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Interleukin-17-Induced Neutrophil Extracellular Traps Mediate Resistance To Checkpoint Blockade In Pancreatic Cancer, Yu Zhang, Vidhi Chandra, Erick Riquelme Sanchez, Prasanta Dutta, Pompeyo R. Quesada, Amanda Rakoski, Michelle Zoltan, Nivedita Arora, Seyda Baydogan, William Horne, Jared Burks, Hanwen Xu, Perwez Hussain, Huamin Wang, Sonal Gupta, Anirban Maitra, Jennifer M. Bailey, Seyed J. Moghaddam, Sulagna Banerjee, Ismet Sahin, Pratip Bhattacharya
Interleukin-17-Induced Neutrophil Extracellular Traps Mediate Resistance To Checkpoint Blockade In Pancreatic Cancer, Yu Zhang, Vidhi Chandra, Erick Riquelme Sanchez, Prasanta Dutta, Pompeyo R. Quesada, Amanda Rakoski, Michelle Zoltan, Nivedita Arora, Seyda Baydogan, William Horne, Jared Burks, Hanwen Xu, Perwez Hussain, Huamin Wang, Sonal Gupta, Anirban Maitra, Jennifer M. Bailey, Seyed J. Moghaddam, Sulagna Banerjee, Ismet Sahin, Pratip Bhattacharya
Faculty Publications
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenvironment that is resistant to most therapies. IL17 is involved in pancreatic tumorigenesis, but its role in invasive PDAC is undetermined. We hypothesized that IL17 triggers and sustains PDAC immunosuppression. We inhibited IL17/IL17RA signaling using pharmacological and genetic strategies alongside mass cytometry and multiplex immunofluorescence techniques. We uncovered that IL17 recruits neutrophils, triggers neutrophil extracellular traps (NETs), and excludes cytotoxic CD8 T cells from tumors. Additionally, IL17 blockade increases immune checkpoint blockade (PD-1, CTLA4) sensitivity. Inhibition of neutrophils or Padi4-dependent NETosis phenocopies IL17 neutralization. NMR spectroscopy revealed changes in …
Hypotensive And Antihypertensive Effects Of An Aqueous Extract From Guinep Fruit (Melicoccus Bijugatus Jacq) In Rats, Chukwuemeka R. Nwokocha, Alexia Gordon, Javier Palacios, Adrian Paredes, Fredi Cifuentes, Sheena Francis, Je Ann Watson, Rupika Delgoda, Magdalene Nwokocha, Ruby Alexander-Lindo, Rory Thompson, Donna Minott-Kates, Momoh A. Yakubu
Hypotensive And Antihypertensive Effects Of An Aqueous Extract From Guinep Fruit (Melicoccus Bijugatus Jacq) In Rats, Chukwuemeka R. Nwokocha, Alexia Gordon, Javier Palacios, Adrian Paredes, Fredi Cifuentes, Sheena Francis, Je Ann Watson, Rupika Delgoda, Magdalene Nwokocha, Ruby Alexander-Lindo, Rory Thompson, Donna Minott-Kates, Momoh A. Yakubu
Faculty Publications
Melicoccus bijugatus Jacq (Mb) has been reported to have cardiovascular modulatory effects. In this study, we evaluated the antihypertensive effects and mechanism of action of Mb on NG-Nitro-l-arginine Methyl Ester (l-NAME) and Deoxycorticosterone Acetate (DOCA) rat models. Aqueous extract of Mb fruit (100 mg/kg) was administered for 6 weeks to rats by gavage and blood pressure was recorded. Effects of the extract on vascular reactivity was evaluated using isolated organ baths, and tissues were collected for biochemical and histological analysis. The systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were significantly (P < 0.05) reduced with extract (100 mg/kg) administration and treatment compared to the hypertensive models. Mb (100 µg/mL) reduced the vascular contractility induced by phenylephrine (PE), and caused a dose-dependent relaxation of PE-induced contraction of aortic vascular rings. The vasorelaxation properties seemed to be endothelium dependent, as well as nitric oxide (NO) and guanylyl cyclase, but not prostaglandin dependent. Histomicrograph of transverse sections of the ventricles from the Mb group did not show abnormalities. The extract significantly (P < 0.05) reduced an l-NAME induced elevation of cardiac output and Creatine Kinase Muscle-Brain (CKMB), but had no significant impact on the activities of arylamine N-acetyltransferase. In conclusion, Mb significantly decreased blood pressure in hypertensive models. The extract possesses the ability to induce endothelium dependent vasodilation, which is dependent on guanylyl cyclase but not prostaglandins.
