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Neurophysiology Of Spared Motor Tracts In Spinal Cord Injury, Dalton Louis Wolfe
Neurophysiology Of Spared Motor Tracts In Spinal Cord Injury, Dalton Louis Wolfe
Digitized Theses
Recent experimental and therapeutic initiatives have been directed towards enhancing the survival and function of preserved central axons following spinal cord injury (SCI). The continued development of these initiatives depends largely on the sensitivity of techniques to detect the presence of residual innervation in descending motor tracts. Detection of preserved innervation in SCI patients provided the focus of the present thesis.;Preserved motor innervation was investigated in patients with established SCI using transcranial magnetic stimulation of the motor cortex to elicit motor evoked potentials (MEPs) in muscles innervated below the level of the lesion. In particular, a set of experiments was …
Visualization And Analysis Of Multiple Sclerosis Lesions In Magnetic Resonance Images, J Ross Mitchell
Visualization And Analysis Of Multiple Sclerosis Lesions In Magnetic Resonance Images, J Ross Mitchell
Digitized Theses
Magnetic Resonance Imaging (MRI) provides very sensitive indication of the presence and extent of the lesions of Multiple Sclerosis (MS). As a result, quantifying changes in the number and extent of lesions in MR images has been used to indicate disease activity in clinical trials of new therapies. However, lesion quantification is long, arduous, and subject to variability between and within operators. These factors limit the application of quantitative techniques and increase the duration, and thus cost, of clinical trials which rely on their measurements to assess therapeutic effect.;A computerised system was developed for assisted 3-D quantification and analysis of …
Characterization Of Intestinal Epithelial Cells In Acute Intestinal Allograft Rejection, Xian-Chang Li
Characterization Of Intestinal Epithelial Cells In Acute Intestinal Allograft Rejection, Xian-Chang Li
Digitized Theses
Intestinal transplantation (IT) remains highly experimental compared to other solid organ transplants because of poorly defined mechanisms of graft rejection. In this project, the role of luminal bacteria-derived endotoxin and inflammatory cytokines (IL-1, IL-6, TNF-{dollar}\alpha){dollar} in intestinal epithelial damage during acute graft rejection was examined. In a novel mouse model of IT, the acute intestinal rejection was associated with elevated levels of endotoxin, IL-6, and TNF-{dollar}\alpha{dollar} in the peripheral blood. The progressive increase in endotoxin and TNF-{dollar}\alpha{dollar} levels correlated well with the histologic severity of epithelial damage. To further define the role of endotoxin and inflammatory cytokines on intestinal epithelial …
Cardiorespiratory And Peripheral Adaptations After Cardiac Transplantation, Lizanne Marie Bussieres
Cardiorespiratory And Peripheral Adaptations After Cardiac Transplantation, Lizanne Marie Bussieres
Digitized Theses
The cardiovascular, pulmonary and musculoskeletal systems were investigated in seven studies of patients with end-stage heart failure before and/or after receiving a heart transplant. The purposes of the studies were to determine the time course and magnitude of the changes in peak oxygen uptake, cardiopulmonary response to exercise and peripheral skeletal muscle histology and biochemistry after cardiac transplantation. In addition, the physiological basis for the limited exercise capacity and the effect of exercise posture on cardiac performance and secretion of atrial natriuretic peptide was also evaluated in cardiac transplant patients.;In the first study, the peak oxygen uptake almost doubled from …
Myocardial Electrophysiological Alterations In Pacing-Induced Heart Failure And Defibrillation Shock Delivery, Huagui Li
Digitized Theses
Heart failure patients frequently have ventricular arrhythmias and high incidence of sudden death. Current antiarrhythmic drug therapies have failed to improve the survival of these patients as the arrhythmogenesis is poorly understood. The only effective therapy for lethal arrhythmia, ventricular fibrillation, is electrical shock (defibrillation). Studies on arrhythmogenesis and potential antiarrhythmic therapies in heart failure are needed.;This thesis investigated: (1) cardiac electrophysiological changes and arrhythmogenesis in a heart failure model; (2) cellular electrophysiological effects of defibrillation shocks.;Heart failure was produced by rapid ventricular pacing (240 beats/min, 4-5 weeks) in 35 dogs. Twenty-one operated, non-paced dogs served as control. Increased impulse …
Determinants Of Critical Power And Anaerobic Work Capacity In Young And Elderly Men, Thomas James Overend
Determinants Of Critical Power And Anaerobic Work Capacity In Young And Elderly Men, Thomas James Overend
Digitized Theses
Determinants of critical power (CP, the theoretical maximal rate of non-fatiguing work) and anaerobic work capacity (AWC, a finite energetic reserve from intra-muscular sources) were determined in young (n = 13, 24.5 y) and elderly men (n = 12, 70.7 y). The purposes of the four studies were to: (1a) determine and compare CP and AWC in young and elderly men; (1b) determine if CP does represent a true maximal rate of non-fatiguing work; (2) determine thigh component cross-sectional areas (CSA) and volumes; (3) determine the strength and strength/CSA ratios of the knee extensors and knee flexors; and (4) identify …
31-Phosphorous, Nuclear Magnetic Resonance Spectroscopy Studies Of Exercising Human Muscle, Gregory D. Marsh
31-Phosphorous, Nuclear Magnetic Resonance Spectroscopy Studies Of Exercising Human Muscle, Gregory D. Marsh
Digitized Theses
Phosphorous 31, nuclear magnetic resonance spectroscopy {dollar}(\sp{lcub}31{rcub}{dollar}P NMRS) was used as a non-invasive probe of forearm muscle metabolism in three studies of healthy men and women. Specific objectives of the studies were to: (1) observe the changes in high energy phosphates and intracellular pH in muscle, during a ramp exercise protocol, (2) study the effect of endurance training on muscle metabolism and evaluate the utility of the forearm ramp test as a means to assess muscle oxidative capacity, and (3) describe the kinetics of phosphocreatine (PCr) and inorganic phosphate (Pi) metabolism during the on and off transient response to moderate …
Parasitization Of Spirillum Serpens By Bdellovibrio Bacteriovirus, Jay Chen Huang
Parasitization Of Spirillum Serpens By Bdellovibrio Bacteriovirus, Jay Chen Huang
Digitized Theses
No abstract provided.
Chromosome Studies In Full-Term Low Birth Weight Mental Retardates, Andrew Tat-Leng Chen
Chromosome Studies In Full-Term Low Birth Weight Mental Retardates, Andrew Tat-Leng Chen
Digitized Theses
No abstract provided.
Changes In Dorsal Root Ganglia Of The Rat Following Peripheral Nerve Section, Shiu Hong Kung
Changes In Dorsal Root Ganglia Of The Rat Following Peripheral Nerve Section, Shiu Hong Kung
Digitized Theses
No abstract provided.
The Oxygen Consumption Of Relaxed And Active Arterial Smooth Muscle, Rafael Louis Kosan
The Oxygen Consumption Of Relaxed And Active Arterial Smooth Muscle, Rafael Louis Kosan
Digitized Theses
No abstract provided.
The Response Of L-Cells To Sulphur Mustard, Brian Douglas Reid
The Response Of L-Cells To Sulphur Mustard, Brian Douglas Reid
Digitized Theses
No abstract provided.