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Integrated Assessment Of Groundwater Quality And Human Health Risks In A Semiarid Region Of Kemaliye (Türkiye), Veli̇ Keski̇n, Celaletti̇n Şi̇mşek
Integrated Assessment Of Groundwater Quality And Human Health Risks In A Semiarid Region Of Kemaliye (Türkiye), Veli̇ Keski̇n, Celaletti̇n Şi̇mşek
Turkish Journal of Earth Sciences
In this study, the hydrochemical characteristics, drinking water suitability, and potential human health risks of groundwater in the Karapınar region (Kemaliye, Erzincan, Türkiye), which has become a critical drinking water resource due to drought associated with climate change and the depletion of surface water resources, were investigated using an integrated multiparameter approach. Within the scope of the study, a total of 18 water samples, comprising 13 spring water samples and 5 groundwater samples obtained from wells, were collected during the dry season (October 2021) and analyzed for major ions, physicochemical parameters, nitrate, and trace elements. The suitability of the samples …
Signals In The Ionosphere Ahead Of Tsunami Arrival, Svetlana Riabova, Sergey Shalimov
Signals In The Ionosphere Ahead Of Tsunami Arrival, Svetlana Riabova, Sergey Shalimov
Turkish Journal of Earth Sciences
We consider the impact of the tsunami propagating after the earthquake in Tohoku on the ionosphere according to measurements from the Hawaiian Islands, i.e., at a fairly large distance from the epicenter of the earthquake. These measurements, taken at a tidal tsunami monitoring station, at a magnetometric station, and by GPS, were used to record the arrival of the tsunami. We experimentally establish that the arrival of atmospheric waves generated by the tsunami significantly advanced the arrival of sea waves at the observation point, and this advance from one source was recorded in both the lower and upper ionosphere. Attention …
Paleoecology Of Loftusia Species (Large Benthic Foraminifera) In The Zagros Basin, North Of The Neotethys, Hossein Ghanbarloo, Amrollah Safari
Paleoecology Of Loftusia Species (Large Benthic Foraminifera) In The Zagros Basin, North Of The Neotethys, Hossein Ghanbarloo, Amrollah Safari
Turkish Journal of Earth Sciences
Paleoecological analyses based on the wall structure of the genus Loftusia were carried out in the Maastrichtian deposits of seven outcrops of the Zagros Basin. Two types of particles are present within the wall structure: (1) tiny fossil grains and (2) detrital grains. Tiny fossil grains consist of smaller foraminifera and other small microorganism tests. Foraminiferal tests are associated with miliolid, textulariid, and rotaliid forms. Detrital grains include intraclasts and extraclasts. The presence of different particles in the test wall of this genus and the abundance of this genus in nutrient-rich conditions indicate that Loftusia are probably opportunistic foraminifera. This …
Empowering Edge Intelligence Through Reparameterized Lightweight Transformers And Distributed Inference, Hosein Esmaeili, Mohammad Ali Afshar Kazemi, Reza Radfar, Nazanin Pilevari
Empowering Edge Intelligence Through Reparameterized Lightweight Transformers And Distributed Inference, Hosein Esmaeili, Mohammad Ali Afshar Kazemi, Reza Radfar, Nazanin Pilevari
Turkish Journal of Electrical Engineering and Computer Sciences
Deploying advanced transformer-based models on resource-constrained edge devices remains a significant challenge due to their high memory footprint and substantial compute requirements. In this paper, we propose a reparameterized transformer framework that integrates High-Rank Factorization (HRF) during training, layer merging at inference, and dynamic, load-balanced distributed inference across multiple devices. To further reduce resource usage, our framework supports mixed-precision quantization down to 4-bit, enabling flexible accuracy–latency–energy trade-offs. Experimental evaluations on the ESC-50 environmental sound dataset demonstrate that our method matches or exceeds the performance of larger baseline models while using 20–30% fewer parameters, achieving up to 48% latency reduction in …
