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- Perezone; sulfur derivates; natural products; cytotoxic activity; DFT; PARP-1 (1)
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Articles 1 - 30 of 127
Full-Text Articles in Entire DC Network
Effects Of Varying Ph, Temperature, And Sucrose Concentration On The Activity Of Invertase Enzyme, B. Rainwater, S. Pratihar
Effects Of Varying Ph, Temperature, And Sucrose Concentration On The Activity Of Invertase Enzyme, B. Rainwater, S. Pratihar
Journal of the Arkansas Academy of Science
The purpose of this research is to study the factors that affect the enzymatic activity of invertase, extracted from baker’s yeast, on hydrolysis of sucrose in aqueous medium. Invertase, a glycoprotein, is an enzyme in the glycoside hydrolase family. It catalyzes the hydrolysis of sucrose producing equimolar mixture of a-D-glucose and b-D-fructose. Invertase shows high affinity for the substrate, and is capable of both cleaving the glycosidic linkage in sucrose and transferring ab-D-O-fructofuranoside residue to an acceptor substrate. (Toledo et al. 2019). A detailed mechanism of the action of invertase was postulated by Shall et al. (Shall et al. 1971). …
Design Of Two New Sulfur Derivatives Of Perezone: In Silico Study Simulation Targeting Parp-1 And In Vitro Study Validation Using Cancer Cell Lines, Alejandro Rubiales-Martínez, Joel Martinez, Elvia Mera-Jiménez, Javier Perez-Flores, Guillermo Tellez-Isaias, Rene Miranda Ruvacalba, Maricarmen Hernandez-Rodriguez, Teresa Mancillo Percino, Martha Edith Macia Perez, Maria Ines Nicholas-Vazquez
Design Of Two New Sulfur Derivatives Of Perezone: In Silico Study Simulation Targeting Parp-1 And In Vitro Study Validation Using Cancer Cell Lines, Alejandro Rubiales-Martínez, Joel Martinez, Elvia Mera-Jiménez, Javier Perez-Flores, Guillermo Tellez-Isaias, Rene Miranda Ruvacalba, Maricarmen Hernandez-Rodriguez, Teresa Mancillo Percino, Martha Edith Macia Perez, Maria Ines Nicholas-Vazquez
Poultry Science Faculty Publications and Presentations
Poly-ADP-Ribose Polymerase (PARP-1) is an overexpressed enzyme in several carcinomas; consequently, the design of PARP-1 inhibitors has acquired special attention. Hence, in the present study, three compounds (8–10) were produced through a Michael addition protocol, using phenylmethanethiol, 5-fluoro-2-mercaptobenzyl alcohol, and 4-mercaptophenylacetic acid, respectively, as nucleophiles and perezone as the substrate, expecting them to be convenient candidates that inhibit PARP-1. It is convenient to note that in the first stage of the whole study, the molecular dynamics (MD) simulations and the quantum chemistry studies of four secondary metabolites, i.e., perezone (1), perezone angelate (2 …
Mole Street Journal, January 2020, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, January 2020, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, June 2019, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, June 2019, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, April 2019, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, April 2019, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, February 2019, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, February 2019, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, December 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, December 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, October 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, October 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, August 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, August 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Conformationally-Controlled Late-Stage Modifications For Sar Studies Of The C-3-Glcp Moiety Of Ipomoeassin F, Lucas Whisenhunt
Conformationally-Controlled Late-Stage Modifications For Sar Studies Of The C-3-Glcp Moiety Of Ipomoeassin F, Lucas Whisenhunt
Graduate Theses and Dissertations
The resin glycoside, ipomoeassin F has been shown to be extremely potent against multiple cancer lines (IC50 = 4.2-36 nM). However, the mechanism of action of this potent and complex natural product is still not fully understood. The α,β-unsaturated esters of the glucosyl moiety have been shown to be vital for the overall cytotoxicity of ipomoeassin F. Nevertheless, the importance of the tigloyl ester of the glucosyl moiety is still largely unknown. This work aimed to study the pharmacophore importance of the tigloyl ester by creating, an efficient, scalable, and flexible synthesis route for various analogs. The 18-linear step synthesis …
Mole Street Journal, June 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, June 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, April 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, April 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, February 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, February 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, December 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, December 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, October 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, October 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, August 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, August 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, June 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, June 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, April 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, April 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, February 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, February 2017, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, December 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, December 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, October 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, October 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, August 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, August 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, June 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, June 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, April 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, April 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, February 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, February 2016, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, December 2015, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, December 2015, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, October 2015, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, October 2015, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, August 2015, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, August 2015, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Mole Street Journal, June 2015, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal, June 2015, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry
Mole Street Journal
No abstract provided.
Fluorescent Cell Imaging Studies Of Antitumor Natural Macrocycle Ipomoeassin F, Margaret Grace Oliver
Fluorescent Cell Imaging Studies Of Antitumor Natural Macrocycle Ipomoeassin F, Margaret Grace Oliver
Biological Sciences Undergraduate Honors Theses
Ipomoeassin F is one member of a family of macromolecules isolated from the leaves of the morning glory flower, ipomoea squamosa, which has been used as a homeopathic cancer remedy for centuries (Zhu, Huang, Zheng, Zhu, & Yang, 2013). It has been proven to be highly cytotoxic to many cancer cell lines, but nothing is yet known of its mode of action in the cell (Cao, et al., 2007). To begin progress towards understanding the mode of action of ipomeoassin F, this study aimed to perform fluorescence imaging studies for the ultimate purpose of determining its cellular localization in MDA-MB-231 …