie Bryan

Electronic Theses and Dissertations

Atlantic white (Penaeus setiferus) and brown shrimp (Penaeus aztecus) are ecologically and economically important species in the southeastern United States, supporting coastal food webs and valuable commercial fisheries. To understand their trophic dynamics in the North Inlet-Winyah Bay estuary, we conducted a spatial and temporal analysis using carbon (δ¹³C), nitrogen (δ¹⁵N), and sulfur (δ³⁴S) stable isotopes to evaluate trophic position and basal source contributions across three habitat types (river, bay, and marsh). Linear models were used to evaluate the effects of size (rostrum–carapace length, RCL, in mm), habitat, and species on trophic position, as well as the effects of habitat …

Presence And Impact Of Herbicides On Intertidal Benthic Communities, Marco Sanderson

Electronic Theses and Dissertations

The growing reliance and widespread use of herbicides on a global scale is negatively affecting non-targeted biota and, consequently, their ecosystems. Herbicide levels and their impacts have been extensively researched around the world in riverine and lacustrine ecosystems. However, studies of the levels and effects of herbicides on coastal intertidal benthic communities have been lacking. This study focused on testing spectrophotometric methodologies for herbicides (atrazine and glyphosate) and documenting their presence and levels in sediment, water, and biotic tissue of intertidal coastal beaches and marshes of Waties Island and Singleton Swash, Horry County, South Carolina. A laboratory microcosm was employed …

Trophic Ecology Of A South Carolina Estuarine Predator Guild, Shane John Molander

Electronic Theses and Dissertations

Estuaries are among the world’s most productive ecosystems in the world and are characterized by the convergence of two distinct habitats, creating a mosaic of environmental conditions from inland rivers to the nearshore ocean. Many fishes occupy estuaries during various life stages for growth, reproduction, or foraging, and may reside in them seasonally. The co-occurrence of species, particularly upper-trophic level carnivores, can result in competitive interactions for prey resources within a shared environment. Identifying the degree of these interactions as well as understanding basal energy consumption can inform food web dynamics and how overlapping species use shared spaces. I used …

Compact 1 Ghz Electron Paramagnetic Resonance Spectrometers For Preclinical Imaging Studies, Tanden A. Hovey

Electronic Theses and Dissertations

Magnetic resonance is one of the most generally useful scientific techniques. New horizons of understanding are revealed as technological advances make possible explorations of nuclear spins and electron spins at higher and lower magnetic fields and electromagnetic frequencies. While the greatest current effort is on ever higher magnetic fields and microwave frequencies, both in nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR), the Eaton lab focusses on developing high signal-to-noise performance EPR at low microwave frequencies. EPR provides information about O2, pH, viscosity, glutathione concentrations, and reactive oxygen species in living organisms that MRI cannot. To yield clinically or …

Unmaking Crane Hall: Institutional Change And The Politics Of Exhibit Closures At The Denver Museum Of Nature And Science, Abigail Genene Duff

Electronic Theses and Dissertations

This thesis examines the June 2023 closure of the North American Indian Cultures Hall (NAICH) at the Denver Museum of Nature and Science (DMNS) as a critical moment of institutional transformation. Through a case study approach grounded in archival research, interviews, surveys, and discourse analysis of social media posts and public commentary, this project investigates how exhibit closures reflect shifting dynamics of curatorial authority, Indigenous representation, and settler colonial structures. Guided by theoretical frameworks of settler colonial theory, desire-based research, institutional critique, and museum anthropology, this study explores how internal museum politics, community opinion, and public narratives reshape accountability and …

Initial Pilot Test Of A Single-Session Social Support Program For Increasing Social Approach Behavior And Social Support In Emerging Adults, Emily L. Jones

Electronic Theses and Dissertations

Emerging adulthood, the developmental stage between adolescence and young adulthood (Arnett, 2000), is marked by increases in autonomy, changes in social dynamics, and identity exploration (Arnett, 2015). During this stage, social stressors may trigger or exacerbate preexisting mental health problems (Slavich & Auerbach, 2018), though few emerging adults seek or receive mental health support (Zhao et al., 2025). Single-session interventions, or “specific, structured programs that intentionally involve just one visit or encounter” (Schleider et al., 2019), may present an opportunity to provide some support to those who face barriers to participation in traditional forms of treatment (Janota et al., 2022). …

