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Sharksrx Newsletter Summer 2023, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Perspectives, Spring 2022, Volume 10, Number 1, Nova Southeastern University

Perspectives

"Perspectives" was the College of Health Care Sciences' official magazine that connects students, faculty and staff from CHCS’s academic programs all over the state of Florida.

Sharksrx Newsletter Spring 2023, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Using 3d Modeling To Describe The Electromotility Of The Outer Hair Cell Protein Prestin, And Its Role In Sound Perception Among Mammals, Marqus Colon, Syed Hussain, Russel Robert Reside, Emily Schmitt-Lavin, Arthur Sikora

Protein Modeling Reports

Prestin is one of the key motor proteins that has been identified in enabling auditory perception in mammals. By modulating its electromotility in response to changes in environmental voltage, prestin contracts and elongates in the plasma membrane of cochlear outer hair cells (OHCs). This allows different frequencies of sound to be processed quickly and precisely. Belonging to the SLC26A5 family of anion transporters, prestin is especially adept at binding anions in order to facilitate its oscillation through a series of unique conformations. Previous research has demonstrated that prestin is reversibly inhibited in the presence of salicylate. However, the broader mechanisms …

Drug-Excipient Interactions, Maria Ballester

Biophysical Chemistry Laboratory Manual

No abstract provided.

Bomb Calorimeter, Maria Ballester, Arthur Sikora

Biophysical Chemistry Laboratory Manual

The purpose of this laboratory is to determine the heat of combustion of a sample of sugar and artificial sweeteners by using an IKA Bomb Calorimeter (C200si).

Formation Of Iron(Iii) Thiocyanate - Stopped Flow, Maria Ballester, Victor Castro

Biophysical Chemistry Laboratory Manual

The purpose of this laboratory is to determine the equilibrium constant and the forward and reverse rate constants for the formation of Iron(III) Thiocyanate.

Calculating Avogadro's Number, Maria Ballester, Victor Castro Ph.D.

Biophysical Chemistry Laboratory Manual

The value of Avogadro's number is found by using kinetic theory along with (a) the volume change upon sublimation of a small quantity of dry ice (CO₂), and (b) the diffusion length, as a function of time, of iodine in air at a certain temperature.

Apparent Dissociation Constant Of A Porphyrin, Maria Ballester, Victor Castro

Biophysical Chemistry Laboratory Manual

The purpose of this laboratory is to determine the apparent acid dissociation constant, 𝐾_a, by estimating the p𝐾_a value of a porphyrin using visible spectrophotometry. This apparent p𝐾_a value is measured by graphic interpolating the absorbance changes obtained at varied wavelengths for different acid concentrations using the Henderson–Hasselbach equation.

Introduction To 2-D Plots With Excel, Maria Ballester, Victor Castro Ph.D.

Biophysical Chemistry Laboratory Manual

No abstract provided.

Modeling The Binding Of Tetrodotoxin And Saxitoxin To The Nav1.7 Voltage-Gated Sodium Channel, Isabella G. Fiore, Smrithi Mukund, Laasya Buddharaju

Protein Modeling Reports

Approximately 1.5 billion people suffer from chronic pain, with 68 million people suffering in the U.S alone. Chronic pain is defined as pain that persists longer than 12 weeks despite medication or treatment. Within the U.S, about 5.5 million cancer patients experience chronic pain. Around 20% of these cancer pains have neuropathic origins and develop from radiation therapy. Halneuron, a new drug currently in development, seeks to provide pain relief to those suffering from chemotherapy-induced neuropathic pain. This drug includes Tetrodotoxin (TTX), a potent neurotoxin found in most species of pufferfish, as its main active ingredient. Our 3D printed model …

Modeling Cysteinyl Leukotriene Receptor Antagonist Knw For Possible Optimized Asthma Treatment, Shalet James, Sreejani Jonnalagadda, Emily Schmitt Lavin, Arthur Sikora

Protein Modeling Reports

Underdiagnosed and under-treated, particularly in low- and middle-income countries, asthma has affected 262 million people globally. Current anti-asthmatic medications such as pranlukast inhibit cysteinyl leukotriene receptor 1 (CysLT1R), yet many patients do not respond to this drug. CysLT1R is associated with bronchoconstriction, inflammation, and mucus production in the airways of the lungs and bronchial tissues. When cysteinyl leukotrienes bind to CysLT1R, these effects are triggered contributing to the symptoms of asthma. The potential role of the related receptor CysLT2 in asthma remains poorly understood. To better understand this process, CysLT2R has been identified as a promising drug target for not …

Identifying The Binding Residues On Cyp3a4 To Naringin Using Protein Modeling And Docking, Parth Shah, Vraj Patel, Sanjana Ananthula, Emily Schmitt Lavin, Arthur Sikora

Protein Modeling Reports

Cytochrome (CYP) enzymes are a superfamily of monooxygenase hemoprotein enzymes that are found throughout the body but are heavily concentrated in the endoplasmic reticulum and mitochondria of liver cells. These enzymes catalyze reactions that modify a wide range of substrates into more hydrophilic and, therefore, more readily excreted forms. Cytochrome enzymes are heavily involved in the detoxification process of many medically relevant drugs. As such, the inhibition and activation of these enzymes can substantially alter the effective bioavailability of medications and can introduce additional variables or modifiable variables into a pharmacological-based treatment.

