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Three Essays On Market Dynamics: Counterfeits, Tipping Policies, And Probabilistic Promotions, Yongqin Lei May 2024

Three Essays On Market Dynamics: Counterfeits, Tipping Policies, And Probabilistic Promotions, Yongqin Lei

Electronic Thesis and Dissertation Repository

I study the complexities of market dynamics through the lens of investigating counterfeit goods, online platforms' tipping policies, and probabilistic price promotions. This dissertation consists of three essays that examine the strategic interactions between companies and consumers, aiming to offer insights into solutions companies can make to both better protect consumers' rights and enhance their profits. In the first essay, I investigate the issue of counterfeits in online marketplaces, focusing on credence goods such as nutritional supplements whose quality is hard to ascertain. I analyze a two-stage competition between genuine sellers and counterfeiters. I show that counterfeiters may utilize fake …


Listening To Transgender And Autistic Voices: Reflecting On Affirming Research And Mental Health Practices, Kameron Bm Kirbyson Apr 2024

Listening To Transgender And Autistic Voices: Reflecting On Affirming Research And Mental Health Practices, Kameron Bm Kirbyson

Electronic Thesis and Dissertation Repository

Those who are both autistic and transgender/gender diverse, an often-overlooked group, face difficulties accessing gender-affirming care and appropriate therapy and have higher rates of mental health complications. This study focused on listening to the voices of people who live with both of these identities through semi-structured interviewing and by centring the writer who is also autistic and transgender. Seven participants shared their experiences and highlighted issues they have come up against while trying to access care. Thematic analysis revealed several themes that were sorted into barriers and strengths. Barriers included autism symptoms, complex medical factors, interactions with institutions, traumatic events, …


Towards Effective Communication: An Exploration Of Evidence-Based Strategies For Informal Care Partners Engaged In Difficult Conversations With Individuals With Parkinson's Disease, Emily Brinovec Apr 2024

Towards Effective Communication: An Exploration Of Evidence-Based Strategies For Informal Care Partners Engaged In Difficult Conversations With Individuals With Parkinson's Disease, Emily Brinovec

Electronic Thesis and Dissertation Repository

Communication deficits are common in Parkinson’s disease and can compromise the ability for informal care partners to communicate effectively with their partner. This may result in the avoidance of critically important conversations, thus placing strain on the relationship, and can harm the well-being of both parties. The aim of this thesis is to explore evidence-informed communication strategies that can be utilized to assist care partners of individuals with Parkinson’s Disease (IWPD) in conducting difficult conversations. Utilizing a scoping review methodology, seven themes emerged from peer-reviewed literature on communication: selecting an appropriate physical environment; conversation preparation; verbal communication skills; non-verbal communication …


Towards Understanding And Improving Speech Processing, Sonia Yasmin Apr 2024

Towards Understanding And Improving Speech Processing, Sonia Yasmin

Electronic Thesis and Dissertation Repository

This dissertation explores mechanisms for understanding and improving speech processing. First, I used EEG to investigate the acoustic and semantic processing of continuous naturalistic speech masked by multi-talker babble. I found that different features of the same speech signal are reflected in different aspects of the neural tracking response, which are themselves differentially affected by noise. These findings point to a complex relationship between speech intelligibility and neural speech encoding.

Next, I systematically reviewed the current advancements in speech enhancement technologies. I find that speech enhancement algorithms are limited in their generalizability to speech-noise (i.e., babble). I demonstrate that, for …


Exploring The Quality Performance Of Ethno-Specific And Mainstream Not-For-Profit Long-Term Care Homes In Ontario, Lanei Amein Apr 2024

Exploring The Quality Performance Of Ethno-Specific And Mainstream Not-For-Profit Long-Term Care Homes In Ontario, Lanei Amein

Electronic Thesis and Dissertation Repository

The purpose of this retrospective study was to determine how ethno-specific not-for-profit long-term care (LTC) homes in Ontario perform in comparison to mainstream not-for-profit LTC homes using nine RAI-MDS 2.0 quality indicators. Publicly available data from three sources: the Canadian Institute for Health Information "Your Health System: In Depth" database from the Continuing Care Reporting System, data on Ontario ethno-specific not-for-profit LTC homes from the Home and Community Care Support Services, and data on home and ownership records from the Ministry of Long-Term Care “Public Reporting” website, between 2017-2022, were retrieved and analyzed. Descriptive analysis suggests that for all quality …


