Digital Commons Network^™

Possible Fluid Contributions From Active Faults To Mercury Distribution In Surface Sediments Of The Gemlik Gulf And Health Risk Assessment, Erol Sari, M. Namik Çağatay, Tuğçe Nagi̇han Arslan Kaya, Zeynep Çeti̇n, Nuray Çağlar

Turkish Journal of Earth Sciences

The Gemlik Gulf, located in the eastern part of the Sea of Marmara (Türkiye), is recognized as a relatively contaminated marine environment, influenced by a variety of natural and anthropogenic inputs. A comprehensive geochemical study was performed to examine the distribution of total mercury (THg) in surface sediments and to elucidate the possible sources contributing to its accumulation. The analysis revealed that THg concentrations ranged from 485 to 6486 ng/g, with all measured values substantially exceeding the average shale background concentration of 400 ng/g, indicating significant enrichment. According to sediment quality guidelines, none of the samples exceeded the effects range …

Paleoecology Of Loftusia Species (Large Benthic Foraminifera) In The Zagros Basin, North Of The Neotethys, Hossein Ghanbarloo, Amrollah Safari

Turkish Journal of Earth Sciences

Paleoecological analyses based on the wall structure of the genus Loftusia were carried out in the Maastrichtian deposits of seven outcrops of the Zagros Basin. Two types of particles are present within the wall structure: (1) tiny fossil grains and (2) detrital grains. Tiny fossil grains consist of smaller foraminifera and other small microorganism tests. Foraminiferal tests are associated with miliolid, textulariid, and rotaliid forms. Detrital grains include intraclasts and extraclasts. The presence of different particles in the test wall of this genus and the abundance of this genus in nutrient-rich conditions indicate that Loftusia are probably opportunistic foraminifera. This …

Zoonotic Fish Parasites That Pose Risks To Human Health In Türkiye, Ahmet Özer

Turkish Journal of Zoology

Fish-borne zoonotic diseases have been documented as the causative agents of considerable problems for humans on a global scale. This paper, for the first time, reveals the current zoonotic parasites of fish from wild and cultured hosts in marine, freshwater, and aquarium environments, as well as in native, endemic, and introduced hosts across different geographical areas and seas in Türkiye, based on published data to date. According to the latest global reports, zoonotic fish parasites in Türkiye are dominated by nematodes (17 species), trematodes (11 species), and cestodes (four species), followed by acanthocephalans (two species) and myxozoans (two species). The …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Revealing Cryptic Lineage Diversity In The Persian Gulf And Oman Sea Groupers (Perciformes: Epinephelidae): Phylogenetic And Species Delimitation Insights, Ehsan Damadi, Faezeh Yazdani Moghaddam, Masoumeh Gholipour Cheshm Gilak, Mehdi Ghanbarifardi

Turkish Journal of Zoology

Groupers (Epinephelidae) are a taxon of great commercial interest due to their large body size and high market value, and are also an important ecological species for biodiversity conservation in coral reef ecosystems. Despite their importance, phenotypic convergence among species generally leads to incorrect taxonomic identification, an issue enhanced by molecular studies revealing the presence of a high cryptic diversity and complicating conventional systematic frameworks. Herein, grouper species diversity in the ecologically heterogeneous Persian Gulf and Oman Sea was investigated to resolve taxonomic ambiguities and assess patterns of cryptic diversity. Mitochondrial COI gene sequencing was used in conjunction with integrative …

Otolith Morphological Variations Reveal Intraspecific Diversity In Two-Spot Barb, Pethia Ticto (Hamilton, 1822), Inhabiting The Riverine Ecosystem, Insha Hassan, Lubna Yasmeen, Mohd Sadiq, Ameer Hamza, Mohammad Afzal Khan

