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Career Pathways Program Annual Report For Ay 2025/26, Wie Yusuf Jul 2026

Career Pathways Program Annual Report For Ay 2025/26, Wie Yusuf

Career Pathways

Career Pathways launched in August 2017 as the university-wide initiative to provide career and professional development to graduate students. It encompasses both the Preparing Future Faculty (PFF) and the Preparing Future Professionals (PFP) Certificates. The Preparing Future Faculty Certificate was established in 2007, while the Preparing Future Professionals Certificate was launched in 2017, concurrently with the introduction of Career Pathways. The Career Pathways program prepares graduate students for a successful transition into thriving careers. With the PFP Certificate, the emphasis has been on addressing the existing gap in career and professional development for master’s and doctoral students with career plans …


Phishing Restraint: University Simulated Phishing Campaigns, Alexander M. Abou Khir Apr 2026

Phishing Restraint: University Simulated Phishing Campaigns, Alexander M. Abou Khir

Cybersecurity Undergraduate Research Showcase

Universities face heightened vulnerability to phishing attacks due to their open information-sharing culture and diverse user populations. This study examines how phishing exploits human factors within campus environments and evaluates three major training strategies: embedded phishing, microlearning, and role-based instruction to understand their individual and combined effectiveness. I explored studies that implement these strategies in pairs and use the strategies alone, identified trends in susceptibility reduction, behavioral reinforcement, and contextual relevance. I suggest that, while each method independently improves user awareness, multiple approaches offer stronger, more adaptable protection by addressing both psychological triggers and role-specific risks. The paper contributes a …


Security Risks Of Ai-Generated Code In Software Development, Maame Agyekum Apr 2026

Security Risks Of Ai-Generated Code In Software Development, Maame Agyekum

Cybersecurity Undergraduate Research Showcase

Artificial Intelligence(AI) has recently forced change globally, public Institutions and as well as national security. Advancement in machine learning, mixed datasets have enabled significantly powerful systems while being capable of operating at a large scale. As innovation and technological advancement increases at rapid pace, issues like a regulation gap where scientific development far exceeds the government’s ability to regulate and establish an effective oversight. As a result, Artificial Intelligence has been controlled by private companies, leading to an industry where speed and profit often outweigh safety and ethical responsibility.


Bio-Cybersecurity: Securing The Healthcare Industry, Amanda D. Coleman Apr 2026

Bio-Cybersecurity: Securing The Healthcare Industry, Amanda D. Coleman

Cybersecurity Undergraduate Research Showcase

Bio-cybersecurity refers to the aspect of cybersecurity that applies to the biological sciences and the protection of digital biomedical information. Today’s healthcare industry has evolved with the enhancement of internet and biomedical technology. While hospitals and private medical providers remain compliant with the Health Information Portability and Accountability Act (HIPAA) through traditional means of securing documented patient information, the emergence of beneficial internet-based healthcare services like virtual appointments and digital patient records requires new policies and healthcare cybersecurity frameworks to protect sensitive information from unauthorized access. This paper examines the role of cybersecurity in healthcare, the vulnerabilities that exist and …


Mechanisms Of Synergy Between Nanosecond Pulsed Electric Field (Nspef) And Cold Atmospheric Pressure Plasma Discharge (Cap) In Pancreatic Cancer: The Role Of Ros-Mediated Oxidative Stress And Apoptosis, Zobia Minhas Apr 2026

Mechanisms Of Synergy Between Nanosecond Pulsed Electric Field (Nspef) And Cold Atmospheric Pressure Plasma Discharge (Cap) In Pancreatic Cancer: The Role Of Ros-Mediated Oxidative Stress And Apoptosis, Zobia Minhas

Theses and Dissertations in Biomedical Sciences

Pancreatic ductal adenocarcinoma is a highly lethal malignancy characterized by poor prognosis and resistance to conventional therapies. Novel treatment strategies are needed to overcome this resistance. Non-thermal physical modalities, including nanosecond pulsed electric field (nsPEF) and cold atmospheric pressure plasma discharge (CAP), have emerged as potential anticancer approaches; however, the mechanisms underlying their combined effects remain unclear.

