Digital Commons Network^™

Rgs14 Is A Mitotic Spindle Protein Essential From The First Division Of The Mammalian Zygote., Luke Martin-Mccaffrey, Francis S Willard, Antonio J Oliveira-Dos-Santos, David R C Natale, Bryan E Snow, Randall J Kimple, Agnieszka Pajak, Andrew J Watson, Lina Dagnino, Josef M Penninger, David P Siderovski, Sudhir J A D'Souza

Obstetrics & Gynaecology Publications

Heterotrimeric G protein alpha subunits, RGS proteins, and GoLoco motif proteins have been recently implicated in the control of mitotic spindle dynamics in C. elegans and D. melanogaster. Here we show that "regulator of G protein signaling-14" (RGS14) is expressed by the mouse embryonic genome immediately prior to the first mitosis, where it colocalizes with the anastral mitotic apparatus of the mouse zygote. Loss of Rgs14 expression in the mouse zygote results in cytofragmentation and failure to progress to the 2-cell stage. RGS14 is found in all tissues and segregates to the nucleus in interphase and to the mitotic spindle …

Predicting Death In Young Offenders: A Retrospective Cohort Study, Carolyn Coffey, Rory Wolfe, Andrew W. Lovett, Paul Moran, Eileen Cini, George C. Patton

Aboriginal Policy Research Consortium International (APRCi)

Objective: To examine predictors of death in young offenders who have received a custodial sentence using data routinely collected by juvenile justice services.

Design: A retrospective cohort of 2849 (2625 male) 11–20-year-olds receiving their first custodial sentence between 1 January 1988 and 31 December 1999 was identified. Main outcome measures: Deaths, date and primary cause of death ascertained from study commencement to 1 March 2003 by data-matching with the National Death Index; measures comprising year of and age at admission, sex, offence profile, any drug offence, multiple admissions and ethnic and Indigenous status, obtained from departmental records.

Results: Theoverallmortalityratewas7.2deathsper1000person-yearsofobservation. Younger …

Interpreting Workplace Learning In Terms Of Discourse And Community Of Practice, Adrian K. Ho

Western Libraries Publications

Based on the ethnographic data collected from the workplace of an academic library, I argue that workplace learning (WL) is a situated socio-cognitive process. It is expedited by knowledge management (KM), which is a collective effort to generate, share, and institutionalize work-related knowledge. KM is inherent in the face-to-face conversational interactions embedded in planned formal training, planned informal sharing, and spontaneous informal learning. When face-to-face interaction is not possible, KM is accomplished through textualization. It helps the members of the workplace acquire new work-related knowledge and integrate it to their common, contextualized knowledge base. The contents of the knowledge base …

Kosovo And The International Community: The Prolonging And Exacerbation Of A Crisis, Lindsay Scorgie

Faculty Publications

No abstract provided.

Desire, Heavenly Bodies, And A Surrealist's Fascination With The Celestial Theatre, John G. Hatch

Visual Arts Publications

In 1922, the German Surrealist artist Max Ernst produced a montage work that included a woman's bare buttocks protruding out of the rings of Saturn. It is, to say the least, an unusual combination of images, but one that addresses some very basic human impulses. Largely, It expresses Ernst's understanding that inscribed upon the night sky are some of our deepest held fears and fantasies. Ernst sought to generate contemporary rephrasings of our mythologizing of the cosmos in a complex and often enigmatic way, drawing on such varied sources as Freudian psychology, late nineteenth-century symbolism, alchemy, and Surrealism. Ultimately, Ernst …

Policies, Rules And Their Engines: What Do They Mean For Slas?, Mark Perry, Michael Bauer

Computer Science Publications

In our model for autonomic management of service level agreements (SLA), the roles played by policy and rules must be clearly differentiated. Although policy is typically an ideal we wish to achieve through the implementation of rules, the use of the terms policy and rule are often treated similarly and that consequently policy-engine and rule-engine are often used synonymously. It is our position that in the management of SLAs these terms have specific meanings. The definitions and models embodied are illustrated.