Trends In Appendicitis Among Pregnant Women, The Risk For Cardiac Arrest, And Maternal–Fetal Mortality, Deepa Dongarwar, Jalyce Taylor, Veronica Ajewole, Nmelichukwu Anene, Oladapo Omoyele, China Ogba, Abiodun Oluwatoba, Dominique Giger, Au Thuy, Erika Argueta, Eknath Naik, Jason L. Salemi, Kiara Spooner, Omonike Olaleye, Hamisu M. Salihu
Trends In Appendicitis Among Pregnant Women, The Risk For Cardiac Arrest, And Maternal–Fetal Mortality, Deepa Dongarwar, Jalyce Taylor, Veronica Ajewole, Nmelichukwu Anene, Oladapo Omoyele, China Ogba, Abiodun Oluwatoba, Dominique Giger, Au Thuy, Erika Argueta, Eknath Naik, Jason L. Salemi, Kiara Spooner, Omonike Olaleye, Hamisu M. Salihu
Faculty Publications
Background: Appendicitis is the most common extra-uterine surgical emergency requiring immediate intervention during pregnancy. However, risks for mortality and morbidity among pregnant women with appendicitis remain poorly understood. This study was conducted to determine the temporal trends of appendicitis in pregnant women, and to calculate the risk of maternal–fetal mortality and near-miss marker (i.e., cardiac arrest) among pregnant women in general, and by race/ethnicity. Methods: We conducted this retrospective study using data from the Nationwide Inpatient Sample (NIS) from January 1, 2002, through December 31, 2015. Joinpoint regression was used to estimate and describe temporal changes in the rates of …
Addressing Power Dynamics In Community-Engaged Research Partnerships, Lauri Andress, Tristen Hall, Sheila Davis, Judith Levine, Kimberly Cripps, Dominique Guinn
Addressing Power Dynamics In Community-Engaged Research Partnerships, Lauri Andress, Tristen Hall, Sheila Davis, Judith Levine, Kimberly Cripps, Dominique Guinn
Faculty Publications
Background: Successful community-engaged research depends on the quality of the collaborative partnerships between community -members and academic researchers and may take several forms depending on the purpose which dictates the degree to which power dynamics are handled within the collaborative arrangement. Methods: To understand the power dynamics and related concepts within community-engaged research arrangements, a secondary analysis of an existing qualitative data set was undertaken. Two models of community-engaged research, a review of literature, and the applied experiences of researchers familiar with community engagement practices confirmed the power dynamics concepts used to carry out the analysis of the qualitative data …
The Lyophilized Aqueous Leaf Extract Of Moringa Oleifera Blunts Streptozocin-Induced Diabetes In Rats Through Upregulation Of Glut 4 Signaling Pathway And Anti-Oxidant Effect, Adeolu Alex Adedapo, Iyanuoluwa Omolola Ogunmiluyi, Olufunke Olubunmi Falayi, Blessing Seun Ogunpolu, Ademola Adetokunbo Oyagbemi, Abayomi Orishadipe, Temidayo Olutayo Omobowale, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju
The Lyophilized Aqueous Leaf Extract Of Moringa Oleifera Blunts Streptozocin-Induced Diabetes In Rats Through Upregulation Of Glut 4 Signaling Pathway And Anti-Oxidant Effect, Adeolu Alex Adedapo, Iyanuoluwa Omolola Ogunmiluyi, Olufunke Olubunmi Falayi, Blessing Seun Ogunpolu, Ademola Adetokunbo Oyagbemi, Abayomi Orishadipe, Temidayo Olutayo Omobowale, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju
Faculty Publications
The anti-diabetic property of aqueous leaf extract of Moringa oleifera was performed in streptozocin-induced diabetic rats using serum chemistry, histology and immunochemical parameters as indices of diabetes. The blood glucose level of the diabetic untreated group continues to increase while that of the treated group after 21 days decreased. While the animals in the diabetic untreated group experienced increase in the levels of markers of organ damage when compared to the control group (P values < 0.0001). ALT increased from 61.83±1.5 to 96.1±22.4, AST was 225.1±26.6 from 172.6±13.9, ALP 13.5±0.006 to 13.6±0.002, UREA 1.0±0.08 to 3.0±0.4, their reduction was observed in the extract-treated groups. ALT reduced from 96.1±22.4 to 73.70±9.7; AST from 225.1±26.6 to 184.4±18.2; ALP from 13.6±0.002 to 13.6±0.01; UREA from 3.0±0.4 to 2.0±0.4. Treatment with the extract significantly reduced markers of oxidative stress in the kidney [hydrogen peroxide (898.8±6.26 to 688.0±13.7), malondialdehyde (640±0.1 to 600±0.2) and protein carbonyl (548.4±1.5 to 458.1±1.6)]; heart [hydrogen peroxide (389.4±1.8 to 358.2±1.5), malondialdehyde (264.0±0.5 to 122.0±0.3), protein carbonyl (196.8±0.5 to 162.7±3.5)]; and liver [hydrogen peroxide (119.36±3.2 to 103.94±10.7), malondialdehyde (236.0±0.4 to 73.0±0.2), protein carbonyl (269.3±1.0 to 174.2±1.1) respectively. The levels of antioxidants were reduced in the diabetic untreated group but there was increase in the Moringa treated group. Glucose transporter 4 (GLUT 4) was down regulated in the diabetic untreated group while it was well expressed in the treated groups. The histology of pancreas and liver showed varied levels of infiltration of inflammatory cells, congestion and necrotic lesions, but these were mild in the treated groups. The result shows that the extract does have an anti-diabetic effect with the decrease in the levels of blood glucose and markers of oxidative stress as well as increase in the amount of antioxidants in the treated group when compared to the diabetic untreated group. More importantly, the extract caused upregulation of GLUT 4, which is relevant in reversing insulin resistance in the same manner as pioglitazone, the standard antidiabetic agent used in this study.
