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Ms 069 Guide To The Harold S. Skjonsby, Dds Papers (1967-1987), Harold S. Skjonsby, Dds

Manuscript Finding Aids

The Harold S. Skjonsby, DDS, papers (MS069) contains reports, committee notes, curriculum and modules for teaching, grant information, faculty workshop programs, and student handbooks that document Harold S. Skjonsby’s time as faculty the University of Texas Dental Branch at Houston. See more at MS 069.

Ms 115 Guide To John P. Mcgovern, Md Papers (1901-2002), John P. Mcgovern (1921 - 2007)

Manuscript Finding Aids

The papers of John P. McGovern document his medical career, the creation of the McGovern Allergy Clinic, his editorial and writing leadership, and his founding assistance and support for the American Osler Society. Dr. McGovern was energetic in leading many medical associations, promoting humanism in medicine. See more at MS 115.

Patient-Derived Ipscs Link Elevated Mitochondrial Respiratory Complex I Function To Osteosarcoma In Rothmund-Thomson Syndrome, Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee

Journal Articles

Rothmund-Thomson syndrome (RTS) is an autosomal recessive genetic disorder characterized by poikiloderma, small stature, skeletal anomalies, sparse brows/lashes, cataracts, and predisposition to cancer. Type 2 RTS patients with biallelic RECQL4 pathogenic variants have multiple skeletal anomalies and a significantly increased incidence of osteosarcoma. Here, we generated RTS patient-derived induced pluripotent stem cells (iPSCs) to dissect the pathological signaling leading to RTS patient-associated osteosarcoma. RTS iPSC-derived osteoblasts showed defective osteogenic differentiation and gain of in vitro tumorigenic ability. Transcriptome analysis of RTS osteoblasts validated decreased bone morphogenesis while revealing aberrantly upregulated mitochondrial respiratory complex I gene expression. RTS osteoblast metabolic assays …

Can The Hunger Vital Sign™ Act As A Prescreen For Other Social Needs?, Richard Sheward, Charlotte Bruce, Deborah A. Frank, Sharon Coleman, Stephanie Ettinger De Cuba, Blair Robinson, Diana B. Cutts

Journal of Applied Research on Children: Informing Policy for Children at Risk

Background: Addressing health-related social needs is essential for improving health and reducing longstanding disparities. However, barriers to screening – including clinician and patient time burden of screening for multiple social needs – limit identification. To address this concern and promote the uptake of screening by clinicians, it is important that screening tools effectively and efficiently identify social needs’ presence and absence among patients.

Objective: This study evaluated whether a validated and widely implemented 2-question food insecurity screening tool, the Hunger Vital Sign™ (HVS™), has adequate negative predictive value to serve as a pre-screen for other social needs.

Methods: In 2007-2015, …

Ms 034 Guide To Paul V. Ledbetter, Md Papers, 1966-1977, Paul V. Ledbetter (1899-1983)

Manuscript Finding Aids

The Paul V. Ledbetter, MD papers contains biographical information, correspondence, administrative records, newspaper clippings, manuals, publications, audio cassettes, notes, notebooks, loose monographs, glass slides, patient data, membership directories, and rosters related to Dr. Ledbetter's life, career, practice (Ledbetter Clinic Association) and professional organizations, such as American Heart Association, Houston Heart Association, Houston Society of Internal Medicine, and Texas Academy of Internal Medicine. See more at MS 034.

Ms 096 Guide To Ernst Knobil, Phd Papers (1942-2000), Ernst Knobil (1926-2000)

Manuscript Finding Aids

The notebooks from Dr. Knobil's research laboratories comprise the largest series (X). General Files, Series IV, contains material including correspondence, lectures and speeches from the early 1980s to 2000. It was retained in the alphabetical order it was received. Material in Series II was labeled Harvard and deals primarily with Dr. Knobil's tenure at Harvard University in the 1950s. Material about his Deanship of the University of Texas Medical School at Houston can be found in Series III and IV. See more at MS 096.

Ms 210 Guide To The Judson L. Taylor, Md Papers (1940-1951), Judson L. Taylor (1881-1949)

Manuscript Finding Aids

The Judson L. Taylor, MD papers consists of one oversize photograph portrait, two full sheet newspapers, and other newspapers clippings related to Judson Taylor and his brother, Dr. Martin Junius Taylor. The collection is in good condition, and all materials are stored in one oversize box. See more at MS 210.

Ms 003 Guide To Edward Trowbridge Wolf, Md Papers (1928-1982), Edward Trowbridge Wolf (1900-1987)

Manuscript Finding Aids

The Edward Trowbridge Wolf, MD, papers (MS003) is 3 cubic feet and consists of 7 document boxes with some materials also located in the communal oversize box. It contains biographical information, personal and professional correspondence, certificates, official documents, news clippings, telegrams, drawings, and books that detail the personal life, professional activities, medical related records and papers associated with the World War II experiences of Dr. Edward Trowbridge Wolf in the Pacific Theater, various stateside military posts and also the Houston Texas Medical Center. See more at MS 003.

