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Articles 1 - 14 of 14
Full-Text Articles in Entire DC Network
Nanostructured Apatite-Mullite Glass-Ceramics For Enhanced Primary Human Osteoblast Cell Response, Gordon Cooke, Conor Dunne, Sarah Keane, Daithi De Faoite, Seamas Donnelly, Kenneth Stanton
Nanostructured Apatite-Mullite Glass-Ceramics For Enhanced Primary Human Osteoblast Cell Response, Gordon Cooke, Conor Dunne, Sarah Keane, Daithi De Faoite, Seamas Donnelly, Kenneth Stanton
Articles
This work investigates the difference in viability of primary human foetal osteoblast cells on a glass-ceramic surface with nanoscale topography relative to viability on a smooth glass-ceramic surface containing a bioactive phase. Apatite-mullite glass-ceramics containing bioactive fluorapatite (Ca10(PO4)6F2) and bioinert mullite (Si2Al6O13) were synthesised and subsequent heat-treatment was optimised to form nano-sized fluorapatite crystals. Etching was used to selectively remove the bioactive phase, producing a surface with disordered nanoscale topography. Cells were seeded onto a smooth polished glass-ceramic substrate with the bioactive phase intact, an etched …
The Potential Of Raman Spectroscopy In The Diagnosis Of Premalignant Oral Lesions, Ola Ibrahim
The Potential Of Raman Spectroscopy In The Diagnosis Of Premalignant Oral Lesions, Ola Ibrahim
Doctoral
Thesis submitted in partial fulfilment for the degree of Doctor of Philosophy (PhD) Technological University Dublin, School of Physics December 2017.
Patient Experience Informs Health Care Strategies In Irish Hospitals, Heba Habib
Patient Experience Informs Health Care Strategies In Irish Hospitals, Heba Habib
Doctoral
Patients are central to health care facilities and institutions; therefore, a dire need arises to include feedback of their experience in the decision-making process. Patient experience is increasingly recognised as one of the three pillars of quality in healthcare alongside clinical effectiveness and patient safety. A comprehensive literature review (more than 2500 peer-reviewed articles) has identified five key frameworks for patient experience including: UK Picker Institute Principles and US H-CAHPS. The frameworks have enabled the identification of a potential range of patient experience dimensions and helped in grouping them into nine categories. However, there are still opportunities to address research …
Dietary Phytochemicals As Inhibitors Of Primary Amine Oxidase, Padraig Shanahan, Jeffrey O'Sullivan, Keith F. Tipton, Gemma Kinsella, Barry J. Ryan, Gary T. Henehan
Dietary Phytochemicals As Inhibitors Of Primary Amine Oxidase, Padraig Shanahan, Jeffrey O'Sullivan, Keith F. Tipton, Gemma Kinsella, Barry J. Ryan, Gary T. Henehan
Articles
Phytochemicals such as methylxanthines, catechins and polyphenols show health benefits in a range of diseases although their mechanism of action is not fully understood. Primary Amine Oxidase (PrAO) is widely recognised as a therapeutic drug target for the treatment of inflammatory, vascular and neurodegenerative diseases. Previous work in our laboratories showed that caffeine inhibited bovine PrAO activity with a Ki of 1.0mM. In the present study we examined a range of methylxanthines and catechins as inhibitors of bovine PrAO. The methylxanthines tested were caffeine, paraxanthine, theophylline, theobromine and 7-methylxanthine. Of these, only theobromine was an inhibitor with an IC50 of …
Extraoral Maxillofacial Prosthesis Implant Retention Systems: A Critical Review., Hugh Byrne, Marina L. Pimentel
Extraoral Maxillofacial Prosthesis Implant Retention Systems: A Critical Review., Hugh Byrne, Marina L. Pimentel
Articles
Objectives: The purpose of this literature review is to provide information on the different available techniques for implant-supported prosthetic retention, which are bar-clip, o-ring or magnets. Through presenting the practitioner preferences reported in literature, although limited from strict comparison due to the heterogeneity of methodologies and studied individuals, this review aims to identify the choices for maxillofacial prosthesis implant retention systems, regarding patient comfort and good aesthetic outcome, as an aid to surgical and prosthetic planning for implant-supported extraoral maxillofacial prosthetics. With proper knowledge of each implant retention system, a practitioner can design a treatment plan which allows for a …
Improved Protocols For Pre-Processing Raman Spectra Of Formalin Fixed Paraffin Preserved Tissue Sections, Hugh Byrne, Fiona Lyng, Ola Ibrahim, Adrian Maguire, Aidan Meade, Steven Flint, M. Toner
Improved Protocols For Pre-Processing Raman Spectra Of Formalin Fixed Paraffin Preserved Tissue Sections, Hugh Byrne, Fiona Lyng, Ola Ibrahim, Adrian Maguire, Aidan Meade, Steven Flint, M. Toner
Articles