Zoonotic Fish Parasites That Pose Risks To Human Health In Türkiye, Ahmet Özer
Zoonotic Fish Parasites That Pose Risks To Human Health In Türkiye, Ahmet Özer
Turkish Journal of Zoology
Fish-borne zoonotic diseases have been documented as the causative agents of considerable problems for humans on a global scale. This paper, for the first time, reveals the current zoonotic parasites of fish from wild and cultured hosts in marine, freshwater, and aquarium environments, as well as in native, endemic, and introduced hosts across different geographical areas and seas in Türkiye, based on published data to date. According to the latest global reports, zoonotic fish parasites in Türkiye are dominated by nematodes (17 species), trematodes (11 species), and cestodes (four species), followed by acanthocephalans (two species) and myxozoans (two species). The …
Revealing Cryptic Lineage Diversity In The Persian Gulf And Oman Sea Groupers (Perciformes: Epinephelidae): Phylogenetic And Species Delimitation Insights, Ehsan Damadi, Faezeh Yazdani Moghaddam, Masoumeh Gholipour Cheshm Gilak, Mehdi Ghanbarifardi
Revealing Cryptic Lineage Diversity In The Persian Gulf And Oman Sea Groupers (Perciformes: Epinephelidae): Phylogenetic And Species Delimitation Insights, Ehsan Damadi, Faezeh Yazdani Moghaddam, Masoumeh Gholipour Cheshm Gilak, Mehdi Ghanbarifardi
Turkish Journal of Zoology
Groupers (Epinephelidae) are a taxon of great commercial interest due to their large body size and high market value, and are also an important ecological species for biodiversity conservation in coral reef ecosystems. Despite their importance, phenotypic convergence among species generally leads to incorrect taxonomic identification, an issue enhanced by molecular studies revealing the presence of a high cryptic diversity and complicating conventional systematic frameworks. Herein, grouper species diversity in the ecologically heterogeneous Persian Gulf and Oman Sea was investigated to resolve taxonomic ambiguities and assess patterns of cryptic diversity. Mitochondrial COI gene sequencing was used in conjunction with integrative …
Otolith Morphological Variations Reveal Intraspecific Diversity In Two-Spot Barb, Pethia Ticto (Hamilton, 1822), Inhabiting The Riverine Ecosystem, Insha Hassan, Lubna Yasmeen, Mohd Sadiq, Ameer Hamza, Mohammad Afzal Khan
Otolith Morphological Variations Reveal Intraspecific Diversity In Two-Spot Barb, Pethia Ticto (Hamilton, 1822), Inhabiting The Riverine Ecosystem, Insha Hassan, Lubna Yasmeen, Mohd Sadiq, Ameer Hamza, Mohammad Afzal Khan
Turkish Journal of Zoology
The intraspecific variation in otolith wavelet coefficients, contours, and morphometric variables (six size and nine shape indices) was analyzed to discriminate stock variation in Pethia ticto collected from four selected sites along the River Ganga (Narora, Kanpur, Varanasi, and Bhagalpur). The wavelet coefficients extracted revealed symmetrical yet site-specific contour variations, particularly along the rostral, dorsal, and posterior margins, with the fourth-level wavelet explaining 98% of the cumulative accuracy and being selected for contour analysis. Permutational analysis of multivariate dispersion (PERMDISP) (F = 6.11, p = 0.002) and permutational multivariate analysis of variance (PERMANOVA) (F = 8.42, R2 = 0.179, p …
Toxicokinetics And Multibiomarker Assessment Of Coexposure To Sulfamethoxazole And Titanium Dioxide Nanoparticles In Cyprinus Carpio, Nazish Iftikhar, Rabeea Zafar, Imran Hashmi, Asma Jamil, Christopher Joseph Martyniuk, Munib Ahmed Shafique
Toxicokinetics And Multibiomarker Assessment Of Coexposure To Sulfamethoxazole And Titanium Dioxide Nanoparticles In Cyprinus Carpio, Nazish Iftikhar, Rabeea Zafar, Imran Hashmi, Asma Jamil, Christopher Joseph Martyniuk, Munib Ahmed Shafique
Turkish Journal of Zoology
