Digital Commons Network^™

Consumption Of A Western Diet Enhanced Colitis-Associated Colorectal Cancer And Dysbiosis Of The Fecal Microbiome In Mice Notwithstanding Dietary Intervention Or Fecal Microbiome Transfer, Daphne Michelle Rodriguez Jimenez

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In a rodent model of inflammation-associated colorectal cancer, consumption of a Western-style diet increases gut inflammation and enhances risk of developing colon tumors. The goal of this dissertation was to understand the contribution of bacteria within the large intestine on colon inflammation and colon tumorigenesis. Two pre-clinical animal studies were performed using two different intervention strategies to shift the microbiome, and potentially gut inflammation and tumor development: 1) an experiment using dietary supplementation with black raspberries, a functional food enriched in bioactive anthocyanins with purported antiinflammatory activity, and 2) an experiment using fecal microbiota transfer from mice fed a healthy …

Influence Of Hydrologic History On Nitrogen Cycling In Lake Sediments, Emily Jainarain

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Water quality is declining in freshwater lakes around the world due to environmental change and anthropogenic activities that threaten the physical, ecological, and geochemical integrity of freshwater ecosystems. Excess N and P in lakes can cause eutrophication, a major driver of water quality impairment that leads to excessive algal growth, or harmful algal blooms (HABs), and poses risks to recreation, fisheries, and public drinking water. Water level fluctuations in lakes are expected to become more frequent and intense as climate change increases periods of drought and alters precipitation patterns, and fluctuations may stimulate biogeochemical reactions in littoral sediments that add …

Similarities And Differences In Correlates And Trends In Prescription Stimulant And Prescription Opioid Misuse Among College Students, Julie Murray

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

When used as medically intended, prescription opioid and stimulant medications can have therapeutic benefits. Misuse of these medications, however, presents significant health risks, including increased risk of death and injury. Young adults, ages 18 to 25, have the highest rates of misuse of prescription opioids and stimulants nationally and within this age group, college students may be particularly at risk. This two-study dissertation explored factors related to prescription opioid and prescription stimulant misuse in college students in order to assess similarities and differences in correlates and trends.

Study #1 assessed for similarities and differences in correlates of prescription opioid misuse …

Overcoming Barriers To Aquatic Plant Restoration: Addressing Gaps In Species Identification And Planting Techniques In The Intermountain West, Kate A. Sinnott

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Aquatic ecosystems provide many critical and economically valuable benefits, including drinking water, food, recreational opportunities, and water supply for irrigation and agriculture. However, the health of these systems has been severely impacted by human activities such as pollution, land conversion, and introductions of harmful species. Restoring native aquatic plants can help reverse this damage and reestablish benefits, though it is not a common practice. With an objective to increase capacity for aquatic plant restoration in the Intermountain West, I identified and addressed two major barriers: 1) a lack of confidence in aquatic species identification among wetland professionals, and 2) underdeveloped …

Treatment Of Yellow Fever Virus With The Ns4b Inhibitor Bdaa And Effects On Rna‐Sensing Innate Immune Pathways In Hamster And Mouse Models, Abbie E. Weight

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Yellow fever (YF) is an acute and often severe disease cause by yellow fever virus (YFV). Although there is an effective vaccine available to prevent YF, there are no antiviral drugs approved to treat the disease, which has a considerable disease burden in endemic areas of South America and Africa. BDAA is an experimental antiviral treatment which has shown efficacy against YFV both in cell culture and when administered before infection in an animal model of disease. BDAA targets the YFV protein NS4B and has two reported mechanisms of action: the primary mechanism of action is the direct inhibition of …

Effects Of Soil Amendments On Water Quality And Hydrologic Properties In Low Impact Development Systems, Lily Wetterlin

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Low impact development (LID) systems are practices that use natural elements, such as soils and vegetation, to absorb and filter stormwater to protect water quality and aquatic habitats. Many LID designs use native soils; however, urban soils typically have a limited potential for infiltrating and treating stormwater. Incorporation of soil amendments, such as compost and biochar, into LID soils can improve the physical properties of soil. However, soil amendments may increase or decrease pollutants in the water leaving the site. A comparison of the effects of different types and application rates of amendments on water quality is necessary to determine …

