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A Micro-Computed Tomographic Evaluation Of Root Canal Isthmuses In Maxillary And Mandibular First Molars Of A Black South African Population, Casper Jonker, Anna Catherina Oettlé Sep 2026

A Micro-Computed Tomographic Evaluation Of Root Canal Isthmuses In Maxillary And Mandibular First Molars Of A Black South African Population, Casper Jonker, Anna Catherina Oettlé

Peninsula Dental School

Objective:To evaluate root canal isthmuses in maxillary and mandibular first molars of Black South Africans usingmicro-computed tomography.Methods:The prevalence, location (root third) and type of isthmuses were recorded on 93 maxillary and 84mandibular first molars from 116 skeletonized individuals. Associations with arch side, sex and age were examined bychi-squared test, with strength of association given as the bias-adjusted Cramér’s V and 95% confidence interval (CI).Reliability used percentage agreement and Cohen’s kappa (κ) coefficient.Results:Intra- and inter-observer agreement were excellent: 96.73% (κ= 0.90) and 97.78% (κ= 0.95) for themaxillary teeth and 94.12% (κ= 0.75) and 96.08% (κ= 0.94) for the mandibular teeth. Apical …

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Bidirectional Eeg Neurofeedback Of Sensorimotor Beta Oscillations Reveals Asymmetric Modulation And Strategy-Dependent Learning, Krithika Anil, Stephen Hall, Jennifer Freeman, Jonathan Marsden, Giorgio Ganis Sep 2026

Bidirectional Eeg Neurofeedback Of Sensorimotor Beta Oscillations Reveals Asymmetric Modulation And Strategy-Dependent Learning, Krithika Anil, Stephen Hall, Jennifer Freeman, Jonathan Marsden, Giorgio Ganis

Peninsula Medical School

EEG-based neurofeedback (ENF) may be utilised as an intervention for improvement of motor performance in Parkinson's movement impairment. This exploratory study aimed to determine the ability of healthy participants to bidirectionally modulate sensorimotor beta power using ENF in real time and examine learning trends. The protocol trained participants to increase and decrease the amplitude of their individual beta power over C3 using a double-blind sham-controlled and within-subjects design. Fifteen healthy participants completed the study (mean age = 38.9, SD = 14.9, age range = 20–66; nine female and six male). Thirteen participants successfully decreased beta activity, three participants successfully increased …

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Global, Regional, And National Prevalence Of Second-Hand Smoke And Attributable Disease Burden In 204 Countries And Territories, 1990–2023: A Systematic Analysis For The Global Burden Of Disease Study 2023, Gbd 2023 Second-Hand Smoke Collaborators, Debasish Kar Sep 2026

Global, Regional, And National Prevalence Of Second-Hand Smoke And Attributable Disease Burden In 204 Countries And Territories, 1990–2023: A Systematic Analysis For The Global Burden Of Disease Study 2023, Gbd 2023 Second-Hand Smoke Collaborators, Debasish Kar

Peninsula Medical School

SummaryBackground Second-hand smoke (SHS) exposure remains a major source of morbidity and mortality among nonsmokers. This study presents the first dedicated Global Burden of Diseases, Injuries, and Risk Factors Study (GBD)publication to systematically quantify SHS prevalence and evaluate its effect as a global risk factor across a broaderrange of outcomes.Methods Using the GBD 2023 comparative risk assessment framework, we estimated SHS exposure prevalence andattributable disease burden across 204 countries and territories from 1990 to 2023, stratified by age and sex. Exposureestimates were derived by synthesising population-based surveys and household composition data throughspatiotemporal Gaussian process regression. Relative risks for nine health …

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Recommencement Of Anti-Thrombotics Following Traumatic Intracranial Haemorrhage; A Preliminary Survey Of Uk Consultant Neurosurgeons Informing The Restart-Ticrh Trial Design, Jack Read, Peter Whitfield, Michael D. Jenkinson, Catherine J. Mcmahon, Ellie Edlmann Sep 2026

Recommencement Of Anti-Thrombotics Following Traumatic Intracranial Haemorrhage; A Preliminary Survey Of Uk Consultant Neurosurgeons Informing The Restart-Ticrh Trial Design, Jack Read, Peter Whitfield, Michael D. Jenkinson, Catherine J. Mcmahon, Ellie Edlmann

Peninsula Medical School

IntroductionTraumatic intracranial haemorrhage (tICH) commonly follows falls in elderly people, around half of whom are taking anti-thrombotic (AT) medications pre-injury. ATs are typically stopped acutely, but guidance on safe recommencement is limited.Research questionWe surveyed UK neurosurgical consultants to understand variations in AT recommencement practice and inform trial design.Materials and methodsAn online cross-sectional survey was distributed via the Society of British Neurological Surgeons mailing list to assess self-reported consultant practice regarding cessation and recommencement of AT therapy following tICH.ResultsSixty-two consultant neurosurgeons responded. Following tICH most are very likely or likely to stop AT therapy for AF (92%), stroke prevention (85-90%), or …