Bioanalytical Assay Development And Validation For The Pharmacokinetic Study Of Gmc1, A Novel Fkbp52 Co-Chaperone Inhibitor For Castration Resistant Prostate Cancer, Oscar Ekpenyong, Candace Cooper, Jing Ma, Naihsuan C. Guy, Ashley N. Payan, Fuqiang Ban, Artem Cherkasov, Marc B. Cox, Dong Liang, Huan Xie
Bioanalytical Assay Development And Validation For The Pharmacokinetic Study Of Gmc1, A Novel Fkbp52 Co-Chaperone Inhibitor For Castration Resistant Prostate Cancer, Oscar Ekpenyong, Candace Cooper, Jing Ma, Naihsuan C. Guy, Ashley N. Payan, Fuqiang Ban, Artem Cherkasov, Marc B. Cox, Dong Liang, Huan Xie
Faculty Publications
Background: GMC1 (2-(1H-benzimidazol-2-ylsulfanyl)-N-[(Z)-(4-methoxyphenyl) methylideneamino] acetamide) effectively inhibits androgen receptor function by binding directly to FKBP52. This is a novel mechanism for the treatment of castration resistant prostate cancer (CRPC). Methods: an LC-MS/MS method was developed and validated to quantify GMC1 in plasma and urine from pharmacokinetics studies in rats. An ultra-high-performance liquid chromatography (UHPLC) system equipped with a Waters XTerra MS C18 column was used for chromatographic separation by gradient elution with 0.1% (v/v) formic acid in water and methanol. A Sciex 4000 QTRAP® mass spectrometer was used for analysis by multiple reaction monitoring (MRM) in positive mode; the specific …
Deficiency Of Splicing Factor 1 (Sf1) Reduces Intestinal Polyp Incidence In ApcMin/+ Mice, Jyotsna D. Godavarthi, Shahrazad Polk, Lisa Nunez, Amruthesh Shivachar, Nancy L. Glenn Griesinger, Angabin Matin
Deficiency Of Splicing Factor 1 (Sf1) Reduces Intestinal Polyp Incidence In ApcMin/+ Mice, Jyotsna D. Godavarthi, Shahrazad Polk, Lisa Nunez, Amruthesh Shivachar, Nancy L. Glenn Griesinger, Angabin Matin
Faculty Publications
Background: Splicing factor 1 (SF1) is a conserved alternative splicing factor expressed in many different mammalian cell types. The genetically modified Sf1+/− (or Sf1β-geo/+ ) mice express reduced levels of SF1 protein in mouse tissues, including in cells of the intestines. Mutational inactivation of human adenomatous polyposis coli (APC) gene deregulates the Wnt signaling pathway and is a frequent genetic event in colon cancers. Mice with a point mutation in the Apc gene (ApcMin/+ ) also develop numerous intestinal polyps at a young age. Our aim was to determine the effect of reduced SF1 levels on polyp development due to …
Trends And Associated Characteristics For Chagas Disease Among Women Of Reproductive Age In The United States, 2002 To 2017, Chioma Ikedionwu, Deepa Dongarwar, Manvir Kaur, Lisa Nunez, Annabella Awazi, Jere' Mallet, Ka Shena Kennedy, Michelle Cano, Chinwe Dike, Jessica Okwudi, Justice Stewart, David Igwegbe, Flora G. Estes, Kiara K. Spooner, Jason L. Salemi, Hamisu M. Salihu, Omonike A. Olaleye
Trends And Associated Characteristics For Chagas Disease Among Women Of Reproductive Age In The United States, 2002 To 2017, Chioma Ikedionwu, Deepa Dongarwar, Manvir Kaur, Lisa Nunez, Annabella Awazi, Jere' Mallet, Ka Shena Kennedy, Michelle Cano, Chinwe Dike, Jessica Okwudi, Justice Stewart, David Igwegbe, Flora G. Estes, Kiara K. Spooner, Jason L. Salemi, Hamisu M. Salihu, Omonike A. Olaleye
Faculty Publications
Background: American trypanosomiasis, commonly referred to as Chagas disease, is caused by a single cell protozoan known as Trypanosoma cruzi (T. cruzi). Although those affected are mainly in Latin America, Chagas has been detected in the United States (US), Canada and in many European countries due to migration. Few studies have explored the epidemiology of Chagas within the US or changes in disease burden over the past decade. The objective of this study was to explore the trends and associated characteristics for Chagas disease among hospitalized women of reproductive age in the US. Methods: We analyzed admissions data including socio-demographic …
Histone Deacetylase Inhibitors As Multitarget-Directed Epi-Drugs In Blocking Pi3k Oncogenic Signaling: A Polypharmacology Approach, Kasturi Ranganna, Chelliah Selvam, Amruthesh Shivachar, Zivar Yousefipour
Histone Deacetylase Inhibitors As Multitarget-Directed Epi-Drugs In Blocking Pi3k Oncogenic Signaling: A Polypharmacology Approach, Kasturi Ranganna, Chelliah Selvam, Amruthesh Shivachar, Zivar Yousefipour
Faculty Publications