This study evaluated whether nsPEF enhances CAP-induced cytotoxicity and investigated the associated molecular mechanisms using the murine Pan02 pancreatic cancer cell line. Cell viability was assessed by WST-1 metabolic activity assays and electric cell–substrate impedance sensing (ECIS). Intracellular reactive oxygen species (ROS) were …


Downstream Effects Of Post Aerobic Digestion And Divalent Cation Treatment: Dewaterability, Phosphorus Mitigation, And Process Odors, Maya Marisol Quijano Garcia Apr 2026

Downstream Effects Of Post Aerobic Digestion And Divalent Cation Treatment: Dewaterability, Phosphorus Mitigation, And Process Odors, Maya Marisol Quijano Garcia

Civil & Environmental Engineering Theses & Dissertations

This study evaluated post-aerobic digestion (PAD) with aeration, mixing, and divalent cation addition to improve phosphorus capture, dewaterability, and odor control in thermal hydrolysis process (THP)–treated anaerobic digestate at the Hampton Roads Sanitation District’s Atlantic Treatment Plant. A three-day PAD process was operated under constant air flow (5 LPM) and dissolved oxygen (DO)-setpoint (0.2 mg/L) aeration conditions with Ca(OH)₂ or Mg(OH)₂ dosing. Aeration and mixing alone increased polymer demand by 14–46 % relative to untreated influent, indicating enhanced extracellular polymeric substance release. Chemical conditioning partially mitigated this increase but did not restore polymer demand to baseline levels. Dewatered cake total …


Early Parenting Stress And Later Abuse Risk: Dyadic Mediation By Maternal And Paternal Negative Attributions, Jewelian N. Fairchild Apr 2026

Early Parenting Stress And Later Abuse Risk: Dyadic Mediation By Maternal And Paternal Negative Attributions, Jewelian N. Fairchild

Psychology Theses & Dissertations

Parenting stress and negative parental attributions are key contributors to child abuse risk. Early parenting stress may increase a parent’s risk of negatively appraising their child’s behaviors, which, in turn, may influence their likelihood of harsh or abusive parenting. Grounded in Social Information Processing (SIP) Theory, the present study explored how these processes evolve over time and differ between mothers and fathers. Specifically, this study investigated whether parental negative attributions mediated the relationship between early parenting stress and later abuse risk. A sample of 203 first-time mothers and 151 of their male partners were recruited prenatally as part of a …


Bug-In-Ear ECoaching To Enhance Parents' Use Of Embedded Learning Opportunities With Preschool-Age Children With Autism Spectrum Disorder, Aeshah Alturki Apr 2026

Bug-In-Ear ECoaching To Enhance Parents' Use Of Embedded Learning Opportunities With Preschool-Age Children With Autism Spectrum Disorder, Aeshah Alturki

Human Movement Studies & Special Education Theses & Dissertations

The increasing prevalence of autism spectrum disorder (ASD) has heightened the need for effective communication interventions. Parents are key partners in intervention and, with appropriate support, can serve as effective intervention agents. However, parents often require ongoing support to implement evidence-based practices. The purpose of this study was to experimentally evaluate the effects of online Bug-in-Ear (BIE) eCoaching on parents’ fidelity of embedded choice-making during family routines with their preschool-aged children with ASD. This study also examined the generalization and maintenance, children’s communicative responses, and parents’ perceptions of the intervention. A single-subject nonconcurrent multiple baseline design across two parent–child dyads …


The Leadership Lens: A Phenomenological Study Of The Lived Sensemaking Experiences Of School Leaders Implementing Virginia's New Standards Of Accreditation And Accountability, Paul M. Wilson Jr. Apr 2026

The Leadership Lens: A Phenomenological Study Of The Lived Sensemaking Experiences Of School Leaders Implementing Virginia's New Standards Of Accreditation And Accountability, Paul M. Wilson Jr.