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Hidden In Plain Sight: Uk Social Work Educator Views Of Preparedness To Work With Individuals And Families Affected By Abi., Caroline Bald, Alyson Norman, Akudo Amediegwu, Talis Spirit, Temi Ademakinwa, Mark A. Linden, Mark Holloway, Michael Clarke, Andrew Bateman Sep 2026

Hidden In Plain Sight: Uk Social Work Educator Views Of Preparedness To Work With Individuals And Families Affected By Abi., Caroline Bald, Alyson Norman, Akudo Amediegwu, Talis Spirit, Temi Ademakinwa, Mark A. Linden, Mark Holloway, Michael Clarke, Andrew Bateman

School of Psychology

Acquired brain injury (ABI) is the leading cause of adulthood injury-related death and disability worldwide. Despite ABI’s prevalence, little is known about the extent to which social workers are prepared for brain injury working and specifically pre-qualifying brain injury curricula. This study employed a nine-item survey regarding brain injury social work knowledge. The survey asked about curricula inclusion within social work pre-qualification via multiple education providers to understand the extent to which brain injury training is incorporated within UK courses. This included a series of open-ended questions. Data from 36 survey respondents identified that 1) there was an acknowledged gap …

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The Giant Antarctic Amphipod Paraceradocus Miersi Will Not Fare Well If Freshening Continues In The Southern Ocean, John I. Spicer, Simon A. Morley, Katie N.G. Thiessen, Lloyd S. Peck Aug 2026

The Giant Antarctic Amphipod Paraceradocus Miersi Will Not Fare Well If Freshening Continues In The Southern Ocean, John I. Spicer, Simon A. Morley, Katie N.G. Thiessen, Lloyd S. Peck

School of Biological and Marine Sciences

Sea water provides a stable environment for marine animals. Most oceanic invertebrates have body fluids similar in ionic composition to sea water. However, Antarctic coastal ecosystems are increasingly exposed to freshening—a reduction in salinity driven by glacial melt, increased precipitation, and extreme weather events. Such changes can cause mortality in Antarctic invertebrates, which generally are intolerant to reduced salinity. This study investigated osmotic and ionic regulation of the Antarctic amphipod Paraceradocus miersi exposed to simulated freshening. When salinity was reduced (from S = 34.6 to 28.0) for 12–48 h, haemolymph osmolality and sodium concentration declined, while calcium remained stable; magnesium …

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Calibrated Simulations For Dynamic Focusing Of Ultrasound Through The Temporal Window, Ehsan Dadgar-Kiani, Vibha Hebbale, Malachy W. Newman, Grace Attalla, John L. Alvarez, Suraya Dunsford, Kevin A. Caulfield, Cameron H. Good, Andrew D. Krystal, Leo P. Sugrue, Joline M. Fan, Elsa Fouragnan, Charles F. Caskey, Samuel Pichardo, Kim Butts Pauly, Keith R. Murphy Aug 2026

Calibrated Simulations For Dynamic Focusing Of Ultrasound Through The Temporal Window, Ehsan Dadgar-Kiani, Vibha Hebbale, Malachy W. Newman, Grace Attalla, John L. Alvarez, Suraya Dunsford, Kevin A. Caulfield, Cameron H. Good, Andrew D. Krystal, Leo P. Sugrue, Joline M. Fan, Elsa Fouragnan, Charles F. Caskey, Samuel Pichardo, Kim Butts Pauly, Keith R. Murphy

School of Psychology

Focused ultrasound can be delivered through the temporal window to modulate heterogeneously located brain areas. Acoustic simulations allow for safety assessments when dynamically targeting brain structures, but the mismatch between simulation and measured focal pressure can vary across the steerable range due to mechanically inaccurate assumptions made about the skull and transducer. Here, we describe efficient methods for simulation-measurement calibration using axisymmetric projections and sparse sampling across a 3D steerable subspace encompassing deep brain targets across 157 subjects. To address the simulation-reality mismatch in skull transmission, we used the measured and predicted pressure values through eight human temporal window fragments …

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Social Prescribing For People In Vulnerable Situations In Europe: Protocol For A Process Evaluation Of An Rct In Eight Countries, Kerryn Husk, Elizabeth Gilmour, Stephanie Tierney, Debra Westlake, Anuschka Arni, Hendrik Napierala, Farhad Rezvani, Marius Dierks, Wolfram J. Herrmann Aug 2026

Social Prescribing For People In Vulnerable Situations In Europe: Protocol For A Process Evaluation Of An Rct In Eight Countries, Kerryn Husk, Elizabeth Gilmour, Stephanie Tierney, Debra Westlake, Anuschka Arni, Hendrik Napierala, Farhad Rezvani, Marius Dierks, Wolfram J. Herrmann

Peninsula Medical School

Objective Social prescribing is a pathway that connects individuals to non-clinical services. It supports and addresses social needs, such as those related to loneliness, housing instability and mental health. Social Prescribing Europe (SP-EU), a European Union funded project, seeks to co-create an adaptation of the social prescribing pathway based on the needs of the following target groups: LGBTIQ+ people, refugees and first-generation immigrants, older people living alone. This adapted social prescribing pathway will be tested in a pragmatic randomised controlled trial (RCT) in ten hubs, covering eight countries, across Europe. The aim of this process evaluation is to explore the …