Asian American Men's Experiences Of Gendered Racism In Online Competitive Gaming, Calvin Weiting Lee

Electronic Theses and Dissertations

In the U.S., Asian Americans men make up a large portion of active players in online competitive video games. In these settings, harassment, racism, and hate speech are prevalent and often normalized. The purpose of this study was to explore Asian American men’s experiences of gendered racism in online competitive gaming spaces. Using an Interpretative Phenomenological Analysis approach (Smith, Flowers, & Larkin, 2022) and applying the Intersectionality Framework (Crenshaw, 1989; Collins, 2000), six Asian American men were interviewed about their experiences of gendered racism while playing online competitive games. Two Group Experiential Themes emerged from their accounts: 1) Gendered racism …

Mystical Revelation And Knowledge Of God: Reclaiming Spirituality In Theology Through The Mystics, Elizabeth A. Merski

Electronic Theses and Dissertations

Since the scholastic era, the pursuit of God has occurred preeminently through reason, leading to an imbalanced theology of God that persists to the present day in the form of intellect-centered theology. As a resolution, this work proposes that the mobilization of private, mystical revelation as a source of legitimized theological knowledge of God has the potential to close the existent epistemological gap between reason/belief and theology/spirituality, demonstrating the integral unity between authentic knowledge of God and the receiver’s personal acceptance of God in faith. After examining the required methodological components for the discipline of theology and identifying criteria for …

"Help Me Live It The Way You Do": Grounding Singaporean Responses To The Rorschach Situation, Casey Y. Lee

Electronic Theses and Dissertations

Contemporary research on the Rorschach and culture is striking for the latter’s disappearance as a variable of significance (Meyer et al., 2015; Meyer et al., 2007; Mihura et al., 2013; Viglione & Hilsenroth, 2001). This erasure is chronicled and reproduced in the narratives of universal objectivity, of extensive international meta-analyses, of replications, of standardized norms (Ritzler, 2004; Smith et al., 2018; Smith et al., 2020; Weiner, 2004). A different story emerges, however, when we ask, how has culture disappeared? The proposed study is a multimethod qualitative analysis of Singaporean responses to the Rorschach, aimed at generating sensitive yet critical discourses …

Development Of Minimalist Trifunctional Building Blocks For Chemical Biology Probe Synthesis, Luke E. Bohrer

Electronic Theses and Dissertations

The completion of the Human Genome Project in 2003 generated expectations that genomic information would accelerate the discovery of new protein drug targets and FDA-approved therapies. However, many small-molecule drug candidates continue to fail in clinical trials, and much of the human proteome remains undercharacterized in terms of structure, function, and disease relevance. Chemical tools are therefore essential for defining protein function, mapping protein interactions, and identifying disease-associated molecular mechanisms. Among these tools, small-molecule chemical probes provide a powerful strategy for connecting biological activity with target identification, functional analysis, and the development of effective therapies.

This dissertation describes the development …

Dialogic Communication Ethics As A Hopeful Response To Artificial Intelligence, Kristen Haldeman

Electronic Theses and Dissertations

Within the past five years, a new technology has dominated modern culture: artificial intelligence. With a multiplicity of ways to respond to this new environment, this dissertation situates a response to artificial intelligence by combining the media ecology and communication ethics perspectives. Media ecology explores historical roots and biases of technology to learn about their influence of humanity. A dialogic communication ethics seeks to find an opening for hope to emerge. Hope, grounded in the works of Jacques Ellul and the Christian tradition, offers a new rhetorical perspective by shifting focus away from technology and to our neighbor.

