Digital Commons Network^™

June 23, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

A Modular Saponin Adjuvant Platform: Development, Structure–Activity Relationships, And Applications, Di Bai

ETDs from 2020-2029

ABSTRACT Saponin-based vaccine adjuvants have attracted considerable attention owing to the clinical success of QS-21, a potent immunostimulant capable of inducing balanced humoral and cellular immune responses, yet its widespread application is limited by supply constraints, chemical instability, and dose-dependent toxicity. To address these challenges, we previously developed two semisynthetic saponin adjuvants, VSA-1 and VSA-2, derived from abundant Momordica saponins through a single-step modification, which exhibit QS-21–comparable immunopotentiating activity with improved accessibility and stability. Here, we first performed a systematic structure–activity relationship (SAR) study of the VSA series using MS I as the lead scaffold. Modulation of the side-chain length …

Impact Of Institutional Expected Practice Guidelines On Oral And Long-Acting Intravenous Antibiotic Use For Serious Bacterial Infections, William Bradford

ETDs from 2020-2029

Expected practice interventions are a type of antimicrobial stewardship intervention in which local guidelines regarding antimicrobial prescribing are developed and released at an institutional level to establish an institutional standard of care. An expected practice intervention to encourage use of oral and long-acting IV (PO/LAIV) antibiotics for serious infections was performed at the University of Alabama at Birmingham Hospitals in November of 2022. We conducted a quasi-experimental pre/post study using a difference in differences approach to evaluate the effect of these guidelines on a primary outcome of length of stay (LOS) and secondary outcomes of inpatient antibiotic days, 3-month readmission, …

Mortality Risk Factors In Pediatric Invasive Fungal Rhinosinusitis: The Care-Pifrs Multicenter Study, Charis C. Hodges, Brenton T. Bicknell, Emily Miller, Christopher Naranjo, Daniel Du, Matthew Harris, Jeeho Kim, Beth Osterbauer, Yassi Baghshomali, Scott Hirsh, Victoria Huynh, Uma Ramaswarmy, Sarah Gitomer, Heather Koehn, Jeffrey Koempel, Vijay A. Patel, Kenneth Kennedy, Kate Dunsky, Ryan H. Belcher, Jessica W. Grayson

Heersink School of Medicine Student Presentations

No abstract provided.

Cysteine Protease Activity In Allergen Recognition And Initiation Of Th2 Allergic Responses, Audrey Rae Meloun

ETDs from 2020-2029

Allergens are non-infectious environmental proteins that can trigger T helper 2 (Th2) cell-mediated inflammation in atopic individuals. Allergens are structurally diverse and typically lack pathogen-associated molecules patterns (PAMPs), which are recognized by pathogen recognition receptors (PRRs). PRRs are the canonical sensors of the innate immune system that typically detect PAMPs in microbes, initiating signaling pathways that drive pathogen clearance. Because allergens generally do not activate PRRs in the same way as infectious agents, alternative detection mechanisms are likely responsible for their recognition and the subsequent initiation of Th2 cell-mediated inflammation. House Dust Mite (HDM), a major indoor allergen, and other …

When Therapy Becomes The Trigger: An Antibiotic With A Twist, Hinal Rathi, Roshini Raghu, Parekha Yedla

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster

A Case Of Delayed Cutaneous Manifestation Of Mrsa Bacteremia In A Hemodialysis Patient, Ndukeabasi Nze, Jenna Alkhatib, Morgan Caradonna, Soumyadeep Bag, Alan Baggett

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster

Changing Characteristics Of Cryptococcal Infections And Outcomes: A Single-Center Retrospective Cohort, Charis C. Hodges, Kenneth Long, Gerald Mcgwin, Todd Mccarty, Peter Pappas

Heersink School of Medicine Student Presentations

No abstract provided.