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Closing The Gap In Offshore Wind Environmental Evidence Chains: A Workshop-Derived White Paper, Jiaxin Chen, Lilian Lieber, Matthew Palmer, Dan Lear, Deborah Greaves Aug 2026

Closing The Gap In Offshore Wind Environmental Evidence Chains: A Workshop-Derived White Paper, Jiaxin Chen, Lilian Lieber, Matthew Palmer, Dan Lear, Deborah Greaves

School of Biological and Marine Sciences

Offshore wind development is accelerating at a time when environmental assessment is increasingly required to support timely consenting, cumulative-effects understanding, nature recovery, regional planning, floating offshore wind deployment and public trust. The workshop underpinning this White Paper was convened in recognition that the sector's central challenge is no longer simply a lack of data, but the weak connection between data, monitoring approaches, models, uncertainty, governance and decision-making.Environmental monitoring often remains project-specific and receptor-focused, while models remain component-specific or scenario-specific. Data systems are similarly fragmented across owners, repositories, formats, access arrangements and project lifecycle stages. Yet regulators and statutory advisers require …

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An Interdisciplinary Approach To Sampling Hard Rock Cores Of The Oceanic Crust For Microbiological And Biogeochemical Research, William J. Brazelton, Oscar Cavazos, Jordyn A. Robare, Gordon Southam, Johanna Suhonen, Fengping Wang, Susan Q. Lang, Andrew Mccaig, Peter Blum, Natsue Abe, Remi Coltat, Jeremy R. Deans, Kristin L. Dickerson, Marguerite Godard, Barbara E. John, Frieder Klein, Rebecca Kuehn, Kuan-Yu Lin, C. Johan Lissenberg, Haiyang Liu, Ethan L. Lopes, Toshio Nozaka, Andrew J. Parsons, Vamdev Pathak, Mark K. Reagan, C. Geoffrey Wheat Aug 2026

An Interdisciplinary Approach To Sampling Hard Rock Cores Of The Oceanic Crust For Microbiological And Biogeochemical Research, William J. Brazelton, Oscar Cavazos, Jordyn A. Robare, Gordon Southam, Johanna Suhonen, Fengping Wang, Susan Q. Lang, Andrew Mccaig, Peter Blum, Natsue Abe, Remi Coltat, Jeremy R. Deans, Kristin L. Dickerson, Marguerite Godard, Barbara E. John, Frieder Klein, Rebecca Kuehn, Kuan-Yu Lin, C. Johan Lissenberg, Haiyang Liu, Ethan L. Lopes, Toshio Nozaka, Andrew J. Parsons, Vamdev Pathak, Mark K. Reagan, C. Geoffrey Wheat

School of Geography, Earth and Environmental Sciences

Studying life in the deep, rocky subseafloor involves many layers of technological and methodological challenges, and each drilling project or expedition must make a series of choices to address these challenges. We report on the workflow for sampling hard rock cores for microbiological and biogeochemical research that was developed and optimized during International Ocean Discovery Program (IODP) Expedition 399. All steps of the workflow, including selection of the sample and its shipboard homogenization and subsampling for specific analyses, were designed to maximize the potential for interdisciplinary collaborations and syntheses of results. Furthermore, multiple strategies to minimize and detect potential microbial …

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Staged Bilateral Magnetic Resonance‐Guided Focused Ultrasound For Treating Essential Tremor: Systematic Review And Meta‐Analysis, Nima Norbu Sherpa, Andrea Gonzalez Lezana, Gabriela Prilip, Kenji Fukutome, Nathan J. Pertsch, Ruth Reeve, Nadège Bault, Elsa Fouragnan Aug 2026

Staged Bilateral Magnetic Resonance‐Guided Focused Ultrasound For Treating Essential Tremor: Systematic Review And Meta‐Analysis, Nima Norbu Sherpa, Andrea Gonzalez Lezana, Gabriela Prilip, Kenji Fukutome, Nathan J. Pertsch, Ruth Reeve, Nadège Bault, Elsa Fouragnan

School of Psychology

BackgroundUnilateral magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy reduces tremor in essential tremor, yet disability often persists on the untreated side. The added benefit and safety of a staged contralateral lesion remain uncertain.ObjectiveThe aim was to evaluate the efficacy and safety of staged bilateral MRgFUS thalamotomy for essential tremor.MethodsWe searched MEDLINE, EMBASE, Web of Science, Cochrane CENTRAL, Scopus, ClinicalTrials.gov, and World Health Organization International Clinical Trials Registry Platform from inception to April 12, 2026 (PROSPERO CRD420251027624). Eligible studies were staged bilateral MRgFUS with Clinical Rating Scale for Tremor outcomes and adverse events, and at least 3 months of follow up. …