The Narrative In The Algorithm: Storytelling, World Literature, And The Smartphone, Chad Szalkowski-Ference

Electronic Theses and Dissertations

In this dissertation, I interrogate the role algorithms, artificial intelligence, and smartphone technology play in contemporary world literature. My analysis begins with the post-truth condition, which speaks to the contemporary era’s embrace of alternative facts, authoritarianism, and conspiratorial thinking. I draw on narrative theory and paradigms of world literature to show how “algorithmic reasoning” has led to a state of paranoid persecution. This reasoning has forged new collectivities across traditional borders. Additionally, I show that these new collectivities and new technologies have produced new narrative points of view: the algorithmic first- and third-person, allowing narratives to retain the intimacy and …

Mitigation Of The Seductive Details Effect In Children, Allison S. Dobuler

Electronic Theses and Dissertations

The present thesis examines if interspersing guiding questions between sections of an expository text can mitigate the seductive details effect, in which the addition of interesting but tangentially related information to the base text may hinder the ability to learn the essential material, for typically developing children. Participants were given two passages to read, one with seductive details and one without. They either had no guiding questions for both passages or guiding questions interspersed between the text of both passages. They were given retention and comprehension assessments for both passages. While the guiding questions did not mitigate the seductive details …

Algebraic And Topological Methods In Computational Neuroscience, Trong-Thuc Trang

Electronic Theses and Dissertations

Neural data is incredibly rich in combinatorial, topological, and geometrical information, reflecting the intricate shape and connectivity of neural firing patterns. To decipher these structures, neuroscience increasingly relies on advanced mathematical tools to analyze neural activity. Here we study (1) neural codes within the poset P_Code of neural codes and (2) the connectivity of neural population activity within the insular cortex when responding to interoceptive information. In (1), we establish combinatorial constructions for all upward covering relations based on what we call “isolated subsets” with supporting theorems and give a slight modification of the existing downward covering relations. We …

Changes In Water Quality And Microbiota Over Two Years In Florida Hard Clam (Mercenaria Mercenaria) Hatcheries, Bonnie Getter

Electronic Theses and Dissertations

This thesis characterized the water quality and bacterial communities in nine hard clam hatcheries over two production years through weekly or biweekly water quality and chemistry monitoring, monthly bacterial plating in the second year of production, and select 16S microbiome sampling at select hatcheries to address production bottlenecks and support the reliable production of high-quality seed for Florida’s growing hard clam aquaculture industry. Logistic regression models showed that water source was distinguished by pH, salinity, alkalinity, and nitrite, whereas geographic location was distinguished by temperature, salinity, nitrate, and calcium; temperature, dissolved oxygen, salinity, and alkalinity distinguished seasons. Vibrio bacteria differed …

Contributions Of Arginine And Nitrosative Stress To Huntington’S Disease Progression, Ian D. Gaudet

Electronic Theses and Dissertations

Neuroinflammation is a well-established component of Huntington's disease (HD) pathogenesis, yet the intricate molecular mechanisms that govern this process remain a topic of ongoing research and debate. This dissertation elucidates a novel pathway linking arginine metabolism and nitrosative stress to core HD pathology. We found that the arginine transporter SLC7A2 is selectively upregulated in various HD cellular models and patient samples. Our findings reveal that this upregulation drives an overactive inflammatory response, leading to abnormally high inducible nitric oxide synthase (iNOS) induction and subsequent nitric oxide (NO) production, which causes excessive protein nitrosylation and an increase in mitochondrial fragmentation.

To …

A Large And Robust Legless Lizard (Squamata, Anguinae) From The Gray Fossil Site Of Eastern Tennessee, Justice D. Lamer

Electronic Theses and Dissertations

The early Pliocene Gray Fossil Site in Tennessee preserved an abundance of microfossils, including numerous anguid lizard specimens. This includes the following elements: dentaries, a pterygoid fragment, a jugal, frontals, parietal fragments, dorsal and caudal vertebrae, and many osteoderms. Because these specimens had not been placed taxonomically beyond the subfamily level, comparative anatomy of similar elements from extant anguids and some quantitative data were used to provide more refined identifications. Using these methods, it was determined that a new, robust type of Ophisaurus is represented at the Gray Fossil Site. Important novel features include relatively robust dentaries, fewer but broader …