Turkish Journal of Zoology

The intraspecific variation in otolith wavelet coefficients, contours, and morphometric variables (six size and nine shape indices) was analyzed to discriminate stock variation in Pethia ticto collected from four selected sites along the River Ganga (Narora, Kanpur, Varanasi, and Bhagalpur). The wavelet coefficients extracted revealed symmetrical yet site-specific contour variations, particularly along the rostral, dorsal, and posterior margins, with the fourth-level wavelet explaining 98% of the cumulative accuracy and being selected for contour analysis. Permutational analysis of multivariate dispersion (PERMDISP) (F = 6.11, p = 0.002) and permutational multivariate analysis of variance (PERMANOVA) (F = 8.42, R2 = 0.179, p …

Toxicokinetics And Multibiomarker Assessment Of Coexposure To Sulfamethoxazole And  Titanium Dioxide Nanoparticles In Cyprinus Carpio, Nazish Iftikhar, Rabeea Zafar, Imran Hashmi, Asma Jamil, Christopher Joseph Martyniuk, Munib Ahmed Shafique

Turkish Journal of Zoology

The combined effects of pharmaceuticals and nanoparticles (NPs) on aquatic organisms remain insufficiently characterized. The present study examined toxicokinetics and multibiomarker responses of Cyprinus carpio (common carp) following exposure to sulfamethoxazole (SMX) and titanium dioxide (TiO₂) NPs. Juvenile fish were treated with SMX (25, 50, and 100 μg/L) alone and in combination with 1.5 mg/L TiO₂ NPs (96 h). TiO₂ NPs had a significant effect on the bioaccumulation of SMX in muscle tissues, with SMX reaching peak concentrations of 2286.54 ng/g in the 100 μg/L SMX + 1.5 mg/L TiO₂ NPs group after 72 h, compared to 1477.2 ng/g with …

Involvement Of Melatonin In The Regulation Of Reactive Oxygen Species Levels In Plants, Bariş Uzi̇lday, Oğuzhan Yilmaz, Tolga Yalçinkaya, Zehra Özgecan Tanyolaç, İsmai̇l Türkan, Rengi̇n Özgür Uzi̇lday

Turkish Journal of Botany

Abiotic stress conditions impair plant metabolism partly by inducing the excessive production of reactive oxygen species (ROS). Melatonin, a multifunctional indoleamine, has emerged as an important regulator of plant responses to oxidative stress. This review highlights recent findings on the interactions among phytomelatonin, ROS homeostasis, antioxidant metabolism, photosynthetic protection, stress priming, and abiotic stress tolerance. We discuss how melatonin modulates the antioxidative response under diverse stress conditions and evaluate its effects on photosynthetic performance, ROS signaling, and membrane stability. Special attention is given to priming studies showing that melatonin pretreatment can improve stress tolerance. Emerging evidence from plant tissue culture …

Complete Chloroplast Genome Analysis Of Critically Endangered Endemic Prangos Denticulata And Insights Into Its Evolutionary Dynamics, Ayşenur Bozkurt, Doğa Seli̇n Kayihan, Hali̇s Batuhan Ünal, Ceyhun Kayihan

Turkish Journal of Botany

Prangos denticulata (Apiaceae) is a critically endangered and narrowly endemic species restricted to Ankara, Türkiye. To provide genomic resources for its conservation and evolutionary study, we sequenced, assembled, and annotated its complete chloroplast genome using short-read next-generation sequencing. The circular plastome was 153,486 bp in length, exhibiting the typical quadripartite structure with a large single-copy (86,440 bp), small single-copy (17,894 bp), and two inverted repeats (49,152 bp), and an overall GC content of 37.8%. A total of 116 genes were identified, including 92 protein-coding, 31 tRNA, and 5 rRNA genes, of which 20 contained introns. Comparative analyses with P. trifida, …

Drought Priming Improves Waterlogging Tolerance In Alfalfa, But Less Effectively Than Waterlogging Priming, Gürkan Demi̇rkol, Ni̇lüfer Kara

