Digital Commons Network^™

Association Among Neurophysiology, Cognition And Mobility In Older Adults, Nikou Nikoumanesh

Masters Theses

Age-related structural and molecular changes in older adults have been shown to significantly affect their cognitive and motor functions (Trollor and Valenzuela, 2001). Given the growing population of older adults, it is imperative to bridge the gaps in scientific understanding of cognition and motor capabilities in healthy older adults’ population. This study investigates five major neurochemicals and their potential correlations with gait, balance, executive function, and attention in healthy older adults. Additionally, we explore the interplay between cognition and motor performance in our participants. Furthermore, we hypothesize that the neurochemical values of interest may serve as predictive indicators for motor …

(K)Ein Ausweg Für Hedda? Eine Analyse Von Henrik Ibsens Hedda Gabler (1890) Aus Der Feministischen Perspektive Von Helene Stöcker Und Rosa Mayreder, Nikoletta Strasser

Masters Theses

My research identifies the existing parallels between the repressive societal structures portrayed in the play Hedda Gabler (1890) and central political issues addressed by representatives of the German and Austrian women’s movement at the turn of the 19th century. Norwegian playwright Henrik Ibsen shows how oppressive social conditions negatively affect his female characters, but he does not offer satisfactory alternatives to their suffering. I selected the theoretical writings of Helene Stöcker and Rosa Mayreder as more “radical” opinions of the first German and Austrian women’s movement because they present solutions to the repressive societal structures Ibsen addresses. Since many voices …

A Multi-Regional Assessment Of Eastern Whip-Poor-Will (Antrostomus Vociferus) Occupancy In Managed And Unmanaged Forests Using Autonomous Recording Units, Jeffery T. Larkin

Masters Theses

State and federal agencies spend considerable time and resources to enhance and create habitat for wildlife. Understanding how target and non-target species respond to these efforts can help direct the allocation of limited conservation resources. However, monitoring species response to habitat management comes with several logistical challenges that are exacerbated as the area of geographic focus increases. I used autonomous recording units (ARUs) to mitigate these challenges when assessing Eastern Whip-poor-will (Antrostomus vociferus) response to forest management. I deployed 1,265 ARUs across managed and unmanaged public and private forests from western North Carolina to southern Maine. I then …

The Near-Synonymous Classifiers In Mandarin Chinese: Etymology, Modern Usage, And Possible Problems In L2 Classroom, Irina Kavokina

Masters Theses

Many Chinese classifiers are nearly synonymic – they can be used with the same head nouns without changing the meaning of the sentence, in other words, such classifiers can be used interchangeably or almost interchangeably. This poses a challenge for Chinese language learners, especially those who lack such a grammatical category in their own native language. Another complication arises from the ambiguous English translations of many classifiers.

In this paper we investigate the collocation behavior of near-synonymous Chinese classifiers, focusing on their semantic nuances and interchangeability. Analyzing 6 pairs of classifiers — 栋 and 幢, 匹 and 头, 批 and …

Optimizing Channel Formation In Peg Maleimide Hydrogels, Bakthavachalam Kannadasan

Masters Theses

Blood vessels including the arteries, veins, and capillaries are a critical and indispensable component of various organisms. Some studies estimate that if all the blood vessels present in our body are arranged in line, they would amount to a total length of approximately 60,000 miles. This distance is enough to circle the world two and a half times! In addition to being all pervasive, blood vessels perform certain key functions such as delivery of oxygen and nutrients to various tissues in the body. They also assist in the spread of diseases such as cancer. Therefore, it is important to study …

Production And Characterization Of Monoclonal Antibodies To Xenopus Proteins, Brett A. Horr

Masters Theses

Monoclonal antibodies are powerful and versatile tools that enable the study of proteins in diverse contexts. They are often utilized to assist with identification of subcellular localization and characterization of the function of target proteins of interest. However, because there can be considerable sequence diversity between orthologous proteins in Xenopus and mammals, antibodies produced against mouse or human proteins often do not recognize Xenopus counterparts. To address this issue, we refined existing mouse monoclonal antibody production protocols to generate antibodies against Xenopus proteins of interest. Here, we describe several approaches for the generation of useful mouse anti-Xenopus antibodies to multiple …