Gaps In Accessing Treatment For Anxiety And Depression: Challenges For The Delivery Of Care., Kerry A Collins, Henny A Westra, David J A Dozois, David D Burns

Psychology Publications

Epidemiological studies have identified high prevalence rates of anxiety and depression in North America [e.g., J. of Nerv. Ment. Dis. 182 (1994) 290]. However, only a small percentage of these individuals access effective treatment. The undertreatment of anxiety and depression is a major public health issue and is associated with significant personal, social, and economic burden. This article describes the existing discrepancy between prevalence of anxiety and depression and access to effective treatment for adults and children, the contributors to this discrepancy, and suggests various means through which access to effective treatment may be enhanced. We begin with a brief …

Treatment Patterns For Cancer In Western Australia: Does Being Indigenous Make A Difference?, Sonja E. Hall, Caroline E. Bulsara, Max K. Bulsara, Timothy G. Leahy, Margaret R. Culbong, Delia Hendrie, C D'Arcy J. Holman

Aboriginal Policy Research Consortium International (APRCi)

Objective: To examine whether hospital patients with cancer who were identified as Indigenous were as likely to receive surgery for the cancer as non-Indigenous patients. Design, setting and patients: Epidemiological survey of all Western Australian (WA) patients who had a cancer registration in the state-based WA Record Linkage Project that mentioned cancer of the breast (1982–2000) or cancer of the lung or prostate (1982–2001).

Main outcome measures: The likelihoods of receiving breast-conserving surgery or mastectomy for breast cancer, lung surgery for lung cancer, or radical or non-radical prostatectomy for prostate cancer were compared between the Indigenous and non-Indigenous populations using …

Family Structures And Children’S Behavioral Problems: A Latent Growth Curve Analysis, Don Kerr, Joseph Michalski

PSC Discussion Papers Series

The current article analyzes 1994-2000 data from the Canadian National Longitudinal Survey of Children and Youth to examine the relevance of family structures to trajectories of parental reports on hyperactivity - inattention among elementary school aged children. A latent growth modelling approach is used to compare children living in intact families, lone-parent families, stepfamilies, and families where parents divorced or separated. The results highlight the apparent advantages to living in intact families and the slightly greater risks experienced by children living in stepfamilies. Children in lone-parent families, while experiencing an initial disadvantage, displayed a similar trajectory on hyperactivity to children …

Calibration, Verification And Sensitivity Analysis Of The Hec-Hms Hydrologic Model, Juraj Cunderlik, Slobodan P. Simonovic

Water Resources Research Report

The main objective of this report is to describe the calibration, verification, and sensitivity analysis of the United States Army Corps of Engineers (USACE) Hydrologic Engineering Center’s Hydrologic Modeling System (HEC-HMS) on the data from the Upper Thames River basin (UTRb) study area. The HEC-HMS model was chosen to be the most appropriate hydrologic modeling tool for achieving the goals set in the Canadian Foundation for Climatic and Atmospheric Sciences (CFCAS) funded project “Assessment of Water Resources Risk and Vulnerability to Changing Climatic Conditions” (“project” hereafter), (Cunderlik and Simonovic, 2003). The calibration, verification and sensitivity analysis of the HMS model …

Individual And Regional Determinants Of Mammography Uptake, Anita Kothari, Stephen Birch

Health Studies Publications

Background: Analysis of mammography utilization has traditionally been performed from an individual-level perspective. The purpose of this study was to explore the combined influence of individual- and regional-level determinants of mammography utilization.

Methods: Logistic hierarchical multilevel modelling was used to investigate the influences of region of residence and individual characteristics on mammography utilization. Socioeconomic status information about health planning regions was derived from the 1996 Canadian Census. Individual-level information was extracted from the 1996 National Population Health Survey.

Results: After controlling for individual-level education, regions with fewer high school graduates had lower levels of mammography utilization. A cross-level interaction between …

Aboriginal Housing Assessment, Lisa Hardess, Rodney C. Mcdonald, Darren Thomas

Aboriginal Policy Research Consortium International (APRCi)

No abstract provided.

Work And Family Life Trajectories Of Young Canadians: Evidence From The 2001 General Social Survey, Zenaida Ravanera, Rajulton Fernando

PSC Discussion Papers Series

From the 1980s, there has been a trend among young Canadians to delay their transition to adulthood. This is seen as an indicator of greater investment in career and work life (most often, with parental help) before investing in reproduction. However, there are concerns expressed particularly for women that those with smaller parental and personal resources follow a different life course trajectory. They become parents at younger ages and are more likely to experience family dissolution and lone parenthood.

The study uses Statistics Canada’s 2001 General Social Survey on Family History and focuses on men and women born from 1966 …

An Investigation Of Integrating Change Through Participatory Processes In Police Service Business Planning, Tobi Hermann

MPA Major Research Papers

This paper examines the extent to which Ontario police business planning processes include effective citizen engagement and participation. A content analysis of public consultation data in the London Police Services was conducted and compared to municipal police department documentation in Windsor, Waterloo, and Sudbury. The findings reveal that police services in Ontario have embraced participatory mechanisms to engage the citizenry in an effort to renew democratic principles, increase perceptions of accountability, and legitimize the decisions made in the policy process.