The combined effects of pharmaceuticals and nanoparticles (NPs) on aquatic organisms remain insufficiently characterized. The present study examined toxicokinetics and multibiomarker responses of Cyprinus carpio (common carp) following exposure to sulfamethoxazole (SMX) and titanium dioxide (TiO₂) NPs. Juvenile fish were treated with SMX (25, 50, and 100 μg/L) alone and in combination with 1.5 mg/L TiO₂ NPs (96 h). TiO₂ NPs had a significant effect on the bioaccumulation of SMX in muscle tissues, with SMX reaching peak concentrations of 2286.54 ng/g in the 100 μg/L SMX + 1.5 mg/L TiO₂ NPs group after 72 h, compared to 1477.2 ng/g with …
Involvement Of Melatonin In The Regulation Of Reactive Oxygen Species Levels In Plants, Bariş Uzi̇lday, Oğuzhan Yilmaz, Tolga Yalçinkaya, Zehra Özgecan Tanyolaç, İsmai̇l Türkan, Rengi̇n Özgür Uzi̇lday
Involvement Of Melatonin In The Regulation Of Reactive Oxygen Species Levels In Plants, Bariş Uzi̇lday, Oğuzhan Yilmaz, Tolga Yalçinkaya, Zehra Özgecan Tanyolaç, İsmai̇l Türkan, Rengi̇n Özgür Uzi̇lday
Turkish Journal of Botany
Abiotic stress conditions impair plant metabolism partly by inducing the excessive production of reactive oxygen species (ROS). Melatonin, a multifunctional indoleamine, has emerged as an important regulator of plant responses to oxidative stress. This review highlights recent findings on the interactions among phytomelatonin, ROS homeostasis, antioxidant metabolism, photosynthetic protection, stress priming, and abiotic stress tolerance. We discuss how melatonin modulates the antioxidative response under diverse stress conditions and evaluate its effects on photosynthetic performance, ROS signaling, and membrane stability. Special attention is given to priming studies showing that melatonin pretreatment can improve stress tolerance. Emerging evidence from plant tissue culture …
Drought Priming Improves Waterlogging Tolerance In Alfalfa, But Less Effectively Than Waterlogging Priming, Gürkan Demi̇rkol, Ni̇lüfer Kara
Drought Priming Improves Waterlogging Tolerance In Alfalfa, But Less Effectively Than Waterlogging Priming, Gürkan Demi̇rkol, Ni̇lüfer Kara
Turkish Journal of Botany
Waterlogging severely restricts growth and productivity in alfalfa (Medicago sativa L.), necessitating effective strategies to improve stress tolerance. This study investigated whether drought priming or waterlogging priming could enhance tolerance to subsequent waterlogging stress in the alfalfa cultivar “Bilensoy-80”. Plants were subjected to drought priming, waterlogging priming, or no priming prior to progressive waterlogging stress for 0, 4, 8, 12, 16, and 20 days. Waterlogging priming consistently alleviated growth inhibition, maintained chlorophyll content, and reduced oxidative damage under prolonged stress. Drought priming was associated with partial cross-tolerance, particularly through improved root growth, plant water status, and oxidative stress responses, although …
Electrochemical Determination Of Terbutaline Using A Sno2 Nanoparticle-Modified Carbon Paste Electrode, Rauf Gulamov, Şenol Alpat, Si̇bel Kilinç Alpat
Electrochemical Determination Of Terbutaline Using A Sno2 Nanoparticle-Modified Carbon Paste Electrode, Rauf Gulamov, Şenol Alpat, Si̇bel Kilinç Alpat
Turkish Journal of Chemistry
Terbutaline hemisulfate (THS), a selective beta-2 agonist, is preferred as a bronchodilator for the treatment of asthma and bronchitis, as well as a tocolytic agent to delay labor in acute situations during premature birth. The use of beta-2 agonists above a certain dose is considered doping in sports competitions. Therefore, it is important that they be determined with high sensitivity and selectivity within a short analysis time. In this study, a SnO2 nanoparticle-modified carbon paste electrode was developed for the determination of THS. Cyclic voltammetry and differential pulse voltammetry were employed as electrochemical methods. The operating conditions of the developed …
Chitosan Microparticle-Based Antibacterial Nasal Barrier Formulation And In Vivo Evaluations, Güli̇z Ak, Ayça Erek, Tuğba Karakayali, Şadi̇ye Çeti̇n, Şenay Şanlier
