The Ramifications Of Covid-19 On Young Adults With Ocd, Clare E. Mcintosh

Dissertations

The coronavirus disease of 2019 (COVID-19) pandemic was a profound event in modern history, contributing to significant disruptions on a societal and individual level. This period of time was marked by elevated uncertainty and fear among individuals. COVID-19 contributed to deterioration in not only physical health but also psychological well-being. One mental health condition frequently under-examined and saturated with misconceptions is obsessive-compulsive disorder. Obsessive-compulsive disorder is a condition characterized by the presence of obsessions and/or compulsions. Intolerance of uncertainty is a core component of the condition, and the pandemic was riddled with unpredictability. The purpose of this study was to …

Well-Being, Resilience, And Trauma During Migration: A Mixed Methods Study Of Venezuelan Migrants In Transit, Margaret S. Port

Dissertations

A substantial body of research has examined the psychological impact of experiences preceding and following migration, yet comparatively little attention has been given to the psychological toll of the migration journey itself. Moreover, due to the relative novelty of the Venezuelan migrant crisis and the community’s arrival in the United States, the psychological impact of Venezuelan migrants’ unique migration experience has been underexamined. This study utilized an explanatory sequential mixed methods design to investigate the relationships between well-being, resilience, and trauma among Venezuelan migrants in Chicago, Illinois, while also exploring their lived experiences of the migration journey. Study participants (n …

Long-Covid And Cognition, Mychael Bruce

Dissertations

COVID-19 is an evolving virus that can harm the body’s respiratory and cardiovascular systems. Directly related to COVID-19 are individuals who do not recover from their initial infection, making them long haulers. Long-COVID is transitioning from a range of isolated phenomena to higher prevalence rates in patients who contracted COVID-19. Many individuals report issues with cognitive function, referred to as ‘brain fog’, that affect memory, attention, and even language skills. This literature review addresses the available research on Long-COVID and how persistent infection correlates with cognitive difficulties. It aims to explain the neurobiology of Long-COVID and how Long-COVID interacts within …

Membrane-Engineered Nanotherapeutic Platforms For Drug Delivery: Hollow Fiber Membrane Synthesis Of Lipid Nanoparticles, Biomimetic Nanocarriers, And Nanobubbles, Zhixiang Liu

Dissertations

Lipid-based nanocarriers have emerged as a cornerstone technology for RNA therapeutics, enabling effective intracellular delivery for applications ranging from vaccination to gene regulation. However, current manufacturing approaches, particularly microfluidic-based platforms, face inherent limitations in scalability, throughput, and structural tunability due to their reliance on confined channel geometries and restricted mixing architectures. Addressing these challenges requires fundamentally new strategies that decouple nanoparticle formation from traditional microscale flow constraints while maintaining precise control over physicochemical properties.

This dissertation presents a comprehensive framework for the design, engineering, and application of advanced lipid-based nanocarriers, centered on a hollow fiber membrane (HFM)—assisted nanopore-mediated assembly platform. …

Barriers To Climate Change And Sustainability Action: Nursing Education And Practice, Dawn Marie Smith

Dissertations

Climate change is one of the most pressing public health emergencies of our time and nurses can have a great impact in their current practice and in the education of future nurses (The Alliance of Nurses for Healthy Environments, n.d.; American Nurses Association, 2023; Health Care without Harm, 2025). Deaths due to rising temperatures, vector-borne illness, and food insecurity related to drought and extreme weather are on the rise (WHO, 2024). It has been estimated that globally over 250,000 additional deaths will be attributed to climate related effects between 2030 and 2050 (Watts et al., 2020; WHO, 2023).

A primary …

The Art Of Crisis Leadership By Exemplary Naval Frontline Leaders, Broadus Brooks

Dissertations

Purpose: This qualitative, multiple-case study held significant importance because it aimed to identify and describe the strategies used by exemplary naval frontline leaders to lead in crisis, particularly during the COVID-19 pandemic. The study focused on the five critical tasks of strategic crisis leadership (sensemaking, decision making/coordination, meaning making, accounting, and learning), providing a unique insight into the experiences of these leaders during a crisis.Methodology: This qualitative, multiple-case study employed interviews to collect data from exemplary naval frontline leaders to identify and describe their leadership strategies during the unprecedented COVID-19 global health crisis.

