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Characterization Of Putative Porphyromonas Gingivalis Rna-Binding Proteins, Holly Dwyer
Characterization Of Putative Porphyromonas Gingivalis Rna-Binding Proteins, Holly Dwyer
Theses and Dissertations
Porphyromonas gingivalis (P. gingivalis) is a gram-negative, anaerobic bacterium recognized as a major player in progression of periodontal disease. P. gingivalis survives in the oral cavity while being exposed to dynamic environmental conditions such as pH, temperature, nutrient availability and host immune responses such as oxygen tension and nitrosative stress. Survival and pathogenesis of P. gingivalis in the oral cavity require mechanisms to regulate gene expression in response to the extracellular signals. Little is known about the regulatory mechanisms of P. gingivalis in the oral cavity, so it is important to investigate and characterize these regulatory mechanisms. Adaptation to environmental …
Characterization Of The Biological Role Of A Putative Porphyromonas Gingivalis Rna-Binding Protein, Ramana Cvitkovic
Characterization Of The Biological Role Of A Putative Porphyromonas Gingivalis Rna-Binding Protein, Ramana Cvitkovic
Theses and Dissertations
Porphyromonas gingivalis, a gram-negative anaerobic bacterium, is a major etiological agent in the initiation and progression of severe forms of periodontal disease. Oral bacteria like P. gingivalis are subject to continually changing conditions as a consequence of host eating, oral hygiene patterns and subgingival temperatures. As such survival requires an adaptive response to environmental cues, but little is known about the mechanism by which P. gingivalis controls co- and post-transcriptional regulation of RNA levels and potentially protein expression. RNA-binding proteins (RBPs) are evolutionarily conserved across species and are involved in such regulatory mechanisms. However, P. gingivalis currently has no identified …