Turkish Journal of Botany

Waterlogging severely restricts growth and productivity in alfalfa (Medicago sativa L.), necessitating effective strategies to improve stress tolerance. This study investigated whether drought priming or waterlogging priming could enhance tolerance to subsequent waterlogging stress in the alfalfa cultivar “Bilensoy-80”. Plants were subjected to drought priming, waterlogging priming, or no priming prior to progressive waterlogging stress for 0, 4, 8, 12, 16, and 20 days. Waterlogging priming consistently alleviated growth inhibition, maintained chlorophyll content, and reduced oxidative damage under prolonged stress. Drought priming was associated with partial cross-tolerance, particularly through improved root growth, plant water status, and oxidative stress responses, although …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Red Light Accelerates Adventitious Root Primordium Initiation And Differentiation In Phoebe Bournei Cuttings By Modulating Auxin Signaling And Hormonal Balance, Yuewang Niu, Yuanyang Bi, Chenyu Gong, Shipin Chen

Turkish Journal of Botany

Adventitious root formation in stem cuttings of Phoebe bournei, an economically and ecologically significant woody species, is a major bottleneck in clonal propagation. To elucidate the impact of spectral quality on early adventitious root development, we characterized the morphological, hormonal, and transcriptomic dynamics of primordium initiation and differentiation under white, red, and blue light. Under red light, cuttings exhibited the earliest and most pronounced formation of white filamentous structures at lenticels, indicative of root primordium initiation, as early as 20 days after cutting, whereas white and blue light treatments showed delayed responses. Paraffin section analysis confirmed the induced origin of …

A Delayed Siamr Prostate Cancer Model With Vertical Transmission And Treatment: Stability Analysis And Numerical Simulation, Hüseyi̇n Demir, İnci̇ Çi̇li̇ngi̇r Süngü, İbrahi̇m Keles

Turkish Journal of Mathematics

​In this paper, we propose and analyse a delayed-compartmental mathematical model of prostate cancer dynamics that incorporates vertical transmission and therapeutic intervention. The population is stratified into five compartments: susceptible (S), infected/virally activated (I), asymptomatic infectious under treatment (A), malignant untreated (M), and recovered (R). A discrete time delay τ > 0 is introduced in the force-of-infection term to model the age-dependent onset of susceptibility in middle-aged adult males. Vertical transmission of viral etiology at a rate qΛ ensures that a fraction of newborns enter the infected compartment directly, rendering the disease persistent regardless of the basic reproduction number R₀. We …

Hyers-Ulam And Hyers-Ulam Rassias Stability Of Caputo Fractional Hahn Difference Equations, Karima Mohamed Oraby, Alaa E. Hamza, Afrah Al-Bossly

Turkish Journal of Mathematics

​In this paper, we investigate Hyers–Ulam and Hyers–Ulam–Rassias stability for fractional linear Hahn difference equations of Caputo Type. To the best of our knowledge, this is the first work concerning Hyers–Ulam type stability in the framework of Caputo fractional Hahn difference equations, thereby filling a significant gap in the literature on fractional stability theory. Our approach is based on establishing an equivalence between the fractional Hahn difference initial value problem and a corresponding fractional integral equation, via the Caputo–Hahn inversion formula. These results lay a strong groundwork for analyzing the stability of Hahn fractional systems, which could be useful in …

A Note On The Periodic Orbits Of Wolbachia Spread Dynamics In Mosquito Populations In Periodic Environments, Jose S. Cánovas

Turkish Journal of Mathematics

We consider the periodic model introduced by B. Zheng and J. Yu, and disprove the conjectures on the number of periodic orbits the model can have. We rebuild the conjecture to prove that for periodic sequences of maps of any period, the number of nonzero periodic trajectories is bounded by two.