Genetic mutations and aberrant epigenetic alterations are the triggers for carcinogenesis. The emergence of the drugs targeting epigenetic aberrations has provided a better outlook for cancer treatment. Histone deacetylases (HDACs) are epigenetic modifiers playing critical roles in numerous key biological functions. Inappropriate expression of HDACs and dysregulation of PI3K signaling pathway are common aberrations observed in human diseases, particularly in cancers. Histone deacetylase inhibitors (HDACIs) are a class of epigenetic small-molecular therapeutics exhibiting promising applications in the treatment of hematological and solid malignancies, and in non-neoplastic diseases. Although HDACIs as single agents exhibit synergy by inhibiting HDAC and the PI3K …
Temporal Trends Of Gestational Malaria In The United States, Justin Alexander, Deepa Dongarwar, Emmanuella Oduguwa, Larianna Varnado, Adesola Adenote, Jade Bailey, Chibueze Ezeudu, Patrice Nelson, Alexis Shavers, Abimbola Telufusi, Kiara K. Spooner, Jason L. Salemi, Omonike A. Olaleye, Hamisu M. Salihu
Temporal Trends Of Gestational Malaria In The United States, Justin Alexander, Deepa Dongarwar, Emmanuella Oduguwa, Larianna Varnado, Adesola Adenote, Jade Bailey, Chibueze Ezeudu, Patrice Nelson, Alexis Shavers, Abimbola Telufusi, Kiara K. Spooner, Jason L. Salemi, Omonike A. Olaleye, Hamisu M. Salihu
Faculty Publications
Background: Although regarded as rare in the United States (US), increased global traffic and importation of malaria from endemic countries may lead to a rise in gestational malaria in the US. Methods: This multi-year retrospective study analyzed trends in diagnosed cases of gestational malaria from 2002 to 2017 using joinpoint regression models. We also assessed the association between gestational malaria and selected maternal-fetal adverse outcomes. Results: Mothers diagnosed with gestational malaria tended to be older, and the majority of diagnosed cases (52.9%) were among Non-Hispanic (NH) Blacks. Diagnosed cases of gestational malaria are on the rise in the US. Mothers …
Analysis Of Factors Contributing To The Severity Of Large Truck Crashes, Jinhong Li, Jinli Liu, Pengfei Liu, Yi Qi
Analysis Of Factors Contributing To The Severity Of Large Truck Crashes, Jinhong Li, Jinli Liu, Pengfei Liu, Yi Qi
Faculty Publications
Crashes that involved large trucks often result in immense human, economic, and social losses. To prevent and mitigate severe large truck crashes, factors contributing to the severity of these crashes need to be identified before appropriate countermeasures can be explored. In this research, we applied three tree‐based machine learning (ML) techniques, i.e., random forest (RF), gradient boost decision tree (GBDT), and adaptive boosting (AdaBoost), to analyze the factors contributing to the severity of large truck crashes. Besides, a mixed logit model was developed as a baseline model to compare with the factors identified by the ML models. The analysis was …
Short-Term Intersection Traffic Flow Forecasting, Wenrui Qu, Jinhong Li, Lu Yang, Delin Li, Shasha Liu, Qun Zhao, Yi Qi
Short-Term Intersection Traffic Flow Forecasting, Wenrui Qu, Jinhong Li, Lu Yang, Delin Li, Shasha Liu, Qun Zhao, Yi Qi
Faculty Publications
The intersection is a bottleneck in an urban roadway network. As traffic demand increases, there is a growing congestion problem at urban intersections. Short-term traffic flow forecasting is crucial for advanced trip planning and traffic management. However, there are only a handful of existing models for forecasting intersection traffic flow. In addition, previous short-term traffic flow forecasting models usually were for predicting roadway conditions in a very short period, such as one minute or five minutes, which is often too late given that a driver may well be approaching the bottleneck already. Being able to accurately predict traffic congestions in …
Statistical Analysis Of Safety Performance Of Displaced Left-Turn Intersections: Case Studies In San Marcos, Texas, Wenrui Qu, Qiao Sun, Qun Zhao, Tao Tao, Yi Qi
Statistical Analysis Of Safety Performance Of Displaced Left-Turn Intersections: Case Studies In San Marcos, Texas, Wenrui Qu, Qiao Sun, Qun Zhao, Tao Tao, Yi Qi
Faculty Publications