Diagnostic Feature Detection And Sequential Eyewitness Lineups, Jerome D. Hoover

Masters Theses

Prior work has demonstrated that the sequential presentation of lineup members in eyewitness lineups can result in undesirable position effects. For example, some studies have shown that placing the suspect in later positions increases discriminability. However, the evidence for this late-position discriminability advantage is mixed and the processes by which the discriminability increase occurs are unclear. However, one theory in particular, diagnostic feature detection theory (DFDT) explicitly predicts a late-position discriminability increase. According to DFDT, because shared features across lineup members cannot be used as reliable recognition cues to guide identification, discounting these features from consideration improves recognition. In sequential …

Evaluating The Potential Of Ozone Microbubbles For Inactivation Of Tulane Virus, A Human Norovirus Surrogate, Bozhong Guan

Masters Theses

Microbubbles are small gas-filled bubbles with diameters ranging from 50 to 1 μm, and less than 200 nm are called nanobubbles. Their small sizes and large specific surface area result in a high gas dissolution rate and long lifetime in liquid. Ozone is a strong oxidant that destroys microorganisms and only produces oxygen as the final by-product in fresh water. However, due to the poor stability of aqueous ozone, critical gas waste happens during treatments which leads to a high economic loss. Microbubbles have shown promising enhancement of ozone treatment. In previous studies, ozone microbubbles exhibited excellent efficacy in the …

Impact Of Fermented And Non-Fermented Plant-Based Foods Supplementation On Gut Microbiota And Metabolites In C57bl/6j Mice, Priya Darshan Gandhi

Masters Theses

Plant-based proteins have gained popularity because of their high nutritional value and more sustainable alternative to animal-based proteins. Soybean and chickpea are two widely consumed plant-based proteins, whereas tempeh is a popular plant-based fermented whole food product that is rich in protein. With the increase in the development of plant-based food products, there is little research into how plant proteins affect gut microbiota characteristics and metabolites. Therefore, there is a need to understand the underlying mechanisms surrounding the consumption of these foods. The purpose of this study was to investigate the health benefits of soybean, chickpea, and their tempeh counterparts’ …

Device Design For Inducing Aneurysm-Susceptible Flow Conditions Onto Endothelial Cells, Hans F. Foelsche

Masters Theses

Aneurysms are a deadly asymptomatic cardiovascular disease that may occur especially where there are bends and bifurcations in the cerebral vasculature. A region where these features are especially prominent is the Circle of Willis (COW) in the brain, where aneurysms are known to occur. In the carotid artery, which feeds into the COW, the Reynolds number of blood flow is typically around 200-500. Even with such a low Reynolds number, turbulent-like flow, or tortuous flow, can occur due to bends, bifurcations and highly pulsatile flow which lower the effective Reynolds number where tortuous flow can occur. Highly pulsatile flow is …

The Discovery Of A Novel Bacteria From A Large Co-Assembly Of Metagenomes, Matthew Finkelberg

Masters Theses

In the summer of 2022, a co-assembly of metagenome was created using the microbes found at Barres Woods in Harvard Forest. 14 samples were taken, and sample was split into the organic and mineral layer, which totals 28 Bulk MAGs. Within this Co-assembly, 4 different genomes were found which were designated with the phylum of FCPU426. Three of which were considered medium quality and one being assigned high quality. The novel phyla first appeared in NCBI and GTDB databases in June 2018. The name FCPU426 dates to 2010 and was named based on the 16s amplicon sequencing.

The novel phylum …

Machine Learning Modeling Of Polymer Coating Formulations: Benchmark Of Feature Representation Schemes, Nelson I. Evbarunegbe

Masters Theses

Polymer coatings offer a wide range of benefits across various industries, playing a crucial role in product protection and extension of shelf life. However, formulating them can be a non-trivial task given the multitude of variables and factors involved in the production process, rendering it a complex, high-dimensional problem. To tackle this problem, machine learning (ML) has emerged as a promising tool, showing considerable potential in enhancing various polymer and chemistry-based applications, particularly those dealing with high dimensional complexities.