Positron Emission Tomography In The Covid-19 Pandemic Era, Chentao Jin, Xiaoyun Luo, Shufang Qian, Kai Zhang, Yuanxue Gao, Rui Zhou, Peili Cen, Zhoujiao Xu, Hong Zhang, Mei Tian

Journal Articles

Coronavirus disease 2019 (COVID-19) has become a major public health problem worldwide since its outbreak in 2019. Currently, the spread of COVID-19 is far from over, and various complications have roused increasing awareness of the public, calling for novel techniques to aid at diagnosis and treatment. Based on the principle of molecular imaging, positron emission tomography (PET) is expected to offer pathophysiological alternations of COVID-19 in the molecular/cellular perspectives and facilitate the clinical management of patients. A number of PET-related cases and research have been reported on COVID-19 over the past one year. This article reviews the current studies of …

Flowcharts Improve Periodontal Diagnosis By Dental And Dental Hygiene Students, Karo Parsegian, Srinivas Ayilavarapu, Tulsi Patel, Harold A Henson, Nikola Angelov

Journal Articles

BACKGROUND: In 2017, the American Academy of Periodontology and the European Federation of Periodontology updated the classification of periodontal and peri-implant diseases and conditions. The goal of the present crossover study was to develop straightforward, illustrative flowcharts and determine their impact on the accuracy and speed of diagnosing periodontal conditions by predoctoral dental students (DS) and dental hygiene students (DHS).

METHODS: Two flowcharts (a decision-tree flowchart and one based on the periodontal disease/condition entity) were developed using updated diagnostic determinants proposed by the 2017 classification. A total of 26 second-, third-, and fourth-year DS (DS2, DS3, and DS4, respectively) and …

The Effects Of Cumulative Natural Disaster Exposure On Adolescent Psychological Distress, Gabriella Y. Meltzer, Meghan Zacher Phd, Alexis Merdjanoff Phd, Mai P. Do Md Drph, Nhungoc K. Pham Mph, David Abramson Phd Mph

Journal of Applied Research on Children: Informing Policy for Children at Risk

Natural disasters are becoming more frequent and destructive due to climate change and have been shown to be associated with a variety of adverse mental health outcomes in children and adolescents. This study utilizes data from three cohort studies of Hurricane Katrina survivors—including low-income mothers from New Orleans; displaced and highly impacted families from Louisiana and Mississippi; and Vietnamese immigrants in New Orleans—to examine the relationship between cumulative natural disaster exposure and adolescent psychological distress approximately 13 years after Katrina. Among 648 respondents with children ages 10-17, 112 (17.2%) reported that their child had exhibited one or more symptoms of …

Virulence And Biofilm Formation In Candida Albicans Are Inhibited By Short Peptide Subunits Of Entv, Shane Cristy

Dissertations & Theses (Open Access)

Candida albicans, the most clinically significant fungal pathogen, commonly causes topical mucosal infections such as oral cavity and urogenital tract infections. It also less frequently causes severe invasive and bloodstream infections. Invasive infections are most prevalent amongst patients with compromised innate immune responses, such as those receiving chemotherapy or recovering from surgery. C. albicans can also form biofilms on implanted medical devices. Fungal infections are difficult to treat due to the paucity of therapeutic options, and this problem is compounded by the resistance properties of biofilm infections.

Candida albicans exists as a member of the commensal flora of the …

Research Hotspots And Trends Of Microrna In Periodontology And Dental Implantology: A Bibliometric Analysis, Kang Gao, Yiping Dou, Menghao Lv, Yihui Zhu, Sitong Hu, Pan Ma

Journal Articles

BACKGROUND: Periodontal disease is a leading cause of tooth loss, and microRNA (miRNA) has been shown to regulate various biological processes. This study aimed to quantitatively analyze the literature related to miRNA in periodontology and dental implantology and summarize the research hotspots and trends in this field.

METHODS: Literature records from 1985 to 2020 were obtained from the Web of Science Core Collection database. After manual selection, the data was used for cooperative network analysis, keyword co-occurrence analysis, and reference co-citation analysis and visualized by CiteSpace.