Cytochrome p450 3A4 (CYP3A4) is one of the …

Modeling Calcium Binding To Yersinia Pestis Type Iii Secretion Needle, Kaya Olszewski, Priyanka Prasanna, Chetana Movva, Arthur Sikora, Emily Schmitt Lavin, Julie Torruellas Garcia

Protein Modeling Reports

A type III secretion system (T3SS) is utilized by a variety of bacteria to inject toxins into host cells to cause disease, including Yersinia pestis, the bacterium that causes the bubonic plague. The Y. pestis T3SS needle subunit is a polymer made up of YscF proteins. Calcium is thought to play a role in regulation of toxin secretion by the YscF needle. High levels of Ca2+ binding inhibit secretion while low levels of Ca2+ binding cause secretion to be stimulated. According to a study done in 2005 by Torruellas et. al, different mutations of YscF can interfere with secretion regulation, …

Review Of The Central And South Atlantic Shelf And Deep-Sea Benthos: Science, Policy, And Management, Amelia E.H. Bridges, Kerry L. Howell, Teresa Amaro, Lara Atkinson, David K. A. Barnes, Narissa Bax, James B. Bell, Angelo F. Bernardino, Lydia Beuck, Andreia Braga-Henriques, Angelika Brandt, María E. Bravo, Saskia Brix, Stanley Butt, Alvar Carranza, Brenda L. Doti, Isa O. Elegbede, Patricia Esquete, André Freiwald, Sylvie M. Gaudron, Maila Guilhon, Dierk Hebbeln, Tammy Horton, Paulus Kainge, Stefanie Kaiser, Daniel Lauretta, Pablo Limongi, Kirsty A. Mcquaid, Rosanna J. Milligan, Patricia Miloslavich, Bhavani E. Narayanaswamy, Covadonga Orejas, Sarah Paulus, Tabitha R. R. Pearman, Jose Angel A. Perez, Rebecca E. Ross, Hanieh Saeedi, Mauricio Shimabukuro, Kerry Sink, Angela Stevenson, Michelle Taylor, Jürgen Titschack, Rui P. Vieira, Beatriz Vinha, Claudia Wienberg

Marine & Environmental Sciences Faculty Books and Book Chapters

128 129The Central and South Atlantic represents a vast ocean area and is home to a diverse range of ecosystems and species. Nevertheless, and similar to the rest of the global south, the area is comparatively understudied yet exposed to increasing levels of multisectoral pressures. To counteract this, the level of scientific exploration in the Central and South Atlantic has increased in recent years and will likely continue to do so within the context of the United Nations (UN) Decade of Ocean Science for Sustainable Development. Here, we compile the literature to investigate the distribution of previous scientific exploration of …

Pchcs Link (Inaugural Issue), Winter/Spring 2023, Nova Southeastern University

Perspectives

PCHCS LINK (which replaced Perspectives), an official magazine of the College of Health Care Sciences, connects students, faculty and staff from CHCS’s academic programs all over the state of Florida.

Sharksrx Newsletter Fall 2022, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Sharksrx Newsletter Summer 2022, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Com Outlook (Winter/Spring 2022 - Volume 23 Number 1), Nova Southeastern University

COM Outlook

No abstract provided.

Sharksrx Newsletter Spring 2022, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Experiment 2.05: Wheatstone Bridge, Diego Castano

Physics Lab Experiments with Simulated Data for Remote Delivery

The Wheatstone Bridge is used to determine the resistances of five resistors.

Experiment 2.04: Kirchhoff’S Laws, Diego Castano, Andrew Kiene

Physics Lab Experiments with Simulated Data for Remote Delivery

A non-trivial resistor arrangement is analyzed

Experiment 2.06: Series Rc Dc-Circuit, Diego Castano, Victor Castro

Physics Lab Experiments with Simulated Data for Remote Delivery

The capacitances of two unknown capacitors are determined examining their charging behavior.

Experiment 2.02: Electric And Potential Fields, Diego Castano

Physics Lab Experiments with Simulated Data for Remote Delivery

Electric field line maps for three 2-dimensional charge distributions are determined using a voltmeter.

Experiment 2.03: Ohm’S Law, Diego Castano, Victor Castro

Physics Lab Experiments with Simulated Data for Remote Delivery

The resistances of three resistors are determined by varying the applied voltage and measuring the resulting current.

Experiment 2.01: Coulomb’S Law, Diego Castano

Physics Lab Experiments with Simulated Data for Remote Delivery

The charge resulting from the static electrification of a Teflon plate is determined through its interaction with a neutral conducting sphere.

Experiment 2.09: Reflection And Refraction, Diego Castano, Victor Castro

Physics Lab Experiments with Simulated Data for Remote Delivery

The laws of geometrical optics are studied by tracking light rays refracting across an air-glass boundary and reflecting off convex and concave mirrors.

Experiment 2.08: Series Rlc Ac-Circuit, Diego Castano, Victor Castro

Physics Lab Experiments with Simulated Data for Remote Delivery

Using the resonant behavior of a circuit consisting of a coil and known capacitor, the coil’s self-inductance and resistance are determined.

Experiment 2.07: Magnetic Field Of The Earth, Diego Castano, Victor Castro

Physics Lab Experiments with Simulated Data for Remote Delivery

The earth’s horizontal component of magnetic field is determined using a tangent galvanometer.

Experiment 2.10: Lenses, Diego Castano, Victor Castro

Physics Lab Experiments with Simulated Data for Remote Delivery

The focal lengths of converging and diverging lenses are determined.