Our research aims to develop a physics-guided ML approach to facilitate the formulations of polymer coatings. As the first step, this …

Effect Of Metabolic Rate On Mitochondrial Efficiency During Exercise In Human Skeletal Muscle In Vivo, Muhammet Enes Erol

Masters Theses

Introduction: Recent evidence in isolated mitochondria and permeabilized muscle fibers in ex vivo using simultaneous measurements of O₂ consumption and ATP production suggest that mitochondrial efficiency provides an additional mechanism to fine-tune oxidative phosphorylation rate to ATP demand in skeletal muscle. However, in the absence of a direct measurement of both VO₂ and ATP synthesis from the same region of the contracting muscle, whether this mechanism plays a role in the skeletal muscle in vivo is still unknown. Purpose: Using a noninvasive approach combining phosphorus and proton magnetic resonance spectroscopy (³¹P/¹H-MRS), the present study …

Analog Cancellation Of A Known Remote Interference: Hardware Realization And Analysis, James M. Doty

Masters Theses

The onset of quantum computing threatens commonly used schemes for information secrecy across wireless communication channels, particularly key-based data-level encryption. This calls for secrecy schemes that can provide everlasting secrecy resistant to increased computational power of an adversary. One novel physical layer scheme proposes that an intended receiver capable of performing analog cancellation of a known key-based interference would hold a significant advantage in recovering small underlying messages versus an eavesdropper performing cancellation after analog-to-digital conversion. This advantage holds even in the event that an eavesdropper can recover and use the original key in their digital cancellation. Inspired by this …

Not All Numbers Were Created Equal: Evidence The Number One Is Unique, Jenna L. Croteau

Masters Theses

Universally across modern cultures children acquire the meaning of the words one, two, and three in order. While much research has focused on how children acquire this knowledge and what this knowledge represents, the question of why children learn numbers in order has been comparatively neglected. To address this question, a non-verbal anticipatory looking task was implemented. In this task, 35 14- to 23-month-old infants were assessed on their ability to form implicit category structures for the numbers one, two, and three. We hypothesized that children would be able to form the implicit category structure for the number one …

Sucrose Concentration And Fermentation Temperature Impact The Sensory Characteristics And Liking Of Kombucha, Gil Cohen

Masters Theses

Kombucha is a fermented tea beverage consumed for its probiotics and functional properties and has a unique sensory profile driven by the properties of tea polyphenols and fermentation products, including organic acids. Fermentation temperature and sucrose content affect the fermentation process and the production of organic acids, yet less is known about the impact on the sensory profile and consumer acceptance. Thus, we aim to examine the impact of sucrose concentration and fermentation temperature on sensory attributes and liking. For this study, kombucha tea was fermented at three different concentrations of sucrose and fermented at two temperatures for 11 days. …

Antifascist Autobiographical Writing By Three Southern European Women Writers: Natália Correia, Concha Zardoya, And Ludovica Ripa Di Meana, Jessica R. Beasley

Masters Theses

This thesis puts three antifascist writers in dialogue: Concha Zardoya, Natália Correia, and Ludovica Ripa di Meana. It does so based on their similarities as women who lived in Southern European fascist regimes, who wrote autobiographical poetry books about those regimes. Comparing and qualifying the regimes based on Umberto Eco’s Ur-Fascism, in which he highlights common “family resemblance” characteristics of fascist regimes, I set up the positionality of each women within her specific milieu. I then discuss the resulting poetry books, which all utilize a multi-temporal, teleological construction of the regime based on the writer’s own memory as someone who …

Elucidating The Priming Mechanism Of Clpxp Protease By Single-Domain Response Regulator Cpdr In Caulobacter Crescentus, Kimberly E. Barker

Masters Theses

In Caulobacter crescentus, progression through the cell cycle is regulated by the AAA+ protease ClpXP, and there are several classes of cell-cycle substrates that require adaptors in order to be degraded. CpdR, a single domain-response regulator, binds the N-terminal domain of ClpXP and primes the protease for degradation of downstream factors (Lau et al., 2015). The ability of CpdR to bind ClpX is regulated by its phosphorylation state. In the unphosphorylated state, CpdR binds ClpXP and guides its localization to the cell pole during the swarmer to stalked transition, where CpdR is mediates degradation of substrates such as PdeA. …