Educational Leadership & Workforce Development Theses & Dissertations

This phenomenological study exposes the complex cognitive and organizational processes school leaders navigate as they translate high-stakes state mandates into localized action. By examining the implementation of Virginia’s revised Standards of Accreditation and Accountability (SOA), this study challenges the prevailing managerial paradigm that views policy implementation as a linear, mechanical execution of directives. Instead, grounded in sensemaking theory and SDT, this research conceptualizes implementation as a situated and interpretive act shaped by leaders’ prior experiences, beliefs, and psychological needs for autonomy, competence, and relatedness.

Using a qualitative phenomenological design, data were collected through semi structured interviews with 12 school and …


Electromyography, Prosthetic Properties, And Running Biomechanics In Recreationally Active Persons With Lower Extremity Amputation, Paige M. Agnew Apr 2026

Electromyography, Prosthetic Properties, And Running Biomechanics In Recreationally Active Persons With Lower Extremity Amputation, Paige M. Agnew

Rehabilitation Sciences Theses & Dissertations

Lower extremity loss affects nearly 150,000 individuals in the United States yearly yielding extreme health care costs annually. Typically, prosthetic devices are prescribed for 5-8 years despite known changes to an individual’s gait as time progresses. Patients can expect to undergo approximately 8-12 weeks of gait retraining to improve their comfort and efficiency. Biomechanical changes occur when running with a specific running prosthetic including considerable biomechanical and neuromuscular interlimb asymmetries and alterations in loading patterns. The purpose of this dissertation was to investigate the biomechanical demands for lower extremity prosthesis users during running. The first study synthesized peer reviewed evidence …


Biocrude From Organic Waste And Its Conversion To Hard Carbon: Experimental And Modeling Study, Isamu Umeda Apr 2026

Biocrude From Organic Waste And Its Conversion To Hard Carbon: Experimental And Modeling Study, Isamu Umeda

Civil & Environmental Engineering Theses & Dissertations

This study establishes a technical and theoretical foundation for the efficient conversion of organic waste into biocrude and high-value carbon materials, aiming to facilitate the industrialization of hydrothermal and solvothermal liquefaction. The dissertation research is structured as follows:

Chapter 2 developed a novel chemical kinetic model for the HTL of corn stover based on elemental balances (C, H, N, and O). By incorporating temperature, residence time, solid loading as an independent variable, the model successfully predicted product yields and properties, revealing that there was non-pseudo-first-order reaction pathways in the conversion of water soluble organics in aqueous phase (AP) to hydrochar. …


Shadowrunning The Human: Harebrained Schemes' Shadowrun Series And Transhumanism, Alexander P. Orelup Apr 2026

Shadowrunning The Human: Harebrained Schemes' Shadowrun Series And Transhumanism, Alexander P. Orelup

English Theses & Dissertations

I argue that Harebrained Schemes’ video game series Shadowrun critiques transhumanism in three distinct yet related ways: in terms of religion, political control, and identity capitalism. In doing so, Shadowrun attempts to counter claims that video games are an inherently transhumanist medium and provides an opportunity for players to resist a potential transhuman future. This further elucidates the trends and perceptions of transhumanism within American culture around the time period. I utilize a variety of methodologies in my argument, ranging from cultural studies, narratology, ludology, and close reading in order to grasp all of the audio-visual and gameplay elements that …


Quantifying Nutrient Fluxes Across The Sediment-Water Interface In The Lafayette River Estuary, Adriana E. Amrhein Apr 2026

Quantifying Nutrient Fluxes Across The Sediment-Water Interface In The Lafayette River Estuary, Adriana E. Amrhein