Findings: Crisis leadership among U.S. naval frontline …

Identifying And Prioritizing Essential Healthcare Services For A Private Start-Up Healthcare Hub In Laxmipasha, Bangladesh, Ferdous Ara Mostofa

Dissertations

This quantitative study identifies and prioritizes essential healthcare services for developing a private start-up healthcare hub in Laxmipasha, Bangladesh, a rural community with significant gaps in healthcare access. Using secondary data from national and international sources, the research analyzed disease burden, population characteristics, and service availability to determine the most urgent health priorities. A structured, evidence-based framework was used to evaluate services based on mortality and morbidity, service gaps, and potential health impact. The findings indicate that Maternal and Child Health (MCH), Non-Communicable Disease (NCD) management, and infectious disease control represent the most critical priorities for initial implementation. The study …

Effects Of Exercise Timing On Circadian Rhythm And Functional Outcomes In Cancer Patients Undergoing Treatment, Buck Williams Covington Ii

Dissertations

Poor sleep quality and circadian rhythm disruption are commonly reported among cancer survivors and may contribute to worsened health outcomes, including increased fatigue, psychological distress, and reduced quality of life. While some recent studies suggest that exercise can improve sleep and circadian regulation in cancer survivors, limited research exists on how the timing of this exercise affects these outcomes in cancer survivors. The purpose of this study was to examine the effects of a 12-week supervised exercise intervention, performed either in the morning (AX) or evening (PX), on functional capacity, subjective and objective sleep quality, and peripheral markers of circadian …

Adsorption-Based Electrochemical Assay For Nucleic Acid Detection On 2d Nanomaterials, Prabhangshu Kumer Das

Dissertations

Electrochemical biosensing based on the adsorption of nucleic acids onto two-dimensional (2D) nanomaterials offers distinct advantages over conventional techniques, including enhanced sensitivity, selectivity, and simplified probe immobilization. Significant efforts have been directed toward developing sensing platforms that exploit the high surface area and unique physicochemical properties of materials such as graphene oxide (GO) and molybdenum disulfide (MoS₂) to achieve efficient signal transduction. This adsorption-based approach eliminates the need for complex surface modifications or labeling, as nucleic acids interact with 2D surfaces through π–π stacking, van der Waals forces, hydrogen bonding, electrostatic interactions, and ion bridging.The efficiency of nucleic acid immobilization …

A Phenomenographical Study Of Rural Teacher Retention Before, During, And After The Covid-10 Global Pandemic, Stacey Lb Collins

Dissertations

ABSTRACT

This phenomenographical study investigated rural teachers’ perceptions regarding their decisions to remain teaching in rural areas, with attention to experiences before, during, and after the COVID-19 global pandemic. The research was guided by two questions: (1) What experiences do rural teachers perceive impact their decision to remain teaching in rural school systems before, during, and after the COVID-19 global pandemic? and (2) How do rural teachers perceive the role of school administrators in retaining teachers in rural systems, before, during, and after the COVID-19 global pandemic? Participants were teachers who served in rural districts prior to, during, and after …

Increasing Pediatric Hpv Vaccination Rates, Brooke A. Nicholas

Dissertations

Increasing Pediatric HPV Vaccination Rates

Abstract

Problem: The human papillomavirus (HPV) is a sexually transmitted infection that affects more than 80% of the population within the United States (Eisenhauer et al., 2020). HPV can develop into cervical, anogenital, and oropharyngeal cancers (Eisenhauer et al., 2020). About 4,000 individuals die from cervical cancer alone each year (O’Leary, 2022). The HPV vaccine, though recommended by the ACIP and AAP, is below national vaccination rates in comparison to other vaccines (O’Leary, 2022).

Methods: This quality improvement project is a non-randomized controlled trial that observed HPV vaccine dose completion rates for patients aged 9-14 …

Problems In Extremal Graph Theory And Spectral Graph Theory, Fareeha Jamal

Dissertations

Spectral graph theory is a subfield of algebraic graph theory that studies the matrices associated with graphs. It lives at the nexus of Linear Algebra and Combinatorics. Many intriguing results in the domains of Matrix Theory and Combinatorics have come from studying the eigenvalues of graph matrices; in fact, several open problems in both areas have been resolved. Beyond its theoretical appeal, spectral graph theory has found meaningful applications in theoretical chemistry, particularly in the mathematical classification of chemical graphs. These classifications underpin quantitative structure–property relationships (QSPRs), facilitating the prediction of physicochemical properties such as enthalpy of vaporization, molar refractivity, …

Client And Clinician Priorities For Same-Day Prep And Doxy-Pep Awareness, Uptake, And Persistence In Primary Care, Nathaniel Albright