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Exploring The Gaps And Opportunities For Development Of An Amr Educational Package For Higher Education. Project Dataset., Michael Dillon, Delphine Kayem, Thiru Vanniasinkam, Charlotte Cornbill, Muriel Dresen, Arya Gupta, Kristina Kadlec, Priyanka More, Afolake Atinuke Olanbiwoninu, Désirée Schaaf, Raju Sekar, Christina Stylianou Aug 2026

Exploring The Gaps And Opportunities For Development Of An Amr Educational Package For Higher Education. Project Dataset., Michael Dillon, Delphine Kayem, Thiru Vanniasinkam, Charlotte Cornbill, Muriel Dresen, Arya Gupta, Kristina Kadlec, Priyanka More, Afolake Atinuke Olanbiwoninu, Désirée Schaaf, Raju Sekar, Christina Stylianou

Faculty of Health Datasets

Anonymous cross-sectional survey of higher education educators worldwide teaching antimicrobial resistance (AMR) or related subjects. The dataset captures educators’ teaching experience, curriculum content, and resource needs to identify gaps in AMR education and support development of openly available teaching resources.

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Large-Scale Dna Barcoding Reveals Highly Distinct Insect Distribution Patterns Across Costa Rican Ecosystems, José A. Hernández Ugalde, Daniel H. Janzen, Winnie Hallwachs, Bert Kohlmann, Paul D.N. Hebert, Brian V. Brown, James Whitfield, José. L. Fernández-Triana, Roberto Fernández Ugalde, Eugenie Phillips Rodriguez, Ronald Zúñiga, M. Alex Smith, Dirk Steinke, Michael Sharky, Donald Quicke, Ramya Manjunath, Robert Puschendorf Aug 2026

Large-Scale Dna Barcoding Reveals Highly Distinct Insect Distribution Patterns Across Costa Rican Ecosystems, José A. Hernández Ugalde, Daniel H. Janzen, Winnie Hallwachs, Bert Kohlmann, Paul D.N. Hebert, Brian V. Brown, James Whitfield, José. L. Fernández-Triana, Roberto Fernández Ugalde, Eugenie Phillips Rodriguez, Ronald Zúñiga, M. Alex Smith, Dirk Steinke, Michael Sharky, Donald Quicke, Ramya Manjunath, Robert Puschendorf

School of Biological and Marine Sciences

Although insects are fundamental to understanding and conserving global biodiversity, they are vastly understudied. Here, we present a national inventory of Costa Rican insects based upon 3.78 million DNA barcodes representing 152 891 Barcode Index Numbers (BINs, proxies for species) from 28 localities sampled from 2017 to 2023 through the national BioAlfa program of Costa Rica. Although only 3.6% of BINs are linked to Linnean species, barcode-based community analyses revealed strong, consistent ecogeographic structure. Clustering of BIN data using bootstrapped Jaccard distances revealed seven distinct mainland assemblages and a distinct island cluster, shaped primarily by Costa Rica’s mountain ranges, elevation, …

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Drivers Of Stopover Distribution Across Two Autumn Migration Routes Of A Long-Distance Afro-Palearctic Migrant, The Common Cuckoo (Cuculus Canorus), Alex Gale, Máire Kirkland, Phil Atkinson, Robert Puschendorf, Chris Hewson Aug 2026

Drivers Of Stopover Distribution Across Two Autumn Migration Routes Of A Long-Distance Afro-Palearctic Migrant, The Common Cuckoo (Cuculus Canorus), Alex Gale, Máire Kirkland, Phil Atkinson, Robert Puschendorf, Chris Hewson

School of Biological and Marine Sciences

Across the globe, many long-distance migratory birds have undergone population declines. Understanding the environmental factors which underly migratory stopover locations can inform conservation strategies for such species. Here, we identify environmental predictors of autumn stopover sites used by UK-breeding male cuckoos (Cuculus canorus) migrating to centralAfrican wintering grounds via two alternative flyways. Between 2011 and 2021, 88 male cuckoos from UK breeding grounds were fitted with <5 g satellite tags connected to the Argos satellite-based tracking system. Filtered stopovers were used to build presence-pseudoabsence distribution models for each flyway, using Boosted Regression Tree and Random Forest algorithms with thirteen climatic, habitat, topographic and anthropogenic variables. Performance was evaluated using 10-fold cross-validation, and weighted ensembles were generated. To assess drought sensitivity, we produced predictions for high- and low-drought years based on Standardised Precipitation–Evapotranspiration Indices (SPEI). Models performed well (AUC=0.79–0.88; TSS=0.50– 0.66) and revealed route-specific environmental predictors. Along the western route, stopover probability was highest in cooler, semi-humid, high-elevation areas with low contemporaneous drought; Iberian mountain ranges emerged as key sites. Along the eastern route, stopover probability was greatest in heterogeneous habitat, with lowlands and uplands favoured over intermediate elevations; the Po watershed appears particularly important. Hunting risk (included to assess anthropogenic threat) was also high at key areas. The spatial extent of stopover regions—and the probability of them being utilised—declined during years ofhigh short-term drought along the western route, and high long-term drought along the eastern route. Whilst Iberian montane stopover regions are sensitive to increasing drought and aridity under climate change, their topographic heterogeneity may provide climatic refuge while limiting intensive land uses. Preference for heterogeneous habitat within the Po watershed highlightsthe need to retain semi-natural habitat within agricultural landscapes. We recommend route-specific conservation measures and higher resolution models using newly available GPS tags to better understand fine-scale site selection within the regions highlighted here.