Bioarchaeological Knowledge Mobilization And The Museum As Knowledge Broker, Teegan Muggridge Apr 2024

Bioarchaeological Knowledge Mobilization And The Museum As Knowledge Broker, Teegan Muggridge

Electronic Thesis and Dissertation Repository

Knowledge mobilization – the process of creating, disseminating, and using knowledge to generate real-world value and impact – is essential in research. The highly contextual nature of human remains poses unique challenges for successful bioarchaeological knowledge mobilization, requiring these projects to address historico-cultural, sociopolitical, and ethical contexts in order to mobilize knowledge in a way that is both accurate and appropriate for diverse communities. This thesis considers the way that museums, as places of community heritage and engagement, may serve as knowledge brokers, facilitating meaningful interactions between researchers and the wider public. Exploring museum professional perspectives in conjunction with an …


Educators’ Perspectives On Teacher Mental Health And Professional Development., Sybil Hw Chan Apr 2024

Educators’ Perspectives On Teacher Mental Health And Professional Development., Sybil Hw Chan

Electronic Thesis and Dissertation Repository

Educator wellness is inextricably linked to their ability to teach and support students in the classroom. However, limited research has examined the factors that influence educator mental health in Canada, and the role of mental health-based professional development in these relationships. Therefore, the present mixed-method, multi-phase study examined the current knowledge, understandings, and beliefs about professional development and mental wellness for Canadian teacher candidates and associate teachers. Results from a binomial logistic regression found that higher educator psychological distress was positively correlated with presenteeism, and negatively correlated with workplace psychological safety. A reflexive thematic analysis of twelve semi-structured interviews further …


Understanding Mechanisms Underlying Changes In Parental Care Behaviour In Response To Perceived Paternity In Sunfish, Emma Churchman Apr 2024

Understanding Mechanisms Underlying Changes In Parental Care Behaviour In Response To Perceived Paternity In Sunfish, Emma Churchman

Electronic Thesis and Dissertation Repository

Parental care is essential for the survival of many young animals but presents significant costs to the caring parent. To mitigate these costs, parental care systems have evolved to optimize survival and fitness. According to parental investment theory, care allocation is influenced by the offspring’s value, which is often linked to their relatedness to the parent. In this thesis, I explore how hormones and gene expression influence parental care, focusing on bluegill sunfish (Lepomis macrochirus) and the hybrids they produce with pumpkinseed sunfish (Lepomis gibbosus). By manipulating direct and indirect paternity cues – swapping eggs between …


Scale-Up And Measurement Enhancements Of A Biogenerator Bioreactor, Jason J. Glas Apr 2024

Scale-Up And Measurement Enhancements Of A Biogenerator Bioreactor, Jason J. Glas

Electronic Thesis and Dissertation Repository

Renewable energies in the form of wind and solar have seen steadfast growth across the world, however the abundance of these technologies that demonstrate short-term variability in power output threatens power grid stability and necessitates the use of fossil fuels for rapid throttling capability. A requirement for large scale energy storage systems becomes necessary and a system based on hydrogen generation, storage, and consumption for electrical grid supply-demand stabilization using a ferric sulfate oxidant is herein explored, named the BioGenerator. As the name implies, the system functions as an indirect microbial fuel cell using a biologically active broth dominated by …


Optimizing The Management Of Anterior Monteggia Fractures: A Biomechanical Evaluation Of Treatment Options, Kirk D. Vannitamby Apr 2024

Optimizing The Management Of Anterior Monteggia Fractures: A Biomechanical Evaluation Of Treatment Options, Kirk D. Vannitamby

Electronic Thesis and Dissertation Repository

Anterior Monteggia injuries are frequently complicated by persistent radial head instability and suboptimal outcomes. Using a cadaveric elbow motion simulator, we quantified the contributions of ligaments of the proximal radius on maintaining radial head stability, evaluated the effectiveness of ulnar overcorrection to create an apex dorsal angulation in stabilizing the radiocapitellar joint, and finally compared the stabilizing effect of annular ligament repair to three different reconstruction techniques. Our results showed increased anterior radial head translation with progressive soft tissue sectioning with the annular ligament as the primary stabilizer. Ulnar overcorrection and forearm pronation were shown to decrease anterior translation of …


Retrospective Pre-Post Evaluation Of A Healthy Relationships And Mental Health Promotion Program For 2s/Lgbtqia+ Youth, Nikita Kalwani Apr 2024