Displaced left-turn (DLT) intersections are designed to increase the mobility of vehicles by relocating the left-turn lane (lanes) to the far-left side of the road upstream of the main signalized intersection. Since DLT is a relatively new design and very limited crash data are available, previous studies have focused mainly on the analysis of its operational performance rather than its safety performance. To fill this gap, in this study, we investigated the safety performance of two DLT intersections located in San Marcos, Texas. Crash data from 2011 to April 2018 were extracted from the TxDOT Crash Record Information System (CRIS). …
Guest Editorial: Selected Papers From The Ubiquitous Clouds And Cognitive Communication Networks (Ucccn 2019), Kamel, Jennifer S. Raj, Joy Iong Zong Chen, Ivan Kotuliak
Guest Editorial: Selected Papers From The Ubiquitous Clouds And Cognitive Communication Networks (Ucccn 2019), Kamel, Jennifer S. Raj, Joy Iong Zong Chen, Ivan Kotuliak
Faculty Publications
No abstract provided.
A Glance Of P53 Functions In Brain Development, Neural Stem Cells, And Brain Cancer, Yuqing Xiong, Yun Zhang, Shunbin Xiong, Abie E. Williams-Villalobo
A Glance Of P53 Functions In Brain Development, Neural Stem Cells, And Brain Cancer, Yuqing Xiong, Yun Zhang, Shunbin Xiong, Abie E. Williams-Villalobo
Faculty Publications
p53 is one of the most intensively studied tumor suppressors. It transcriptionally regulates a broad range of genes to modulate a series of cellular events, including DNA damage repair, cell cycle arrest, senescence, apoptosis, ferroptosis, autophagy, and metabolic remodeling, which are fundamental for both development and cancer. This review discusses the role of p53 in brain development, neural stem cell regulation and the mechanisms of inactivating p53 in gliomas. p53 null or p53 mutant mice show female biased exencephaly, potentially due to X chromosome inactivation failure and/or hormone-related gene expression. Oxidative cellular status, increased PI3K/Akt signaling, elevated ID1, and metabolism …
N-Element Beam Antennas System Design For Wireless Sensor Node Using Semi-Markov Decision Process With Variable Sojourn Time, Abayomi Ajofoyinbo, David O. Olowokere, Oye Ibidapo-Obe
N-Element Beam Antennas System Design For Wireless Sensor Node Using Semi-Markov Decision Process With Variable Sojourn Time, Abayomi Ajofoyinbo, David O. Olowokere, Oye Ibidapo-Obe
Faculty Publications
Abstract-The paper presents N-element switchable beam antennas (BAs) system design for Wireless Sensor Node (WSN), in which the operation of the BAs was characterized by semi-Markov Decision Process (SMDP) with variable sojourn time. A matrix-based switching methodology was introduced for selecting an operational BA, based on the received signal power by each BA. Optimal analysis was carried-out to obtain optimal results in terms of the maximum total of sum of discounted reward in current states. Also developed in the study is the methodology for switching a BA from non-operational to operational state and vice-versa. The effectiveness of this switchable BAs …
Simulation And Analysis Of The Carrying Capacity For Road Networks Using A Grid-Based Approach, Junqing Shi, Linwu Chen, Fengxiang Qiao, Lei Yu, Qing Li, Guilian Fan
Simulation And Analysis Of The Carrying Capacity For Road Networks Using A Grid-Based Approach, Junqing Shi, Linwu Chen, Fengxiang Qiao, Lei Yu, Qing Li, Guilian Fan
Faculty Publications
The number of vehicles that a road network can carry is limited. When the limit is exceeded, the network system is not able to function effectively. In this paper, an updated cellular automaton model for grid networks with all-way stop-controlled intersections is proposed to simulate the network level critical density and carrying capacity under different conditions, which essentially indicates the limit number of vehicles that the network can handle before going into gridlock. In the proposed model, two update rules, including lane-changing and the longitudinal location update, are adopted to describe the vehicle's movements on road segments according to the …
Targeting Severe Acute Respiratory Syndrome-Coronavirus (Sars-Cov-1) With Structurally Diverse Inhibitors: A Comprehensive Review, Maryam S. Hosseini-Zare, Ramasamy Thilagavathi, Chelliah Selvam
Targeting Severe Acute Respiratory Syndrome-Coronavirus (Sars-Cov-1) With Structurally Diverse Inhibitors: A Comprehensive Review, Maryam S. Hosseini-Zare, Ramasamy Thilagavathi, Chelliah Selvam
Faculty Publications
