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Bone Benefits Of Fish Oil Supplementation Depend On Its Epa And Dha Content, Haissam Abou-Saleh, Allal Ouhtit, Ganesh V. Halade, Md Mizanur Rahman
Bone Benefits Of Fish Oil Supplementation Depend On Its Epa And Dha Content, Haissam Abou-Saleh, Allal Ouhtit, Ganesh V. Halade, Md Mizanur Rahman
Internal Medicine Faculty Publications
Licensee MDPI, Basel, Switzerland. The preventive effect of high-dose (9%) regular-fish oil (FO) against bone loss during aging has been demonstrated, but the effects of a low-dose (1%–4%) of a highly purified concentrated FO (CFO) has not been elucidated. The aim of this study was to determine the dose-dependent effect of a CFO against bone loss in C57BL/6 female mice during aging. Twelve-month old mice were fed with 1% and 4% CFO and 4% safflower oil (SFO) diets, including a group with a 4% regular-FO diet and a group with a lab chow diet for 12 months. Bone mineral density …
Home-Based Cognitive Monitoring: The Role Of Personality And Predictors Of Adherence And Satisfaction, Nasreen A. Sadeq
Home-Based Cognitive Monitoring: The Role Of Personality And Predictors Of Adherence And Satisfaction, Nasreen A. Sadeq
USF Tampa Graduate Theses and Dissertations
Over the last several decades, a growing awareness of the benefits of regular screening for common health conditions, such as cancer and cardiovascular diseases, has paved the way for preventative screenings to become routine in medical settings. Given that cognitive impairment is frequently reported as the number one worry of older adults, home-based cognitive monitoring may be an innovative solution that allows middle aged and older adults to take an active role in monitoring an important aspect of their health. Although several home-based cognitive monitoring programs have been validated for use in clinical and home-based settings, the Cogstate Brief Battery …
Effects Of Medications With Anticholinergic Properties And Opioids On Cognitive Function And Neural Volumetric Changes In Elderly Australians, Malinee Neelamegam
Effects Of Medications With Anticholinergic Properties And Opioids On Cognitive Function And Neural Volumetric Changes In Elderly Australians, Malinee Neelamegam
USF Tampa Graduate Theses and Dissertations
Introduction: Multiple comorbidities are common among older adults. Pharmaceutical interventions are the most common form of medical management of the multiple health conditions that the older adult population faces. Almost 90% of adults aged 65 years and above take at least one prescription medication. Polypharmacy (5 medication or more) occurs with 50% of the older adult population. Most medications used to treat common ailments affecting the geriatric population have anticholinergic properties. These medications are known to cause a range of side effects from peripheral effects to central nervous system effects. These adverse effects are of particular concern in the older …
Small Heat Shock Proteins, Big Impact On Protein Aggregation In Neurodegenerative Disease, Jack M. Webster, April L. Darling, Vladimir N. Uversky, Laura J. Blair
Small Heat Shock Proteins, Big Impact On Protein Aggregation In Neurodegenerative Disease, Jack M. Webster, April L. Darling, Vladimir N. Uversky, Laura J. Blair
Molecular Medicine Faculty Publications
Misfolding, aggregation, and aberrant accumulation of proteins are central components in the progression of neurodegenerative disease. Cellular molecular chaperone systems modulate proteostasis, and, therefore, are primed to influence aberrant protein-induced neurotoxicity and disease progression. Molecular chaperones have a wide range of functions from facilitating proper nascent folding and refolding to degradation or sequestration of misfolded substrates. In disease states, molecular chaperones can display protective or aberrant effects, including the promotion and stabilization of toxic protein aggregates. This seems to be dependent on the aggregating protein and discrete chaperone interaction. Small heat shock proteins (sHsps) are a class of molecular chaperones …
Hormone Replacement Therapy Attenuates Hearing Loss: Mechanisms Involving Estrogen And The Igf-1 Pathway, Tanika T. Williamson, Bo Ding, Xiaoxia Zhu, Robert D. Frisina
Hormone Replacement Therapy Attenuates Hearing Loss: Mechanisms Involving Estrogen And The Igf-1 Pathway, Tanika T. Williamson, Bo Ding, Xiaoxia Zhu, Robert D. Frisina
Chemical, Biological and Materials Engineering Faculty Publications
Estradiol (E) is a multitasking hormone that plays a prominent role in the reproductive system, and also contributes to physiological and growth mechanisms throughout the body. Frisina and colleagues have previously demonstrated the beneficial effects of this hormone, with E-treated subjects maintaining low auditory brainstem response (ABR) thresholds relative to control subjects (Proceedings of the National Academy of Sciences of the United States of America, 2006;103:14246; Hearing Research, 2009;252:29). In the present study, we evaluated the functionality of the peripheral and central auditory systems in female CBA/CaJ middle-aged mice during and after long-term hormone replacement therapy (HRT) via …