Chitosan Microparticle-Based Antibacterial Nasal Barrier Formulation And In Vivo Evaluations, Güli̇z Ak, Ayça Erek, Tuğba Karakayali, Şadi̇ye Çeti̇n, Şenay Şanlier
Turkish Journal of Chemistry
Microorganisms remain a major cause of infectious diseases, emphasizing the need for alternative and complementary antimicrobial strategies. In this context, plant-derived materials have attracted increasing attention for their antimicrobial and protective properties. Chitosan, a biocompatible and cationic biopolymer, has emerged as an effective carrier system for encapsulating such plant-derived components. In this study, chitosan microparticles were prepared through ionic gelation followed by spray drying and loaded with thyme oil and olive leaf extract. The resulting microparticles exhibited an average size of approximately 1.8 μm and a total phenolic content of 23 mg GAE/g. These microparticles were incorporated into a glycerin–starch …
Probiotic Intervention In Colorectal Cancer: The Cytotoxic And Apoptotic Potential Of Lactobacillus Cell-Free Supernatants, Bahar Yilmaz, Berna Erdal
Probiotic Intervention In Colorectal Cancer: The Cytotoxic And Apoptotic Potential Of Lactobacillus Cell-Free Supernatants, Bahar Yilmaz, Berna Erdal
Turkish Journal of Biology
Background/aim: Failures in the treatment of colorectal cancer (CRC) have increased scientific interest in the potential of the bioactive compounds contained in cell-free supernatants (CFSs) obtained from probiotic bacteria for cancer treatment. The aim in this study was to investigate the effects of CFSs obtained from Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus) and Lactobacillus paracasei subsp. paracasei (L. paracasei) on colorectal cancer cell lines (HT-29 and Caco-2) and a healthy colon epithelial cell line (CCD841 CoN).
Materials and methods: Cytotoxic effects on the cell lines were determined by MTT assay. In line with the IC50 values obtained, morphological changes were …
Antiatopic Dermatitis Activity Of Lissachatina Fulica Mucin: Network Pharmacology Analysis And Experimental Validation, Atin Supiyani, Wasmen Manalu, Lina Noviyanti Sutardi, Mawar Subangkit, Andriyanto Andriyanto
Antiatopic Dermatitis Activity Of Lissachatina Fulica Mucin: Network Pharmacology Analysis And Experimental Validation, Atin Supiyani, Wasmen Manalu, Lina Noviyanti Sutardi, Mawar Subangkit, Andriyanto Andriyanto
Turkish Journal of Biology
Background/aim: Lissachatina fulica mucin (LFM) has been used as a nutraceutical, therapeutic agent, and cosmetic ingredient. The bioactivity of mucin depends on bioactive compounds whose composition is strongly influenced by the snail’s diet. This study investigated the bioactive compounds in L. fulica mucin as potential therapeutic agents for atopic dermatitis (AD).
Materials and methods: LFM was collected from snails fed long beans and melon rinds for 4 weeks, freeze-dried, and analyzed using liquid chromatography–mass spectrometry followed by network pharmacology (NP) analysis to identify its bioactive compounds. A total of 60 BALB/c mice were sensitized on the dorsal skin with 1% …
The N-Terminal, Wd40, And C-Terminal Domains Of Wdr-31 Control Ciliary Localization And Cooperate With Elmod/Rp2 Gaps To Maintain Membrane Compartmentalization, Sebi̇ha Çevi̇k, Fatma Güzel
The N-Terminal, Wd40, And C-Terminal Domains Of Wdr-31 Control Ciliary Localization And Cooperate With Elmod/Rp2 Gaps To Maintain Membrane Compartmentalization, Sebi̇ha Çevi̇k, Fatma Güzel
Turkish Journal of Biology
Background/aim: WD40 repeats are found in many ciliary proteins. Although the WD40 repeat-containing WD repeat-containing protein 31 (WDR-31) is known to regulate ciliary protein trafficking and morphology, the specific contributions of its N-terminal, WD40, and C-terminal domains to protein localization and ciliary gate integrity remain unclear. Aim of this study is to dissect the functional roles of WDR-31 domains by investigating their contributions to ciliary localization, ciliary protein trafficking, and gate integrity.
