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Characterization Of Intestinal Epithelial Cells In Acute Intestinal Allograft Rejection, Xian-Chang Li
Characterization Of Intestinal Epithelial Cells In Acute Intestinal Allograft Rejection, Xian-Chang Li
Digitized Theses
Intestinal transplantation (IT) remains highly experimental compared to other solid organ transplants because of poorly defined mechanisms of graft rejection. In this project, the role of luminal bacteria-derived endotoxin and inflammatory cytokines (IL-1, IL-6, TNF-{dollar}\alpha){dollar} in intestinal epithelial damage during acute graft rejection was examined. In a novel mouse model of IT, the acute intestinal rejection was associated with elevated levels of endotoxin, IL-6, and TNF-{dollar}\alpha{dollar} in the peripheral blood. The progressive increase in endotoxin and TNF-{dollar}\alpha{dollar} levels correlated well with the histologic severity of epithelial damage. To further define the role of endotoxin and inflammatory cytokines on intestinal epithelial …