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A Scoping Review Of Health Outcomes Examined In Randomized Controlled Trials Using Guided Imagery, Peter R. Giacobbi Jr., Jonathan Stewart, Keeley Chaffee, Anna-Marie Jaeschke, Meagan Stabler, George A. Kelley

Clinical and Translational Science Institute

Introduction—Guided imagery involves the controlled visualization of detailed mental images. This integrative health technique is used for healing, health maintenance, or the treatment of specific conditions. Guided imagery is an integral part of mindfulness meditation, hypnosis, and various relaxation exercises. However, evidence to support the widespread use and dissemination of guided imagery interventions has been lacking. The purposes of this scoping review were to document the scope of health outcomes and disease processes examined by guided imagery researchers and the journal outlets where this work has been published. Secondary purposes were to review the efficacy of guided imagery, risk of …

Gingival Perfusion And Tissue Biomarkers During Early Healing Of Postextraction Regenerative Procedures: A Prospective Case Series, Lamees Alssum, Timothy D. Eubank, Sashwati Roy, Barbaros S. Erdal, Vedat O. Yildiz, Dimitris N. Tatakis, Binnaz Leblebicioglu

Clinical and Translational Science Institute

Background—Post-extraction alveolar bone loss, mostly affecting the buccal plate, occurs despite regenerative procedures. To better understand possible determinants, this prospective case series assessed gingival blood perfusion and tissue molecular responses in relation to postextraction regenerative outcomes. Methods—Adults scheduled to receive bone grafting in maxillary, non-molar, single tooth extraction site were recruited. Clinical documentation included probing pocket depth (PD), keratinized tissue width (KT), tissue biotype (TB), plaque (P) and bleeding. Wound closure was clinically evaluated. Gingival blood perfusion was measured by Laser Doppler Flowmetry (LDF). Wound fluid (WF) and gingival biopsies were analyzed for protein levels and gene expression, respectively, of …

An Electronic Health Record Data-Driven Model For Identifying Older Adults At Risk Of Unintentional Falls, Adam Baus, Jeffrey Coben, Keith Zullig, Cecil Pollard, Charles Mullett, Henry Taylor, Jill Cochran, Traci Jarrett, Dustin Long

Clinical and Translational Science Institute

Screening for risk of unintentional falls remains low in the primary care setting because of the time constraints of brief office visits. National studies suggest that physicians caring for older adults provide recommended fall risk screening only 30 to 37 percent of the time. Given prior success in developing methods for repurposing electronic health record data for the identification of fall risk, this study involves building a model in which electronic health record data could be applied for use in clinical decision support to bolster screening by proactively identifying patients for whom screening would be beneficial and targeting efforts specifically …

Dental Workforce Availability And Dental Services Utilization In Appalachia: A Geospatial Analysis, Xue Feng, Usha Sambamoorthi, R. Constance Wiener

Clinical and Translational Science Institute

Objectives—There is considerable variation in dental services utilization across Appalachian counties, and a plausible explanation is that individuals in some geographical areas do not utilize dental care due to dental workforce shortage. We conducted an ecological study on dental workforce availability and dental services utilization in Appalachia. Methods—We derived county-level (n = 364) data on demographic, socio-economic characteristics and dental services utilization in Appalachia from the 2010 Behavioral Risk Factor Surveillance System (BRFSS) using person-level data. We obtained county-level dental workforce availability and physician-to-population ratio estimates from Area Health Resource File, and linked them to the county-level BRFSS data. The …

Direct And Indirect Cost Of Managing Alzheimer's Disease And Related Dementias In The United States, Arijita Deb, James Douglas Thornton, Usha Sambamoorthi, Kim Innes

Clinical and Translational Science Institute

Introduction—Care of individuals with Alzheimer’s Disease and Related Dementias (ADRD) poses special challenges. As the disease progresses, individuals with ADRD require increasing levels of medical care, caregiver support, and long-term care which can lead to substantial economic burden. Areas covered—In this expert review, we synthesized findings from studies of costs of ADRD in the United States that were published between January 2006 and February 2017, highlighted major sources of variation in costs, identified knowledge gaps and briefly outlined directions for future research and implications for policy and program planning. Expert commentary—A consistent finding of all studies comparing individuals with and …