Materials and methods: Using CRISPR/Cas9 technology, we generated Caenorhabditis elegans strains with in-frame deletions that removed the N-terminus (WDR-31(ΔN)), WD40 (WDR-31(ΔWD)), and C-terminus (WDR-31(ΔC)). We next examined the …
Discovery And Functional Characterization Of Novel Programmed Death-Ligand 1 Monoclonal Antibodies, Nurşah Ersezen, Mai̇de Şeker, Arzu Aysan, Durmuş Akdoğan, Mehmet Ender Avci, Asli Kurden Pekmezci̇, Si̇bel Kalyoncu Uzunlar, Mehmet İnan, Tamer Yağci
Discovery And Functional Characterization Of Novel Programmed Death-Ligand 1 Monoclonal Antibodies, Nurşah Ersezen, Mai̇de Şeker, Arzu Aysan, Durmuş Akdoğan, Mehmet Ender Avci, Asli Kurden Pekmezci̇, Si̇bel Kalyoncu Uzunlar, Mehmet İnan, Tamer Yağci
Turkish Journal of Biology
Background/aim: Targeted therapies with monoclonal antibodies provide cancer patients with better prognosis and diseasefree survival. The blockade of immune checkpoints, including programmed cell death protein-1 (PD-1) and its ligand PD-L1, with monoclonal antibodies may boost immune responses against tumors and is regarded as an effective strategy in cancer immunotherapy. We describe the generation of anti-PD-L1 monoclonal antibodies with high affinity and specificity, and we assess their potential for therapeutic use in cancer.
Materials and methods: Hybridomas were selected for PD-L1 specificity and cross-reactivity with other immune checkpoint proteins and PD-L1 orthologs using indirect ELISA. Immunofluorescence and Western blotting assays were …
An In-Depth Study Of Fruit Preservation: Effect Of Calcium Chloride And Methyl Jasmonate Applications On Quality And Biochemical Properties Of Cherry Fruits During Cold Storage, Muhammet Ali̇ Gündeşli̇
An In-Depth Study Of Fruit Preservation: Effect Of Calcium Chloride And Methyl Jasmonate Applications On Quality And Biochemical Properties Of Cherry Fruits During Cold Storage, Muhammet Ali̇ Gündeşli̇
Turkish Journal of Agriculture and Forestry
Sweet cherry (Prunus avium L.) is a highly perishable fruit that undergoes rapid quality deterioration during postharvest storage. This study evaluated the effects of postharvest applications of Methyl Jasmonate (MeJA, 1 mM) and Calcium Chloride (CaCl₂, 2%), applied individually and in combination, on maintaining the quality and biochemical properties of cherries during 21 days of cold storage at 0 ± 1 °C. Key parameters including weight loss, decay rate, soluble solids content (SSC), pH, titratable acidity, respiration rate, phenolic profile, and organic acid composition were monitored. The combined MeJA + CaCl₂ treatment was consistently more effective than individual applications in …
Sewage Sludge Legislation In Central Europe: Contamination Concerns And Cross-Border Comparisons, Valerie Vranová, Aleš Kučera, Vlastimil Skoták, Erika Fialová, Rahul Datta
Sewage Sludge Legislation In Central Europe: Contamination Concerns And Cross-Border Comparisons, Valerie Vranová, Aleš Kučera, Vlastimil Skoták, Erika Fialová, Rahul Datta
Turkish Journal of Agriculture and Forestry
Sewage sludge management represents a major challenge in Europe, carrying significant environmental and legal implications that require strong regulatory enforcement. Here, we explore the legislative measures, technological developments, and environmental impacts of sewage sludge management in Central Europe (Czechia, Slovakia, Germany, Austria, and Poland). Sludge management is regulated at the EU level through a series of directives (e.g., Council Directive 86/278/EEC, which forms the basis of national regulatory frameworks). However, national adaptations vary considerably: Croatia and Slovenia have invested in sludge phosphorus-recovery systems, while Poland and Slovakia have focused on the agricultural use of sludge as a fertilizer. Several countries, …
A Comparative Analysis Of Clinical Quality And Readability Of Neuropathic Pain Patient Information Leaflets: Türkiye Versus The United States, Gonul Sari, Argun Pire
A Comparative Analysis Of Clinical Quality And Readability Of Neuropathic Pain Patient Information Leaflets: Türkiye Versus The United States, Gonul Sari, Argun Pire
Turkish Journal of Medical Sciences
Background/aim: Neuropathic pain management requires high patient adherence and complex dose-titration regimens, making the readability of patient information leaflets (PILs) a critical patient safety factor. This study aimed to compare the clinical content quality and linguistic readability of PILs for neuropathic pain medications between Türkiye (TİTCK) and the United States (DailyMed).
