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Quantitative Assessment Of Lung Microstructure In Healthy Mice Using An Mr-Based 3he Lung Morphometry Technique, Emir Osmanagic
Quantitative Assessment Of Lung Microstructure In Healthy Mice Using An Mr-Based 3he Lung Morphometry Technique, Emir Osmanagic
All Theses and Dissertations (ETDs)
Recently developed in our laboratory the MRI-based technique - 3He Lung Morphometry - is a unique tool allowing in vivo measurements of lung microstructural parameters such as alveolar volume, surface-to-volume ratio and alveolar density. These parameters are commonly used by lung physiologists and pathologists but were previously available only from invasive biopsy studies. 3He Lung Morphometry was originally developed for human studies but there is a need to expand it for studies of small animals like mice and rats that are used to advance our knowledge of lung physiology in health and disease and for development of drugs. Such an …
Mechanics Of Heart Tube Formation In The Early Chick Embryo, Victor Varner
Mechanics Of Heart Tube Formation In The Early Chick Embryo, Victor Varner
All Theses and Dissertations (ETDs)
The heart is the first functioning organ to form in the embryo. For decades, biologists have worked to identify many of the genetic and molecular factors involved in heart development, and over the years, these efforts have helped elucidate the vast biochemical signaling networks, which drive cardiac specification and differentiation in the embryo. Still, the biophysical mechanisms which link these molecular factors to actual, physical changes in cardiac morphology remain unclear. The aim of this thesis is to identify some of the mechanical forces which drive heart tube assembly in the early chick embryo. A unique feature of this work …
The Effect Of Sensory Experience And Movement Observation On Motor Adaptation To Novel Force Perturbations, Paul Wanda
The Effect Of Sensory Experience And Movement Observation On Motor Adaptation To Novel Force Perturbations, Paul Wanda
All Theses and Dissertations (ETDs)
On a daily basis, humans capably and effortlessly interact with their surrounding environment through the performance of accurate movements. Movements are often perturbed through the physical influence of the surrounding environment, interaction with objects, or injury, yet adaptation is both rapid and flexible. When adapting, humans are informed by their direct trial-and-error movement experience, incrementally updating predictive control on the next movement; how the brain processes sensed errors into adaptation is not fully known. We may also learn to move through the observation of the movements of others, as visually observed movement information may be transformed into motor memories that …
Optimal Control In Gene Mutation, Juanyi Yu
Optimal Control In Gene Mutation, Juanyi Yu
All Theses and Dissertations (ETDs)
Gene mutations are the radical causes of many diseases, including inheritance diseases and cancers. Current medical treatments usually focus on changing the concentrations of related chemicals or mRNAs at the cellular level to stop protein productions or cell duplications, which can only control the diseases under certain circumstances but cannot cure them. Little research work has been done at the molecular level, the fundamental of inheritance, to search possible ways to cure those severe diseases. In this dissertation, we propose a molecular level control system view of the gene mutations in DNA replication from the finite field concept. By treating …
Novel Plasmonic Nanostructures For Applications In Sensing, Imaging, And Controlled Release, Weiyang Li
Novel Plasmonic Nanostructures For Applications In Sensing, Imaging, And Controlled Release, Weiyang Li
All Theses and Dissertations (ETDs)
This research placed emphasis on engineering the properties of novel plasmonic nanostructures, especially silver: Ag) and gold: Au) nanostructures with well-defined shapes, for biomedical applications in sensing, imaging and drug delivery. The first part of this work focused on the development of novel dimeric nanostructures of Ag for surface-enhanced Raman scattering: SERS) applications. In this section, I successfully demonstrated the synthesis of well-defined Ag dimers consisting of nanospheres with a broad range of sizes by using two methods. The first method was based on polyol process and the second was based on wet etching. The key for the dimerization process …