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Fabrication Of Extracellular Matrix-Derived Foams And Microcarriers As Tissue-Specific Cell Culture And Delivery Platforms, Anna Kornmuller, Cody F.C. Brown, Claire Yu, Lauren E. Flynn
Fabrication Of Extracellular Matrix-Derived Foams And Microcarriers As Tissue-Specific Cell Culture And Delivery Platforms, Anna Kornmuller, Cody F.C. Brown, Claire Yu, Lauren E. Flynn
Bone and Joint Institute
© 2017 Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Cell function is mediated by interactions with the extracellular matrix (ECM), which has complex tissue-specific composition and architecture. The focus of this article is on the methods for fabricating ECM-derived porous foams and microcarriers for use as biologically-relevant substrates in advanced 3D in vitro cell culture models or as pro-regenerative scaffolds and cell delivery systems for tissue engineering and regenerative medicine. Using decellularized tissues or purified insoluble collagen as a starting material, the techniques can be applied to synthesize a broad array of tissue-specific bioscaffolds with customizable geometries. The approach involves mechanical …