Materials and methods: A total of 11 pairs of innovator medications were analyzed. Clinical content was assessed using the 15-item Keystone Clinical Content Checklist (KCCC). Readability was assessed using the Ateşman index for Turkish texts and the Flesch Reading Ease Score (FRES) for English texts. Information quality and reliability …
Changes In T-Cell Subsets And Their Relationships With Disease Severity In Patients With Alopecia Areata, Hati̇ce Türk Daği, Hülya Özdemi̇r, Mehmet Akyürek, Fatma Tunçez Akyürek, Hasi̇be Artaç
Changes In T-Cell Subsets And Their Relationships With Disease Severity In Patients With Alopecia Areata, Hati̇ce Türk Daği, Hülya Özdemi̇r, Mehmet Akyürek, Fatma Tunçez Akyürek, Hasi̇be Artaç
Turkish Journal of Medical Sciences
Background/aim: Alopecia areata (AA) is a nonscarring hair loss disorder characterized by genetic susceptibility, environmental triggers, and T-cell–mediated autoimmunity. While various CD4+ and CD8+ T-cell subsets are implicated in its pathogenesis, the roles of follicular T-cell (Tfh), peripheral T-cell (Tph), and regulatory T-cell (Treg) subsets– particularly within the CD8+ population–remain incompletely defined. This study aimed to characterize circulating CD4+ and CD8+ T-cell subsets in Turkish patients with AA and to evaluate their associations with disease activity, duration, and severity.
Materials and methods: A total of 40 patients with AA and 40 healthy controls were enrolled. CD4+ and CD8+ T-cell subsets—including …
Histomorphological Changes In Human Septal Cartilage Stored In Different Preservation Solutions , Özlem Akkoca, Aki̇f Si̇nan Bi̇lgen, Harun Çoban, Fatma Aslan Yay, Zeynep Kaptan, Funda Balkiliç Akkaya, Rahmi̇ Kiliç, Sami̇ Engi̇n Muz
Histomorphological Changes In Human Septal Cartilage Stored In Different Preservation Solutions , Özlem Akkoca, Aki̇f Si̇nan Bi̇lgen, Harun Çoban, Fatma Aslan Yay, Zeynep Kaptan, Funda Balkiliç Akkaya, Rahmi̇ Kiliç, Sami̇ Engi̇n Muz
Turkish Journal of Medical Sciences
Background/aim: To assess the histopathological effects of three preservation solutions (70% ethanol, povidone-iodine, and ciprofloxacin) on human septal cartilage obtained during septoplasty and to compare their preservation characteristics for potential future graft applications. Optimal preservation of septal cartilage is clinically important because well-preserved grafts may reduce the need for secondary cartilage harvesting and the associated donor-site morbidity while facilitating reconstructive procedures during revision surgery.
Materials and methods: A total of 90 septal cartilage specimens obtained from 30 patients undergoing septoplasty were allocated to three preservation groups and stored in the designated preservation solutions at +4 °C. Samples were examined histologically …
Erratum To “Effects Of Colchicine On Sah-Induced Vascular Damage In An Experimental Subarachnoid Hemorrhage Model’’ [Turkish Journal Of Medical Sciences 56 (2) 2026 597-607] , Emi̇ne Demi̇r, Cumaali̇ Demi̇rtaş, Cansu Sönmez, Eray Meti̇n Güler, Sarper Kocaoğlu, Hakan Beyaztaş, Eyüp Çeti̇n
Erratum To “Effects Of Colchicine On Sah-Induced Vascular Damage In An Experimental Subarachnoid Hemorrhage Model’’ [Turkish Journal Of Medical Sciences 56 (2) 2026 597-607] , Emi̇ne Demi̇r, Cumaali̇ Demi̇rtaş, Cansu Sönmez, Eray Meti̇n Güler, Sarper Kocaoğlu, Hakan Beyaztaş, Eyüp Çeti̇n
Turkish Journal of Medical Sciences
The original article can be accessed at https://doi.org/10.55730/1300-0144.6192.
Background/aim: Subarachnoid haemorrhage (SAH) is a severe cerebrovascular condition with high morbidity and mortality. Inflammation and oxidative stress are key factors in its pathophysiology, particularly in secondary vascular injury. This study aimed to evaluate the effects of colchicine on vascular integrity and biochemical markers following SAH in an experimental rat model.
