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A Novel In Vitro Multiple-Stress Dormancy Model For Mycobacterium Tuberculosis Generates A Lipid-Loaded, Drug-Tolerant, Dormant Pathogen, Chirajyoti Deb, Chang-Muk Lee, Vinod S. Dubey, Jaiyanth Daniel, Bassam Abomoelak, Tatiana D. Sirakova, Santosh Pawar, Linda Rogers, Pappachan E. Kolattukudy
A Novel In Vitro Multiple-Stress Dormancy Model For Mycobacterium Tuberculosis Generates A Lipid-Loaded, Drug-Tolerant, Dormant Pathogen, Chirajyoti Deb, Chang-Muk Lee, Vinod S. Dubey, Jaiyanth Daniel, Bassam Abomoelak, Tatiana D. Sirakova, Santosh Pawar, Linda Rogers, Pappachan E. Kolattukudy
Faculty Bibliography 2000s
Background: Mycobacterium tuberculosis (Mtb) becomes dormant and phenotypically drug resistant when it encounters multiple stresses within the host. Inability of currently available drugs to kill latent Mtb is a major impediment to curing and possibly eradicating tuberculosis (TB). Most in vitro dormancy models, using single stress factors, fail to generate a truly dormant Mtb population. An in vitro model that generates truly dormant Mtb cells is needed to elucidate the metabolic requirements that allow Mtb to successfully go through dormancy, identify new drug targets, and to screen drug candidates to discover novel drugs that can kill dormant pathogen. Methodology/Principal Findings: …
Changes In Dry State Hemoglobin Over Time Do Not Increase The Potential For Oxidative Dna Damage In Dried Blood, April Marrone, Jack Ballantyne
Changes In Dry State Hemoglobin Over Time Do Not Increase The Potential For Oxidative Dna Damage In Dried Blood, April Marrone, Jack Ballantyne
Faculty Bibliography 2000s
Background: Hemoglobin (Hb) is the iron-containing oxygen transport protein present in the red blood cells of vertebrates. Ancient DNA and forensic scientists are particularly interested in Hb reactions in the dry state because both regularly encounter aged, dried bloodstains. The DNA in such stains may be oxidatively damaged and, in theory, may be deteriorated by the presence of Hb. To understand the nature of the oxidative systems potentially available to degrade DNA in the presence of dried Hb, we need to determine what molecular species Hb forms over time. These species will determine what type of iron (i.e. Fe(2+)/Fe(3+)/Fe(4+)) is …
Improved Resolution Haplogroup G Phylogeny In The Y Chromosome, Revealed By A Set Of Newly Characterized Snps, Lynn M. Sims, Dennis Garvey, Jack Ballantyne
Improved Resolution Haplogroup G Phylogeny In The Y Chromosome, Revealed By A Set Of Newly Characterized Snps, Lynn M. Sims, Dennis Garvey, Jack Ballantyne
Faculty Bibliography 2000s
Background: Y-SNP haplogroup G (hgG), defined by Y-SNP marker M201, is relatively uncommon in the United States general population, with only 8 additional sub-markers characterized. Many of the previously described eight sub-markers are either very rare (2-4%) or do not distinguish between major populations within this hg. In fact, prior to the current study, only 2% of our reference Caucasian population belonged to hgG and all of these individuals were in sub-haplogroup G2a, defined by P15. Additional Y-SNPs are needed in order to differentiate between individuals within this haplogroup. Principal Findings: In this work we have investigated whether we could …