Coronaviruses, which were discovered in 1968, can lead to some human viral disorders, like severe acute respiratory syndrome (SARS), Middle East respiratory syndrome-related (MERS), and, recently, coronavirus disease 2019 (COVID-19). The coronavirus that leads to COVID-19 is rapidly spreading all over the world and is the reason for the deaths of thousands of people. Recent research has revealed that there is about 80% sequence homology between the coronaviruses that cause SARS and COVID-19. Considering this fact, we decided to collect the maximum available information on targets, structures, and inhibitors reported so far for SARS-CoV-1 that could be useful for researchers …
Highlights Of Clinical Practice Guideline For The Management Of Community-Acquired Pneumonia: 2019 Update By The American Thoracic Society And Infectious Diseases Society Of America, Hongmei Wang, Molly Brong, Shirley Pham, Diane Dreucean
Highlights Of Clinical Practice Guideline For The Management Of Community-Acquired Pneumonia: 2019 Update By The American Thoracic Society And Infectious Diseases Society Of America, Hongmei Wang, Molly Brong, Shirley Pham, Diane Dreucean
Faculty Publications
Pneumonia is the leading cause of morbidity and mortality in the United States. The American Thoracic Society and The Infectious Diseases Society of America recently published updated guidelines for the diagnosis and treatment of community-acquired pneumonia. Initial antibiotic therapy should cover for Streptococcus pneumoniae, Haemophilus influenzae, and other gram-negative bacilli. Patients who have risk factors for the development of antibiotic resistant pathogens, such as methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa should have appropriate empiric coverage for these pathogens. The recommended duration of treatment of community-acquired pneumonia is a minimum of 5 days in conjunction with clinical improvement, which has remained …
A Discrete Hidden Markov Model For Sms Spam Detection, Tian Xia, Xuemin Chen
A Discrete Hidden Markov Model For Sms Spam Detection, Tian Xia, Xuemin Chen
Faculty Publications
Many machine learning methods have been applied for short messaging service (SMS) spam detection, including traditional methods such as naive Bayes (NB), vector space model (VSM), and support vector machine (SVM), and novel methods such as long short-term memory (LSTM) and the convolutional neural network (CNN). These methods are based on the well-known bag of words (BoW) model, which assumes documents are unordered collection of words. This assumption overlooks an important piece of information, i.e., word order. Moreover, the term frequency, which counts the number of occurrences of each word in SMS, is unable to distinguish the importance of words, …
In Vitro And In Vivo Characterization Of Potent Antileishmanial Methionine Aminopeptidase 1 Inhibitors, Felipe Rodriguez, Sarah F. John, Eva Iniguez, Sebastian Montalvo, Karina Michael, Lyndsey White, Dong Liang, Omonike A. Olaleye, Rosa A. Maldonado
In Vitro And In Vivo Characterization Of Potent Antileishmanial Methionine Aminopeptidase 1 Inhibitors, Felipe Rodriguez, Sarah F. John, Eva Iniguez, Sebastian Montalvo, Karina Michael, Lyndsey White, Dong Liang, Omonike A. Olaleye, Rosa A. Maldonado
Faculty Publications
Leishmania major is the causative agent of cutaneous leishmaniasis (CL). No human vaccine is available for CL, and current drug regimens present several drawbacks, such as emerging resistance, severe toxicity, medium effectiveness, and/or high cost. Thus, the need for better treatment options against CL is a priority. In the present study, we validate the enzyme methionine aminopeptidase 1 of L. major (MetAP1Lm), a metalloprotease that catalyzes the removal of N-terminal methionine from peptides and proteins, as a chemotherapeutic target against CL infection. The in vitro antileishmanial activities of eight novel MetAP1 inhibitors (OJT001 to OJT008) were investigated. Three compounds, OJT006, …
An Image Processing Method For Extraction Of The Stresswave Reflection Period, Panpan Gong, Mingzhang Luo, Luoyu Zhou, Liming Jiang, Xuemin Chen
An Image Processing Method For Extraction Of The Stresswave Reflection Period, Panpan Gong, Mingzhang Luo, Luoyu Zhou, Liming Jiang, Xuemin Chen
Faculty Publications