RESULTS: A total of 287 papers were analyzed between 2007 and 2020, and more …

An Assessment Of Outpatient Clinic Room Ventilation Systems And Possible Relationship To Disease Transmission, Kristin G King, George L Delclos, Eric L Brown, Susan Tortolero Emery, Jose Miguel Yamal, Robert J Emery

Journal Articles

BACKGROUND: With healthcare shifting to the outpatient setting, this study examined whether outpatient clinics operating in business occupancy settings were conducting procedures in rooms with ventilation rates above, at, or below thresholds defined in the American National Standards Institute/American Society of Heating, Refrigerating and Air-Conditioning Engineers/American Society for Health Care Engineering Standard 170 for Ventilation in Health Care Facilities and whether lower ventilation rates and building characteristics increase the risk of disease transmission.

METHODS: Ventilation rates were measured in 105 outpatient clinic rooms categorized by services rendered. Building characteristics were evaluated as determinants of ventilation rates, and risk of disease …

Med-Bert: Pretrained Contextualized Embeddings On Large-Scale Structured Electronic Health Records For Disease Prediction., Laila Rasmy, Yang Xiang, Ziqian Xie, Cui Tao, Degui Zhi

Journal Articles

Deep learning (DL)-based predictive models from electronic health records (EHRs) deliver impressive performance in many clinical tasks. Large training cohorts, however, are often required by these models to achieve high accuracy, hindering the adoption of DL-based models in scenarios with limited training data. Recently, bidirectional encoder representations from transformers (BERT) and related models have achieved tremendous successes in the natural language processing domain. The pretraining of BERT on a very large training corpus generates contextualized embeddings that can boost the performance of models trained on smaller datasets. Inspired by BERT, we propose Med-BERT, which adapts the BERT framework originally developed …

Med-Bert: Pretrained Contextualized Embeddings On Large-Scale Structured Electronic Health Records For Disease Prediction., Laila Rasmy, Yang Xiang, Ziqian Xie, Cui Tao, Degui Zhi

Journal Articles

Deep learning (DL)-based predictive models from electronic health records (EHRs) deliver impressive performance in many clinical tasks. Large training cohorts, however, are often required by these models to achieve high accuracy, hindering the adoption of DL-based models in scenarios with limited training data. Recently, bidirectional encoder representations from transformers (BERT) and related models have achieved tremendous successes in the natural language processing domain. The pretraining of BERT on a very large training corpus generates contextualized embeddings that can boost the performance of models trained on smaller datasets. Inspired by BERT, we propose Med-BERT, which adapts the BERT framework originally developed …

Opportunities And Challenges In Developing A Cryptosporidium Controlled Human Infection Model For Testing Antiparasitic Agents, Rajiv S Jumani, Johanne Blais, Hanns-Christian Tillmann, Florencia Segal, Dean Wetty, Christian Ostermeier, Natko Nuber, Jay Lakshman, Natasha Aziz, Richa Chandra, Wilbur H Chen, Cynthia L Chappell, Thierry T Diagana, Ujjini H Manjunatha

Journal Articles

Cryptosporidiosis is a leading cause of moderate-to-severe diarrhea in low- and middle-income countries, responsible for high mortality in children younger than two years of age, and it is also strongly associated with childhood malnutrition and growth stunting. There is no vaccine for cryptosporidiosis and existing therapeutic options are suboptimal to prevent morbidity and mortality in young children. Recently, novel therapeutic agents have been discovered through high-throughput phenotypic and target-based screening strategies, repurposing malaria hits, etc., and these agents have a promising preclinical in vitro and in vivo anti-

Genetic Pathway Analysis Of Abnormal Facial Development In Nonsyndromic Cleft Lip And Palate, Lorena Maili

Dissertations & Theses (Open Access)

Nonsyndromic cleft lip with or without cleft palate (NSCLP) is the most common craniofacial birth defect resulting from incomplete fusion of the facial prominences during development, which leaves a gap in the lip, primary palate and/or the secondary palate. NSCLP affects 135,000 NSCLP newborns worldwide each year based on a birth prevalence of 1 per 700 live births. While surgical treatments have dramatically improved, many long-term health issues persist, imposing significant medical, psychosocial and economic burdens. Familial aggregation and segregation analyses suggest genetic contributions underlie NSCLP, but despite decades of study, only a small portion of the NSCLP genetic liability …

Oral Versus Gastrointestinal Mucosal Immune Niches In Homeostasis And Allostasis, Lina J Suárez, Silie Arboleda, Nikola Angelov, Roger M Arce

Journal Articles

Different body systems (epidermis, respiratory tract, cornea, oral cavity, and gastrointestinal tract) are in continuous direct contact with innocuous and/or potentially harmful external agents, exhibiting dynamic and highly selective interaction throughout the epithelia, which function as both a physical and chemical protective barrier. Resident immune cells in the epithelia are constantly challenged and must distinguish among antigens that must be either tolerated or those to which a response must be mounted for. When such a decision begins to take place in lymphoid foci and/or mucosa-associated lymphoid tissues, the epithelia network of immune surveillance actively dominates both oral and gastrointestinal compartments, …