Retrospective Pre-Post Evaluation Of A Healthy Relationships And Mental Health Promotion Program For 2s/Lgbtqia+ Youth, Nikita Kalwani

Electronic Thesis and Dissertation Repository

Research has found that 2S/LGBTQIA+ youth experience disproportionately high mental health concerns and barriers to accessing support. Protective factors such as school-based support, peer support, and mental health interventions have been found to buffer this risk. The Healthy Relationships Program (HRP) for 2S/LGBTQIA+ Youth is a positive mental health promotion program that aims to build resiliency, bolster healthy relationship skills, and promote well-being among 2S/LGBTQIA+ youth. This study aimed to evaluate the outcomes, effectiveness, and feasibility of implementing this program within Gender and Sexuality/Gay-Straight Alliances (GSAs) in secondary schools. Data from students (N = 17) and GSA advisors who …


Evaluating A Daily Physical Activity (Dpa) Toolkit For Elementary School Teachers, Shelby T. Singh Apr 2024

Evaluating A Daily Physical Activity (Dpa) Toolkit For Elementary School Teachers, Shelby T. Singh

Electronic Thesis and Dissertation Repository

The present study investigated whether a centralized toolkit containing easy-to-access resources, and that could be implemented without training, could help to promote greater adherence to Ontario’s Daily Physical Activity (DPA) policy and encourage more physical activity within the classroom. From January to March 2023, 142 Ontario elementary teachers completed pre-/post-surveys assessing DPA practices and were given access to the DPA toolkit. The findings demonstrate that access to the DPA toolkit improved DPA fidelity, as well as increased teacher engagement/enjoyment with DPA, and perception of students’ cognitive functioning, academic performance and mental health. In conclusion, providing accessible, easy-to-use resources that require …


Older Adolescent Perspectives On The Use Of Research Within Online Communities, Ahrrabie Thirunavukkarasu Apr 2024

Older Adolescent Perspectives On The Use Of Research Within Online Communities, Ahrrabie Thirunavukkarasu

Electronic Thesis and Dissertation Repository

This study explores the attitudes of older adolescents (aged 16 to 19) regarding researchers collecting personal information from Social Networking Sites (SNSs) through passive observation to support Non-Suicidal Self-Injury (NSSI) research. The aim of this study is to add to the ongoing discourse in the scientific community, by providing a unique perspective on how researchers can uphold ethical conduct throughout their research process. This study adopts a mixed-methods approach and incorporates a QualtricsXM survey and online focus groups (FGs). The findings reveal that participants have reservations toward passive, hidden observational researchers. Despite their concerns, participants support researchers using their …


Black Tio2 Nts And Zno-Tio2 Nts Heterostructure: Synthesis, Characterization, And Synchrotron-Based Spectroscopy Studies, Lu Yao Apr 2024

Black Tio2 Nts And Zno-Tio2 Nts Heterostructure: Synthesis, Characterization, And Synchrotron-Based Spectroscopy Studies, Lu Yao

Electronic Thesis and Dissertation Repository

The one-dimensional (1D) TiO2 nanotubes (NTs), and their derivatives have been extensively studied due to their potential use in water-splitting, solar cells, and lithium-ion batteries. Since TiO2 has a large band gap (~3.2 eV for anatase), there has been a search for higher photocatalytic efficiency by shifting the band gap into the visible range. This thesis presents a study of black TiO2 NTs and ZnO-TiO2 heterostructures using synchrotron-based X-ray spectroscopy and X-ray diffraction techniques. It involves the transformation from as-prepared TiO2 NTs to black TiO2 NTs via an electrochemical reduction method. ZnO-TiO2 NT …


Exploring Counsellors’ Insights Into Effective Support For Clients With Low Income, Skylar Rego Apr 2024

Exploring Counsellors’ Insights Into Effective Support For Clients With Low Income, Skylar Rego

Electronic Thesis and Dissertation Repository

Individuals with low income may experience a greater need for mental health services due to the substantial life challenges and stressors they experience. However, more research needs to explore what has been effective in improving services for this population. The present study addressed this gap through counsellors’ perspectives to identify what has been helpful when working with low-income populations. Counsellors completed an interview regarding their personal and professional experiences working with low-income populations, answering the question, “What have you found to be the most helpful aspects of counselling with clients facing low income?”. Participants then completed a sorting task using …


Exploring The Feasibility And Outcomes Of Concurrent Parent And Child Mindfulness-Based Interventions, Melissa Read Apr 2024

