Digital Commons Network^™

The Characteristics Of Digital Transformation Leadership: Theorizing The Practitioner Voice, Pat Mccarthy, David Sammon, Ibrahim Alhassan

Department of Computer Science Publications

Digital Transformation (DT) is more than simply integrating a new digital technology into the organization. Despite a growing volume of research, however, there is little coverage of the characteristics of DT leadership. Using a grounded approach, where 16 practitioner voices are central to the theorizing output, we present 10 DT leadership characteristics. Each characteristic links what action a DT leader needs to take and how a DT leader enables that action. We also asked 30 DT leaders to evaluate the importance of each of the 10 DT leadership characteristics. Our approach strengthens the relevance for practitioners striving for the best …

Assessing The Role Of Public Policy In Fostering Global Eco-Innovation, Phaninee Naruetharadhol, Aisling Conwaylenihan, Helen Mcguirk

Publications

The growing urgency of environmental problems, such as climate change, pollution, and waste management, has highlighted the importance of eco-innovation. It includes the development of sustainable solutions for goods and services. As corporations adopt sustainability practices, governments are increasingly essential in propelling eco-innovation.

Innovation and economic growth are inextricably linked since innovation helps reduce costs, increases productivity, and builds knowledge. Eco-innovation, requiring stakeholders' collaboration and knowledge sharing where public policy plays a critical role in fostering eco-innovation, is frequently catalyzed by climate change and environmental issues.

This paper provides an assessment of the public policy of several countries and its …

Farm Electricity System Simulator (Fess): A Platform For Simulating Electricity Utilisation On Dairy Farms, F. Buckley, J. Upton, R. Prendergast, L. Shalloo, Michael D. Murphy

Publications

The objective of this paper was to define, validate and demonstrate a model capable of accurately simulating dairy farm electricity consumption across varying herd and parlour sizes, to facilitate research investigating renewable energy systems (RES) and demand side management (DSM). The Farm Electricity System Simulator (FESS) was developed using grey-box modelling techniques utilizing empirical data for parameter tuning. Empirical data were gathered from nine spring calving, pasture based dairy farms located in the Republic of Ireland. A k-means clustering analysis was conducted, separating the farms into three, near homogenous groups, from which representative farms were selected. FESS was trained using …

Optimal Environmental And Economic Performance Trade-Offs For Fifth Generation District Heating And Cooling Network Topologies With Waste Heat Recovery, Michael D. Murphy

Publications

Network topology greatly influences both the economic and environmental performance of fifth generation district heating and cooling (5GDHC) systems. In this study the optimal trade-offs between the environmental and economic performance of 5GDHC network topologies for a five-building district with waste heat recovery were explored. A life cycle assessment method was used to calculate the total life cycle CO2 emissions (LCCO2) associated with the installation and operation of various network topologies. Twelve months of empirical data from a data center cooling system were analyzed to assess its suitability for integration into a 5GDHC system. The most suitable method for utilizing …

Unravelling The Genetic Basis Of Schizophrenia, Clara Casey, John F. Fullard, Roy D. Sleator

Department of Biological Sciences Publications

Neuronal development is a highly regulated mechanism that is central to organismal function in animals. In humans, disruptions to this process can lead to a range of neurodevelopmental phenotypes, including Schizophrenia (SCZ). SCZ has a significant genetic component, whereby an individual with an SCZ affected family member is eight times more likely to develop the disease than someone with no family history of SCZ. By examining a combination of genomic, transcriptomic and epigenomic datasets, large-scale ‘omics’ studies aim to delineate the relationship between genetic variation and abnormal cellular activity in the SCZ brain. Herein, we provide a brief overview of …

Review Of Methodological Decisions In Life Cycle Assessment (Lca) Of Biorefinery Systems Across Feedstock Categories, James Gaffey, Maurice N. Collins, David Styles

Publications

The application of life cycle assessment (LCA) to biorefineries is a necessary step to estimate their environmental sustainability. This review explores contemporary LCA biorefinery studies, across different feedstock categories, to understand approaches in dealing with key methodological decisions which arise, including system boundaries, consequential or attributional approach, allocation, inventory data, land use changes, product end-of-life (EOL), biogenic carbon storage, impact assessment and use of uncertainty analysis. From an initial collection of 81 studies, 59 were included within the final analysis, comprising 22 studies which involved dedicated feedstocks, 34 which involved residue feedstocks (including by-products and wastes), and a further 3 …

Performing Distributed Quantum Calculations In A Multi-Cloud Architecture Secured By The Quantum Key Distribution Protocol, Jose Luis Lo Huang, Vincent C. Emeakaroha