Bog Turtle (Glyptemys Muhlenbergii) Population Dynamics And Response To Habitat Management In Massachusetts, Julia Vineyard

Masters Theses

The Bog Turtle (Glyptemys muhlenbergii) is a federally threatened species that occupies isolated pockets of open-canopy fens. This long-lived species is susceptible to habitat loss and degradation; thus, the conservation of known populations and management of their habitat is critical to the species’ survival. Long-term (multi-decadal) assessment is important for determining population trends and responses to ongoing habitat management. I assessed population demographics (abundance, survival) and spatial distribution (home range) of two Bog Turtle populations in Massachusetts that have been managed since the late 1990s by treating invasive species, thinning woody vegetation, and mitigating flooding. The results of …

A Latent Profile Analysis Of Four Characteristics Of Intimate Partner Violence And Associations With Posttraumatic Stress Symptoms, Ana Uribe

Masters Theses

Intimate partner violence (IPV) is a prevalent potentially traumatic experience that increases risk for posttraumatic stress symptoms (PTSS). However, there is still considerable heterogeneity in PTSS among women exposed to IPV. Research on IPV has examined the ways in which different characteristics of IPV exposure have separately related to risk for PTSS, specifically the type (physical, psychological, economic, sexual), frequency (number of incidents), severity (minor, severe), and mode of violence (in-person, online). However, it may be important to examine how the integration of these characteristics of IPV differ across ���������������������� ���� ������ ���� ������������ �������������������� �������������� ���������� The current study …

Climate Change, Giant Viruses And Their Putative Hosts, Sarah K. Tucker

Masters Theses

Viruses hold our attention for the horrific impact they have on human health and welfare. However, viruses are a critical part of our ecosystem and facilitate the cycling of carbon and other important nutrients. The cycle of virus infection, followed by host resistance and the subsequent evolution of new strains enables adaptation to changing hosts and the environment. Giant viruses, some with particle sizes large enough to be visible in light microscopes and their bewildering array of accessory genes, have captivated scientists and the general public since their discovery two decades ago. Giant viruses are part of the Nucleocytoviricota (NCV) …

Tracing Microplastics In Municipal Potable Water Across Residential Buildings, Jimmy Tran

Masters Theses

Limited research on microplastics makes it increasingly difficult to measure the potential dangers of their toxicological effect on humans and the environment. Today, evidence has revealed that microplastics have been located in highly remote areas of the world. There are few studies that examine the movement of microplastics within urban landscapes and even fewer that observe different communities within cities. To this end, a study was devised that utilized filtration, dehydration, and Laser Direct Infrared Spectroscopy to monitor drinking water microplastics found in residential buildings across different communities.

Houses and apartments of low and high-income at different distances from the …

Heat Flow In The Southern Margin Of Salar De Atacama: Deep Groundwater Temperature Distributions And The Implications For Subsurface Flow And Land Surface Energy Budgets, Graham Thomas

Masters Theses

Salar de Atacama (SdA) located in Northern Chile is home to one of the planet’s largest salar systems and lithium resources. Managing groundwater resources in salars is not obvious due to the lack of scientific understanding on the connectivity between the freshwater and brine systems. Using heat as a tracer in SdA provides a cost-effective method to further investigate groundwater flow in salars. This study employs 372 temperature-depth profiles from 90 boreholes between 2013-18 to understand the distinct thermal zones and flow between them in SdA. Three thermal zones exist within the southern margin of SdA’s thermal regime, at higher …

Fat Lowering Effects Of Piperine In Caenorhabditis Elegans, Zhoutai Teng

Masters Theses

P iperine is an alkaloid found in pepper plant, w hich exhibits many health benefits including anti aging, anti cancer, anti diabetic, and anti inflammatory effects. However, the anti obesity research of piperine is limited. Therefore, th is study was done to determine the effects of piperine on fat accumulation, using in vivo model, Caenor habditis elegans . Treatment with 100 μ M piperine reduce fat content of wild type C. elegans by 17% over control. Pumping rate was not affected by piperine, suggesting piperine has no effects on food intake of worms. Mutant strains were tested to determine t …

