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Sex Differences In The Co-Expression Of Estrogen Receptor Alpha With Corticotropin Releasing Factor, Deborah Ariyibi
Sex Differences In The Co-Expression Of Estrogen Receptor Alpha With Corticotropin Releasing Factor, Deborah Ariyibi
Biological Sciences
Women are far more likely to develop anxiety and depression than men. It is believed that the dysregulation of the HPA axis by the binding of corticotropin -releasing factor (CRF) to the corticotropin-releasing factor receptor 1 (CRFR1) contributes to the likelihood of these stress- related disorders. Estrogens acting through Estrogen receptor alpha (ERa) have been shown to increase anxiety production upon activating the HPA axis. In this current study, we explored whether CRF-expressing neurons in various regions of the brain express ERa. The levels of ERa were counted in the bed nucleus of the stria terminalis (BST), the medial preoptic …
Intergenerational Embodiment Of Stress : How The Broader Sociocultural Environment Can Shape Child Growth And Development, Elizabeth A. Holdsworth
Intergenerational Embodiment Of Stress : How The Broader Sociocultural Environment Can Shape Child Growth And Development, Elizabeth A. Holdsworth
Legacy Theses & Dissertations (2009 - 2024)
Childhood growth has been a means of identifying systemic, material inequalities within populations. The plasticity of growth is responsive to multiple environmental factors, most notably adequate nutrition, but also psychosocial stress. Psychosocial stress can be a function of the social and political economic ecology, reinforcing power hierarchies within societies. This dissertation proposes that childhood growth can also reflect inequality in the distribution of psychosocial stress exposure through mothers’ feelings of a chronically stressful environment conveyed through maternal-infant interactions.
Black Women Social Workers : A Qualitative Exploration Of Stress And Coping, Collina D. Cooke
Black Women Social Workers : A Qualitative Exploration Of Stress And Coping, Collina D. Cooke
Legacy Theses & Dissertations (2009 - 2024)
Black women social workers (BWSW) represent essential workforce members. They are burdened by overlapping expectations associated with their multiple marginalized and unique identities. Their definitions of stress and creation of strategies to deal with highly stressful situations have been absent from the research literature, leaving intervention strategies to support highly stressed BWSW unknown. This study was developed to explore stress perceptions and holistic manifestations of stress. A primary focus was to highlight the coping responses used by BWSW to decrease stress levels. In addition, the researcher sought to investigate various ways organizations have created stressful situations for BWSW and identify …
Methamphetamine-Induced Modulation Of Anxiety/Depressive-Like Behaviors And Hpa Axis Output : Contributing Factors Within Stress Associated Brain Regions, Jason Jacobskind
Methamphetamine-Induced Modulation Of Anxiety/Depressive-Like Behaviors And Hpa Axis Output : Contributing Factors Within Stress Associated Brain Regions, Jason Jacobskind
Legacy Theses & Dissertations (2009 - 2024)
Methamphetamine (MA) is a psychostimulant drug of addiction that induces a wide range ofeffects. Among its many side effects is the potentiation of cellular, physiological, and behavioral changes in the stress response system. Upon exposure, the hypothalamic-pituitary-adrenal (HPA) axis is initiated. This process entails many factors. Receiving input from other brain regions, the paraventricular nucleus (PVN) of the hypothalamus secretes corticotropin-releasing factor (CRF) and arginine vasopressin into the anterior pituitary gland. These together stimulate the synthesis and release of adrenocorticotropic hormone, which circulates via the blood stream to cause the release of glucocortoicoids, the stress hormone (CORT). Binding of glucocorticoids …
Behavioral, Endocrine, And Neural Responses To Stress In Postpartum And Nulliparous Rats : Potential Mechanisms Of Postpartum Stress Resilience, Joanna Medina
Legacy Theses & Dissertations (2009 - 2024)
Major depressive disorder is one of the most pervasive psychiatric illnesses in the United States. Women are at greater risk for developing depression, particularly during their childbearing years. Approximately 17% of new mothers develop postpartum depression within 4 weeks after parturition. The risk for postpartum depression is even greater in women who do not breastfeed or stop breastfeeding early. Major depressive disorder and postpartum depression share the same symptomology and common etiological bases. Dysregulated stress responses, dopamine activity, and neuroinflammation are recognized mechanisms for depression. The transition to motherhood encompasses physiological and behavioral adaptations in the brain essential for ensuring …