The Relationship Between Discipline-Specific Subject Matter Knowledge And Discipline-Specific Science Teaching Efficacy Of Elementary Teachers, Douglas Ball

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Because a teacher's confidence in their ability to teach science is associated with instructional methods and their persistence in the face of challenges, improving science teaching confidence becomes critical for improving science teaching of young children. Science teaching confidence also varies by discipline for elementary teachers: physical science teaching confidence tends to measure lower than life science. This discrepancy leads to elementary teachers engaging in less effective science teaching practices with physical science than life science. A teacher's subject matter knowledge influences their confidence in their ability to teach that subject. Subject matter knowledge impacts science teaching confidence because when …

Surface-Functionalized Silica Nanocarriers For Mitigating Water Stress In Wheat And Benefiting The Root Microbiome, Anthony Cartwright

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Changes in climate and shifting patterns of drought threaten the growth of important cash crops like wheat. The element silicon serves as a plant nutrient and shows promise for strengthening wheat against drought while remaining safe to both the crop and the positive bacteria that grow on its roots. Silicon can be added to wheat in the form of silicon-dioxide nanoparticles featuring protective coatings made from plant-beneficial nutrients. These nanoparticles can be engineered with high surface area or porous structures allowing them to be loaded with additional nutrients that can be delivered to crops. In a laboratory setting, such nanoparticles …

Exploring Versatile Glycosyltransferases From Microorganisms For Natural Product Biosynthesis, Jie Ren

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This dissertation is mainly focused on exploring versatile glycosyltransferases from different microorganisms with the purpose of biosynthesizing bioactive natural product glycosides through microbial fermentation. This engineered biosynthesis approach is environmentally friendly, safe, and efficient compared with plant extraction, chemical synthesis, and enzymatic synthesis. Additionally, we applied these characterized glycosyltransferases as efficient biocatalytic tools to produce novel glycosides to expand the chemical repertoire of nature. These novel compounds showed improved water solubility and some of them exhibited enhanced stability and biological activity, which laid the foundation for the development of new therapeutic agents.

In my dissertation research, I have discovered two …

Fishing Out Nutrients: The Spatiotemporal And Ecological Dynamics Of Fishery-Based Nutrient Extraction, Adrián A. González Ortiz

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Marine fisheries are one of the most impactful human activities on the planet. Since the 1950s, marine fisheries have removed billions of metric tons of marine biomass leading to substantial declines in many fish populations. Among their impacts, we have begun to investigate the role of fisheries in disrupting marine nutrient cycles. Specifically, removing biomass can change nutrient cycles by reducing the amount of nutrients stored within animal biomass.

No studies have investigated the large-scale geographical and ecological contexts of nutrient removal by fisheries over a large timescale. For my thesis, we compiled data on fishery-targeted organisms' carbon, nitrogen, and …

Connectedness And Wellbeing: Investigating Community And Nature-Based Connection In The Context Of Utah's Rapid Growth, Sarah E. Wilson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Research suggests that feeling connected to the natural world and feeling socially connected to your community positively influence wellbeing. However, significant demographic shifts within communities may reduce the amount of social and nature-based connectedness enjoyed by residents. As one of the fastest growing states, data from within Utah likely provides important insights related to how population growth impacts connectedness and wellbeing. Considering this, the present research investigated the relationships between personal wellbeing, community connection, and connection with nature in the context of Utah's rapid population growth by utilizing quantitative survey data from the Utah Wellbeing Project and demographic information from …

#Bodypositivity Or #Bodypolitics?: A Rhetorical Analysis Of The Body Positivity Myth Formed By Narratives Of Political Myth, Sydney Berenyi Lasike

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Body Positivity movement is well-known for advocating for the acceptance of all body types—including size, shape, color, and ability. Images online in support of the movement often showcase stretch marks, cellulite, and other “unattractive” bodily features to protest against the thin-ideal and strict standards of beauty placed upon women. Despite the goal to inspire self-love and celebration of all bodies, the hashtag #BodyPositivity has been taken-over by white, female influencers who have the idolized, female body. They contradict the original message of the movement through their posts on Instagram that centralize white feminine features and thin, Eurocentric bodies. This …