OES Theses and Dissertations

The Lafayette River, a shallow, eutrophic tributary of the Chesapeake Bay, experiences seasonal harmful algal blooms (HABs). While management efforts focus on reducing external nutrient inputs, internal loading from benthic sediments remains poorly constrained. This study quantifies spatial and seasonal variability in nutrient and radium isotope fluxes across the sediment–water interface at three sites where HABs are known to initiate and represent contrasting sediment textures and hydrodynamic conditions. Sediment cores and porewater samples were collected in summer 2023 and winter 2024 to measure grain size, porosity, dissolved nutrients (NH₄⁺, NOₓ⁻, PO₄³⁻), and radionuclide activities (²²⁴Ra and ²²⁸Th). Radium isotope disequilibrium …


“Recollecting The Told Story”: Storytelling, Activism, And The Black Maternal Health Emergency, Lamaya C. Williams Apr 2026

“Recollecting The Told Story”: Storytelling, Activism, And The Black Maternal Health Emergency, Lamaya C. Williams

English Theses & Dissertations

Storytelling is a foundational component of Black knowledge creation and transmission. This dissertation centers Black women’s stories of birth and mothering—drawing on both primary source birth stories and fictional narratives—to examine the United States’ Black Maternal Health Emergency (BMHE). The BMHE is a complex and urgent issue wherein structural racism, medical bias, and intersecting social determinants disproportionately endanger the health of Black mothers. As such, Black mothers in the United States are three times more likely to die from a pregnancy-related condition compared to their white counterparts.

This study examines the birth stories of women who survived the BMHE and …


The Effects Of Covid 19 Job Demands On Public Sector Employees’ Organizational Commitment: The Mediating Roles Of Work Engagement And Job Burnout, And The Moderating Role Of Supervisor Support, Benjamin R. Kaufman Apr 2026

The Effects Of Covid 19 Job Demands On Public Sector Employees’ Organizational Commitment: The Mediating Roles Of Work Engagement And Job Burnout, And The Moderating Role Of Supervisor Support, Benjamin R. Kaufman

Psychology Theses & Dissertations

United States citizens rely on state government employees to provide essential public services. During the COVID-19 pandemic, these employees responded by administering both routine and novel procedures to protect public health, often placing them on the frontlines and at increased risk of contagion. Concurrently, the pandemic-driven economic downturn created budget shortfalls that threatened the job and financial security of the state workforce. Together, these conditions substantially increased job demands for state government employees.

Guided by the Job Demands–Resources (JDR) Model, this study examined how COVID‑19-related job demands influenced state employees’ work engagement, job burnout, and organizational commitment, and whether supervisor …


Program: Virginia Academy Of Science 104th Annual Meeting, 2026, Virginia Academy Of Science Apr 2026

Program: Virginia Academy Of Science 104th Annual Meeting, 2026, Virginia Academy Of Science

Virginia Journal of Science

Full program of the 104th Annual Meeting of the Virginia Academy of Science. Held at  Christopher Newport University, Newport News, Virginia on May 28, 2026.


Proceedings Of The 104th Annual Virginia Academy Of Science Meeting, 2026, Virginia Academy Of Science Apr 2026

Proceedings Of The 104th Annual Virginia Academy Of Science Meeting, 2026, Virginia Academy Of Science

Virginia Journal of Science

Proceedings (abstracts) of the 104th Annual Meeting of the Virginia Academy of Science, May 28, 2026, at Christopher Newport University, in Newport News, Virginia.


A Test Case For Raccoon Roundworm Anthelmintic Baiting In Western Virginia, Karen Powers, W. Jayme Viers, Carolyn K. Rossmeisl, L Kristen Page Apr 2026

A Test Case For Raccoon Roundworm Anthelmintic Baiting In Western Virginia, Karen Powers, W. Jayme Viers, Carolyn K. Rossmeisl, L Kristen Page

Virginia Journal of Science

As a test case to determine the efficacy of anthelmintic baiting to reduce raccoon roundworm (Baylisascaris procyonis) prevalence in western Virginia, we deployed baits in a mountainous area of Roanoke Co., Virginia that historically was occupied by Allegheny woodrats (Neotoma magister). We deployed anthelmintic baits at 6-wk intervals from August to December 2024 at a density of 100/km2. We opportunistically collected raccoon (Procyon lotor) scat in the drop area from August 2024 to May 2025 and found a marked decline in prevalence of raccoon roundworm in the samples. Deeming this a measured …


Production Of Black And Navy Beans In Virginia, Harbans L. Bhardwaj, Satya S. S. Narina Ph.D. Apr 2026

Production Of Black And Navy Beans In Virginia, Harbans L. Bhardwaj, Satya S. S. Narina Ph.D.

