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Sex Differences In The Intestinal Microbiome: Interactions With Risk Factors For Atherosclerosis And Cardiovascular Disease, Shamon Ahmed, J. David Spence
Sex Differences In The Intestinal Microbiome: Interactions With Risk Factors For Atherosclerosis And Cardiovascular Disease, Shamon Ahmed, J. David Spence
Department of Medicine Publications
Background: There are clearly sex differences in cardiovascular disease. On average, women experience cardiovascular events at an older age, and at any age, women, on average, have less atherosclerotic plaque than men. The role of the human intestinal microbiome in health and disease has garnered significant interest in recent years, and there have been indications of sex differences in the intestinal microbiome. The purpose of this narrative review was to evaluate evidence of sex differences in the interaction between the intestinal microbiome and risk factors for cardiovascular disease. Several studies have demonstrated changes in microbiota composition and metabolic profile as …
The Indigenous Determinants Of Health As Predictors For Diabetes And Unmet Health Needs Among Urban Indigenous People: A Respondent-Driven Sampling Study In Toronto, Ontario, Stephanie Rachael Mcconkey
The Indigenous Determinants Of Health As Predictors For Diabetes And Unmet Health Needs Among Urban Indigenous People: A Respondent-Driven Sampling Study In Toronto, Ontario, Stephanie Rachael Mcconkey
Electronic Thesis and Dissertation Repository
National statistics commonly present Indigenous peoples as a falsely homogenous group of people experiencing disproportionate ill health when compared to non-Indigenous peoples. There are significant gaps in statistical information regarding the health services access barriers experienced by Indigenous people that disrupts the quality of care they receive or prevents them from accessing care altogether. Our Health Counts Toronto is a community-based study that employed respondent-driven sampling (RDS) methodologies to sample 917 urban Indigenous adults. Prevalence estimates and prevalence ratios were calculated using RDS-II weights and adjusting for clustering by shared recruiter in SAS 9.4 and SAS-callable SUDAAN 11.0 software. This …
Switch From Canonical To Noncanonical Wnt Signaling Mediates High Glucose-Induced Adipogenesis, Emily C. Keats, James M. Dominguez, Maria B. Grant, Zia A. Khan
Switch From Canonical To Noncanonical Wnt Signaling Mediates High Glucose-Induced Adipogenesis, Emily C. Keats, James M. Dominguez, Maria B. Grant, Zia A. Khan
Paediatrics Publications
Human bone marrow mesenchymal progenitor cells (MPCs) are multipotent cells that play an essential role in endogenous repair and the maintenance of the stem cell niche. We have recently shown that high levels of glucose, conditions mimicking diabetes, cause impairment of MPCs, resulting in enhanced adipogenesis and suppression of osteogenesis. This implies that diabetes may lead to reduced endogenous repair mechanisms through altering the differentiation potential of MPCs and, consequently, disrupting the stem cell niche. Phenotypic alterations in the bone marrow of long-term diabetic patients closely resemble this observation. Here, we show that high levels of glucose selectively enhance autogenous …
Vascular Stem Cells In Diabetic Complications: Evidence For A Role In The Pathogenesis And The Therapeutic Promise, Emily C. Keats, Zia A. Khan
Vascular Stem Cells In Diabetic Complications: Evidence For A Role In The Pathogenesis And The Therapeutic Promise, Emily C. Keats, Zia A. Khan
Paediatrics Publications
Long standing diabetes leads to structural and functional alterations in both the micro- and the macro-vasculature. Vascular endothelial cells (ECs) are the primary target of the hyperglycemia-induced adverse effects. Vascular stem cells that give rise to endothelial progenitor cells (EPCs) and mesenchymal progenitor cells (MPCs) represent an attractive target for cell therapy for diabetic patients. A number of studies have reported EPC dysfunction as a novel participant in the culmination of the diabetic complications. The controversy behind the identity of EPCs and the similarity between these progenitor cells to hematopoietic cells has led to conflicting results. MPCs, on the other …