Multispecies Genomic Sex Identification Using Ddx3 Gene Polymorphisms, Jessica Felts

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

PCR sex determination assays must be reliable and cost effective due to the frequent and integral use of these assays in biological research and the animal production industry. Thus, the design of proof of a primer pair with a built-in control is warranted to not only bypass the extra cost of a multiplex reaction, but also to prevent anomalous results that have been documented with other primer pairs.

The objective of this study was to design primer pairs with built in PCR amplification control to identify sex in Equus caballus (domestic horse), Homo sapiens (humans), Macaca mulatta (rhesus macaque), and …

Investigating Mitochondrial Influence On The Rate Of Anaerobic Glycolysis In An In Vitro Model, Mackenzie Jenna' Taylor

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The rate at which the muscle acidifies after an animal is harvested has a profound effect on the quality of the resulting pork. When acidification increases gradually, desirable pork quality characteristics are developed. In contrast, rapid acidification deteriorates pork quality, exemplified by the pale, soft, and exudative (PSE) pork defect. The rate of acidification is determined by the rate of anaerobic metabolism in postmortem muscle. Yet the processes controlling postmortem anaerobic metabolism are not well understood. Recent research suggests that mitochondria, the powerhouse of the cell, may influence this process by competing for substrate (pyruvate) with anaerobic metabolism, thereby reducing …

Antimicrobial Peptides In Transgenic Silkworm Silk, David Jaden Turner

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Overview: People in India and China have produced silk textiles for thousands of years. Silk is a biodegradable, biocompatible compound used in the production of clothing, bedding, furniture, industrial materials, and medical applications. Over the last 30 years, research has increasingly investigated silk’s antimicrobial effects and how to augment its natural abilities. Antimicrobial peptides, or AMPs, are also an area of increasing interest as the rise of antibiotic resistance reduces the efficacy of current treatments. This project plans to systematically synthesize a fusion protein that incorporates the beneficial properties of each constituent into commercial silkworms.

Innovation: This project seeks to …

Water Conservation Through Drought-Resilient Landscape Plants And Deficit Irrigation, Ji-Jhong Chen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Increases in urban population and inadequate rainfall result in imbalanced water budgets in urban and sub-urban regions. Water conservation becomes important in urban landscapes because of increased water demands. Modern landscape designs require drought-resistant plants to maintain urban landscape greenness during water scarcity. Irrigating plants at their irrigation requirements, which is the minimum irrigation rate that can achieve acceptable aesthetic quality, can also conserve water. However, the drought tolerance and irrigation requrements of most landscape plants have not been widely evaluated. Shepherdia ×utahensis ‘Torrey’ (‘Torrey’ buffaloberry) and Penstemon species (beardtongues) are low-water-use landscape plants, but their drought resistance mechanisms are …

Anthropogenic Factors Affecting Common Raven Occurrence And Depredation Of Artificial Nests Within Greater Sage‐Grouse Habitat In Southern Utah, Zoë S. Moffett

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Certain species of wildlife are more generalist and adaptive than others. These species often flourish when supported by human activities that provide additional food and habitat for them. The common raven (Corvus corax; hereafter raven) is one such species; their populations have risen and spread throughout the Intermountain West. As generalist scavengers and predators, ravens have been found to pose a severe threat to several threatened or sensitive species, including the greater sage-grouse (Centrocercus urophasianus; hereafter sage-grouse). The purpose of my research was to determine the specific anthropogenic and habitat factors that may increase the threat …

Physiological Consequences Of Adrenal Enlargement And Implications For Toxin Resistance In North American Snakes, Megen E. Kepas

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The long observed relationship between enlarged adrenal glands and toad-eating in snakes has remained a mystery in physiological ecology and herpetology. It has been predicted that large adrenal glands may be capable of producing higher amounts of key hormones, and that higher plasma hormone levels may lend some behavioral or physiological benefits after a toxic toad has been eaten. I address questions surrounding adrenal enlargement and its potential benefits to toad eaters in four research chapters. In my second chapter, I quantify adrenal hormone output at different embryonic stages in the toad-generalist snake Thamnophis elegans and examine the ability of …