Department of Computer Science Publications

Quantum computing (QC) is an emerging area that yearly improves and develops more advances in the number of qubits and the available infrastructure for public users. Nowadays, the main cloud service providers (CSP) are implementing different mechanisms to support access to their quantum computers, which can be used to perform small experiments, test hybrid algorithms and prove quantum theories. Recent research work have discussed the low capacity of using quantum computers in a single CSP to perform quantum computation that are needed to solve different experiments for real world problems. Thus, there are needs for computing powers in the form …

A Note On Umbilic Points At Infinity, Brendan Guilfoyle

Publications

In this note a definition of umbilic point at infinity is proposed, at least for surfaces that are homogeneous polynomial graphs over a plane in Euclidean 3-space. This is a stronger definition than that of Toponogov in his study of complete convex surfaces, and allows one to distinguish between different umbilic points at infinity. It is proven that all such umbilic points at infinity are isolated, that they occur in pairs and are the zeroes of the projective extension of the third fundamental form, as developed in Guilfoyle and Ortiz-Rodríguez (Math Proc R Ir Acad 123A(2), 63–94, 2023). A geometric …

Investigation Of The Growth Of Listeria In Plant-Based Beverages, Klaudia Bartula, Sambou Biagui, Máire Begley, Michael Callanan

Department of Biological Sciences Publications

The objective of the present study was to evaluate whether the content of sugar, protein, fat, or fibre in commercially available and specially formulated plant-based beverages (oat, soya and pea) influences the growth rates of Listeria. Beverages were inoculated with a strain cocktail of Listeria (approximately 1 × 103 CFU/mL), and the data demonstrated that Listeria could proliferate in all tested beverages. Moreover, varying concentrations of naturally occurring or added sugar (0–3.3%), protein (3.3–5%), fat (1.1–3.5%) and added fibre (0–1.5%) did not have a statistically significant (p > 0.05) impact on the growth rates of Listeria in the tested …

Turbidimetric Bioassays: A Solution To Antimicrobial Activity Detection In Asymptomatic Bacteriuria Isolates Against Uropathogenic Escherichia Coli, Ciara Kenneally, Craig P. Murphy, Roy D. Sleator, Eamonn P. Culligan

Department of Biological Sciences Publications

Traditional bacteriocin screening methods often face limitations due to diffusion-related challenges in agar matrices, which can prevent the peptides from reaching their target organism. Turbidimetric techniques offer a solution to these issues, eliminating diffusion-related problems and providing an initial quantification of bacteriocin efficacy in producer organisms. This study involved screening the cell-free supernatant (CFS) from eight uncharacterized asymptomatic bacteriuria (ABU) isolates and Escherichia coli 83972 for antimicrobial activity against clinical uropathogenic E. coli (UPEC) strains using turbidimetric growth methods. ABU isolates exhibiting activity against five or more UPEC strains were further characterized (PUTS 37, PUTS 58, PUTS 59, S-07-4, and …

Genomic Analysis Of Seven Mycobacteriophages Identifies Three Novel Species With Differing Phenotypic Stabilities, Laura O'Connell, Aidan Coffey Prof., Jim O'Mahony

Department of Biological Sciences Publications

Recently, case studies have been published regarding the application of mycobacteriophage (MP) therapy (MPT) in patients with multi-antibiotic-resistant infections. A major limitation in the development of MPT is the paucity of therapeutically useful MP. As there are approximately 10,000 MP that have yet to be sequenced, it is possible that characterization of this cohort would increase the repertoire of useful MP. This study aims to contribute to such a strategy, by characterizing a cohort of 7 mycobacteriophages. Sequencing analyses revealed that the MP have unique sequences, and subsequent gene annotation revealed differences in gene organization. Notably, MP LOCARD has the …

Bringing Open Science Training Back To Basics: The Foundations In Open Science Oer, Sinéad Hanrahan

Publications

Open Science (OS) seeks to apply the concept of openness across all stages of research practice. It aims to facilitate the dissemination of research at speed and to foster collaboration between researchers (Foster Open Science, 2023). OS is an essential aspect of Responsible Research Practice (ALLEA, 2017) and integral to addressing the complex problems facing the world (UNESCO, 2021). It is thus imperative that research performing organisations provide effective OS training. Anecdotal evidence gleaned over five years of OS Training provision suggests that researchers have less understanding of foundational research practices than library OS instructors anticipate. This further suggests that …

