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Bacterial Diversity Within The Human Subgingival Crevice, Ian Kroes, Paul W. Lepp, David A. Relman
Bacterial Diversity Within The Human Subgingival Crevice, Ian Kroes, Paul W. Lepp, David A. Relman
U.S. Department of Veterans Affairs Staff Publications
Molecular, sequence-based environmental surveys of microorganisms have revealed a large degree of previously uncharacterized diversity. However, nearly all studies of the human endogenous bacterial flora have relied on cultivation and biochemical characterization of the resident organisms. We used molecular methods to characterize the breadth of bacterial diversity within the human subgingival crevice by comparing 264 small subunit rDNA sequences from 21 clone libraries created with products amplified directly from subgingival plaque, with sequences obtained from bacteria that were cultivated from the same specimen, as well as with sequences available in public databases. The majority (52.5%) of the directly amplified 16S …
Absence Of Kaposi's Sarcoma-Associated Herpesvirus Dna In Bacillary Angiomatosis-Peliosis Lesions, David A. Relman, David N. Fredricks, Kristine E. Yoder, Ginat Mirowski, Timothy Berger, Jane E. Koehler
Absence Of Kaposi's Sarcoma-Associated Herpesvirus Dna In Bacillary Angiomatosis-Peliosis Lesions, David A. Relman, David N. Fredricks, Kristine E. Yoder, Ginat Mirowski, Timothy Berger, Jane E. Koehler
U.S. Department of Veterans Affairs Staff Publications
Bartonella henselae and B. quintana induce an unusual vascular proliferative tissue response known as bacillary angiomatosis (BA) and bacillary peliosis (BP) in some human hosts. The mechanisms of Bartonella-associated vascular proliferation remain unclear. Although host factors probably play a role, microbial coinfection has not been ruled out. Because of the vascular proliferative characteristics noted in both Kaposi's sarcoma (KS) and BA and occasional colocalization of KS and BA, the possibility was explored that KS-associated herpes virus (KSHV) might be associated with BA lesions. Tissues with BA and positive and negative control tissues were tested for the presence of KSHV …