Although formalin fixed paraffin preserved (FFPP) tissues are a major resource for retrospective studies of disease progression, their use in vibrational spectroscopy studies has been undermined by issues of contributions of substrate and paraffin wax which persist in the spectra and can compromise spectral analysis. Recognising the microcrystalline nature of the wax in the tissue, which are inhomogeneously oriented with respect to the polarisation of the Raman source laser, in this study, we have developed a novel method for removing the paraffin wax contributions to the spectra using matrices of multiple wax spectra. FFPP tissue sections from the oral mucosa …
Level Anticrossing Of Impurity States In Semiconductor Nanocrystals, Anvar S. Baimuratov, Ivan D. Rukhlenko, Vadim K. Turkov, Irina Ponomareva, Mikhail Yu Leonov, Tatiana S. Perova, Kevin Berwick, Alexander V. Baranov, Anatoly V. Federov
Level Anticrossing Of Impurity States In Semiconductor Nanocrystals, Anvar S. Baimuratov, Ivan D. Rukhlenko, Vadim K. Turkov, Irina Ponomareva, Mikhail Yu Leonov, Tatiana S. Perova, Kevin Berwick, Alexander V. Baranov, Anatoly V. Federov
Articles
The size dependence of the quantized energies of elementary excitations is an essential feature of quantum nanostructures, underlying most of their applications in science and technology. Here we report on a fundamental property of impurity states in semiconductor nanocrystals that appears to have been overlooked—the anticrossing of energy levels exhibiting different size dependencies. We show that this property is inherent to the energy spectra of charge carriers whose spatial motion is simultaneously affected by the Coulomb potential of the impurity ion and the confining potential of the nanocrystal. The coupling of impurity states, which leads to the anticrossing, can be …
Strategies For Enhancing The Mature Student Experience In Higher Education, John O'Carroll, Cathy Ennis, Keith Loscher, Deirdre Ryan, Niall Dixon
Strategies For Enhancing The Mature Student Experience In Higher Education, John O'Carroll, Cathy Ennis, Keith Loscher, Deirdre Ryan, Niall Dixon
Practitioner Research Projects
A principle of the Irish Education system is its endorsement of equity of access to higher education for all Irish citizens. This principle has been enacted through successive government policies including the National Plan for Equity of Access to Higher Education 2015-2019 (HEA, 2015). The aim of this policy is to “ensure that the student body entering, participating in and completing higher education at all levels reflects the diversity and social mix of Ireland’s population” (p.8). Data from this plan shows that participation in higher education by the adult population has increased and that there is a potential for increasing …
Retention Systems For Extraoral Maxillofacial Prosthetic Implants: A Critical Review, M.V. Cobein, N.P. Coto, O. Crivello Junior, J.B.D. Lemos, L.M. Vieira, M.L. Pimentel, Hugh Byrne, R.B. Dias
Retention Systems For Extraoral Maxillofacial Prosthetic Implants: A Critical Review, M.V. Cobein, N.P. Coto, O. Crivello Junior, J.B.D. Lemos, L.M. Vieira, M.L. Pimentel, Hugh Byrne, R.B. Dias
Articles
We describe the techniques available for retention of implant-supported prostheses: bar-clips, O-rings, and magnets. We present reported preferences and, although this is limited by the heterogeneity of methods used and patients studied, we hope we have identified the best retention systems for maxillofacial prosthetic implants. If practitioners know the advantages and disadvantages of each system, they can choose the most natural and comfortable prosthesis. We searched the PubMed and Scopus databases, and restricted our search to papers published 2001–13. MeSH terms used were Maxillofacial prosthesis and Craniofacial prosthesis OR Craniofacial prostheses. We found a total of 2630 papers, and after …
Toxicology Of Engineered Nanoparticles: Focus On Poly(Amidoamine) Dendrines, Pratap Naha, Sourav P. Mukherjee, Hugh Byrne
Toxicology Of Engineered Nanoparticles: Focus On Poly(Amidoamine) Dendrines, Pratap Naha, Sourav P. Mukherjee, Hugh Byrne
Doctoral
Engineered nanomaterials are increasingly being developed for paints, sunscreens, cosmetics, industrial lubricants, tyres, semiconductor devices, and also for biomedical applications such as in diagnostics, therapeutics, and contrast agents. As a result, nanomaterials are being manufactured, transported, and used in larger and larger quantities, and potential impacts on environmental and human health have been raised. Poly(amidoamine) (PAMAM) dendrimers are specifically suitable for biomedical applications. They are well-defined nanoscale molecules which contain a 2-carbon ethylenediamine core and primary amine groups at the surface. The systematically variable structural architecture and the large internal free volume make these dendrimers an attractive option for drug …
Raman Spectroscopic Analysis Of Oral Cells In The High Wavenumber Region, Fiona Lyng, Luis Felipe C.S Carvalho, Franck Bonnier, Cláudio Tellez, Laurita Dos Santos, Kate O´Callaghan, Jeff O'Sullivan, Luis Eduardo S. Soares, Hugh Byrne
Raman Spectroscopic Analysis Of Oral Cells In The High Wavenumber Region, Fiona Lyng, Luis Felipe C.S Carvalho, Franck Bonnier, Cláudio Tellez, Laurita Dos Santos, Kate O´Callaghan, Jeff O'Sullivan, Luis Eduardo S. Soares, Hugh Byrne
Articles
No abstract provided.