A Geometric Morphometric Analysis Of Acetabular Shape Variation Across Bat Families, Jordan L. Huff

Electronic Theses and Dissertations

Bats are the only mammals capable of powered flight, and research is concentrated on this adaptation. Their non-flight locomotion has received comparatively little attention. Previous studies show that non-flight locomotor behaviors vary across families. Members of Pteropodidae are efficient climbers but cannot effectively walk, whereas Phyllostomidae and Vespertilionidae are better at terrestrial locomotion but show reduced arboreal capabilities. The non-flight locomotion of Hipposideridae and Rhinolophidae is less understood, although rhinolophids exhibit limited terrestrial locomotion. This study examined whether differences in locomotor behavior are associated with variation in acetabular morphology. A geometric morphometric analysis of acetabular shape was conducted across multiple …

Effects Of Peer-Mediated Constant Time Delay Instruction On Science Vocabulary Acquisition For Students With Moderate Intellectual Disabilities, Amy S. Roberts

Electronic Theses and Dissertations

This study examined the effectiveness of combining peer-mediated embedded instruction with constant time-delay (CTD) procedures to improve Agriscience vocabulary learning among secondary students with moderate intellectual disability who were educated in an inclusive Agriscience classroom. A multiple-probe across participants design was conducted with three students with moderate intellectual disability. Trained peer tutors provided embedded vocabulary instruction during naturally occurring classroom activities. Results showed an increase in independent correct responding for all participants following the implementation of the intervention. Procedural fidelity, interobserver agreement, Tau-U effect size, and social validity data further demonstrated that the intervention was implemented consistently and was viewed …

Testing P300-Based Biometric Authentication Paradigms, Jordan Razzak

Electronic Theses and Dissertations

Bench research suggests that P300 amplitude is greater in response to self-relevant stimuli compared to familiar stimuli. This effect could enable a novel method of biometric authentication based on the self-relevant P300. This dissertation aims to: (1) determine the optimal presentation paradigm for leveraging self-relevance in P300-based biometric authentication, and (2) investigate P300 responses from self-relevant stimuli versus stimuli learned over the course of a week.

Two presentation paradigms were compared – rapid serial visual presentation (RSVP) and matrix presentation (MP). Participant-specific RSVP and MP classifiers were trained by applying stepwise linear discriminant analysis to data collected during presentations of …

Making Sense Of Generative Ai: A Qualitative Single Case Study Examining How College Students Describe Its Use In Academic Coursework, Hollie L. Reese

Electronic Theses and Dissertations

Generative artificial intelligence has become increasingly present in higher education, creating opportunities and challenges related to teaching, learning, academic integrity, and student preparation for future professional settings. The problem addressed in this study was the growing misalignment between students’ use of generative artificial intelligence tools and the guidance, expectations, and policies provided within college courses. The purpose of this qualitative case study was to explore how college students described their use of these tools in academic courses and to identify the benefits and challenges associated with integrating them into learning experiences. Data were collected through semistructured interviews with undergraduate students …

Microplastic Effect On Behavior Of Nudibranch (Berghia Stephanieae); A Trophic Transfer Study, Isabela Salina Fernandes Beneli

Electronic Theses and Dissertations

With the continuous rise in economic supply and demand, an enormous increase in waste, litter, and pollution has been seen globally, with plastic pollution being the most abundant category. Microplastic (< 5 mm), derived from larger plastics, pollution is intensely widespread across marine ecosystems and can be transferred across trophic levels through predator-prey interactions. Recent studies have shown that ingestion of MPs can damage cells, tissues, and internal organs and increases oxidative stress leading to malformations, reduced feeding and growth, , and slower developmental rates in a wide array of organisms. This study examined the trophic transfer of microplastics (MPs) from the anemone Exaiptasia pallida to its specialist predator Berghia stephanieae, and evaluated the effects of exposure on predator behavior. A dose-response experiment demonstrated that MP retention in E. pallida decreased over time, although higher exposure concentrations resulted in greater initial microplastic concentrations. Trophic transfer to B. stephanieae was confirmed through feeding experiments. Behavioral assays revealed that B. stephanieae did not exhibit a preference between MP-exposed and control prey. However, microplastic …