A Noncanonical Role Of T Follicular Helper Cells In Promoting Peripheral Tolerance By Supporting T Regulatory Cells, Shivangi Dave

All ETDs from UAB

T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells that sup-port germinal center (GC) B cells and promote antibody (Ab)-mediated immunity. There is growing recognition of the heterogeneity and functional diversity of Tfh cells, supported by accumulating evidence that highlights their context-specific roles across a range of disease settings. While their contribution to B cell responses is well-established, our data demonstrate that Tfh cells have a broader and more dynamic function. In this study, we uncover a novel function of Tfh cells in maintaining immune homeostasis by supporting T regulatory cell (Treg) responses under normal physiological …

Air Pollution And Environmental Injustice Are Related To Respiratory Complications In Individuals With Sickle Cell Disease, Kelsey M. Maclin

All ETDs from UAB

Sickle cell disease (SCD) is a genetically inherited blood disorder affecting people of African descent. SCD is characterized by painful episodes and an acute lung injury known as acute chest syndrome (ACS). Patients with SCD have a life expectancy <19 years compared to Blacks without SCD. There is minimal research investigating air pollution and health complications in SCD. The aims of this research were to investigate whether pulmonary function is affected by exposure to ambient air pollution, whether higher air pollution concentrations are associated with hospitalizations for ACS, and whether environmental injustice impacts the respiratory health of children and young adults with SCD. Air pollution data on the criteria air pollutants (CAPs) was obtained from the US Environmental Protection Agency (EPA). Patient health data were obtained from Children’s Hospital of Alabama electronic medical records. Logistic regression, distributed lag non-linear regression, Granger Causality, and Getis-Ord Gi* hot spot analysis were used to analyze our data. The EPA’s EJScreen tool was used as a measure of exposure to environmental injustice. ArcGIS was used to map the EJScreen data. Exposure to short-term air pollution is significantly associated with a reduction in pulmonary function in children and young adults with SCD. Children and young adults exposed to a one-unit increase in the monthly average concentrations of sulfur dioxide (SO2) experienced an increase in the odds of having abnormal pulmonary function. We observed the trends of each criteria air pollutant in our study to be closely aligned with the trends in the hospitalizations for ACS. Most of our study participants with a history of ACS lived in areas burdened by greater environmental injustices. Specifically, the hot spots for ACS overlapped with the hot spots for PM2.5. Unequal exposure to environmental injustices leads to increases in hospitalizations for respiratory complications in individuals with SCD. Reductions in air pollution could be greatly beneficial to the pulmonary function and overall respiratory health of individuals with SCD. Further research is needed to examine associations between air pollution and hospitalizations for ACS in individuals with SCD.

Probiotic Biogeography In The Neonatal Intestine, Sierra Hansen

All ETDs from UAB

Neonatal infection remains a leading cause of both neonatal morbidity and mortality worldwide, particularly in preterm infants. Probiotic bacteria have been demonstrated to protect against the development of neonatal intestinal dysbiosis, however, formulations and efficacy vary substantially, highlighting a critical gap in the current understanding of the mechanisms governing probiotic efficacy in this population. This gap is exacerbated by regulatory standards which favor economic expansion over scientific rigor. Furthermore, current studies on probiotic efficacy largely rely on indirect or relative readouts of intestinal bacterial burden. Herein, we directly quantify the probiotic effects of Ligilactobacillus murinus V10 and Escherichia coli Nissle …

Reducing The Risk Of Phishing Attacks Through Providing Consistent Training Via The Kaizen Education Platform, Dalton E. Pena

All ETDs from UAB

Introduction: Many healthcare organizations have experienced cybersecurity related phishing email attacks, costing these organizations many thousands to many millions of dollars to release ransomed data to maintain patient care delivery and operations. Use of technology alone has proven to be insufficient, as most occurrences of data breaches are related to human behaviors. Background: Cybersecurity is a threat increasingly common to healthcare organizations, and it is gaining in both sophistication and complexity, aided by artificial intelligence. Healthcare organizations have adopted new technologies and increased the prevalence of cybersecurity training to develop a healthy cyber culture and construct a human firewall against …

Prosthetics In The Time Of Proust, Ashley S. Mcguire

Patent Coloring Books

Patent coloring book

Cognitive Diversity, The Keystone To Effective Ptd In The Medical Research And Medical Device Industries, John Gilmartin

ASEM Capstones

2025 ASEM 620 Capstone Project

Serum Analysis For Hiv-1 Envelope Specific And Autoantigen Reactive Igg And Igm Antibody Response In Hvtn 702 Trial Participants, Tatyana Mompoint, Rashi Kalra, James Kobie