Virginia Journal of Science

An urgent need exists in Virginia and adjoining states to identify crops to replace declining tobacco acreage. Although not traditionally grown in the region, dry beans (Phaseolus vulgaris L.) have considerable potential as alternative summer crops due to their nutritional benefits and increasing consumer demand. Information on the production potential of these crops in Virginia, however, is not yet available. To remedy this situation, replicated field trials were conducted over three years with six black and four navy bean varieties to characterize grain yields following three row spacings and three planting times. Black beans significantly out-yielded navy beans (2095 …


Enhancing Urban Garden Capacity By Linking Biodiversity And Ecosystem Function, Mary T. Nguyen, Carleen Rauh, Shelby Gresch, Charlotte Correiro, Heidi Elmendorf, Adriane Fugh-Berman, Gina Wimp, Alexandra L. Decandia Apr 2026

Enhancing Urban Garden Capacity By Linking Biodiversity And Ecosystem Function, Mary T. Nguyen, Carleen Rauh, Shelby Gresch, Charlotte Correiro, Heidi Elmendorf, Adriane Fugh-Berman, Gina Wimp, Alexandra L. Decandia

Virginia Journal of Science

Urban agriculture broadly describes food and plant cultivation in metropolitan areas. While biodiversity is thought to support ecosystem health and resilience, the relationship between above-ground and below-ground diversity has been understudied in urban green spaces. This study examines plant, animal, bacterial, and fungal diversity across three distinct urban habitats: a turf lawn, a forb garden, and a farming space. Using bacterial 16S rRNA and fungal ITS2 sequencing, soil nutrient analyses, and surveys of vegetation and wildlife, we connect diverse philosophies in urban agriculture to their role in advancing community diversity and ecosystem function. We found that different urban gardens support …


The Physiology Of The Work: Chronic Stress, Allostatic Load, And Faculty Wellness In Counselor Education, Ajayla S. Evins Apr 2026

The Physiology Of The Work: Chronic Stress, Allostatic Load, And Faculty Wellness In Counselor Education, Ajayla S. Evins

Counseling & Human Services Theses & Dissertations

Counselor educators embody multifaceted professional roles across teaching, supervision, research, leadership, and service, exerting a profound influence on the formation of counselors and the ongoing development of the profession (CACREP, 2024; Calley & Hawley, 2008). While wellness is recognized as a core professional value in counseling (ACA, 2014), research has focused almost exclusively on emotional and psychological dimensions, leaving the physiological consequences of chronic stress largely underexplored (Bovee, 2024; Faheem et al., 2025; Lewis et al., 2022). In neighboring fields, such as public health and medicine, chronic stress has been linked to dysregulation in cardiovascular, neuroendocrine, immune inflammatory, and metabolic …


Bioengineering The Future Of The Human Species: H+’S Ideological Iterations Of Trans-/Posthumanity As Exemplified By Futurist Literary Texts = (Bio)Technological Solutions For (And/Or) Reification Of Systemic Inequities?, Marjorie E. Bomhower Apr 2026

Bioengineering The Future Of The Human Species: H+’S Ideological Iterations Of Trans-/Posthumanity As Exemplified By Futurist Literary Texts = (Bio)Technological Solutions For (And/Or) Reification Of Systemic Inequities?, Marjorie E. Bomhower