Caulobacter Clpxp Adaptor Popa’S Domain Interactions In The Adaptor Hierarchy Of Ctra Degradation, Thomas P. Scudder

Masters Theses

The degradation and recycling of protein is a process essential for the maintenance and regulation of cellular function. More specifically, in Caulobacter crescentus, the ClpXP protease is responsible for driving progression through the cell cycle and protein quality control. This protease utilizes three known adaptors to selectively degrade proteins that initiate different stages of development. This thesis will elaborate on the specific binding interface on one of these adaptors, PopA, with another, RcdA, and focus in on specific residues on PopA and investigate their roles in adaptor binding and delivery of CtrA, the master regulator of Caulobacter. Finally, I …

Combining Simulation And The Mspa Nanopore To Study P53 Dynamics And Interactions, Samantha A. Schultz

Masters Theses

p53 is a transcription factor and an important tumor suppressor protein that becomes activated due to DNA damage. Because of its role as a tumor suppressor, mutations in the gene that encodes it are found in over 50% of human cancers. The N-terminal transactivation domain (NTAD) of p53 is intrinsically disordered and modulates the function and interactions of p53 in the cell. Its disordered structure allows it to be controlled closely by post-translation modifications that regulate p53’s ability to bind DNA and interact with regulatory binding partners. p53 is an attractive target for developing cancer therapeutics, but its intrinsically disordered …

Participatory Wetland Governance In Ramsar – Assessing Level Of Participation In India, Seema Ravandale

Masters Theses

Due to the alarming rate of global wetland depletion, the Ramsar Convention, an international wetland conservation and management treaty, was signed in 1971. As of today, 172 countries are signatories. The intricate connection of local communities, their indigenous knowledge and hence their participation in the wetland governance has been recently recognized by Ramsar to protect the community's right over wetlands and to establish the joint stewardship of government and communities on these vital resources. Ramsar Convention provides a broader framework for participatory wetland governance; however, there needs to be more clarity on how various countries understand, perceive, and adopt community …

Microplastics In Local Communities’ Tap Water, Zachary T. Rattell

Masters Theses

Microplastics are an emerging environmental contaminant. One of the ways microplastics can get into the environment is by the breakdown of larger plastics. These plastics can come from industrial practices, discarded fabrics, agriculture, and general plastic waste. As these plastics are broken down microplastics leach into the environment. The widespread use of plastics has resulted in the spread of microplastic contaminants all over the world. Microplastics have been reported to be in drinking water, so this paper is looking at the presence of microplastics in local communities of different demographics and socioeconomic statuses. In other studies of different drinking water …

Thermal Conductivity And Mechanical Properties Of Interlayer-Bonded Graphene Bilayers, Afnan Mostafa

Masters Theses

Graphene, an allotrope of carbon, has demonstrated exceptional mechanical, thermal, electronic, and optical properties. Complementary to such innate properties, structural modification through chemical functionalization or defect engineering can significantly enhance the properties and functionality of graphene and its derivatives. Hence, understanding structure-property relationships in graphene-based metamaterials has garnered much attention in recent years. In this thesis, we present molecular dynamics studies aimed at elucidating structure-property relationships that govern the thermomechanical response of interlayer-bonded graphene bilayers.

First, we present a systematic and thorough analysis of thermal transport in interlayer-bonded twisted bilayer graphene (IB-TBG). We find that the introduction of interlayer C-C …

Mining High Impact Combinations Of Conditions From The Medical Expenditure Panel Survey, Arjun Mohan

Masters Theses

The condition of multimorbidity — the presence of two or more medical conditions in an individual — is a growing phenomenon worldwide. In the United States, multimorbid patients represent more than a third of the population and the trend is steadily increasing in an already aging population. There is thus a pressing need to understand the patterns in which multimorbidity occurs, and to better understand the nature of the care that is required to be provided to such patients.

In this thesis, we use data from the Medical Expenditure Panel Survey (MEPS) from the years 2011 to 2015 to identify …