The stress wave reflection method is widely used in the detection of structure size and integrity due to its advantages of low environmental impact and convenience. The detection accuracy depends on the accurate extraction of the stress wave reflection period. The traditional peak-peak method (PPM) measures the time interval between the first two peaks of the reflected waves to extract the reflection period. However, human interpretation is not avoidable for identifying the weak peak due to signal energy leaks into the surrounding environment. This paper proposes an algorithm for automatic extraction of the stress wave reflection period based on image …
Phase 2 Study Of Vismodegib, A Hedgehog Inhibitor, Combined With Gemcitabine And Nab-Paclitaxel In Patients With Untreated Metastatic Pancreatic Adenocarcinoma, Ana De Jesus-Acosta, Elizabeth A. Sugar, Peter J. O’Dwyer, Ramesh K. Ramanathan, Daniel D. Von Hoff, Zeshaan Rasheed, Lei Zheng, Asma Begum, Robert Anders, Anirban Maitra, Florencia Mcallister, N. V. Rajeshkumar, Shinichi Yabuuchi, Roeland F. De Wilde, Bhavina Batukbhai, Ismet Sahin, Daniel A. Laheru
Phase 2 Study Of Vismodegib, A Hedgehog Inhibitor, Combined With Gemcitabine And Nab-Paclitaxel In Patients With Untreated Metastatic Pancreatic Adenocarcinoma, Ana De Jesus-Acosta, Elizabeth A. Sugar, Peter J. O’Dwyer, Ramesh K. Ramanathan, Daniel D. Von Hoff, Zeshaan Rasheed, Lei Zheng, Asma Begum, Robert Anders, Anirban Maitra, Florencia Mcallister, N. V. Rajeshkumar, Shinichi Yabuuchi, Roeland F. De Wilde, Bhavina Batukbhai, Ismet Sahin, Daniel A. Laheru
Faculty Publications
Background: The Hedgehog (Hh) signalling pathway is overexpressed in pancreatic ductal adenocarcinoma (PDA). Preclinical studies have shown that Hh inhibitors reduce pancreatic cancer stem cells (pCSC), stroma and Hh signalling. Methods: Patients with previously untreated metastatic PDA were treated with gemcitabine and nab-paclitaxel. Vismodegib was added starting on the second cycle. The primary endpoint was progression-free survival (PFS) as compared with historical controls. Tumour biopsies to assess pCSC, stroma and Hh signalling were obtained before treatment and after cycle 1 (gemcitabine and nab-paclitaxel) or after cycle 2 (gemcitabine and nab-paclitaxel plus vismodegib). Results: Seventy-one patients were enrolled. Median PFS and …
The Inclusion Of The Term ‘Color’ In Any Racial Label Is Racist, Is It Not?, Anita Kalunta-Crumpton
The Inclusion Of The Term ‘Color’ In Any Racial Label Is Racist, Is It Not?, Anita Kalunta-Crumpton
Faculty Publications
Through an examination of the term people of color, this conceptual paper illustrates how the use of historical racial labels in the US, supposedly aimed at denouncing racism, seems to reproduce that which the labels purport to condemn. With a primary focus on Blacks or African-Americans, this paper draws purely on a review and analysis of secondary information to argue that any antiracist agenda that utilizes terms that were associated with historical racism may well be reproducing the racist ideologies that justified slavery and Jim Crow laws. This paper calls for the elimination of the term people of color and …
Simulation Studies Of Combustion In Spark Ignition Engine Using Openfoam, Lucky Anetor, Edward E. Osakue, Kendall Harris
Simulation Studies Of Combustion In Spark Ignition Engine Using Openfoam, Lucky Anetor, Edward E. Osakue, Kendall Harris
Faculty Publications
The open source Field Operation and Manipulation (OpenFOAM) software was used to investigate the performance of a fully premixed, modern high-performance 4-valve, iso-octane, dual overhead cam (DOHC) engine with quasi-symmetric pent roof combustion chamber running at 1500 revolutions per minute. The peak pressure occurred at the TDC and had a value of about 30 bar. The results from this study show that the maximum combustion temperature occurred at approximately 95 degrees crank angle ATDC and has a volume averaged value of about 2700° K, whereas the actual computed peak temperature was found to be about 3000° K and it occurred …
Simultaneity Of Synchronization And Antisynchronization In A Class Of Chaotic Systems, Zhi Liu, Rongwei Guo, Yi Qi, Cuimei Jiang
Simultaneity Of Synchronization And Antisynchronization In A Class Of Chaotic Systems, Zhi Liu, Rongwei Guo, Yi Qi, Cuimei Jiang
Faculty Publications