Liposomal Encapsulation Of Silver Nanoparticles Enhances Cytotoxicity And Causes Induction Of Reactive Oxygen Species‐ Independent Apoptosis, Azeez Yusuf, A. Brophy, Brian Gorey, Alan Casey
Liposomal Encapsulation Of Silver Nanoparticles Enhances Cytotoxicity And Causes Induction Of Reactive Oxygen Species‐ Independent Apoptosis, Azeez Yusuf, A. Brophy, Brian Gorey, Alan Casey
Doctoral
Silver nanoparticles (AgNP) are one of the most widely investigated metallic NPs due to their promising antibacterial activities. In recent years, AgNP research has shifted beyond antimicrobial use to potential applications in the medical arena. This shift coupled with the extensive commercial applications of AgNP will further increase human exposure and the subsequent risk of adverse effects that may result from repeated exposures and inefficient delivery, meaning research into improved AgNP delivery is of paramount importance. In this study, AgNP were encapsulated in a natural biosurfactant, dipalmitoylphosphatidylcholine, in an attempt to enhance the intracellular delivery and simultaneously mediate the associated …
Development Of Methodology For Raman Microspectroscopic Analysis Of Oral Exfoliated Cells, Hugh Byrne, Fiona Lyng, Alison Malkin, Ola Ibrahim, Genecy Calado, Steven Flint, Isha Behl
Development Of Methodology For Raman Microspectroscopic Analysis Of Oral Exfoliated Cells, Hugh Byrne, Fiona Lyng, Alison Malkin, Ola Ibrahim, Genecy Calado, Steven Flint, Isha Behl
Articles
Oral squamous cell carcinoma ranks as the 15th most common cancer worldwide. The present study was undertaken to standardise a protocol for the analysis of oral exfoliated cells using Raman microspectroscopy. For this purpose, samples were obtained from two different sites, based on prevalence of disease (ventral side of the tongue and buccal mucosa). Different oral rinsing agents were employed and it was concluded that non-alcoholic mouthwash adequately removes food debris. Samples were collected using various collection tools and compared. It was observed that endo-cervical brushes yielded cells from deeper layers of the epithelium. Furthermore, monolayer formation of cells was …
3d Printing Aids Acetabular Reconstruction In Complex Revision Hip Arthroplasty, Andrew J. Hughes, Cathal Debuitleir, Philip Soden, Brian O'Donnchada, Anthony Tansey, Ali Abdulkarim, Colm Mcmahon, Conor J. Hurson
3d Printing Aids Acetabular Reconstruction In Complex Revision Hip Arthroplasty, Andrew J. Hughes, Cathal Debuitleir, Philip Soden, Brian O'Donnchada, Anthony Tansey, Ali Abdulkarim, Colm Mcmahon, Conor J. Hurson
Articles
Revision hip arthroplasty requires comprehensive appreciation of abnormal bony anatomy. Advances in radiology and manufacturing technology have made three-dimensional (3D) representation of osseous anatomy obtainable, which provide visual and tactile feedback. Such life-size 3D models were manufactured from computed tomography scans of three hip joints in two patients. The first patient had undergone multiple previous hip arthroplasties for bilateral hip infections, resulting in right-sided pelvic discontinuity and a severe left-sided posterosuperior acetabular deficiency. The second patient had a first-stage revision for infection and recurrent dislocations. Specific metal reduction protocols were used to reduce artefact. The images were imported into Materialise …