English Theses & Dissertations

While humanity has, throughout our species’ history, endeavored to dream and create astonishing, and ever-evolving, (bio)technologies with the utopian ideals of bettering our day-to day lives and achieving greater longevity, our endeavors have (thus far) not only produced remarkable, beneficial advances in longevity and quality of life, but have also yielded devastating and dire outcomes; often at the cost and victimization of marginalized communities. This dissertation focuses on select (bio)technologies – particularly, those promoted by H+ (the most current and popular technoutopianist non-profit, “educational,” organization) – with an investigation of current and nascent (bio)technological evolutions, futurist literary texts, and critical/digital …


Fabrication Of Flexible Laser-Induced Graphene-Based Non-Enzymatic Glucose Sensor For Diabetes Management, Reagan Aviha Apr 2026

Fabrication Of Flexible Laser-Induced Graphene-Based Non-Enzymatic Glucose Sensor For Diabetes Management, Reagan Aviha

Electrical & Computer Engineering Theses & Dissertations

This research focuses on developing a flexible non-enzymatic glucose sensor to address the issues of cost, stability, and limited sensitivity associated with enzymatic glucose sensors. Regular monitoring of glucose levels is required to manage the global health challenge of diabetes. The sensor is built on a cost-effective, durable, flexible, conductive, and high-surface-area substrate acting as a scaffold for modification with easily tunable and electroactive species to enhance glucose detection. The electroactive materials used are zinc oxide (ZnO), palladium (Pd) and platinum (Pt). Laser-induced graphene (LIG) is created by laser engraving. ZnO, Pd and Pt are electrochemically deposited and optimized based …


Swimming Behavior Of Longfin Squid Doryteuthis Pealeii Paralarvae: Escape Jets To Pirouettes, Mel Lhuillier Apr 2026

Swimming Behavior Of Longfin Squid Doryteuthis Pealeii Paralarvae: Escape Jets To Pirouettes, Mel Lhuillier

Biological Sciences Theses & Dissertations

Upon hatching, squid paralarvae must become proficient at locomotion and prey capture before their yolk reserves are depleted, while also contending with the physical constraints associated with low/intermediate Reynolds number (Re) environments. Although some aspects of behavior and jet dynamics have been examined in squids during early ontogeny, little is known about routine behaviors in paralarvae, whether repeatable patterns are employed, or how these behaviors are achieved dynamically. To better understand swimming behaviors and the propulsive flows that drive them in paralarvae, high-speed video data and digital particle image velocimetry (DPIV) data were collected simultaneously from longfin squid Doryteuthis pealeii …


A Critical Discourse Analysis Of Community College Presidential Job Announcements And The American Association Of Community Colleges Competencies For Community College Leaders, Leslie M. Boon Apr 2026

A Critical Discourse Analysis Of Community College Presidential Job Announcements And The American Association Of Community Colleges Competencies For Community College Leaders, Leslie M. Boon

Educational Leadership & Workforce Development Theses & Dissertations

Women are overrepresented as students and employees of community college, yet they are underrepresented in presidential leadership roles. Prior research has examined the career trajectories and experiences of women aspiring to community college presidencies; however, less research has examined how discourse shapes expectations of leadership. Because community colleges have been described as gendered, the language used to describe leadership competencies may reinforce gendered assumptions about effective leadership. The purpose of this study was to examine the discourse of community college presidential job announcements and the American Association of Community Colleges’ (AACC) Competencies for Community College Leaders (4th edition) to examine …


Profiles Of Science Students’ Achievement Emotions: An Exploration Of Motivational Antecedents And Persistence Outcomes Over Time, Arianna White-Levatich Apr 2026

Profiles Of Science Students’ Achievement Emotions: An Exploration Of Motivational Antecedents And Persistence Outcomes Over Time, Arianna White-Levatich

Educational Leadership & Workforce Development Theses & Dissertations

This is a longitudinal study focused on the importance of students’ beliefs and emotions for their persistence in science majors. The primary goals of this study are threefold. First, to examine how undergraduate science students’ academic achievement emotions combine into profiles across two time points in the context of introductory Chemistry and Biology Courses. Second, to examine how students’ beliefs and perceptions of belonging relate to profile membership and to the likelihood that students will transition between profiles of emotions over time. Third, to evaluate how emotion profile membership and transition are related to students’ intentions to pursue science and …