All Good Women Are Mothers: Exploring Gender Binaries In How I Met Your Mother, Jessica Marinho

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Television is thought to be a form of entertainment through its many genres from comedy to drama, however, it is more than a relaxing pastime. Television series construct messages that influence audiences to accept specific behaviors. In this thesis, I analyzed the portrayal of the two main female characters in the popular television series How I Met Your Mother (2005-2009) and I argued how their depiction served to represent childless women as unwomanly and mothers as the ideal woman.

Cislunar Navigation Techniques And Navigation Performance Optimization, Quinn P. Moon

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Nova-C is a lunar lander developed by the private company Intuitive Machines to deliver commercial payloads to the Moon. The IM-1 mission set for 2023 will launch and land the Nova-C near the Moon's south pole. In this research, various navigation techniques are explored to determine the lander's position and velocity during key segments. This process is studied for key mission events including trajectory correction maneuvers (TCMs), lunar orbit insertion (LOI), and descent orbit insertion (DOI). Each mission segment, referred to as an Orbit Determination Segment (OD), is analyzed with three different navigation techniques: Monte Carlo Analysis, Linear Covariance Analysis, …

An Interval-Valued Random Forests, Paul Gaona Partida

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

There is a growing demand for the development of new statistical models and the refinement of established methods to accommodate different data structures. This need arises from the recognition that traditional statistics often assume the value of each observation to be precise, which may not hold true in many real-world scenarios. Factors such as the collection process and technological advancements can introduce imprecision and uncertainty into the data.

For example, consider data collected over a long period of time, where newer measurement tools may offer greater accuracy and provide more information than previous methods. In such cases, it becomes crucial …

Precipitation And Soil Properties Determine Long-Term Consequences Of Disturbance And Invasion In Drylands, Tyson Terry

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Disturbance and invasive species have dramatic effects on desert plant communities, often resulting in degradation or shifts to alternative plant communities. Climate and soil properties determine water availability to plants, and have been thought to drive patterns of recovery following disturbance and potential for invasion.

In chapter II we used a combination of natural gas pipelines and satellite imagery to understand how recovery from a uniform disturbance differs across precipitation and soil gradients. We used a recovery ratio (disturbed/undisturbed) of pipeline pixels and their undisturbed nearest neighbor pixel to quantify recovery in a comparable way across precipitation gradients. We found …

Black–White Disparities In Body Mass Index Trajectories From Adolescence To Adulthood: Assessing The Roles Of Adverse Childhood Experiences And Exposures To Short Sleep Durations, Olusola Akintoye Omisakin

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In comparison to Whites and other racial groups, the Black population in the U.S. has experienced one of the highest prevalences of obesity. Research into the role of adverse childhood experiences (ACEs) has increased recently because the effects of ACEs often persist for a significant portion of a person’s lifetime. Furthermore, the reduction in sleep duration in recent decades has sparked worries about public health. This dissertation assesses Black-White disparities in the associations between (1) ACEs and BMI, and (2) short sleep durations and BMI from adolescence to adulthood. Public-use datasets from the National Longitudinal Study of Adolescent to Adult …

Opening The Black Box: Soil Microbial Communities In Field-Based Plant-Soil Feedback Experiments, Julia Kate Aaronson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Plant-soil feedback is a process through which plants modify the properties of their associated soils, affecting their growth. PSF can play a key role in regulating plant growth and communities including altering plant invasion, rarity, and abundance. However, our understanding of the soil organisms that drive these plant growth responses is limited. Most studies treat soils as a ‘black box’ and do little to reveal which specific microbes or microbial communities may be responsible. This chapter examines two recent large PSF field experiments conducted in Minnesota, USA, and Jena, Germany. These experiments revealed that plants altered their soils, changing subsequent …

