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Search, The Jackson Laboratory
Induction Of Stress-Induced Renal Cellular Senescence In Vitro: Impact Of Mouse Strain Genetic Diversity., Chieh Ming Liao, Vera Christine Wulfmeyer, Maxine Swallow, Christine Susanne Falk, Hermann Haller, Ron Korstanje, Anette Melk, Roland Schmitt
Induction Of Stress-Induced Renal Cellular Senescence In Vitro: Impact Of Mouse Strain Genetic Diversity., Chieh Ming Liao, Vera Christine Wulfmeyer, Maxine Swallow, Christine Susanne Falk, Hermann Haller, Ron Korstanje, Anette Melk, Roland Schmitt
Faculty Research 2021
Cellular senescence, a stress-induced state of irreversible cell cycle arrest, is associated with organ dysfunction and age-related disease. While immortalized cell lines bypass key pathways of senescence, important mechanisms of cellular senescence can be studied in primary cells. Primary tubular epithelial cells (PTEC) derived from mouse kidney are highly susceptible to develop cellular senescence, providing a valuable tool for studying such mechanisms. Here, we tested whether genetic differences between mouse inbred strains have an impact on the development of stress-induced cellular senescence in cultured PTEC. Kidneys from 129S1, B6, NOD, NZO, CAST, and WSB mice were used to isolate PTEC. …
Search, The Jackson Laboratory
Search, The Jackson Laboratory
Germline Maintenance Through The Multifaceted Activities Of Glh/Vasa In, Elisabeth A Marnik, J Heath Fuqua, Catherine S Sharp, Jesse D Rochester, Emily L Xu, Sarah E Holbrook, Dustin L Updike
Germline Maintenance Through The Multifaceted Activities Of Glh/Vasa In, Elisabeth A Marnik, J Heath Fuqua, Catherine S Sharp, Jesse D Rochester, Emily L Xu, Sarah E Holbrook, Dustin L Updike
Faculty Research 2019
Vasa homologs are ATP-dependent DEAD-box helicases, multipotency factors, and critical components that specify and protect the germline. They regulate translation, amplify piwi-interacting RNAs (piRNAs), and act as RNA solvents; however, the limited availability of mutagenesis-derived alleles and their wide range of phenotypes have complicated their analysis. Now, with clustered regularly interspaced short palindromic repeats (CRISPR/Cas9), these limitations can be mitigated to determine why protein domains have been lost or retained throughout evolution. Here, we define the functional motifs of GLH-1/Vasa in
Search, The Jackson Laboratory
Search, The Jackson Laboratory
Search, The Jackson Laboratory
Search, The Jackson Laboratory
John Langworthy Fuller (1901-1992) Papers, The Jackson Laboratory
John Langworthy Fuller (1901-1992) Papers, The Jackson Laboratory
Personal Papers Collection
No abstract provided.
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
Clarence Cook Little Papers (1888-1971), The Jackson Laboratory
Clarence Cook Little Papers (1888-1971), The Jackson Laboratory
Personal Papers Collection
No abstract provided.
Philip R. White Papers (1901-1968), The Jackson Laboratory
Philip R. White Papers (1901-1968), The Jackson Laboratory
Personal Papers Collection
No abstract provided.
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
2009 Annual Report, The Jackson Laboratory
The Search, The Jackson Laboratory
The Search, The Jackson Laboratory
2004 Annual Report, The Jackson Laboratory
2003 Annual Report, The Jackson Laboratory