Imaging Thiol Redox Status In Murine Tumors In Vivo With Rapid-Scan Electron Paramagnetic Resonance, Boris Epel, Subramanian V. Sundramoorthy, Martyna Krzykawska-Serda, Matthew C. Maggio, Mark Tseytlin, Gareth R. Eaton, Sandra S. Eaton, Gerald M. Rosen, Joseph P. Y. Kao, Howard J. Halpern

Clinical and Translational Science Institute

Thiol redox status is an important physiologic parameter that affects the success or failure of cancer treatment. Rapid scan electron paramagnetic resonance (RS EPR) is a novel technique that has shown higher signal-to-noise ratio than conventional continuous-wave EPR in in vitro studies. Here we used RS EPR to acquire rapid three-dimensional images of the thiol redox status of tumors and normal tissues in living mice. This work presents, for the first time, in vivo RS EPR images of the kinetics of the reaction of 2H,15N-substituted disulfide-linked dinitroxide (PxSSPx) spin probe with intracellular glutathione. The cleavage rate is proportional to the …

Stimulated Hyposalivary Flow Rates In Healthcare Students In An Interprofessional Awareness Educational Program Curriculum, R Constance Wiener

Faculty & Staff Scholarship

Purpose. Hyposalivation influences quality of life and medication compliance. However, oral health knowledge (in general) and knowledge about hyposalivation (in particular) are often lacking in nondental healthcare professional’s curricula. Additionally, hyposalivation has not been adequately studied in young adults. The purpose for this study is twofold: to use an interprofessional educational curriculum to increase nondental healthcare students’ knowledge about oral health and salivary testing and determine whether hyposalivation is different between sexes in young adults. Method. First-year medical and pharmacy students () learned the process of saliva collection and provided samples in an interprofessional program. Results. There were 14.4% of …

Ex Libris, Winter 2017, West Virginia University. Library.

Ex Libris: The WVU Libraries Magazine

Forever a West Virginia Boy: Basketball Legend Jerry West returned to campus to announce WVRHC will preserve the Jerry West Collection

Orthodontic Treatment Completion And Discontinuation In A Rural Sample From North Central Appalachia In The Usa, Chris A. Martin, Breana M. Dieringer, Daniel W. Mcneil

Faculty & Staff Scholarship

Background: Orthodontics has inherent demands, requiring regular appointments and active patient engagement, but relatively little is established in regard to rates of completion of treatment and possible factors affecting successful completion. These factors may be particularly important for cultural minority groups, such as those in rural Appalachia, given the environmental, social, and economic complexities affecting access to and utilization of treatment.

Design and methods: A naturalistic study design was employed, using retrospective data from a rural outpatient general dental office in July 2012. Chart abstraction yielded 219 (55.3% female) orthodontic patients (M age = 11.0 [3.7]). Chi-square tests for independence …

Researchmedical And Pharmacy Students’ Attitudes Towards Physician-Pharmacist Collaboration In Kuwait, Maram G. Katoue, Abdelmoneim I. Awad, Aishah Al-Jarallah, Ebaa Al-Oazairi, Terry L. Schwinghammer

Faculty & Staff Scholarship

Objective : To assess and compare the attitudes of medical and pharmacy students towards physician - pharmacist collaboration and explore their opinions about the barriers to collaborative practice in Kuwait. Methods : A cross - sectional survey of p harmacy and medical students (n=467) was conducted in Faculties of Medicine and Pharmacy, Kuwait University. Data were collected via self - administered questionnaire from first - year pharmacy and medical students and students in the last two professional yea rs of the pharmacy and medical programs. Descriptive and comparative analyses were performed using SPSS, version 22. Statistical significance was accepted at …

The Role Of Laminins In Cartilaginous Tissues: From Development To Regeneration, Y Sun, T L. Wang, W S. Toh, M Pei