The Role Of Religious Congregations In Providing Programs And Social Services In The Local Community: A Case Study Of London, Ontario, William Jaques

MPA Major Research Papers

This paper examines the extent to which religious congregations contribute to the provision of programs and social services within their respective communities based on a survey of 30 religious congregations in London, Ontario. The findings reveal that religious congregations are working diligently to provide programs and services to residents in their communities and the programs and services that they offer contribute to the overall health and well-being of these areas

Potential Alternative Revenue Sources For Municipal Infrastructure Maintenance – A Case Study: County Of Peterborough Transportation Infrastructure, Chris Bradley

MPA Major Research Papers

This paper examines whether the funding system for local infrastructure is adequate to ensure a sustainable, well-maintained transportation network and if there is a single, more effective means of funding local infrastructure maintenance based on a case study of the County of Peterborough. The findings reveal that the current funding system for local infrastructure maintenance is inadequate to ensure a sustainable, well-maintained transportation network and alternative revenue sources include the federal GST, the provincial PST, the gas tax, income tax, subsidies and transfers, infrastructure maintenance funding programs, and user fees.

Community Accountability In Ontario’S Healthcare Sector: A Case Study Of Six Hospitals, Catherine Cuylle

MPA Major Research Papers

This paper examines how community accountability is exercised by the governing boards of hospitals based on case studies of six hospitals in Ontario – London Health Sciences Centre (LHSC), Hamilton Health Sciences Corporation (HHS), The Ottawa Hospital (TOH), University Health Network (UHN), Sunnybrook and Women’s College Health Sciences Centre (S&W), and Toronto East General Hospital (TEGH). The findings reveal that hospital boards face a number of issues and tensions that stem from directing their accountability efforts towards the organization, the government, and the community in which they serve.

Intergovernmental Relations: An Analysis To Test The Effectiveness Of The Position Of An Intergovernmental Relations Officer At The Local Level, Michael Di Lullo

MPA Major Research Papers

This paper examines whether an intergovernmental relations officer is an effective position for local government based on surveys administered to chief administrators in 33 mid-sized Ontario municipalities. The findings reveal that having the position in local government is advantageous and effective for a municipality because it can generate greater opportunities with regards to revenue sourcing from the provincial and federal government.

Business Process Re-Engineering (Bpr): A Tool For Improved Customer Service In Municipalities, Lee Doyle

MPA Major Research Papers

This paper examines the appropriateness of business process re-engineering (BPR) in the improvement of customer service in local government. A content analysis of documents, a survey administered to municipal managers in 26 municipalities in Ontario, and a case study analysis of BPR implementation in four municipalities were conducted. The findings reveal that there is no clearly defined process or format for conducting BPR in Ontario municipalities.

The Establishment Performance Measures And Indicators For Social Housing In Ontario – The Background And The Process: What Are The Challenges?, Kathyrn Zarfas

MPA Major Research Papers

This paper examines the barriers that stakeholders must address with respect to effective public sector performance measurement within the context of social housing in Ontario based on a case study of the Service Managers Expert Panel. The findings reveal that the challenges associated with establishing an effective performance management program include program history, peer support, and having the necessary knowledge and desire to make the program work.

Double Dissociation Between The Effects Of Peri-Postrhinal Cortex And Hippocampal Lesions On Tests Of Object Recognition And Spatial Memory: Heterogeneity Of Function Within The Temporal Lobe., Boyer D Winters, Suzanna E Forwood, Rosemary A Cowell, Lisa M Saksida, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

It is widely believed that declarative memory is mediated by a medial temporal lobe memory system consisting of several distinct structures, including the hippocampus and perirhinal cortex. The strong version of this view assumes a high degree of functional homogeneity and serial organization within the medial temporal lobe, such that double dissociations between individual structures should not be possible. In the present study, we tested for a functional double dissociation between the hippocampus and peri-postrhinal cortex in a single experiment. Rats with bilateral excitotoxic lesions of either the hippocampus or peri-postrhinal cortex were assessed in tests of spatial memory (radial …

The Information Context Of Moral Rights Under The Copyright Regime, Margaret Ann Wilkinson, Natasha Gerolami

Law Publications

Moral rights have not been so uniformly or widely adopted as economic copyrights for authors, perhaps because the actual and potential value of moral rights in ensuring information needs are met has gone unrecognized. The authors demonstrate that moral rights protection can enhance authority control in the new information environment.

