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Cognitive Composites For Genetic Frontotemporal Dementia: Genfi-Cog, Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma Van Der Ende, Esther Van Den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre De Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard
Cognitive Composites For Genetic Frontotemporal Dementia: Genfi-Cog, Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma Van Der Ende, Esther Van Den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre De Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard
Neuroscience Institute Publications
Background: Clinical endpoints for upcoming therapeutic trials in frontotemporal dementia (FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but are lacking in genetic FTD. We aimed to create cognitive composite scores for genetic frontotemporal dementia (FTD) as well as recommendations for recruitment and duration in clinical trial design. Methods: A standardized neuropsychological test battery covering six cognitive domains was completed by 69 C9orf72, 41 GRN, and 28 MAPT mutation carriers with CDR® plus NACC-FTLD ≥ 0.5 and 275 controls. Logistic regression was used to identify the combination of tests that distinguished best between each mutation carrier …
Investigating The Contribution Of White Matter Hyperintensities And Cortical Thickness To Empathy In Neurodegenerative And Cerebrovascular Diseases, Miracle Ozzoude, Brenda Varriano, Derek Beaton, Joel Ramirez, Melissa F. Holmes, Christopher J.M. Scott, Fuqiang Gao, Kelly M. Sunderland, Paula Mclaughlin, Jennifer Rabin, Maged Goubran, Donna Kwan, Angela Roberts, Robert Bartha, Sean Symons, Brian Tan, Richard H. Swartz, Agessandro Abrahao, Gustavo Saposnik, Mario Masellis, Anthony E. Lang, Connie Marras, Lorne Zinman, Christen Shoesmith, Michael Borrie, Corinne E. Fischer, Andrew Frank, Morris Freedman, Manuel Montero-Odasso, Sanjeev Kumar, Elizabeth Finger
Investigating The Contribution Of White Matter Hyperintensities And Cortical Thickness To Empathy In Neurodegenerative And Cerebrovascular Diseases, Miracle Ozzoude, Brenda Varriano, Derek Beaton, Joel Ramirez, Melissa F. Holmes, Christopher J.M. Scott, Fuqiang Gao, Kelly M. Sunderland, Paula Mclaughlin, Jennifer Rabin, Maged Goubran, Donna Kwan, Angela Roberts, Robert Bartha, Sean Symons, Brian Tan, Richard H. Swartz, Agessandro Abrahao, Gustavo Saposnik, Mario Masellis, Anthony E. Lang, Connie Marras, Lorne Zinman, Christen Shoesmith, Michael Borrie, Corinne E. Fischer, Andrew Frank, Morris Freedman, Manuel Montero-Odasso, Sanjeev Kumar, Elizabeth Finger
Neuroscience Institute Publications
Change in empathy is an increasingly recognised symptom of neurodegenerative diseases and contributes to caregiver burden and patient distress. Empathy impairment has been associated with brain atrophy but its relationship to white matter hyperintensities (WMH) is unknown. We aimed to investigate the relationships amongst WMH, brain atrophy, and empathy deficits in neurodegenerative and cerebrovascular diseases. Five hundred thirteen participants with Alzheimer’s disease/mild cognitive impairment, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), Parkinson’s disease, or cerebrovascular disease (CVD) were included. Empathy was assessed using the Interpersonal Reactivity Index. WMH were measured using a semi-automatic segmentation and FreeSurfer was used to measure cortical …
Healthcare Workers And Covid-19-Related Moral Injury: An Interpersonally-Focused Approach Informed By Ptsd, Andrea M. D'Alessandro, Kimberly Ritchie, Randi E. Mccabe, Ruth A. Lanius, Alexandra Heber, Patrick Smith, Ann Malain, Hugo Schielke, Charlene O'Connor, Fardous Hosseiny, Sara Rodrigues, Margaret C. Mckinnon
Healthcare Workers And Covid-19-Related Moral Injury: An Interpersonally-Focused Approach Informed By Ptsd, Andrea M. D'Alessandro, Kimberly Ritchie, Randi E. Mccabe, Ruth A. Lanius, Alexandra Heber, Patrick Smith, Ann Malain, Hugo Schielke, Charlene O'Connor, Fardous Hosseiny, Sara Rodrigues, Margaret C. Mckinnon
Neuroscience Institute Publications
The COVID-19 pandemic has resulted in a still-unfolding series of novel, potentially traumatic moral and ethical challenges that place many healthcare workers at risk of developing moral injury. Moral injury is a type of psychological response that may arise when one transgresses or witnesses another transgress deeply held moral values, or when one feels that an individual or institution that has a duty to provide care has failed to do so. Despite knowledge of this widespread exposure, to date, empirical data are scarce as to how to prevent and, where necessary, treat COVID-19-related moral injury in healthcare workers. Given the …