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Bdelloid Rotifers Harbor A Voltage-Gated Proton Channel With Distinct Mechanistic Features, Liang Yan, Chiara Boschetti, Liang Hong Aug 2026

Bdelloid Rotifers Harbor A Voltage-Gated Proton Channel With Distinct Mechanistic Features, Liang Yan, Chiara Boschetti, Liang Hong

School of Biological and Marine Sciences

Bdelloid rotifers are renowned for their extraordinary resilience. They can survive desiccation and long-term freezing and revive once favorable conditions return. Such remarkable survival abilities suggest that the evolution of specialized molecular adaptations sustain pH homeostasis under extreme environmental stress. In the present study, we identify and functionally characterize an isoform of the voltage-gated proton channel (Hv) from the bdelloid rotifer Adineta ricciae, which we name ArHv2. Unlike its paralog ArHv1 and human Hv1 that activate only at positive membrane potentials and contribute modestly to proton extrusion under normal conditions, the ArHv2 activates even at negative potentials, enabling rapid and …

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Recompression Improves Release Success In Pollack (Pollachius Pollachius): A Step Towards Assessing Post Release Mortality In A Recreational Fishery, T. Stamp, R. Mawer, R. Conlon, A. E. Hall, P. Davies, R. Nesbit, D. Uren, T. Morris, S. Sullivan, S. Thomas, B. D. Stewart, H. Rudd, K. Hyder, T. Osmond, S. Reynell, E. V. Sheehan Aug 2026

Recompression Improves Release Success In Pollack (Pollachius Pollachius): A Step Towards Assessing Post Release Mortality In A Recreational Fishery, T. Stamp, R. Mawer, R. Conlon, A. E. Hall, P. Davies, R. Nesbit, D. Uren, T. Morris, S. Sullivan, S. Thomas, B. D. Stewart, H. Rudd, K. Hyder, T. Osmond, S. Reynell, E. V. Sheehan

School of Biological and Marine Sciences

The recreational fishery for pollack (Pollachius pollachius) in the northeast Atlantic is impacted by the species' high sensitivity to barotrauma. When captured at depth and brought to the surface, gas expansion within the peritoneal cavity can cause a variety of injuries and hinder release. Via an experimental weighted cage, this study evaluated the efficacy of releasing Pollack at depth as a barotrauma mitigation strategy. We found that depth-release significantly increased the probability of released Pollack displaying an active escape response to 83%, compared to 56% for surface-released fish; however, increased capture depth and fish size negatively affected success. Camera observations …

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Tidally Driven Topographic Eddies Exploited By Manta Feeding Aggregations, Harvey Cairns, Daniel Conley, Christopher Stokes, Tim Scott, Philip Hosegood Aug 2026

Tidally Driven Topographic Eddies Exploited By Manta Feeding Aggregations, Harvey Cairns, Daniel Conley, Christopher Stokes, Tim Scott, Philip Hosegood

School of Biological and Marine Sciences

The seasonal feeding aggregations of reef manta rays (Mobula alfredi) in Hanifaru Bay, Maldives, are the largest known of their kind, yet the mechanisms facilitating this phenomenon remain poorly understood. Understanding these drivers is crucial for effective conservation and management, as protecting key foraging habitats requires knowledge of the physical processes influencing prey availability. While previous studies highlight the role of zooplankton in attracting manta, the oceanographic mechanisms responsible for concentrating prey within the bay remain hypothesised but unproven. Specifically, the influence of eddy dynamics, tidal forcing, and regional circulation on zooplankton distribution has not been thoroughly examined.A …

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Pelagic Ecosystem Interactions Of An Offshore Longline Mussel Farm, Llucia Mascorda-Cabre, Philip Hosegood, Martin Attrill, Emma Sheehan Aug 2026

Pelagic Ecosystem Interactions Of An Offshore Longline Mussel Farm, Llucia Mascorda-Cabre, Philip Hosegood, Martin Attrill, Emma Sheehan

School of Biological and Marine Sciences

Long-term interactions of the UK's first large scale offshore mussel farm with the surrounding pelagic environment were studied to assess the farm's ecological impact. Pelagic fishes, zooplankton community and oceanographic parameters such as temperature, salinity, density, chlorophyll- α, dissolved oxygen and CDOM were quantified over seven years. Effects to oceanographic parameters were observed locally comparing samples collected on the east and west parts of the farm, evidencing turbulent mixing of the water column enhanced by the farm. There was no difference between zooplankton assemblage composition inside and outside the farm, only naturally occurring temporal changes were detected, supporting the hypothesis …

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Using Life-History Information To Identify Management Priorities Within An Emergent Multi-Species Grey Mullet Fishery, Calum J. Pritchard, Ayşegül Tuğçe Han, Andrew Macleod, Rachel M. Turnbull, Jamie Small, Sarah Birchenough, Simon Pengelly, Benjamin J. Ciotti Aug 2026