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Physical & Applied Sciences

Organizational Factors That Impact Emergency Room Sepsis Bundle Compliance In U.S. Hospitals, Jason Lee Kimbrell

All ETDs from UAB

ORGANIZATIONAL FACTORS THAT IMPACT EMERGENCY ROOM SEPSIS BUNDLE COMPLIANCE IN U.S. HOSPITALS JASON L. KIMBRELL HEALTH SERVICES ADMINISTRATION ABSTRACT This in-depth study examines the organizational factors within U.S. hospital emergency rooms (ERs) that impact care teams’ adherence to established, time-sensitive sepsis protocols. The regression analysis revealed a concerning trend: for each 1% increase in annual patient walk-out rates, compliance with sepsis protocols declines by 2.10%. Additionally, the impact on poor ER throughput where the ESI level 3 length of stay increases by 1 minute, a hospital's compliance with the 3hr POA sepsis bundle decreases by .08%. These findings underscore the …

February 21, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Exploring The Lived Experiences Of Persons Living With Hiv Who Are Homebound Due To One Or More Comorbidities Within A Southern State Using Photovoice, Anthony Alyn "Deek" Cunningham

All ETDs from UAB

At the end of 2022, there were 1,109,418 adults and adolescents with HIV in the United States and the six dependent areas of American Samoa, Guam, the Northern Mariana Islands, Puerto Rico, the Republic of Palau, and the US Virgin Islands (CDC, 2024). Due to ongoing advances in medications and treatments, people who have been diagnosed with HIV are living longer and healthier lives, making this a chronic health condition. Yet, there are gaps in the literature that focuses on this population growing older and aging in place. This dissertation investigated the lived experiences of individuals fifty years and older …

Black/African American Community Health Workers In Hhs Region 4 And Covid-19 Vaccination: Position Perspective And Power, Cecily A. Gray

All ETDs from UAB

COVID-19 is caused by the novel and easily transmissible SARS-C0V-2 virus. SARS-C0V-2 was first reported in the Chinese Providence of Hubei in December 2019 and in the United States in January 2020. After nearly 120,000 confirmed global cases and 4,200 deaths in 114 countries, the WHO declared COVID-19 a worldwide pandemic in March of 2020. By fall of 2020, COVI9-19 had become the third leading cause of death in the United States. When compared to other groups, Black/African Americans were disproportionately impacted by the COVID-19 pandemic due to ongoing racial inequities/disparities including chronic illness. Black/African Americans who are more likely …

Targeting Streptococcus Mutans Diadenylate Cyclase For The Prevention Of Dental Caries, Edwin Miguel Rojas

All ETDs from UAB

Streptococcus mutans (S. mutans) is the primary etiological agent involved in the initiation and progression of dental caries. S. mutans forms robust biofilms on the tooth surface, and current preventative treatments, such as oral rinses, eliminate both pathogenic and commensal oral species. Therefore, there is an urgent need for therapeutics which selectively inhibit S. mutans biofilms while keeping the oral microbiome intact. The diadenylate cyclase (DAC) enzyme in S. mutans plays a key role in biofilm formation. DAC converts adenosine triphosphate (ATP) into cyclic di-AMP (c-di-AMP), a secondary messenger involved in several cellular pathways. Increased levels of c-di-AMP have shown …

Development Of Momordica Saponin-Based Vaccine Adjuvants, Hyunjung Kim

All ETDs from UAB

Vaccine adjuvants are indispensable substances that help induce a fast, potent, and durable immune response when administered with vaccine antigens. Among the FDA-approved vaccine adjuvants for human use, three of the most recently approved ones contain saponin adjuvant QS-21. To address QS-21’s inherent drawbacks, we investigated the adjuvant activity of a series of saponin-based semisynthetic vaccine adjuvants, including VSA-1 and VSA-2, prepared from natural Momordica saponins I and II in one-step. The natural saponins precursors are isolated from the widely available and inexpensive seeds of Momordica cochinchinensis SPRENG. In general, VSA adjuvants can enhance both humoral and cellular immune responses …

Mitigating The Impacts Of Future Climate Change On Urban Infrastructure In Alabama Through Updating Precipitation Intensity-Duration-Frequency (Idf) Curves, Kofi Ntow Opare