Copyrighting The Past? Emerging Intellectual Property Rights Issues In Archaeology1, George P. Nicholas, Kelly P. Bannister

Aboriginal Policy Research Consortium International (APRCi)

Rights to intellectual property have become a major issue in eth- nobotany and many other realms of research involving Indige- nous communities. This paper examines intellectual-property- rights-related issues in archaeology, including the relevance of such rights within the discipline, the forms these rights take, and the impacts of applying intellectual property protection in archaeology. It identifies the “products” of archaeological re- search and what they represent in a contemporary sociocultural context, examines ownership issues, assesses the level of protec- tion of these products provided by existing legislation, and dis- cusses the potential of current intellectual property protection mechanisms to augment …

Transmission Of Migration Propensity Increases Genetic Divergence Between Populations, Alain Gagnon, Bruno Toupance, Marc Tremblay, Jan Beise, Evelyne Heyer

PSC Discussion Papers Series

The advent of molecular genetics has brought invaluable information, which is now routinely used by anthropologists in their attempt to reconstruct our demographic past. Since the mitochondrial DNA loci are much more similar between populations than are the Y chromosome loci, it has been suggested that women had a much higher migration rate than men throughout history. Based on an examination of intergenerational migration patterns in three large demographic databases, we bring this inference into question. In some early Canadian settlements (St. Lawrence Valley and Saguenay), and in the past Krummhörn region of Northwest Germany, men whose father was a …

Social Status Polarization In The Timing And Trajectories To Motherhood, Zenaida R. Ravanera, Rajulton Fernando

PSC Discussion Papers Series

This paper examines the polarization by socio-economic status of Canadian women’s timing of and trajectories to motherhood. The study uses data gathered through the 2001 GSS on Family History and focuses on women born from 1922 to 1980. Women with high social status are more likely to delay their entry into motherhood and to follow trajectories that include graduation from post-secondary education. In contrast, women with low social status are more likely to follow shorter routes, often bypassing graduation from post-secondary education, regular work, or marriage, and consequently start motherhood at younger age.

Stress And Adult Health: Impact Of Time Spent In Paid And Unpaid Work, And Its Division In Families, Roderic Beaujot, Robert Anderson

PSC Discussion Papers Series

Based on a sample representative of the Canadian population aged 30-59, this paper assesses the impact of time spent on productive activities, and various types of activities, on stress and health. The main finding is that the number of hours spent is a better predictor of stress than is the type of activity. Moreover, the effects of paid and unpaid work are additive rather than multiplicative. That is, the more people work, regardless of what they are doing, the more likely they are to feel stressed. Still, working irregular hours and non-traditional family models are also associated with poorer health …

Indigenous Women: A Gender Perspective, Chandra K. Roy

Aboriginal Policy Research Consortium International (APRCi)

No abstract provided.

Deletion Of The Na/K-Atpase Alpha1-Subunit Gene (Atp1a1) Does Not Prevent Cavitation Of The Preimplantation Mouse Embryo., L C Barcroft, A E Moseley, J B Lingrel, A J Watson

Obstetrics & Gynaecology Publications

Increases in Na/K-ATPase activity occur concurrently with the onset of cavitation and are associated with increases in Na(+)-pump subunit mRNA and protein expression. We have hypothesized that the alpha1-isozyme of the Na/K-ATPase is required to mediate blastocyst formation. We have tested this hypothesis by characterizing preimplantation development in mice with a targeted disruption of the Na/K-ATPase alpha1-subunit (Atp1a1) using embryos acquired from matings between Atp1a1 heterozygous mice. Mouse embryos homozygous for a null mutation in the Na/K-ATPase alpha1-subunit gene are able to undergo compaction and cavitation. These findings demonstrate that trophectoderm transport mechanisms are maintained in the absence of the …

Bifurcation By Social Status In The Onset Of Fatherhood, Zenaida R. Ravanera, Rajulton Fernando

PSC Discussion Papers Series

Abstract not available

P38 Mapk Signaling During Murine Preimplantation Development., David R Natale, Andrew J M Paliga, Frank Beier, S J A D'Souza, Andrew J Watson

Obstetrics & Gynaecology Publications

Mitogen-activated protein kinase (MAPK) pathways mediate some important cellular processes and are likely to also regulate preimplantation development. The role of p38 MAP kinase signaling during murine preimplantation development was investigated in the present study. p38 MAPK, p38-regulated or -activated kinase (PRAK; MK5), map kinase-activated protein kinase 2 (MK2), and heat shock protein 25 (hsp25) mRNAs and proteins were detected throughout preimplantation development. Two-cell stage embryos cultured in the presence of SB220025 and SB203580 (specific inhibitors of p38 MAPK alpha/beta), progressed to the eight-cell stage with the same frequency as controls; however, treated embryos halted their development at the 8- …