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Antibacterial Activity Of Dipeptide Constructions Of Acetylsalicylic Acid And Nicotinic Acid, Ronald Bartzatt, Suat L.G. Cirillo, Jeffrey D. Cirillo
Antibacterial Activity Of Dipeptide Constructions Of Acetylsalicylic Acid And Nicotinic Acid, Ronald Bartzatt, Suat L.G. Cirillo, Jeffrey D. Cirillo
Chemistry Faculty Publications
Two dipeptide drugs are synthesized utilizing an acetylsalicylic acid or nicotinic acid molecule for the framework. A D-alanine-D-alanine dipeptide moiety is attached to the carbonyl carbon of acetylsalicylic acid (I) and nicotinic acid (II). Dipeptide derivatives (I) and (II) showed significant reduction of Escherichia coli (E. coli) bacterial growth and colony-forming units. A mixture of (I) and (II) induced growth inhibition of 8%, 17.5%, 28%, and 42.5% at concentrations of 100, 200, 300, and 400 μg/mL, respectively. Ampicillin demonstrated much less growth inhibition of this penicillin-resistant E. coli bacteria. Derivatives (I) and (II) showed significant reduction of colony-forming units at …
Dirubidium Digallium Oxide Bis(Orthoborate), Robert W. Smith, Chunhua Hu, Christopher D. Despain
Dirubidium Digallium Oxide Bis(Orthoborate), Robert W. Smith, Chunhua Hu, Christopher D. Despain
Chemistry Faculty Publications
The title compound, Rb2Ga2O(BO3)2, is part of the homologous series A2Ga2O(BO3)2 (A = Na, K, Rb and Cs). The structure contains pairs of gallium-centered tetrahedra connected through a shared oxygen vertex. Orthoborate triangles connect the basal vertices of the tetrahedra, forming a three-dimensional network with voids occupied by rubidium ions.