Folic Acid-Targeted Polymeric Complex Imprinted With Doxorubicin And Quercetin For Controlled Drug Delivery In Cancer Therapy, Ceren Türkcan, Emi̇rhan İşeri̇

Turkish Journal of Chemistry

​Cancer therapy is often limited by the systemic toxicity and dose-dependent adverse effects of conventional chemotherapeutic agents such as doxorubicin (DOX). In this study, a folic acid-functionalized molecularly imprinted polymeric complex based on poly(HEMA) crosslinked with ethylene glycol dimethacrylate was synthesized for the controlled release of DOX in combination with quercetin (QUE), a flavonoid known for its antioxidant and chemosensitizing properties. The aim of this work was to develop and physicochemically characterize a preliminary targeted drug delivery platform at a material-design level. The polymeric complex was synthesized via free-radical polymerization following a DOX–QUE precomplex formation step. Structural characterization was performed …

A Poly-L-Lysine-Functionalized Electrochemical Immunosensor Enables Highly Sensitive Detection Of Tumor Necrosis Factor Receptor-Associated Protein 1, Berfi̇n Vural, Mustafa Kemal Sezgi̇ntürk

Turkish Journal of Chemistry

Tumor necrosis factor receptor-associated protein 1 (TRAP-1), a member of the mitochondrial heat shock protein family (HSP90), is essential for protein homeostasis, stress response, and cell cycle. TRAP-1 not only optimizes cellular energy production but also prevents cell death, thereby supporting the survival and proliferation of tumor cells. In addition to cancer, TRAP-1 has been associated with Parkinson’s disease, certain autoimmune disorders, and abnormalities in the kidney and urinary tract. In this study, a unique and useful indium tin oxide-polyethylene terephthalate (ITO–PET)-based electrochemical biosensor is described for detecting the biomarker TRAP-1. The ITO–PET electrode, selected as the working electrode, is …

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.

Aptamer–Gold Nanoparticle-Based Lab-In-A-Tube Colorimetric Detection Of Malathion: Evaluation With Classical And Digital Readout Techniques, Emi̇ne Güler Çeli̇k

Turkish Journal of Chemistry

Colorimetric biosensing devices represent an important class of point-of-care (POC) diagnostics due to their ability to provide visible test outputs, their ease of integration with smartphone-based sensing, and their portability for field testing. In the context of agrifood safety, there is a growing need for portable, robust, and cost-effective detection devices. Pesticide residues can be present in a wide range of environmental and food samples, from water resources to fruits and vegetables, resulting in an increasing global demand for on-site testing. Colorimetric assays, when combined with smartphone-based sensing, can effectively address these needs. In this work, the aggregation-induced color change …

Sensitive Electrochemical Sensor For Simultaneous Determination Of Epinephrine And Norepinephrine By Sio2np@Mwcnt-Cooh Nanoparticle-Modified Spces​, Merve Yilmaz Çilçar, Meli̇ke Bi̇lgi̇ Kamaç, Ayşenur Yilmaz Kabaca, Şahi̇n Toparli, Faruk Terzi̇oğlu, Emi̇r Ateş

Turkish Journal of Chemistry

Epinephrine (EP) and norepinephrine (NEP), both neurotransmitters, are two important biomolecules that play critical roles in the body, from the central nervous system to metabolic processes. They are also important biomarkers for clinical diagnosis and monitoring. In this study, a novel, fast, practical, and high-performance electrochemical sensor based on a SiO2NP@MWCNT-COOH nanocomposite was developed for the simultaneous determination of EP and NEP. The nanocomposite was modified onto the surface of screen-printed electrodes (SPCEs) and its characterization was performed (SEM-EDX, XRD, FTIR, CV, DPV, and EIS). The individual and simultaneous determinations of EP and NEP were performed using square-wave voltammetry, yielding …

Acetylcholinesterase Immobilization On A Natural Thin Membrane For Stable Biocatalyst Design, Si̇nem Öztürk, Ceyhun Işik, Mustafa Teke