Women's Displacement And The Reclamation Of Identity: Navigating Landscapes Of Contestation In The Postcolonial Novel, Carol P. Harvest Apr 2026

Women's Displacement And The Reclamation Of Identity: Navigating Landscapes Of Contestation In The Postcolonial Novel, Carol P. Harvest

English Theses & Dissertations

Landscapes affected by colonial domination are contested landscapes—places not only in danger of environmental destruction through colonial and neocolonial violence but also landscapes of struggle for people who survive in these precarious spaces. Historically, separate postcolonial and ecocritical literary analysis addressed contested landscapes; postcolonial critique centered on the lasting devastation of colonial violence on people and place, while ecocriticism, in its infancy, enjoyed the privilege of ignorance, focusing on endangered species and the preservation of land, but it did not consider the impact of landscapes on the very people who were largely forced to either leave or cross “natural” spaces. …


Dissecting The Etiology Of Alcohol Use Disorder By An Integrative Heritable Component Approach, Ivy Garrenton Apr 2026

Dissecting The Etiology Of Alcohol Use Disorder By An Integrative Heritable Component Approach, Ivy Garrenton

Computer Science Theses & Dissertations

Alcohol Use Disorder (AUD) is a pervasive condition characterized by complex interplay among genetic, phenotypic, and environmental factors. Although previous studies have identi fied genetic loci associated with alcohol consumption, these efforts have not captured the genetic heterogeneity and gene-environment interactions underlying AUD pathogenesis. To address this critical gap, we developed a novel statistical methodology that integrates phenotypic, genotypic, and environmental data through an environmentally modified Genetic Relationship Matrix (GRM) to derive AUD-related traits with enhanced heritability.

This approach demonstrated superior performance in both simulated and real-world datasets. Traits derived using the environmentally modified GRM exhibited significantly higher estimated heritability …


Role Of Listeria Adhesion Protein In Monocyte-Associated And Extracellular Translocation Of Listeria Monocytogenes Across The In Vitro Placental Barrier Co-Culture Model, Ayesha Atique Apr 2026

Role Of Listeria Adhesion Protein In Monocyte-Associated And Extracellular Translocation Of Listeria Monocytogenes Across The In Vitro Placental Barrier Co-Culture Model, Ayesha Atique

Biological Sciences Theses & Dissertations

Listeria monocytogenes is a facultative intracellular foodborne pathogen capable of crossing the placental barrier, leading to miscarriage, stillbirth, and neonatal sepsis, and has a fetal/neonatal fatality rate of ~20–30%. Although the importance of canonical virulence factors such as Internalin A (InlA) and Internalin B (InlB) in L. monocytogenes crossing of the placental barrier has been demonstrated, clinical strains lacking functional canonical internalins have been reported to cause severe neonatal disease, suggesting additional mechanisms of placental translocation.

To investigate these virulence mechanisms, we adapted a physiologically relevant co-culture human placental barrier Transwell model composed of BeWo trophoblasts and primary human placental …


Learning Techniques In Prediction Of Functional Epigenomic Events, Mohammad Shiri Apr 2026

Learning Techniques In Prediction Of Functional Epigenomic Events, Mohammad Shiri

Computer Science Theses & Dissertations

Accurately predicting functional epigenomic events from DNA sequences is critical to understanding gene regulation and the functional impact of non-coding variants. Despite considerable progress, critical challenges hamper the effectiveness and efficiency of existing deep learning approaches. These challenges include negative transfer in multi-task learning (MTL), suboptimal network architectures, and pervasive label noise, particularly the positive-unlabeled problem arising from data sparsity in single-cell assays. This dissertation presents a cohesive framework of novel learning techniques to effectively address these challenges. First, a highly scalable task grouping framework is presented to mitigate negative transfer in deep MTL. This method clusters tasks based on …