Investigating The Accuracy And Comparability Of Various Lime Prediction Methods For Irish Grassland Mineral Soils, F. Mackessy, E. Mccarthy, E. Broderick, B. O'Donnell, Patrick Quille

Publications

Soil pH is a foundational element of agronomy, profoundly influencing biological, chemical and physical soil processes. Adjusting soil pH is a paramount factor for enhancing soil health and productivity with far-reaching environmental benefits. Over time soil naturally tends towards acidity, a process expedited by intensive agriculture practices. To determine the extent of necessary pH corrections, precise soil pH testing is imperative. Various methods including buffer systems, titrations, lime incubations and algorithms considering soil texture are used to assess a soil's lime requirement and each method carries distinct advantages and disadvantages. The Shoemaker–McLean–Pratt (SMP) buffer method is extensively used in Ireland …

Maximizing Ev Profit And Grid Stability Through Virtual Power Plant Considering V2g, A. Selim Türkoğlu, H. Cihan Güldorum, Ibrahim Sengor

Dept. of Electrical & Electronic Engineering Publications

The electrification of transportation through the widespread adoption of electric vehicles (EVs) has raised substantial concerns within the realm of power grid operations. This concern predominantly stems from the elevated electricity demand brought about by the surging population of EVs, consequently exerting strain on the power grid infrastructure which can be reduced with vehicle-to-grid (V2G) technology integration. To address this issue, this paper delves further into the realm of grid integration by introducing a Virtual Power Plant (VPP) concept to enhance the synergy between EVs and power grid. This study aims to compare different realistic objectives, ranging from total active …

Differential Effects Of Fucus Vesiculosus Fucoidan On Fibroblast And Macrophage Cell Lines Inflammatory Activation, Aleksandra Augustyniak, Joanna Przyborska, Helena Mcmahon

Publications

It is estimated that more than one-third of people aged over 16 reported living with inflammation-related chronic illness. Fucoidan, sulfated polysaccharide, has been proven to modulate immune response and inhibit inflammation in both in vitro and in vivo research. In the present study the effect of commercially available fucoidan from Fucus vesiculosus (with purity 97%) on immune response was investigated. Two cell lines, human fibroblasts (HDFa) and mouse macrophages (J774A.1) were used in the study. Cells were activated with pro-inflammatory stimulus (LPS/IFN-γ or PMA) and treated with fucoidan. Results of NO inhibition assay revealed that fucoidan has anti-inflammatory activity and …

Optimal Growth And Development: Are Teenagers Getting Enough Micronutrients From Their Diet?, Niamh M. Walsh, Albert Flynn, Janette Walton, Laura Kehoe

Department of Biological Sciences Publications

The teenage years represent a crucial period of physical and cognitive growth and development with sufficient micronutrient intakes necessary to meet high nutritional requirements. This review examines current micronutrient intakes in teenagers in the Western world in the context of public health implications including the prevalence of inadequate intakes and risk of excessive intakes. Intakes of vitamins A, D, E and C, folate, calcium, iron, magnesium, zinc and potassium in teenagers are low when compared to generally accepted recommendations, while there is little risk of excessive micronutrient intakes based on current dietary patterns. Therefore, strategies should focus on increasing micronutrient …

Where’S The E In Oe? A Critical Analysis Of Irish Outdoor Education, John Pierce, Simon Beames

Publications

Very little empirical research has been conducted on Irish outdoor education practice(s). This inquiry aims to critically explore outdoor education practices in public Outdoor Education and Training Centres in the Republic of Ireland. First, an overview of the development of Irish outdoor education from the mid-twentieth century onwards is provided to locate the study within its unique cultural and historical background. Data were generated through document analysis, participant observation, and informal conversation with practitioners and management through multiple field visits. Creative non-fiction was used as a method to organise and present the data in a coherent and anonymised manner. Thematic …

Connecting In A Remote World: Psychotherapy & Counselling Students’ Experiences Of Remote Teaching And Learning, Geraldine Sheedy

Dept of Applied Social Science

In 2017 Scholl et al. highlighted a growing trend towards online courses in Psychotherapy & Counselling training. With the emergence of the Coronavirus (COVID-19) pandemic, this growth has accelerated, with more training now taking place in an online setting. This study explored students’ experiences of remote learning on a Psychotherapy & Counselling training, with a particular focus on engagement and interaction in an online setting. A Thematic Analysis was carried out on the data and the central organising theme of Connection emerged. Three sub-themes were identified including, ‘Connection to Self’, ‘Connection to Others’ and ‘Connection to Lecturers’. Findings indicate that …

Current Perspectives And Challenges In The Estimation Of Fruit Juice Consumption Across The Lifecycle In Europe, Janette Walton