Using Life-History Information To Identify Management Priorities Within An Emergent Multi-Species Grey Mullet Fishery, Calum J. Pritchard, Ayşegül Tuğçe Han, Andrew Macleod, Rachel M. Turnbull, Jamie Small, Sarah Birchenough, Simon Pengelly, Benjamin J. Ciotti

School of Biological and Marine Sciences

Three grey mullets are native to the United Kingdom: Chelon labrosus, Chelon ramada, and Chelon auratus, for which there is an emergent fishery. These species are managed under a broad grey mullet fishery, but aspects of the life-histories of these populations remain undetermined. The fishery has never been formally assessed. For each species, this research i) investigated their life-history, ii) quantified relative fishing pressure, and iii) investigated their relative vulnerability to overfishing. Grey mullets were collected from commercial fisheries along the southern coast of England. Fish were weighed, measured, and ages were assigned by counting scale annuli. Maturity was determined …

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A Review Of Blue Carbon Credit Projects' Socio-Economic Activities, Nata Tavonvunchai, Holly J. Niner, Abigail Mcquatters-Gollop, Siân E. Rees Aug 2026

A Review Of Blue Carbon Credit Projects' Socio-Economic Activities, Nata Tavonvunchai, Holly J. Niner, Abigail Mcquatters-Gollop, Siân E. Rees

School of Biological and Marine Sciences

Coastal ‘blue carbon’ ecosystems (mangroves, seagrasses and saltmarshes) are critical for climate regulation and biodiversity, yet significant funding gaps persist in marine conservation. While blue carbon credits are increasingly used to bridge these gaps, concerns remain regarding their efficacy in delivering socio-economic benefits. Based on lessons from terrestrial carbon markets, failing to prioritise local community needs can lead to inequitable outcomes and externally mandated constraints, which undermine the legitimacy of nature-based solutions. This research seeks to add to the centralised understanding of the social dimension of blue carbon by delivering a comprehensive review of 77 publicly listed projects from global …

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Incretin-Based Medications In Women And Reproduction: A Systematic Scoping Review And Consensus Guidelines For Clinical Practice, Kate Maslin, Jill Shawe, Sinead Blowers, Michael Ceulemans, Kathryn Hart Jul 2026

Incretin-Based Medications In Women And Reproduction: A Systematic Scoping Review And Consensus Guidelines For Clinical Practice, Kate Maslin, Jill Shawe, Sinead Blowers, Michael Ceulemans, Kathryn Hart

School of Nursing and Midwifery

Introduction: Pregnancy concurrent with incretin-based medications is contraindicated due to unknown risk of teratogenicity, as is breastfeeding. The aim of this systematic scoping review was to investigate potential risks and benefits of incretin-based medications in relation to preconception, pregnancy, and postnatal health, and to propose expert guidelines for clinical practice.Methods: An international expert multidisciplinary group was formed. Research questions relevant to women's reproductive health and incretin-based medications were refined collaboratively, utilizing a lifecourse approach. A systematic search was undertaken on July 23, 2025, across several databases and grey literature sources. Primary data from human studies were prioritized above animal studies. …

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Acalabrutinib Monotherapy As A First-Line Treatment For Cll: 3 Years Follow-Up Of The Real-World Epic Study: 3-Year Follow-Up Of The Real-World Epic Study, Toby A. Eyre, Nicolás Martínez-Calle, Shankara Paneesha, Mohsen Norouzi, David L Tucker, Harriet Sarah Walter, Alison Boden, Mari Kilner, Neil Phillips, Piers Em Patten, Nimish Shah, Meghna Ruparelia, Sharon Oddy, Tan Tsawayo, Francesco Forconi, Helen Wardle, Tobore Gbemre, Chris Gregory, Lucy B. M. Cook, David J Allsup, Anna Morris, Christopher J C Knechtli, Jenni Davies, Joy Galani, Helen Marr, Claire Hutchinson, Stella Williams, Joe Hickey, Hannah Harding, Sukhjit Hunjan Jul 2026

Acalabrutinib Monotherapy As A First-Line Treatment For Cll: 3 Years Follow-Up Of The Real-World Epic Study: 3-Year Follow-Up Of The Real-World Epic Study, Toby A. Eyre, Nicolás Martínez-Calle, Shankara Paneesha, Mohsen Norouzi, David L Tucker, Harriet Sarah Walter, Alison Boden, Mari Kilner, Neil Phillips, Piers Em Patten, Nimish Shah, Meghna Ruparelia, Sharon Oddy, Tan Tsawayo, Francesco Forconi, Helen Wardle, Tobore Gbemre, Chris Gregory, Lucy B. M. Cook, David J Allsup, Anna Morris, Christopher J C Knechtli, Jenni Davies, Joy Galani, Helen Marr, Claire Hutchinson, Stella Williams, Joe Hickey, Hannah Harding, Sukhjit Hunjan