Exploring The Feasibility And Outcomes Of Concurrent Parent And Child Mindfulness-Based Interventions, Melissa Read

Electronic Thesis and Dissertation Repository

Mindfulness-Based Interventions (MBIs) have shown to be effective in improving child and parent outcomes, including parental stress (Burgdorf et al., 2019; Friedmutter, 2016), child behaviour problems, and child executive functioning (Cheang et al., 2019; Donald et al., 2019; Dunning et al., 2019). The field of mindfulness has evolved to include parents and children together in programs, called parallel or concurrent parent and child MBIs. Children who have experienced adversity may be at a greater need for MBIs, as MBIs target stress and emotion regulation, areas where these children may need greater support (Bethell et al., 2016; Brenmer, 2003). As a …


Social Location & Counsellor Identity: A Reflexive Analysis Of Social Power And The Therapeutic Use Of Self, Stephanie R. Page Apr 2024

Social Location & Counsellor Identity: A Reflexive Analysis Of Social Power And The Therapeutic Use Of Self, Stephanie R. Page

Electronic Thesis and Dissertation Repository

It has become widely appreciated that health and mental health are impacted by interconnected systems of inequity and individual social location. With demand for psychological services increasing in Canada, there does exist a need to better understand how social location relates to counselling. A random sample of 19 CCPA registered Canadian Counsellors were interviewed and asked about their social location. Participant responses were transcribed and qualitatively analyzed using the Six-Phase Model for Reflexive Thematic Analysis (Braun & Clarke, 2022). One theme and two sub-themes were carved out: Participant Asset Experiences (25), Self-Identification (15), and Blind Spots (10). Findings relate to …


Investigation Of Segregation In Mixing Pharmaceutical Powders Using Passive Acoustic Emissions In A V-Blender, Omar Salem Apr 2024

Investigation Of Segregation In Mixing Pharmaceutical Powders Using Passive Acoustic Emissions In A V-Blender, Omar Salem

Electronic Thesis and Dissertation Repository

Powder mixing is a crucial and complex step in pharmaceutical production. Monitoring of mixing and segregation processes can be achieved using process analytical technologies to improve product quality. Passive acoustic emissions were examined during mixing in a V-blender. Vibrations from the emissions were measured through an accelerometer affixed to the outer V-shell arm lid. Horizontal and vertical loading configurations of particles were examined. Stable mixtures were reached when the measured amplitude plateaued around the approximate weighted average of the particles in the outer V-shell arm. Horizontal loading trials mixed faster and reached stable mixtures in fewer revolutions than vertical loading …


The Roles Of Fabp3 In Endothelial Dysfunction And The Transcriptomic Insights Into Cardiovascular Disease, Chi Hien Nguyen Apr 2024

The Roles Of Fabp3 In Endothelial Dysfunction And The Transcriptomic Insights Into Cardiovascular Disease, Chi Hien Nguyen

Electronic Thesis and Dissertation Repository

Heart-type fatty acid binding protein (FABP3) is an effective biomarker for cardiac injuries. However, it has also been tested as a biomarker in patients with peripheral artery diseases; these conditions are complications of atherosclerosis, which is driven by endothelial dysfunction. As FABP3 release is not exclusive to the heart but appears to characterize cardiovascular events, whether FABP3 influences endothelial function is not known. Additionally, the transcriptomic profiles of endothelial cells during cardiovascular stresses remain under-investigated. This thesis investigates the multifaceted role of FABP3 and the transcriptomic alterations in endothelial cells under different cardiovascular stressors, offering novel insights into endothelial dysfunction …


The Black-To-White Hole Transition, Farshid Soltani Apr 2024

The Black-To-White Hole Transition, Farshid Soltani

Electronic Thesis and Dissertation Repository

Classically, an isolated black hole is a stable gravitational object. If however semiclassical effects are taken into account, an isolated black hole can be shown to slowly radiate its mass away in a process called evaporation. At the end of the evaporation process, when the size of the horizon becomes Planckian, the quantum nature of the gravitational field can no longer be neglected and the dynamics of the horizon is governed by quantum gravity. The main objective of this thesis is the systematic investigation of a tentative scenario for the “end of the life” of a black hole: the black-to-white …


Determining The Effects Of Mistranslating Transfer Rna Variants On Drosophila Melanogaster, Joshua R. Isaacson Apr 2024

Determining The Effects Of Mistranslating Transfer Rna Variants On Drosophila Melanogaster, Joshua R. Isaacson

Electronic Thesis and Dissertation Repository

Transfer RNAs (tRNAs) play a central role in translation as adaptor molecules between mRNA and protein. Variant tRNAs can cause the misincorporation of an amino acid into a growing polypeptide. Mistranslating tRNA variants are surprisingly common in humans but the effects of mistranslating tRNA variants on eukaryotic biology are poorly understood. My thesis aimed to create a model of tRNA-induced mistranslation using the fruit fly Drosophila melanogaster and characterize the effects of mistranslating tRNA variants on eukaryotic biology.

