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Quantifying The Impact Of Laboratory And Care Systems On Relinkage To Hiv Care In A Southern, Urban Environment, Kellie L. Watkins

Dissertations & Theses (Open Access)

Background: HIV viral suppression reduces the likelihood of transmission to just 5%,1 demonstrating the critical link between care and prevention, yet only 51% of people living with HIV (PLWH) were retained in care and 46% achieved viral suppression in the Houston area (2012), with the out-of-care (OOC) population increasing between 2008-2011.2,3

Methods: Record-search investigations across HIV surveillance and care data systems determined if potentially OOC persons referred to the Houston Health Department (HHD) from 2013-2015 (N=1287) qualified for public health follow up. A portion were randomized to a non-intervention group (n=200) to assess the program effectiveness. Participants without a disposition …

Insights Into The Reactivation, Regulation And Essentiality Of Oxidative Protein Folding Pathways In Actinobacteria, Belkys Sanchez

Dissertations & Theses (Open Access)

Accurate disulfide bond formation is important for proper folding, stability and function of exported proteins. The process of disulfide bond formation, termed oxidative protein folding, is catalyzed by thiol-disulfide oxidoreductase enzymes. Oxidative protein folding pathways influence processes essential for bacterial physiology and pathogenicity. In the Gram-positive actinobacterial pathogens Actinomyces oris and Corynebacterium diphtheriae oxidative protein folding is catalyzed by the primary thiol-disulfide oxidoreductase MdbA. MdbA is required for assembly of adhesive pilus, which mediate receptor-dependent bacterial interactions, or coaggregation, in A. oris. In the first part of this dissertation, I identify components of the electron transport chain (ETC) required for …

Investigation Of Novel Virulence Mechanisms In Candida Albicans, Elisa Marie Tafoya Vesely

Dissertations & Theses (Open Access)

Candida albicans is the most important fungal species associated with humans. Normally present in the human microbiome as a commensal colonizer, C. albicans is also the fourth most prevalent organism isolated from bloodstream infections in hospitals. Disseminated infections have an associated mortality rate of around 40%. The results of the work described in this dissertation cover the broad subject of C. albicans adaptation to the host and the mechanisms by which this organism is able to survive and cause infection through a variety of means. A key determinant in disease progression is interaction with innate immune cells, specifically macrophages and …

Assembly And Display Of Surface Proteins In Actinomyces Oris, Sara Siegel

Dissertations & Theses (Open Access)

Bacteria are an integral part of human health and disease. In the human host, dental plaques form as a result of up to 700 individual bacterial species colonizing oral surfaces and forming a multispecies biofilm. These biofilms are the cause of prevalent human diseases such as dental caries, gingivitis, and periodontitis. The microbes present in the oral biofilm are highly spatially and temporally structured and require a primary colonizing species to adhere to host tissue. As an important primary colonizer of the oral biofilm, the actinobacterium Actinomyces oris utilizes cell wall anchored proteins and glycoconjugates to initiate adherence to host …

Human Trafficking: It’S Not Just A Crime, Frances H. Recknor, Makini Chisolm-Straker

Journal of Family Strengths

Human trafficking, although commonly conceived of as a crime, is also a matter for the fields of health and public health. Trafficked individuals suffering physical, sexual, and/or psychological abuse can experience acute and chronic health sequelae, bringing them to the attention of health and/or mental health professionals. Communicable infections affect many trafficked individuals and can be transmitted to those not trafficked. The factors that contribute to people being trafficked, like poverty, educational disparities, and systematic oppression based upon identities, are multifaceted and interlinked with other trauma experiences. Incorporation of public health principles into anti-trafficking efforts facilitates a comprehensive and holistic …

Ms 098 Guide To John T. Armstrong, Md Papers (1914-1987), John T. Armstrong (1912-1999)

Manuscript Finding Aids

The John T. Armstrong, MD papers contains professional correspondence, personal correspondence, family papers, institutional documents, institutional publications, research, medical data, memos, minutes, newspaper clippings, legal documents, insurance documentation, and professional diaries that document the career and life of Dr. John T. Armstrong. See more at MS 098.

2018 Faculty Meeting Minutes, Thomas R. Cole

Thomas R. Cole, PhD Papers

Original Filename: Faculty Meeting Minutes 020718 SWOT_SACRED VOCATION PROGRAM.docx. Format Details: fmt/412; Microsoft Word for Windows; 2007 onwards.