All ETDs from UAB

Climate change is set to profoundly impact urban infrastructure, causing increased flooding and storm damage, necessitating the reevaluation and adaptation of design methodologies to account for increasing precipitation extremes. This dissertation aims to enhance the resilience of urban infrastructure in Alabama by updating Precipitation Intensity-Duration-Frequency (IDF) curves, which are crucial for designing stormwater management systems, drainage networks, and flood control structures. Traditional IDF curves, derived from historical rainfall data, operate under the assumption of stationarity, an assumption increasingly invalidated by climate change. This research employs the Generalized Extreme Value (GEV) distribution and compares the efficacy of L-moments and Generalized Maximum …

Chronic Inflammation Compromises Natural Killer Cell Phenotype And Function In Myeloid Leukemia, Valeriya Kuznetsova

All ETDs from UAB

Chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) are blood malignancies characterized by clonal expansion and a compromised immune system. Tyrosine kinase inhibitors (TKI) revolutionized CML treatment; however, TKI discontinuation leads to relapses in half of the cases. Further, up to 10% of patients are TKI-resistant and develop a blast crisis resembling AML. Natural killer (NK) cells can clear malignant cells, representing a promising immunotherapy. However, NK cell activity is suppressed in leukemia, and the microenvironmental drivers of this impairment remain understudied. Despite this, the existing mouse models have not been tested to assess the effect of CML on …

Scalable Resonance-Based Multi-Coil Inductive Links For Wireless Power Transmission And Passive Sensing In Biomedical Applications, Reepa Saha

All ETDs from UAB

Type 2 Diabetes (T2D) has become a major health crisis, affecting up to 95% of the 38.4 million diabetes cases in the United States and costing approximately $327 billion annually. Current treatments mainly focus on symptom management rather than reversing the disease. However, clinical observations suggest a promising link between certain stomach surgeries, such as the removal of the upper stomach, and diabetes reversal within a year. This raises the possibility of anatomical changes influencing diabetes outcomes, though the underlying neural mechanisms remain unclear. This dissertation is organized into three interconnected research segments, each contributing to a platform that deepens …

Treatment Of Histoplasmosis With Posaconazole In The Setting Of A Severe Itraconazole Hypersensitivity Reaction: A Case Report, Kinsey M. Johannemann, Megan Z. Roberts, Samir Allos, Madeline Belk, Spencer H. Durham, Jonathan Edwards

UAB Huntsville Research Day - All Presentations

No abstract provided.

Missed Hiv Screening Chances In Adolescents At Emergency Departments, Ethan Barnes, Claudette Poole

UAB Huntsville Research Day - All Presentations

2025 oral presentation

Uncovering The Role Of Heparanase-Armed Extracellular Vesicles In Sepsis-Associated Vascular Endotheliopathy, Robert Patrick Richter

All ETDs from UAB

Sepsis remains one of the most frequent causes of mortality and life-altering morbidity in humans of all ages globally. Though sepsis pathobiology is incompletely understood, it is clear that a unifying feature of all sepsis phenotypes is systemic vascular endotheliopathy and damage to the luminal glycocalyx of endothelial cells, or eGC, that leads to organ injury. While prior work has established that heparan sulfate (HS) is an especially important eGC constituent that helps regulate a host of endothelial cell (EC) functions, its role in promoting endotheliopathy during sepsis has not been fully characterized. Additionally, previous studies in the context of …

Evaluation Of A Multidrug-Resistant Acinetobacter Baumannii Outbreak In A Large Community Hospital And Long-Term Acute Care Hospital, Evan Lawson, Spencer H. Durham, Kelsey Ivey, Jonathan Edwards, Madeline Belk

UAB Huntsville Research Day - All Presentations

2025 research poster

Breathless Battle: Navigating Immunotherapy Complications In Stage 4 Lung Cancer, Brittany Fennell, Megan Roberts, Roger D. Smalligan

UAB Huntsville Research Day - All Presentations

No abstract provided.

Think Twice: A Case Of Syphilitic Endophthalmitis, Ahmed Qaedi, Sarika Mullapudi, Tarek Persaud, Ali Hassoun

UAB Huntsville Research Day - All Presentations

No abstract provided.