Assessment Of Anaerobic Co-Digestion Of High Strength Organic Feedstocks Diverted From Landfills, Sumaiya Sharmin

Electronic Theses and Dissertations

The increasing generation of high-strength organic wastes such as food waste and fats, oils, and grease (FOG) presents challenges for landfill capacity and waste management. Anaerobic co-digestion offers a sustainable alternative by converting these wastes into renewable energy and nutrient-rich digestate. This study evaluated the co-digestion performance of single fruit waste residuals and mixed food waste with wastewater sludge to identify substrate combinations that maximize methane production while maintaining process stability. Laboratory-scale batch experiments were conducted under mesophilic conditions using thickened waste activated sludge (TWAS) with varying proportions of food waste and co-substrates, including seaweed, aquatic weed, grease trap waste, …

Physiological Impacts Of Plastic Ingestion On Sea Turtles, Heather Seaman

Electronic Theses and Dissertations

Over the years, plastic production has increased to astonishing numbers and is predicted to continue. Over time, environmental plastic will degrade into smaller pieces, which sea turtles can mistake for prey. Chemicals associated with plastics have been identified in tissues of sea turtles, and some are suspected to be endocrine disruptors. Sea turtles are known to ingest plastics, but more information is needed to illuminate the potential physiological impacts plastic chemicals may have on sea turtles. This study compared plastic ingestion and toxicant levels across species and ontogenically, as different species and life stages inhabit different areas which will influence …

Dynamical Pathways Of Fear And Anger: Testing The Predictive Validity Of The Basic Evaluation Process Framework, Maryana Borri Madeira

Electronic Theses and Dissertations

The present study tested the predictive validity of the Basic Evaluation Process framework by examining whether Fear and Anger emerge as competing emotional attractors during threat appraisal. Using a mouse-tracking paradigm with audio recording, fifty participants reasoned aloud about a self-selected threatening situation while continuously rating their Fear and Anger. Cross-correlation analysis confirmed dynamic dependence between Fear and Anger, although the coupling was positive rather than negative, indicating co-activation rather than mutual suppression. Vector field analysis identified stable attractor structures for all participants, but the distribution of primary attractors across the Fear by Anger state space did not reveal a …

Hippocampal “Timing Interval Cells” Exhibit Scalable Dynamics For Explicit Timing, Kori-Anne Citrin

Electronic Theses and Dissertations

The ability to organize experiences in time is fundamental to episodic memory and enables animals to predict and guide future behavior. Hippocampal time cells are thought to provide a neural representation for the temporal component of memory. However, time cells have been observed in working memory tasks where animals were not required to keep track of elapsed time. Therefore, it remains unclear what are the hippocampal patterns of activity during explicit timing. Here, utilizing behavioral perturbations and calcium imaging in dorsal CA1, we identified a previously unknown pyramidal neuron subpopulation that flexibly scales its activity during explicit timing. As head-fixed …

Noisy Neighbors: Assessing The Effects Of Anthropogenic Noise On Non-Native Vervet Monkeys’ (Chlorocebus Sabaeus) Behavioral Responses Via Predator-Call Playbacks In Dania Beach, Florida, Jaela Perry

Electronic Theses and Dissertations

South Florida hosts a number of non-native wildlife species, including African monkeys. This study examined wild vervet monkeys (Chlorocebus sabaeus) in Dania Beach, Florida, to determine whether aircraft-related atmospheric noise affected their threat detection capabilities and behavioral responses. Using predator-call playbacks and focal scan samples, behavioral data was recorded across pre-, during-, and post-playback phases. Behaviors were labeled as nonvigilant or vigilant. The study also assessed whether responses differed between the local and novel predator calls as well as whether repeated trials suggested habituation over the course of the experiment. Results showed that the monkeys’ abilities to successfully …