I first integrated a gene encoding a serine tRNA variant that induced proline-to-serine (P>S) mistranslation into the fly genome. Proteins isolated …


Physical And Geometrical Modulation Of Human Fibroblast Behaviour, Sarah M. Brooks Apr 2024

Physical And Geometrical Modulation Of Human Fibroblast Behaviour, Sarah M. Brooks

Electronic Thesis and Dissertation Repository

This thesis investigates the impact of mechanical stimuli, specifically substratum topography and elastic modulus, on dermal and gingival fibroblast behaviour associated with scarring and regeneration. Scar formation presents a significant issue for implanted biomaterials often leading to device failure. Even though scar formation is a normal end point to adult human dermal wound healing, gingival wounds are capable of tissue regeneration or scarless wound healing. Understanding how these cells respond to environmental cues, including substratum topography and elastic modulus, is central to the development of novel biomaterials for stimulation of tissue regeneration. It was hypothesized that topographic features, with submicron …


“We Make Things Today For Tomorrow”: Artists’ Publishing For The Future, Ruth Skinner Apr 2024

“We Make Things Today For Tomorrow”: Artists’ Publishing For The Future, Ruth Skinner

Electronic Thesis and Dissertation Repository

This dissertation is an exploration of artists’ book, artists’ publishing, distribution, and archival practices from a number of vantages in order to explore the activist possibilities of contemporary arts publishing. The concept of urgent artifacts, developed by publisher Paul Soulellis, reverberates throughout this research. The liveliness of this term is enhanced through applying additional modes of experience: clairvoyance, forensics, thinness, as well as their tricky interplay. In exploring what artists’ publishing might require for the present and the immediate future, this research-creation project considers the possibilities that clairvoyance—in particular, the figure of the medium—and archival intuition might offer. Borrowing from …


Anxiety In Children And Adolescents With Autism Spectrum Disorder: Behavioural Phenotypes And Environmental Factors, Caitlin E. Leachman Miss Apr 2024

Anxiety In Children And Adolescents With Autism Spectrum Disorder: Behavioural Phenotypes And Environmental Factors, Caitlin E. Leachman Miss

Electronic Thesis and Dissertation Repository

Anxiety is the most prevalent comorbidity among children and adolescents with autism spectrum disorder (ASD). The phenotypical presentation of anxiety among children and adolescents with ASD is lacking within the literature. This study sought to differentiate behavioral phenotypes associated with anxiety in children with ASD from anxiety in typically-developing children. Participants completed a series of child and parent reports measuring anxiety, depressive symptoms, ASD symptom severity, emotional problems, parental stress, and socioeconomic factors. Three distinct anxiety profiles, including moderate, high, and low, were identified. Results demonstrated that depression is the strongest predictor of high anxiety among children and adolescents with …


Luminescence And Structural Properties Of Silicon-Germanium Quantum Structures Fabricated By Ion Implantation, Matheus Coelho Adam Apr 2024

Luminescence And Structural Properties Of Silicon-Germanium Quantum Structures Fabricated By Ion Implantation, Matheus Coelho Adam

Electronic Thesis and Dissertation Repository

The advancement of semiconductor materials has played a crucial role in driving positive technological breakthroughs that impact humanity in numerous ways. The presence of defects significantly alters the physical properties of semiconductors, making their analysis essential in the fabrication of semiconductor devices. I presented a new method to quantify surface and near-surface defects in single crystal semiconductors. Epitaxially-grown silicon was measured by low energy electron diffraction (LEED) to obtain the surface Debye temperature (θD). The results showed the surface θD of bulk Si (001), 1.0 μm, and 0.6 μm Si on sapphire of 333 K, 299 K, …


Barriers To Working With Low Income Clients As Experienced By Counsellors, Riley Keast Apr 2024

Barriers To Working With Low Income Clients As Experienced By Counsellors, Riley Keast