A Statewide Evaluation Of Fuel Treatment Effectiveness In Altering Wildfire Outcomes On Public Lands In Utah, Jamela Charmaine Thompson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Fuel treatments are land management activities that reduce living and dead flammable materials on the landscape to mitigate undesirable wildfire behavior and effects. Common treatments in the western United States include mechanical methods such as thinning and mastication, prescribed burns, and chemical methods, such as herbicide application. Treatments usually have multiple objectives, including reducing fire intensity, protecting natural and cultural resources, slowing or disrupting a potential future fire’s path, supporting ecosystem health, and reestablishing low to mid severity fire cycles in ecosystems. Although treatments can potentially modify fire behavior and ecological health, they generally cannot prevent fires from igniting, eliminate …

A Mechanistic Examination Of Interspecific Competition Between Wild And Domestic Herbivores, Courtney Check

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Large herbivores, such as mule deer and cattle have similar life histories and likely compete for resources. However, quantifying the extent to which these species compete and the specific resources they compete for has proved challenging. My research examines if cattle influence deer abundance and behavior due to competition for forage, competition for shade, and/or by affecting the predation risk of deer. Using a grid of autonomous trail cameras, I was able to determine if cattle abundance influences local deer abundance in relation to specific resources and habitat features. Using GPS data from collared deer, I was also able to …

Greater Sage-Grouse Response To Tree Canopy Removal: Habitat Vegetation Composition And Sage-Grouse Use 10–15 Years Post Treatment In The Southern Periphery Of The Species Range, Benjamen Donnelly

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Pinyon juniper woodland expansion into Greater sage-grouse (Centrocercus urophasianus, hereafter ‘sage-grouse’) habitat in southern Utah continues to threaten sage-grouse survival. Habitat restoration after pinyo-juniper removal treatment is key to the continued persistence and survival of sage-grouse along the southern edge of their range. Few long-term studies are available that examine sage-grouse use of areas treated to remove pinyon-juniper forests (i.e., ‘restored habitat’). The purpose of this research was to determine if sage-grouse used ‘restored’ areas in the long-term, as a measure of the actual effectiveness of pinyon-juniper woodland control treatments. I compared vegetation composition, shrub height and shrub …

Evaluating Beaver Translocation Methods For Desert River Restoration, Christine E. Sandbach

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Wildlife translocation, or moving wild animals from their original home to a new location, is a common conservation practice; however, translocation programs have variable success rates. Beaver translocation is often used in stream restoration projects due to beavers’ role as ecosystem engineers—beavers enhance riparian habitat by building dams that hold water and create more diverse channels. Beaver translocation success is often limited by high mortality and long distance movement after release, and improvement in translocation methods is needed. My objective was to evaluate two methods of improving beaver translocation success in a degraded desert river in east-central Utah: beaver dam …

From Flames To Forage: How Wildfire Affects Elk Behavior And Abundance, Megan M. Whetzel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Rocky Mountain elk (Cervus elaphus nelsoni) is an ecologically and culturally important wildlife species in the Intermountain West, but it is facing habitat changes caused by increasing fire activity. Wildfire frequency is projected to continue to change into the future, yet increases in annual area burned and increases in area burned at high severity may actually represent opportunities for some species. Large herbivores like elk may benefit from increased access to regenerating areas where forage abundance and quality are often elevated. Therefore, effective management of wildlife populations may depend on quantifying how large ungulates, like elk, alter …

Adverse Childhood Experiences, Discrimination, & Adulthood Health Outcomes: Impacts Of Protective And Compensatory Experiences In Childhood, Sallie A. Mack

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Adversity encompasses a wide range of stress-inducing experiences that are often prolonged and/or recurring in nature. Adverse childhood experiences (ACEs) capture adversity experienced before the age of 18, including abuse, neglect, and general household dysfunction. ACEs are widely linked to physical and mental health outcomes across the lifespan. Racial/ethnic discrimination, a form of adversity that can occur across the lifespan, has also been linked to many negative health outcomes. Protective and compensatory experiences in childhood (PACEs) are a relatively newer conceptualization of early-life resiliency factors. Early life resiliency is linked to positive health outcomes later in life. Our studies investigated …