Materials and methods: Eighteen female Sprague-Dawley rats were divided into three groups: Control (no SAH), SAH (induced without treatment), and SAH + Colchicine (1 mg/kg intraperitoneally at 1 h and 24 h). SAH was induced by autologous blood injection into …
L-Theanine Attenuates Alcl3-Induced Cognitive Dysfunction And Neurotoxicity In Rats: A Behavioral And Biochemical Study, Muhammet Oğuzhan Dönmez, Azi̇ze Şener, Şeyda Karaman Ersoy, Mahdi̇ Marzi̇, Göksel Şener
L-Theanine Attenuates Alcl3-Induced Cognitive Dysfunction And Neurotoxicity In Rats: A Behavioral And Biochemical Study, Muhammet Oğuzhan Dönmez, Azi̇ze Şener, Şeyda Karaman Ersoy, Mahdi̇ Marzi̇, Göksel Şener
Turkish Journal of Medical Sciences
Background/aim: The effects of L-theanine (LTN), a natural compound found in tea leaves, on biochemical parameters and cognitive functions were investigated in an aluminum chloride (AlCl3)-induced Alzheimer’s disease-like experimental model.
Materials and methods: A total of 32 male Wistar rats were allocated into four groups: control, AlCl3-induced AD-like group, LTN-treated AD-like group, and donepezil-treated AD-like group. Donepezil was used as a reference drug. For the induction of AlCl3- induced neurotoxicity, AlCl3 was administered by gavage at a dose of 25 mg/kg/day during the 1st week and 150 mg/kg/day for the subsequent 3 weeks. LTN was administered orally at a dose …
Therapeutic Potential Of Nasal Kisspeptin-54 For Reducing Α-Synuclein Accumulation And Restoring Hippocampal Synaptic Plasticity In A 6-Hydroxydopamine-Induced Rat Model Of Parkinson’S Disease , Ayşegül Gemi̇ci̇ Si̇nen, Emre Savran, Okyanus Bora Güleç, Osman Si̇nen, Nari̇n Deri̇n
Therapeutic Potential Of Nasal Kisspeptin-54 For Reducing Α-Synuclein Accumulation And Restoring Hippocampal Synaptic Plasticity In A 6-Hydroxydopamine-Induced Rat Model Of Parkinson’S Disease , Ayşegül Gemi̇ci̇ Si̇nen, Emre Savran, Okyanus Bora Güleç, Osman Si̇nen, Nari̇n Deri̇n
Turkish Journal of Medical Sciences
Background/aim: Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic neurons and pathological aggregation of α-synuclein (α-syn), leading to significant motor and cognitive impairments. Kisspeptin-54 (KP-54), a neuropeptide primarily involved in reproductive regulation, has recently been implicated in neurorestorative processes, with emerging evidence suggesting beneficial effects on locomotor activity and cognitive function. However, its therapeutic potential in PD has not yet been fully investigated. This study aimed to evaluate the therapeutic efficacy of chronic nasal KP-54 administration in a 6-hydroxydopamine (6-OHDA) rat model of PD, focusing on motor and cognitive outcomes, hippocampal synaptic plasticity, and α-syn pathology.
Materials and …
Boric Acid Enhances The Antitumor Effects Of Paclitaxel By Modulating Apoptosis, Autophagy-Related Protein Expression, And Proinflammatory Cytokine Expression In Ovcar-3 Ovarian Cancer Cells , Nazmi̇ye Bi̇tgen, Gözde Özge Önder, Münevver Baran, Fatma Esen Karakuş, Meli̇ke Akbulut, Arzu Yay
Boric Acid Enhances The Antitumor Effects Of Paclitaxel By Modulating Apoptosis, Autophagy-Related Protein Expression, And Proinflammatory Cytokine Expression In Ovcar-3 Ovarian Cancer Cells , Nazmi̇ye Bi̇tgen, Gözde Özge Önder, Münevver Baran, Fatma Esen Karakuş, Meli̇ke Akbulut, Arzu Yay
Turkish Journal of Medical Sciences
Background/aim: Ovarian cancer is the eighth most prevalent malignancy among women globally and ranks third among gynecological cancers in terms of incidence. The limited efficacy of standard chemotherapy, primarily due to intrinsic drug resistance and high recurrence rates, highlights the urgent need for novel therapeutic strategies that are both effective and selectively cytotoxic.