Faculty & Staff Scholarship

As a key molecule of extracellular matrix, laminin provides a delicate microenvironment for cell functions. Recent findings suggest that laminins expressed by cartilage-forming cells (chondrocytes, progenitor cells and stem cells) could promote chondrogenesis. However, few papers outline the effect of laminins on providing a favorable matrix microenvironment for cartilage regeneration. In this review, we delineated the expression of laminins in hyaline cartilage, fibrocartilage and cartilage-like tissue (nucleus pulposus) throughout several developmental stages. We also examined the effect of laminins on the biological activities of chondrocytes, including adhesion, migration and survival. Furthermore, we scrutinized the potential influence of various laminin isoforms …

Genetic Association Of Mmp10, Mmp14, And Mmp16 With Dental Caries, D D. Lewis, J R. Shaffer, E Feingold, M Cooper, M M. Vanyukov, B S. Maher, R L. Slayton, M C. Willing, S E. Reis, D W. Mcneil, R J. Weyant, A R. Vieira, M L. Marazita

Faculty & Staff Scholarship

Matrix metalloproteinases (MMPs), which degrade extracellular proteins as part of a variety of physiological processes, and their inhibitors have been implicated in the dental caries process. Here we investigated 28 genetic variants spanning the MMP10, MMP14, and MMP16 genes to detect association with dental caries experience in 13 age- and race-stratified () samples from 6 parent studies. Analyses were performed separately for each sample, and results were combined across samples by meta-analysis. Two SNPs (rs2046315 and rs10429371) upstream of MMP16 were significantly associated with caries in an individual sample of white adults and via meta-analysis across 8 adult samples after …

A Preliminary Genome-Wide Association Study Of Pain-Related Fear: Implications For Orofacial Pain, Cameron L. Randall, Casey D. Wright, Jonathan M. Chernus, Daniel W. Mcneil, Eleanor Feingold, Richard J. Crout, Katherine Neiswanger, Robert J. Weyant, John R. Shaffer, Mary L. Marazita

Faculty & Staff Scholarship

Background. Acute and chronic orofacial pain can significantly impact overall health and functioning. Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive components of fear of pain have been elucidated. Little is known, however, regarding the specific genes contributing to fear of pain. Methods. A genome-wide association study (GWAS; ) was performed to identify plausible genes that may predispose individuals to various levels of fear of pain. The total score and three subscales (fear of minor, severe, and medical/dental pain) of the Fear of Pain Questionnaire-9 (FPQ-9) were modeled in a …

Periodontal Status And Quality Of Life: Impact Of Fear Of Pain And Dental Fear, Casey D. Wright, Daniel W. Mcneil, Cierra B. Edwards, Richard J. Crout, Katherine Neiswanger, John R. Shaffer, Mary L. Marzita

Faculty & Staff Scholarship

Background. Oral health-related quality of life (OHRQoL) is impacted by periodontal disease and orofacial pain. There is a limited research examining the impact of avoidance of care or physiological arousal related to the fear of pain response on periodontal-related OHRQoL. Methods. Data are from the Center for Oral Health Research in Appalachia family-based study focusing on 1,339 adults. Measures included a modified Periodontal Screening and Recording Index across sextants of dentition, dental fear survey, Fear of Pain Questionnaire-9, and Oral Health Impact Profile-14. Structural equation modeling was used to estimate the effects of periodontal disease screening indicators on OHRQoL including …

Influence Of Fear Of Pain And Coping Strategies On Health-Related Quality Of Life And Patient-Anticipated Outcomes In Patients With Chronic Pain: Cross-Sectional Study Protocol, Manasi M. Mittinty, David S. Brennan, Cameron L. Randall, Daniel W. Mcneil, Murthy N. Mittinty, Lisa Jameson

Faculty & Staff Scholarship

Background: Fear of pain and coping strategies are emotional-behavioral responses to pain and are known to play an important role in the development and maintenance of pain. It is highly likely that fear of pain and coping strategies influence each other, potentially affecting the course of chronic pain. To our knowledge, the relationship between pain, fear of pain and coping strategies, and how they influence patient-anticipated outcomes and health-related quality of life, have not been investigated.

Objective: The aims of this study are to test (1) if both fear of pain and/or coping strategies are sufficient causes for maintaining pain; …