Turkish Journal of Chemistry

This study involved the immobilization of acetylcholinesterase (AChE) onto a natural thin membrane extracted from the inner epidermal layer of Allium cepa, with the aim of enhancing the enzyme’s stability, activity, and reusability for potential biotechnological applications. The membrane, composed of biocompatible polymers and naturally occurring functional groups, was used as a sustainable support in a combined strategy involving adsorption followed by glutaraldehyde-mediated cross-linking. Immobilization conditions were optimized by evaluating key factors such as enzyme concentration, membrane quantity, cross-linker dosage, and contact time to achieve maximal catalytic efficiency. Structural and morphological changes on the membrane surface were assessed via scanning …

Antifungal Activity Of Isolated Compounds From Centaurea Salicifolia Var. Salicifolia Against Candida Species, Including Multidrug-Resistant C. Auris, C. Inconspicua, And C. Dubliniensis, Seli̇n Tufan, Di̇lek Şatana, Nur Tan

Turkish Journal of Chemistry

Natural compounds obtained from plants have always held great potential for drug discovery and, as such, have drawn the attention of researchers as novel antifungal molecules that can be effective against fungal resistance. The antifungal activity of sesquiterpene lactones has been extensively investigated against various fungal strains, but there is limited data on their antifungal activity against Candida species. Sesquiterpene lactones are abundant in the Asteraceae family, and 90% of identified sesquiterpene lactones have been isolated from members of this family. Three extracts obtained from the aerial parts of Centaurea salicifolia var. salicifolia, which had not been investigated prior to …

Electrochemical Determination Of Terbutaline Using A Sno2 Nanoparticle-Modified Carbon Paste Electrode, Rauf Gulamov, Şenol Alpat, Si̇bel Kilinç Alpat

Turkish Journal of Chemistry

Terbutaline hemisulfate (THS), a selective beta-2 agonist, is preferred as a bronchodilator for the treatment of asthma and bronchitis, as well as a tocolytic agent to delay labor in acute situations during premature birth. The use of beta-2 agonists above a certain dose is considered doping in sports competitions. Therefore, it is important that they be determined with high sensitivity and selectivity within a short analysis time. In this study, a SnO2 nanoparticle-modified carbon paste electrode was developed for the determination of THS. Cyclic voltammetry and differential pulse voltammetry were employed as electrochemical methods. The operating conditions of the developed …

Chitosan Microparticle-Based Antibacterial Nasal Barrier Formulation And In Vivo Evaluations, Güli̇z Ak, Ayça Erek, Tuğba Karakayali, Şadi̇ye Çeti̇n, Şenay Şanlier

Turkish Journal of Chemistry

Microorganisms remain a major cause of infectious diseases, emphasizing the need for alternative and complementary antimicrobial strategies. In this context, plant-derived materials have attracted increasing attention for their antimicrobial and protective properties. Chitosan, a biocompatible and cationic biopolymer, has emerged as an effective carrier system for encapsulating such plant-derived components. In this study, chitosan microparticles were prepared through ionic gelation followed by spray drying and loaded with thyme oil and olive leaf extract. The resulting microparticles exhibited an average size of approximately 1.8 μm and a total phenolic content of 23 mg GAE/g. These microparticles were incorporated into a glycerin–starch …

Profiling Arbutin As A Potent Cholinesterase And Gsk-3Β Inhibitor And Evaluating Its Cytotoxicity In Sh-Sy5y Cells For Alzheimer’S Disease Therapy, Shirin Tarbiat, Tuğba Bal, Deni̇z Gülmez

Turkish Journal of Biology

Background/aim: Alzheimer’s disease (AD) is a neurodegenerative disorder linked to cognitive decline and memory loss, marked by hyperphosphorylated tau tangles and decreased acetylcholine levels, which are affected by acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity. Glycogen synthase kinase-3 beta (GSK-3β) also plays a role in AD through abnormal activation. In this study, the potential of β-arbutin to inhibit cholinesterases and GSK-3β was investigated, utilizing in vitro assays, cytotoxicity analysis, and molecular docking simulations to explore its therapeutic implications.

