Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (4)
- Medicine and Health Sciences (3)
- Neuroscience and Neurobiology (3)
- Cognitive Neuroscience (2)
- Diseases (2)
-
- Nervous System Diseases (2)
- Alternative and Complementary Medicine (1)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Anatomy (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Mental and Social Health (1)
- Nervous System (1)
- Other Rehabilitation and Therapy (1)
- Pharmacology (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Physiology (1)
- Psychiatric and Mental Health (1)
- Rehabilitation and Therapy (1)
Articles 1 - 5 of 5
Full-Text Articles in Entire DC Network
The Use Of Current Steering During Subthalamic Deep Brain Stimulation To Alleviate Upper Limb Symptoms Of Parkinson's Disease, Shabna Iftikar Mohideen
The Use Of Current Steering During Subthalamic Deep Brain Stimulation To Alleviate Upper Limb Symptoms Of Parkinson's Disease, Shabna Iftikar Mohideen
Electronic Thesis and Dissertation Repository
Subthalamic (STN) deep brain stimulation (DBS) is an established treatment to alleviate the appendicular motor symptoms of Parkinson's Disease (PD). Current steering during DBS allows the unequal fractionation of current between two electrodes on the lead, resulting in a non-spherical electrical field. It is hypothesized that the way the electrical field is shaped will affect a patient’s upper limb symptom alleviation. Seven PD patients who underwent bilateral STN-DBS were tested over four weeks post-operation. 16 current fractionation settings were tested each week at an amplitude that increased weekly. Optimal setting was defined as the setting that provided the best …
Dopaminergic Medication Decreases Motor Impulsivity On The Go/No-Go Task In Parkinson's Disease, Xue Qing Yang
Dopaminergic Medication Decreases Motor Impulsivity On The Go/No-Go Task In Parkinson's Disease, Xue Qing Yang
Electronic Thesis and Dissertation Repository
Parkinson’s disease (PD) is characterized by resting tremor, rigidity, and bradykinesia. Dopaminergic medications treat motor symptoms, but have complex effects on cognition, including impulse control. Impulsivity is multifaceted in nature. Motor impulsivity involves inability to withhold prepotent, automatic responses whereas cognitive impulsivity refers to increased risk-taking and reward-seeking. We anticipated that dopaminergic therapy would decrease motor impulsivity. We employed the Go/No-go paradigm to assess motor impulsivity. PD patients were tested on and off their dopaminergic medication. PD patients on medication had a significantly higher proportion of Go Timeouts (i.e., Go responses not completed by the 750 millisecond deadline) compared to …
Role Of The Dorsal Striatum In Learning And Decision Making, Nole M. Hiebert
Role Of The Dorsal Striatum In Learning And Decision Making, Nole M. Hiebert
Electronic Thesis and Dissertation Repository
The striatum, the input region of the basal ganglia, has been shown to mediate many cognitive functions. The striatum itself can be functionally segregated into dorsal (DS) and ventral striatum (VS). For more than 60 years, DS has been reported to mediate stimulus-response learning, though evidence has been accruing pointing to a role in decision making. These literatures have been growing independently and an aim of this thesis was to bridge these two bodies of knowledge. We directly investigated the role of DS in stimulus-response learning versus decision making using functional magnetic resonance imaging (fMRI) in patients with Parkinson’s disease …
Efficacy Of Rhythmic Acquisition On Gait Performance Among Individuals With Parkinson’S Disease, Demian L. Kogutek
Efficacy Of Rhythmic Acquisition On Gait Performance Among Individuals With Parkinson’S Disease, Demian L. Kogutek
Electronic Thesis and Dissertation Repository
The purpose of this study was to identify the ability of individuals with Parkinson’s disease (PD) to acquire different rhythmic complexity levels through individual home-based Improvised Active Music Therapy (IAMT) sessions. The study aimed to identify whether higher acquisition of rhythmic complexity levels improved gait performance, as well as beat perception and production abilities. In this single subject multiple baseline design, the study measured the ability of four right-handed participants with PD to acquire greater density of syncopation, as a measure of rhythmic complexity levels, while playing uninterrupted improvised music on a simplified electronic drum-set. An accredited music therapist led …
Conformational Arrangements Of Ubch7-Ubiquitin With Ospg And Parkin, Tara E. C. Condos
Conformational Arrangements Of Ubch7-Ubiquitin With Ospg And Parkin, Tara E. C. Condos
Electronic Thesis and Dissertation Repository
The E2-ubiquitin conjugate is a key regulator of ubiquitination and is therefore an important component of cellular homeostasis. Disruptions to proper E2-ubiquitin functioning have implications in diseases such as shigellosis and Parkinson’s disease discussed here. E2-ubiquitin conjugates like UbcH7-ubiquitin are extremely dynamic and can adopt multiple conformations in solution or bound to target proteins. However, the conformational arrangements that UbcH7-ubiquitin adopts while free in solution, bound to the shigellosis-associated kinase OspG or to the Parkinson’s disease-related E3 ligase parkin are unknown. Also unknown, is a mechanistic explanation for how UbcH7-ubiquitin interactions with OspG and parkin are associated with disease. Here, …