Peninsula Medical School

Clinical trials indicate that acalabrutinib, a second-generation Bruton tyrosine kinase inhibitor, is safe and effective for treating patients with chronic lymphocytic leukemia (CLL), but real-world evidence on its clinical effectiveness is limited. This ongoing multicenter retrospective chart review included UK adults with previously untreated CLL who received acalabrutinib monotherapy as part of a UK-wide early access program. These patients received their first dose of acalabrutinib between 1 April 2020 and 1 April 2021. Data from 282 patients (male patients, n = 156 [55%]) collected from 29 sites across the United Kingdom revealed a median age of 73.9 years (interquartile range …

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Neural And Computational Mechanisms Of Effort Under The Pressure Of A Deadline, M. Andrea Pisauro, Daniele Pollicino, Lucy Fisher, Matthew A. J. Apps Jul 2026

Neural And Computational Mechanisms Of Effort Under The Pressure Of A Deadline, M. Andrea Pisauro, Daniele Pollicino, Lucy Fisher, Matthew A. J. Apps

School of Psychology

Deadlines fundamentally shape motivation. Research examining effort-based choices finds effort is an avoided cost. However, this overlooks how making progress on longer-term goals to be reached before deadlines motivate people to exert high effort for little immediate reward. Here, we test a framework where motivation depends on deadline pressure (work remaining / time remaining). Across four studies we use computational modelling examining decisions when physical effort makes progress on goals with deadlines. In support of the hypotheses, deadline pressure significantly impacts decision-making, shifting people from avoiding effort, to seeking the progress it makes. Using ultra-high-field fMRI, we show that functionally …

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Novel Integrative Mobilizable Elements (Imes) In Vibrio Chromosomes Linked To Translucent Post-Larvae Disease (Tpd), Ruyi Hao, Yan Fang, Yang Yang, Mingshu Yang Jul 2026

Novel Integrative Mobilizable Elements (Imes) In Vibrio Chromosomes Linked To Translucent Post-Larvae Disease (Tpd), Ruyi Hao, Yan Fang, Yang Yang, Mingshu Yang

School of Biological and Marine Sciences

Translucent post-larvae disease (TPD), caused by specific Vibrio parahaemolyticus strains, poses a global threat to shrimp aquaculture. A key virulence factor in these strains is the vhv gene cluster, which encodes toxins central to TPD pathogenesis. While plasmid-borne vhv genes have been extensively studied, the chromosome-borne vhv genes in TPD-associated strains remain poorly characterized. In this study, we systematically analyzed integrative mobilizable elements (IMEs) on the small secondary chromosomes of TPD-associated V. parahaemolyticus. Seven nearly identical novel IMEs harboring full-length vhv clusters were identified from seven independent strains. These IMEs encode a tyrosine recombinase for site-specific chromosomal integration, yet lack …

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Assessment Of Genetic Susceptibility In Patients With Oral Squamous Cell Carcinoma: A Systematic Review And Meta-Analysis, Kiran Jadhav, Deepak G. S. Pateel, Sonal Grover, Shilpa Gunjal, Srikant Natarajan, Sumanth Kumbargere Nagraj Jul 2026

Assessment Of Genetic Susceptibility In Patients With Oral Squamous Cell Carcinoma: A Systematic Review And Meta-Analysis, Kiran Jadhav, Deepak G. S. Pateel, Sonal Grover, Shilpa Gunjal, Srikant Natarajan, Sumanth Kumbargere Nagraj

Peninsula Dental School

Background: Oral squamous cell carcinoma (OSCC) is associated with many risk factors but not all individuals who are exposed to the risk factors develop OSCC. This aspect warrants the need to understand the genetic susceptibility in presence of risk factors. Methods: The study protocol has been registered with PROSPERO (CRD42023422519). The present study included the English-language literature published from January 2000 to April 2024. The articles were searched using keywords via Ovid platform through various databases. The odds ratio was considered as standard measure of outcome. Meta-analysis was carried out using random effects model with RevMan 5.4, establishing a 95% …

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A Review Of Bast Fibres And Their Composites: Part 5 ~ Sustainability, Luke Branca, Badr Moutik, John Summerscales Jul 2026

A Review Of Bast Fibres And Their Composites: Part 5 ~ Sustainability, Luke Branca, Badr Moutik, John Summerscales

School of Engineering, Computing and Mathematics

Life Cycle Assessment (LCA) is a methodology for the evaluation of the (relative) potential environmental impacts of a product system throughout its life cycle. It is standardised under the ISO14040 and ISO14044 series. When conducted rigorously, LCA provides a quantitative framework for comparing environmental impact and can challenge or substantiate common assumptions regarding environmental performance of the system. However, it is essential that any reported results are read in combination with the defined goal and scope, as the choice of the system boundary and/or the allocation of burdens and other methodological choices can influence the outcome presented. This review will …

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Organising, Sustaining, Experiencing And Integrating Mental Health Crisis Care For Children And Young People: Qualitative Findings From Eight Contrasting Case Studies In England And Wales [Version 1; Peer Review: Awaiting Peer Review], Clare Bennett, Leanne Sawle, Claire Fraser, Rachael Vaughan, Steven Pryjmachuk, Iain Mcmillan, Aled Jones, Euan Hails, Nicola Bennett, Martin Elliott, Mair Elliott, Ben Hannigan, Williams Jessy Jul 2026