Department of Biological Sciences Publications

Fruit juice (FJ) is typically low in energy, contains natural sugars, important amounts of micronutrients and is not permitted to have added sugars/sweeteners. However, its role in a healthy diet is under scrutiny partly due to the wider adoption of the definition for free sugars in nutrition policy. This review aimed to identify data on FJ consumption from national food consumption surveys across Europe, to examine current intakes, percent consumers and its contribution to intakes of energy, total sugars, free sugars, vitamin C, folate and potassium. Data were extracted on the population mean intake of FJ and its contribution to …

Euler’S Prime-Producing Polynomial Revisited, Robert Heffernan, Nick Lord, Des Machale

Department of Mathematics Publications

Euler’s polynomial f (n) = n2 + n + 41 is famous for producing 40 different prime numbers when the consecutive values 0, 1, …, 39 are substituted: see Table 1. Some authors, including Euler, prefer the polynomial f (n − 1) = n2 − n + 41 with prime values for n = 1, …, 40. Since f (−n) = f (n − 1), f (n) actually takes prime values (with each value repeated once) for n = −40, −39, …, 39; equivalently the polynomial f (n − 40) = n2 − 79n + 1601 takes (repeated) prime values …

Exploring Definitions Of Daily Enteric Methane Emission Phenotypes For Genetic Evaluations Using A Population Of Indoor-Fed Multi-Breed Growing Cattle With Feed Intake Data, Clodgah V. Ryan, Thierry Pabiou, Deirdre C. Purfield, Donagh P. Berry, Stephen Conroy, Craig P. Murphy, Ross Evans

Department of Biological Sciences Publications

Genetic selection has been identified as a promising approach for reducing enteric methane (CH₄) emissions; a prerequisite for genetic evaluations; however, these are estimates of the necessary genetic parameters based on a population representative of where the genetic evaluations will be used. The objective of this study was, therefore, to derive genetic parameters for a series of definitions of CH₄, carbon dioxide (CO₂), and dry matter intake (DMI) as well as genetic correlations between CH₄, CO₂, and DMI in a bid to address the paucity of studies involving methane emissions …

A Survey On Training Challenges In Generative Adversarial Networks For Biomedical Image Analysis, Muhammad Muneeb Saad, Ruairi O'Reilly, Mubashir Husain Rehmani

Department of Computer Science Publications

In biomedical image analysis, the applicability of deep learning methods is directly impacted by the quantity of image data available. This is due to deep learning models requiring large image datasets to provide high-level performance. Generative Adversarial Networks (GANs) have been widely utilized to address data limitations through the generation of synthetic biomedical images. GANs consist of two models. The generator, a model that learns how to produce synthetic images based on the feedback it receives. The discriminator, a model that classifies an image as synthetic or real and provides feedback to the generator. Throughout the training process, a GAN …

Evanescent Wave Quartz-Enhanced Photoacoustic Spectroscopy Employing A Side-Polished Fiber For Methane Sensing, Cian F. Twomey, Gabriele Biagi, Albert A. Ruth, Marilena Giglio, Vincenzo Spagnolo, Liam O'Faolain, Anton J. Walsh

Cappa Publications

We present an all-fiber-based laser gas analyzer (LGA) employing quartz-enhanced photoacoustic spectroscopy (QEPAS) and a side-polished fiber (SPF). The LGA comprises a custom quartz tuning fork (QTF) with 0.8 mm prong spacing, two acoustic micro-resonators (mR) located on either side of the prong spacing, and a single-mode fiber containing a 17 mm polished section passing through both mRs and QTF. The SPF polished face is positioned to enable the evanescent wave (EW) to create a photoacoustic wave and excite the fundamental flexural mode of the QTF. Sensor performance was demonstrated using methane in nitrogen gas mixtures, with CH4" role="presentation" style="box-sizing: …

Towards Better Detection And Treatment Of Mycobacterial Disease., Laura O'Connell

ORBioM (Open Research BioSciences Meeting)

Background

Mycobacterial disease is a major cause of fatality, with 1.5 million deaths per 10 million infections annually. Due to the emergence of multi- and extensively-drug resistant clinical isolates, mycobacteriophage (MP) are being investigated as an alternative to antibiotics.

Objectives

The objectives of this study were: to characterise an emerging cohort of MP, to determine suitable in vivo modes of delivery for MP including encapsulation, to examine the application of a MP-based viability assay, and to examine the functionality of MP in raw milk.