Electronic Thesis and Dissertation Repository

This study aimed to answer the question “what are the perceived barriers or challenges counsellors experience when working with low income clients in their practice following COVID-19?”. Participants were recruited via mass email sent to professionals registered with the Canadian Counselling and Psychotherapy Association (CCPA), who then completed a survey via Qualtrics (n = 322). 113 Canadian counsellors from across Canada were interviewed. Data obtained from interviews was analyzed using concept mapping software GroupWisdom. Participants (n = 29) grouped the statements into seven themes including: barriers due to low income and employment, systemic barriers for clients, barriers due to …


Numerical Study Of Ozone Decomposition Reaction Behaviours In Gas-Solids Circulating Fluidized Bed Reactors, Zhengyuan Deng Apr 2024

Numerical Study Of Ozone Decomposition Reaction Behaviours In Gas-Solids Circulating Fluidized Bed Reactors, Zhengyuan Deng

Electronic Thesis and Dissertation Repository

This study numerically investigated the reaction behaviours of catalytic ozone decomposition reaction in a 10.2-meter-tall gas-solids circulating fluidized bed (CFB) reactor. A pseudo-homogeneous reactive transport model for ozone decomposition, integrated with the two-fluid model, was developed and validated using experimental data. Based on the model, the impacts of turbulence models, specularity coefficients, and simulation methods on reaction behaviours in the CFB riser reactor were explored. These three factors were found to significantly affect the hydrodynamic characteristics and the reaction behaviours in the riser. A comparative study of CFB riser and downer reactors was conducted. Operations in the direction of and …


Bioactive And Electrically Conductive Nanocomposite Bone Biomaterials, Rebeca A. Arambula-Maldonado Apr 2024

Bioactive And Electrically Conductive Nanocomposite Bone Biomaterials, Rebeca A. Arambula-Maldonado

Electronic Thesis and Dissertation Repository

Electrically conductive carbon-based materials are emerging as potential biomaterials for bone tissue engineering. Their incorporation into organic-inorganic nanocomposites mimics the structural composition and electrically conductive nature of bone.

The aim of this research was to design bone biomaterials from gelatin-based polymers, tertiary bioactive glasses (BG) via a sol-gel method, and multiwall carbon nanotubes (MWCNT). The incorporation of calcium into organic-inorganic nanocomposites plays an essential role in the development of bioactive bone biomaterials. Calcium chloride and calcium ethoxide were investigated as calcium sources in gelatin-BG-MWCNT nanocomposites. The resulting surface elemental distribution was homogeneous, but the swelling, degradation and porosity properties of …


Examining Fragility Of Health Systems In Afghanistan: Development And Application Of A Theoretical Framework For Fragile Health Systems, Faiza Rab Apr 2024

Examining Fragility Of Health Systems In Afghanistan: Development And Application Of A Theoretical Framework For Fragile Health Systems, Faiza Rab

Electronic Thesis and Dissertation Repository

Globally, health systems face destabilization amidst conflicts and natural disasters, adversely affecting populations' well-being. Understanding domains of health system fragility remains a gap in literature, hampering effective mitigation. In protracted conflict, Afghanistan's health system offers a crucial case for studying health system fragility. This research aimed to bridge gaps in comprehending health system fragility, with research questions:

1. What is the conceptual understanding of the fragility of health systems and its relationship with resilience, and how can it be applied in Afghanistan?

2. Did the introduction of female health workers to support Maternal, Neonatal, and Child Health service delivery by …


Chest Computed Tomography And Magnetic Resonance Imaging Texture Measurements Of Chronic Obstructive Pulmonary Disease, Maksym Sharma Apr 2024

Chest Computed Tomography And Magnetic Resonance Imaging Texture Measurements Of Chronic Obstructive Pulmonary Disease, Maksym Sharma

Electronic Thesis and Dissertation Repository

Pulmonary imaging using computed tomography (CT) and magnetic resonance imaging (MRI) provide a method to measure airway and parenchymal pathologic information that cannot be provided using spirometry. Currently, it remains difficult to predict which chronic obstructive pulmonary disease (COPD) patients will worsen using spirometry, which although safe and inexpensive, does not provide small airway information where COPD is believed to initiate. Quantitative CT and MRI measurements provide regional structure and function information but are not included in mortality risk assessments, prognosis, or COPD staging. Therefore, my overarching hypothesis is that CT and MRI ventilation texture measurements combined with machine learning …