Materials and methods: This study aimed to investigate the combined effects of boric acid (BA), a biologically active boron compound with emerging antitumor potential, and paclitaxel (PTX), a conventional chemotherapeutic agent, on cell viability, cell cycle progression, apoptosis, autophagy-related protein expression, and inflammatory signaling in the chemoresistant …
Robust Soil Moisture Content Detection Based On Data Augmentation Under Different Testing Conditions, Yang Li, Chenghao Liu, Jing Nie, Jingbin Li
Robust Soil Moisture Content Detection Based On Data Augmentation Under Different Testing Conditions, Yang Li, Chenghao Liu, Jing Nie, Jingbin Li
Turkish Journal of Agriculture and Forestry
Accurate and cost-effective monitoring of soil moisture content is essential for the development of precision agriculture and the optimization of water resource management. While low-frequency acoustic signals are used to detect soil moisture content, models trained with controlled laboratory acoustic data often exhibit significant performance degradation with field data due to their sensitivity to environmental noise, soil heterogeneity, and structural variations. This study proposes a novel framework to enhance model robustness and generalization by integrating a WGAN-GP network data augmentation strategy into the soil moisture content workflow. This framework is designed to generate high-quality and diverse data on different soil …
Estimation Of Genetic Parameters In Lemon-Scented Basil (Ocimum Basilicum L.) Lines, Erdi̇nç Günay, İsa Telci̇
Estimation Of Genetic Parameters In Lemon-Scented Basil (Ocimum Basilicum L.) Lines, Erdi̇nç Günay, İsa Telci̇
Turkish Journal of Agriculture and Forestry
Selective breeding of basil (Ocimum basilicum L.) is primarily aimed at improving plant architecture and essential oil quality, which are critical factors in increasing yield. In lemon-scented basil, the citral component responsible for the intense lemony aroma has significant commercial value in the cosmetics and perfumery industries. This study aimed to evaluate the genetic variability, heritability, and genetic advance of nine agronomic and quality related traits in lemon basil lines, and to explore the interrelationships among these traits. The phenotypic coefficient of variation (PCV) was higher than the genotypic coefficient of variation (GCV) for all traits, suggesting the influence of …
Landscape Character Analysis And Assesment At Local Scale, Eli̇f Önal, Serkan Özer
Landscape Character Analysis And Assesment At Local Scale, Eli̇f Önal, Serkan Özer
Turkish Journal of Agriculture and Forestry
Landscape areas are one of the most important elements of human life all over the world. Varied landscape areas are a valuable natural resource and have high cultural value. The first step to ensure the effective landscape use is to identify these areas, analyze them in detail, and determine their characteristics. The northeastern Anatolia region in Türkiye has a rich diversity of landscapes because of varied geographic, climatic, and topographic features. The aim of this study was to identify the landscape character types in the Tortum district, located in the Tortum River basin in northeastern Türkiye, and to assess the …
Readability Of Dermatology Patient Education Materials: A Comparative Analysis Of Turkish Dermatology Association Brochures And Texts Generated By Chatgpt And Gemini , Ahmet Kağan Özdemi̇r, Bengü Reyhan Botsali Özdemi̇r, Akin Aktaş
Readability Of Dermatology Patient Education Materials: A Comparative Analysis Of Turkish Dermatology Association Brochures And Texts Generated By Chatgpt And Gemini , Ahmet Kağan Özdemi̇r, Bengü Reyhan Botsali Özdemi̇r, Akin Aktaş
Turkish Journal of Medical Sciences
Background/aim: In modern healthcare, patient education materials (PEMs) are essential for bridging the gap between clinical knowledge and patient understanding. However, in Türkiye, where 64.6% of the adult population possesses inadequate or problematic health literacy, traditional medical brochures often exceed recommended reading levels. This study aimed to evaluate and compare the readability of Turkish dermatology PEMs prepared by the Turkish Dermatology Association (TDA) with those generated by artificial intelligence (AI) models.
Materials and methods: A total of 68 TDA PEMs were analyzed. Readability was assessed using the Ateşman Readability Index. Responses were generated by AI models to questions extracted from …