Dissertations

Approximately 70% of all new human immunodeficiency virus (HIV) infections are among populations of sexual and gender minorities (SGM) and are primarily attributable to sexual contact. Currently, only 26% of the U.S. population who would benefit from HIV preexposure prophylaxis (PrEP) are prescribed this effective biomedical HIV prevention strategy. Biomedical prevention strategies for bacterial sexually transmitted infections (STI) like doxycycline postexposure prophylaxis (doxy-PEP), are a vital component to the successes of ending the HIV epidemic given the well-known association between STIs and risk for HIV infection. In this multiple methods study, we leveraged group concept mapping and conducted focus groups …

Exploring The Experience Of Nursing Students During Their Community Health Nursing Clinical Placement At Schools, Lina Ghosn Nouwayhed

Dissertations

Community health nursing is an exciting, challenging, and evolving field that creatively integrates various areas of nursing practice with public health knowledge (Stanhope & Lancaster, 2016). Learning in practical settings is invaluable for student nurses; that is why clinical placements account for 50% of nursing curriculum requirements (Henderson, 2011). At Makassed University of Beirut, the community nursing practicum takes place in schools, with school nurses serving as mentors during these placements.

This research study aims to:

• Explore the experiences of student nurses during community clinical practice.
• Develop guidelines to enhance learning during community clinical practice.

The study sample consisted of …

Investigating The Use And Acceptance Of Information And Communication Technologies By University Faculty In Liberia And Its Implications To Sub-Saharan Africa, Michael K. Gray

Dissertations

This descriptive, non-experimental, correlational quantitative study examines the relationship between components of the Technology Acceptance Model (TAM), the Unified Theory of Acceptance and Use of Technology (UTAUT), and Human Capital Development (HCD) in determining the use of Information and Communication Technology (ICT) among university faculty in sub-Saharan Africa (SSA). With the increasing importance of ICT in educational transformation across developing regions like SSA, understanding the underlying factors that influence ICT acceptance is essential for effective policy and implementation strategies. The researcher surveyed 336 university faculty in Liberia using a questionnaire designed to capture perceptions related to TAM constructs (perceived usefulness …

Understanding The Experiences And Perceptions Of Faculty Supporting Undergraduate Students With Mental Health Challenges, Jenna Ranee Parbati Jamieson

Dissertations

College is a big adjustment for students, and it doesn't come without its challenges, including being in a new place with new responsibilities. This is a stressful time that presents new obstacles and frustrations that can lead to increased stress, anxiety, depression, and mental health challenges that may cause faculty to engage and support undergraduate students with mental health challenges. As students adjust and transition to college, it is vital for university faculty to feel confident and comfortable supporting students from diverse backgrounds with varying levels of distress. By interviewing faculty, a better understanding of their lived experiences and perceptions …

Nanoporous Gold Nanoparticles And Model Membrane Systems Applied To The Study Of Lipopolysaccharide (Lps), Dhanbir Lingden

Dissertations

Lipopolysaccharide (LPS), a key structural component of Gram-negative bacteria, is a major trigger of sepsis and septic shock, the systemic inflammatory conditions responsible for millions of deaths annually. Even at concentrations as low as 1 ng/mL, LPS can activate the immune system and initiate inflammatory cascades. According to the Global Burden of Disease Study 2017, sepsis accounted for 48.9 million cases globally, with 11 million deaths, emphasizing the urgent need for improved diagnostic and therapeutic strategies.

Accurate and rapid detection of LPS is vital for early intervention and improved clinical outcomes. While traditional detection methods are still widely used, modern …

Enzymatic Characterization Of Bacterial Enzymes And Inhibitors As Potential Antibiotics With New Mechanisms Of Action, Emma Helene Kelley

Dissertations

Bacteria have become increasingly resistant to antibiotics, therefore there is an urgent need for new drug classes of antibiotics to help fight antibiotic infections. To this end, our research is focused on inhibitors of dizinc metalloenzymes N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), an enzyme in the lysine biosynthesis pathway, N-acetyl-L-ornithine deacetylase enzyme (ArgE), an enzyme in the arginine biosynthesis pathway, and sodium-dependent NADH: ubiquinone oxidoreductase (Na+-NQR) enzyme, a respiratory complex enzyme as promising drug targets. DapE, ArgE, and Na+-NQR and are only present in bacteria, including ESKAPE pathogens that can cause potentially deadly infections, thus inhibitors of DapE, ArgE, and Na+-NQR offer …