In this paper, a new synchronization phenomenon, that is, the simultaneity of synchronization and antisynchronization, is investigated for a class of chaotic systems. First, for a given chaotic system, necessary and sufficient conditions for the simultaneity of synchronization and antisynchronization are proved. Then, based on these conditions, all solutions of such synchronization phenomenon for a given chaotic system are derived. After that, physical controllers that are not only simple but also implementable are designed to realize the simultaneity of synchronization and antisynchronization in the above system. Finally, illustrative examples based on numerical simulations are used to verify the validity and …
Methods For Identifying Truck Crash Hotspots, Wenrui Qu, Shaojie Liu, Qun Zhao, Yi Qi
Methods For Identifying Truck Crash Hotspots, Wenrui Qu, Shaojie Liu, Qun Zhao, Yi Qi
Faculty Publications
The goal of this study was to develop a new method for identifying the actual risky spots by using the geographic information system (GIS). For this purpose, in this study, three different methods for detecting hotspots are developed, i.e., (1) the annual average daily traffic (AADT) normalization method, (2) AK crashes (A is the incapacitating crash, and K is the fatal crash) percentage method, and (3) distribution difference method. To evaluate the performances of these three hotspot detection methods along with a baseline method that only considered the frequency of crashes, we applied these three methods to identify the top …
Methanol Leaf Extract Of Momordica Charantia Protects Alloxan-Induced Hepatopathy Through Modulation Of Caspase-9 And Interleukin-1Β Signaling Pathways In Rats, Sunday Oluwaseun Ofuegbe, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Aduragbenro Deborah Adedapo, Abiodun Emmanuel Ayodele, Momoh Audu Yakubu, Oluwafemi O. Oguntibeju, Adeolu Alex Adedapo
Methanol Leaf Extract Of Momordica Charantia Protects Alloxan-Induced Hepatopathy Through Modulation Of Caspase-9 And Interleukin-1Β Signaling Pathways In Rats, Sunday Oluwaseun Ofuegbe, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Aduragbenro Deborah Adedapo, Abiodun Emmanuel Ayodele, Momoh Audu Yakubu, Oluwafemi O. Oguntibeju, Adeolu Alex Adedapo
Faculty Publications
Background and Aim: Momordica charantia is a highly valued plant, widely distributed in the tropical and subtropical regions. The plant is reported to have a wide range of medicinal uses. This study was designed to explore the ameliorative potential of M. charantia methanol leaf extract in alloxan-induced diabetic animal model with a particular focus on the liver. Materials and Methods: Hepatoprotective effect of methanol leaf extract of M. charantia was assessed in alloxan-induced toxicity in 50 rats divided into five groups (A-E) (n=10). Group A normal control, Group B was toxicant group, and Group C animals received glibenclamide treatment while …
Pressure Control Of High-Pressure Oil Pipe, Wenrui Qu, Lei Liu, Qun Zhao
Pressure Control Of High-Pressure Oil Pipe, Wenrui Qu, Lei Liu, Qun Zhao
Faculty Publications
In this paper, to realize the pressure stability control of high-pressure oil pipe, the dynamic differential equation of fuel oil inlet and outlet is established based on the theory of mass conservation. According to the change of the pressure in the high-pressure tubing, an optimization model is established to achieve precise control of the working time of each part of the high-pressure oil pipe.
Improving Bus Transit Services For Disabled Individuals: Demand Clustering, Bus Assignment, And Route Optimization, Jianbang Du, Fengxiang Qiao, Lei Yu
Improving Bus Transit Services For Disabled Individuals: Demand Clustering, Bus Assignment, And Route Optimization, Jianbang Du, Fengxiang Qiao, Lei Yu
Faculty Publications
Bus transit provides shorter-distance public transportation services, which are subject to various disability discrimination acts with various dedicated features. The Americans with Disabilities Act (ADA) requires that disabled individuals shall have equal rights to receive fare bus transit services, including fixed-route and door-to-door bus services. Most previous studies were mainly focused on policy aspects as part of the efforts of disability rights. The proper planning of demand requests from disabled individuals has been a critical issue but has gained insufficient attention. The existing methodologies in planning route for special transit buses for disabled individuals normally do not consider passengers' waiting …