Organising, Sustaining, Experiencing And Integrating Mental Health Crisis Care For Children And Young People: Qualitative Findings From Eight Contrasting Case Studies In England And Wales [Version 1; Peer Review: Awaiting Peer Review], Clare Bennett, Leanne Sawle, Claire Fraser, Rachael Vaughan, Steven Pryjmachuk, Iain Mcmillan, Aled Jones, Euan Hails, Nicola Bennett, Martin Elliott, Mair Elliott, Ben Hannigan, Williams Jessy

School of Nursing and Midwifery

BackgroundCrisis services are an important part of the system of mental health care for children and young people (CYP), but little is known about them or the experiences of CYP and families. This article reports findings from a normalisation process theory (NPT)-informed sequential mixed methods study, comprising three work packages (WPs), which set out to generate new knowledge in this area.MethodsApproaches to CYP crisis care across England and Wales were mapped in WP1 using survey design. Previously reported findings from this WP point to heterogeneity in service types and interventions. In WP2 eight contrasting services (five in England, three in …

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Early Changes In Soil Organic Carbon Following Ecological Restoration In Mangroves Invaded By Acrostichum Aureum, Julio C. Chávez Barrera, Juan Fernando Gallardo Lancho, Carlos Amado Chan-Keb, Margarita Elizabeth Gallegos Martínez, Ana Carolina Ruiz-Fernández, Robert Puschendorf, Claudia Maricusa Agraz Hernández Jul 2026

Early Changes In Soil Organic Carbon Following Ecological Restoration In Mangroves Invaded By Acrostichum Aureum, Julio C. Chávez Barrera, Juan Fernando Gallardo Lancho, Carlos Amado Chan-Keb, Margarita Elizabeth Gallegos Martínez, Ana Carolina Ruiz-Fernández, Robert Puschendorf, Claudia Maricusa Agraz Hernández

School of Biological and Marine Sciences

Mangrove ecosystems store large amounts of soil organic carbon (SOC). However, degradation processes associated with invasive species can alter vegetation structure, hydrological conditions, and carbon cycling, with uncertain consequences for SOC storage and greenhouse gas emissions. This study evaluated changes in SOC stocks to 0–50 cm depth, soil CO2, CH4, and N2O fluxes, and early restoration responses four years after ecological restoration in the Térraba–Sierpe National Wetland, Costa Rica. Comparisons were conducted among a conserved mangrove, a degraded mangrove dominated by Acrostichum aureum, and three restored sites subjected to hydrological rehabilitation with contrasting reforestation intensities. The degraded site showed significantly …

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An Ecophysiological Approach To Improving Health Outcomes Of Ornamental Shrimp During Aquarium Trade And Transportation, Sancha Conway Holroyd, John Spicer, Robert P. Ellis, Lucy Turner Jul 2026

An Ecophysiological Approach To Improving Health Outcomes Of Ornamental Shrimp During Aquarium Trade And Transportation, Sancha Conway Holroyd, John Spicer, Robert P. Ellis, Lucy Turner

School of Biological and Marine Sciences

Ecophysiology examines the interactions between an organism’s physiology and its environment. It seeks to understand how an organism functions and adapts under changing conditions. This has direct applications to live-trade aquaculture sectors, including the ornamental aquarium trade, where traded animals experience a variety of changing, and often stressful, environmental conditions that can threaten their health and survival. This review proposes a role for ecophysiology in managing organismal health, using Hatch (1962) theoretical framework of disease and dysfunction as a foundation for defining and distinguishing health. We focus on tropical (marine and freshwater) ornamental shrimp as an exemplar group to highlight …

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Correlating High-Resolution Terrestrial Organic Carbon Isotope Records Across The Cretaceous-Paleogene Boundary, Gregory D. Price, Rhodri M. Jerrett, Lauren K. O'Connor, Emily Dearing Crampton-Flood, Bart E. Van Dongen, Sabine K. Lengger, Marc Davies Jul 2026

Correlating High-Resolution Terrestrial Organic Carbon Isotope Records Across The Cretaceous-Paleogene Boundary, Gregory D. Price, Rhodri M. Jerrett, Lauren K. O'Connor, Emily Dearing Crampton-Flood, Bart E. Van Dongen, Sabine K. Lengger, Marc Davies

School of Geography, Earth and Environmental Sciences

The Cretaceous–Paleogene boundary (∼66 million years ago) represents the most recent mass extinction event when an estimated 75% of all species became extinct, including all non-avian dinosaurs. Here we focus on the stable carbon isotope (δ13C) analysis of coal and coaly sediments across the terrestrial K/Pg boundary from 10 sites, between 42 and 64°N, USA and Canada. Our δ13C data set shows a statistically significant positive correlation with paleolatitude that we interpret as a consequence of our lower latitude sites being relatively warmer and more humid than our higher latitude sites. Temporally, our data indicates that …

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