Materials and methods: Ellman’s technique was used to test the inhibitory effects of arbutin on cholinesterase enzymes. An ATP-Glo luminescent assay kit was …

Probiotic Intervention In Colorectal Cancer: The Cytotoxic And Apoptotic Potential Of Lactobacillus Cell-Free Supernatants, Bahar Yilmaz, Berna Erdal

Turkish Journal of Biology

Background/aim: Failures in the treatment of colorectal cancer (CRC) have increased scientific interest in the potential of the bioactive compounds contained in cell-free supernatants (CFSs) obtained from probiotic bacteria for cancer treatment. The aim in this study was to investigate the effects of CFSs obtained from Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus) and Lactobacillus paracasei subsp. paracasei (L. paracasei) on colorectal cancer cell lines (HT-29 and Caco-2) and a healthy colon epithelial cell line (CCD841 CoN).

Materials and methods: Cytotoxic effects on the cell lines were determined by MTT assay. In line with the IC50 values obtained, morphological changes were …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Antiatopic Dermatitis Activity Of Lissachatina Fulica Mucin: Network Pharmacology Analysis And Experimental Validation, Atin Supiyani, Wasmen Manalu, Lina Noviyanti Sutardi, Mawar Subangkit, Andriyanto Andriyanto

Turkish Journal of Biology

Background/aim: Lissachatina fulica mucin (LFM) has been used as a nutraceutical, therapeutic agent, and cosmetic ingredient. The bioactivity of mucin depends on bioactive compounds whose composition is strongly influenced by the snail’s diet. This study investigated the bioactive compounds in L. fulica mucin as potential therapeutic agents for atopic dermatitis (AD).

Materials and methods: LFM was collected from snails fed long beans and melon rinds for 4 weeks, freeze-dried, and analyzed using liquid chromatography–mass spectrometry followed by network pharmacology (NP) analysis to identify its bioactive compounds. A total of 60 BALB/c mice were sensitized on the dorsal skin with 1% …

The N-Terminal, Wd40, And C-Terminal Domains Of Wdr-31 Control Ciliary Localization And Cooperate With Elmod/Rp2 Gaps To Maintain Membrane Compartmentalization, Sebi̇ha Çevi̇k, Fatma Güzel

Turkish Journal of Biology

Background/aim: WD40 repeats are found in many ciliary proteins. Although the WD40 repeat-containing WD repeat-containing protein 31 (WDR-31) is known to regulate ciliary protein trafficking and morphology, the specific contributions of its N-terminal, WD40, and C-terminal domains to protein localization and ciliary gate integrity remain unclear. Aim of this study is to dissect the functional roles of WDR-31 domains by investigating their contributions to ciliary localization, ciliary protein trafficking, and gate integrity.

Materials and methods: Using CRISPR/Cas9 technology, we generated Caenorhabditis elegans strains with in-frame deletions that removed the N-terminus (WDR-31(ΔN)), WD40 (WDR-31(ΔWD)), and C-terminus (WDR-31(ΔC)). We next examined the …

Discovery And Functional Characterization Of Novel Programmed Death-Ligand 1 Monoclonal Antibodies, Nurşah Ersezen, Mai̇de Şeker, Arzu Aysan, Durmuş Akdoğan, Mehmet Ender Avci, Asli Kurden Pekmezci̇, Si̇bel Kalyoncu Uzunlar, Mehmet İnan, Tamer Yağci

Turkish Journal of Biology

Background/aim: Targeted therapies with monoclonal antibodies provide cancer patients with better prognosis and diseasefree survival. The blockade of immune checkpoints, including programmed cell death protein-1 (PD-1) and its ligand PD-L1, with monoclonal antibodies may boost immune responses against tumors and is regarded as an effective strategy in cancer immunotherapy. We describe the generation of anti-PD-L1 monoclonal antibodies with high affinity and specificity, and we assess their potential for therapeutic use in cancer.

Materials and methods: Hybridomas were selected for PD-L1 specificity and cross-reactivity with other immune checkpoint proteins and PD-L1 orthologs using indirect ELISA. Immunofluorescence and Western blotting assays were …