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Relt Stains Prominently In B-Cell Lymphomas And Binds The Hematopoietic Transcription Factor Mdfic, John K. Cusick, Yasmeen Alhomsy, Stephanie Wong, George Talbott, Vladimir N. Uversky, Cara Hart, Nazila Hejazi, Aaron T. Jacobs, Yihui Shi
Relt Stains Prominently In B-Cell Lymphomas And Binds The Hematopoietic Transcription Factor Mdfic, John K. Cusick, Yasmeen Alhomsy, Stephanie Wong, George Talbott, Vladimir N. Uversky, Cara Hart, Nazila Hejazi, Aaron T. Jacobs, Yihui Shi
Molecular Medicine Faculty Publications
Receptor Expressed in Lymphoid Tissues (RELT) is a human tumor necrosis factor receptor superfamily member (TNFRSF) that is expressed most prominently in cells and tissues of the hematopoietic system. RELL1 and RELL2 are two homologs that physically interact with RELT and co-localize with RELT at the plasma membrane. This study sought to further elucidate the function of RELT by identifying novel protein interactions with RELT family members. The transcription factor MyoD family inhibitor domain-containing (MDFIC) was identified in a yeast two-hybrid genetic screen using RELL1 as bait. MDFIC co-localizes with RELT family members at the plasma membrane; this co-localization was …