Methods

The fast-growing Mycobacterium smegmatis was used as a host in all assays to demonstrate phage …

Use Of A Hydrogel Material For In-Vitro Vascular Applications: A Promising Approach For Medical Device Characterization., Wisdom Shadrach

ORBioM (Open Research BioSciences Meeting)

In recent years, there has been significant interest in creating more advanced in-vitro cell culture vascular models to improve pre-clinical screening of medical therapies and devices, and the expanding research field of hydrogels as a culture biomaterial holds promise to meet this need. Hydrogels are now commonly employed in various biomedical areas such as ophthalmology, drug delivery, and cardiovascular applications, and this is due to their unique properties such as biocompatibility and ability to mimic extracellular matrix (ECM). There remains a need for hydrogels with good bio-compatibility index that can serve as robust 3D in-vitro vascular culture material suitable for …

Investigating The Ability Of Saltwater Isolates To Inhibit Biofilm Formation By Clinically Significant Pathogens, Monica Murphy

ORBioM (Open Research BioSciences Meeting)

Background

Nosocomial pathogens are responsible for chronic and persistent infections partly due to their ability to form protective biofilms which enhance their antibiotic tolerance. Biofilm disruption combats antimicrobial resistance as dispersed cells regain antibiotic susceptibility. The goal of this study was to evaluate the antibiofilm potential of isolates from marine environments against a pathogen panel consisting of MRSA and clinical Staphylococcus aureus strains, Acinetobacter baumannii and Escherichia coli pathogens.

Method

A large bank of saltwater bacterial isolates was cultured in glucose-supplemented trypticase soy broth (TSBg) and resulting colonies were screened against the pathogen panel. Isolates of interest were further examined …

Short Chain Fatty Acid Combination Treatment Protects Against 6-Ohda And Wt Α-Synuclein Induced Decreases In Neurite Growth In In Vitro Models Of Parkinson’S Disease., Alex Morris

ORBioM (Open Research BioSciences Meeting)

Background

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron degeneration. This degeneration is partly driven by over expression of α-synuclein (α-syn) and development of α-syn aggregates known as Lewy bodies throughout the substantia nigra. As well as motor dysfunction, PD presents with several chronic gastrointestinal comorbidities, which cause a decline of gut microbial diversity and microbially derived short chain fatty acids (SCFAs). Recent in vivo studies have shown SCFAs to be neuroprotective in various degenerative disease states, suggesting that SCFAs may protect against dopaminergic degeneration.

Methods

Human neuroblastoma SH-SY5Y cells were used as a model of human …

Investigating The Effect Of Agronomic Factors On Microbiome Of Horticulture Produce, Maryada Bohra

ORBioM (Open Research BioSciences Meeting)

The ranged microbiome in fruits and vegetables contributes substantially to the health of vegetation which, in effect, benefits human health. These microorganisms undertake an extensive variety of responsibilities including flavour creation, ripening and health preservation via the production of second-generation metabolites. There is limited information however on the influence of agronomic practices such as crop ripening stage at harvest, storage, packing material and how they impact the microbiome of the crop itself. The overall role of the crop microbiome in gut health is also not fully clear.

The Meta-Hort project will examine the effects of premature harvesting along with tray …

Investigating The Thermotolerance Of Cronobacter Sakazakii In Powdered Infant Formula, Fiona Ryan O'Connor

ORBioM (Open Research BioSciences Meeting)

Background

The powdered infant formula (PIF) sector is a growing global market, with Ireland at the forefront of the European exports market; reaching €1.5bn and accounting for 35% of all dairy exports in 2015. However, a major concern associated with PIF is the risk of contamination with the neonatal pathogen Cronobacter sakazakii. Although PIF undergoes thermal treatment during manufacture, it is possible that re-contamination of the product may occur via later processing measures. We investigated the resistance of C. sakazakii to thermal inactivation following inoculation in commercial PIF as a potential treatment for contaminated powder.

Method

Five strains of C. …

Genomic Diversity And Carbohydrate Utilisation In Human-Associated Bifidobacterial Isolates, Ortensia Catalano Gonzaga

ORBioM (Open Research BioSciences Meeting)

Bifidobacteria are beneficial commensals of the human gastrointestinal tract and their presence in the gut has been associated with positive health effects on the host. They account for a vast proportion of the infant gut microbiota, when the infant is fed on a milk-based diet, with their number progressively decreasing in adult and elderly. The gut microbiota and associated metabolic activities significantly impact on human health by promoting appropriate development of the infant immune system and contributing to the maintenance of the intestinal homeostasis. In recent years it has become clear that microbial colonization of the gut immediately following birth …