Leading Through Crisis: San Diego County Schools' Response To The Social Emotional Needs Of All Students, Johana Bielma

Dissertations

The COVID-19 pandemic led to unprecedented school closures, forcing administrators to take decisive action to radically change the educational system. The imperative to switch to remote learning transformed the dynamics of teaching and learning, leading to both immediate and long-term academic and social emotional consequences for all stakeholders. When schools reopened, administrators faced the challenge of reintegrating students into in-person learning while addressing the pandemic’s lasting effects on academics, mental health, and school safety. While academic regression was evident, the extent of students’ emotional struggles was less anticipated. Many students exhibited increased irritability and mental health issues such as depression …

Unraveling The Antiviral Mechanisms Of Bat Cells: Processing Of Genomic Rnas By Dicer In Bat Cells Limits Sars-Cov-2 Replication, Iyanuoluwani Owolabi

Dissertations

Bats are reservoirs for numerous viruses that cause serious diseases in other animals and humans. Several mechanisms are proposed to contribute to the tolerance of bats to these pathogens. This study investigates the response of bat cells to double-stranded RNA generated by SARS-CoV-2 replication. Here, we found the involvement of Dicer in the processing of viral genomic RNAs during SARS-CoV-2 infection. Examining RNA sequencing of infected cells, small-interfering RNA (siRNA)-like fragments were found derived from viral RNAs. Depletion of Dicer showed a reduction in these RNAs and an increase in viral loads suggesting unlike other mammals, bats may use Dicer …

Quadratic Stochastic Processes: Algebraic Structures And Their Applications, Taimun Saleh Qaisar

Dissertations

This research focuses on the algebraic structures of the Quadratic Stochastic Processes (𝑄𝑆𝑃𝑠). In this work, we first study 𝜉𝑎- Quadratic Stochastic Operators (𝑄𝑆𝑂𝑠) linked to the partition P3. We simultaneously discuss the dynamics of the obtained 𝑄𝑆𝑂𝑠. Moreover, algebraic structure of the associated genetic algebra is studied. Further, we build Quadratic Stochastic Processes (𝑄𝑆𝑃𝑠) using the given Markov processes. Consequently, we obtain an ordinary differential equation for the resultant Quadratic Stochastic Processes (𝑄𝑆𝑃𝑠). Besides, we apply the solution of this ordinary differential equation for the option pricing problem. Thereafter, we construct Quadratic Stochastic Processes (𝑄𝑆𝑃𝑠) in three-dimensional space by …

The Cellular Trafficking And Targeting Of Angiotensin-Converting-Enzyme-2 (Ace2) And Neutral-Amino-Acid-Transporter (B0at1) Variants: Implications For The Pathogenesis Of Associated Diseases And Therapy, Nesreen Fayyad Alkhofash

Dissertations

Angiotensin-converting enzyme 2 (ACE2) and the neutral amino acid transporter B0AT1, encoded by SLC6A19, are membrane proteins with pivotal roles in human physiology. ACE2 is involved in regulating blood pressure and serves as the cellular entry receptor for SARS-CoV-2, while B0AT1 facilitates amino acid absorption in the intestine. The interplay between ACE2 and B0AT1, particularly their physical interaction and co-expression in the intestine, underscores their relevance in both normal physiology and disease. Dysregulation of these proteins has been implicated in conditions such as hypertension, and Hartnup disease and they have been usurped by SARS-CoV-2 to cause COVID-19. Despite their …

The Epidemiology Of Major Congenital Anomalies In The United Arab Emirates: The Mutaba'ah Study, Hiba Mahdi Adam

Dissertations

Major Congenital Anomalies (MCAs) are significant contributors to perinatal morbidity and mortality. The absence of clear baseline prevalence data for MCAs hinders the development of targeted interventions to mitigate their burden. Furthermore, studies on adverse obstetric and birth outcomes in pregnancies complicated by MCAs are scarce, emphasizing the need for research to enhance management strategies. This dissertation aimed to: (1) estimate the live birth prevalence of perinatally diagnosed MCAs and describe study population characteristics by MCA status, (2) investigate the impact of MCAs on fetal presentation and delivery mode, and (3) investigate the impact of MCAs on preterm and low …

Investigating The Proviral And Immunogenic Effects Of Sars-Cov-2 Accessory Protein 7a, Grant Michael Hawkins

