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Ventilation Inhibits Sympathetic Action Potential Recruitment Even During Severe Chemoreflex Stress, Mark B. Badrov, Otto F. Barak, Tanja Mijacika, Leena N. Shoemaker, Lindsay J. Borrell, Mihajlo Lojpur, Ivan Drvis, Zeljko Dujic, J. Kevin Shoemaker
Ventilation Inhibits Sympathetic Action Potential Recruitment Even During Severe Chemoreflex Stress, Mark B. Badrov, Otto F. Barak, Tanja Mijacika, Leena N. Shoemaker, Lindsay J. Borrell, Mihajlo Lojpur, Ivan Drvis, Zeljko Dujic, J. Kevin Shoemaker
Bone and Joint Institute
© 2017 the American Physiological Society. This study investigated the influence of ventilation on sympathetic action potential (AP) discharge patterns during varying levels of high chemoreflex stress. In seven trained breath-hold divers (age 33 ± 12 yr), we measured muscle sympathetic nerve activity (MSNA) at baseline, during preparatory rebreathing (RBR), and during 1) functional residual capacity apnea (FRCApnea) and 2) continued RBR. Data from RBR were analyzed at matched (i.e., to FRCApnea) hemoglobin saturation (HbSat) levels (RBRMatched) or more severe levels (RBREnd). A third protocol compared alternating periods (30 s) of FRC and RBR (FRC-RBRALT). Subjects continued each protocol until …