Dissertations

SARS-CoV-2 and related sarbecoviruses encode a set of accessory proteins (3a, 3b, 6, 7a, 7b, 8, 9b, and 10) that control host responses to infection and promote virus growth. Of these accessory proteins, 7a is set apart by its intracellular localization near coronavirus (CoV) budding sites and its incorporation into secreted virions. Initial studies utilizing a virus-like particle (VLP) system identified significant proviral effects mediated by 7a, but the system lacked the context of an actual CoV infection. To investigate 7a functions during CoV infections, we constructed recombinant Mouse Hepatitis Viruses (rMHV strain A59) that express 7a genes. Comparative infections …

Earthing Practice For Mental Health Among Adults In The United States: A Phenomenological Inquiry, Natalie Greenberg

Dissertations

This study aimed to explore the lived experience of adults in the United States who practice earthing for mental health.

Investigating The Role Of The Nsp15 Amino-Terminal Domain In Nsp15 Function, Viral Replication, And Pathogenesis, Monika Evdokimova

Dissertations

Identifying conserved mechanisms used by viruses to delay host innate responses can reveal potential targets for antiviral therapeutics. Here, we investigated coronavirus nonstructural protein 15 (nsp15), which encodes a highly conserved endoribonuclease (EndoU). EndoU functions as an immune antagonist by limiting the accumulation of viral replication intermediates that would otherwise be sensed by the host. Despite being a promising antiviral target, it has been difficult to develop small molecule inhibitors that target the EndoU active site. We generated nsp15 mutants of SARS-CoV-2 and mouse coronavirus MHV-A59 and identified conserved residues within the amino-terminal domain that are required for EndoU activity. …

Returning To School After A Pandemic And The Lived Experiences Of 9-12 Grade Athletic Coaches On Student-Athlete Success, Louie Vallejo

Dissertations

Purpose: This phenomenological examination examines ninth-12th grade athletic coaches’ perceptions of the impact on athletes returning to athletic competition after being online during the pandemic for 2 years with regard to behavior, athletic achievement, attitude, and social connections.

Methodology: This qualitative study interviewed athletic coaches in the Tri-County Athletic Conference in Central California. Semi structured open-ended interview questions were the main source of data collection. Data were coded and the researcher analyzed the data for themes and patterns, and the results were validated through the interrater process by an experienced researcher.

Findings: After analyzing data, codes, and themes, the researcher …

Examining Pyroptosis In Neutrophil-Like Differentiated Hl-60 Cells, Jared Long

Dissertations

The innate immune system is the first line of defense against pathogens. Innate immune cells, such as macrophages and neutrophils, recognize pathogens through the recognition of pathogen associated molecular patterns or damage associated molecular patterns (PAMPS & DAMPS). When a pathogen is recognized, innate immune cells will start clearing the pathogen and secreting pro-inflammatory cytokines, such as interleukin-1β (IL-1β) to initiate the innate immune response. Release of IL-1β occurs through an unconventional secretory pathway triggered by inflammasome activation. Activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome cleaves both pro-IL-1β into mature IL-1β, and full length gasdermin-D (GSDMD) …

The Impact Of Lactobacillus Supplementation On Gut Microbiome Composition And Phage Induction In Mice, Kimia Boreiri

Dissertations

The mammalian gastrointestinal (GI) tract harbors a dense and dynamic community of microbes known as the gut microbiota, which plays vital roles in digestion, immunity, and overall health. Among these, probiotic bacteria such as Lactobacillus strains have garnered attention for their ability to influence microbial community structure and host physiology. This study investigated the effects of five Lactobacillus strains, Lactobacillus casei R1A482, Lactobacillus casei O3, Lactobacillus rhamnosus GG, Lactobacillus gasseri ATCC 33323, and Lactobacillus paragasseri UMB1065, on the gut microbiome of Swiss Webster mice over a six-week feeding period. To reduce stress, mice were fed Lactobacillus strains using gelatin pellets …

Role Of Coronavirus Envelope Protein On Infectivity, Garrett E. Zaagman

Dissertations

Coronaviruses infect a wide range of hosts and have caused recent human pandemics. While much has been learned, gaps remain in understanding viral assembly and egress, particularly the role of the envelope (E) protein in specific infectivity. To study this, recombinant MHV viruses were created with E gene deletions and HiBiT-tagged spike (S) proteins to monitor virion release. In mouse cells, MHV∆E S-HiBiT secreted less spike and fewer infectious particles, indicating reduced specific infectivity. Comparisons between human HeLa-CEACAM and mouse DBT cells showed species-specific support for virus production. TMED10, a host membrane protein, was tested as a potential E-interacting partner …