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Retraction Notice To "Hydrogen Recovery, Cleaning, Compression, Storage, Dispensing, Distribution System And End-Uses On The University Campus From Combined Heat, Hydrogen And Power System" [International Journal Of Hydrogen Energy 39 (2014) 647-653], Tarek A. Hamad, Abdulhakim A. Agll, Yousif M. Hamad, Sushrut Bapat, Mathew Thomas, Kevin B. Martin, John W. Sheffield
Retraction Notice To "Hydrogen Recovery, Cleaning, Compression, Storage, Dispensing, Distribution System And End-Uses On The University Campus From Combined Heat, Hydrogen And Power System" [International Journal Of Hydrogen Energy 39 (2014) 647-653], Tarek A. Hamad, Abdulhakim A. Agll, Yousif M. Hamad, Sushrut Bapat, Mathew Thomas, Kevin B. Martin, John W. Sheffield
Engineering Management and Systems Engineering Faculty Research & Creative Works
This article has been retracted: please see Elsevier policy on Article Correction, Retraction and Removal (https://www.elsevier.com/about/policies-and-standards/article-withdrawal). This article has been retracted at the request of the Editor.
Toxicity Ahead: Forecasting Conversational Derailment On Github, Mia Mohammad Imran, Robert Zita, Rahat Rizvi Rahman, Preetha Chatterjee, Kostadin Damevski
Toxicity Ahead: Forecasting Conversational Derailment On Github, Mia Mohammad Imran, Robert Zita, Rahat Rizvi Rahman, Preetha Chatterjee, Kostadin Damevski
Computer Science Faculty Research & Creative Works
Toxic interactions in Open Source Software (OSS) communities reduce contributor engagement and threaten project sustainability. Preventing such toxicity before it emerges requires a clear understanding of how harmful conversations unfold. However, most proactive moderation strategies are manual, requiring significant time and effort from community maintainers. To support more scalable approaches, we curate a dataset of 159 derailed toxic threads and 207 non-toxic threads from GitHub discussions. Our analysis reveals that toxicity can be forecast by tension triggers, sentiment shifts, and specific conversational patterns.We present a novel Large Language Model (LLM)-based framework for predicting conversational derailment on GitHub using a two-step …
Individualized Bayesian Inference Identifies Novel Genetic Variants For Parkinson's Disease, Jin Ren, Yasaman J. Soofi, Md Asad Rahman, Qing Lu, Jinling Liu
Individualized Bayesian Inference Identifies Novel Genetic Variants For Parkinson's Disease, Jin Ren, Yasaman J. Soofi, Md Asad Rahman, Qing Lu, Jinling Liu
Engineering Management and Systems Engineering Faculty Research & Creative Works
Parkinson's disease (PD) is a complex neurodegenerative disorder with a significant genetic component. While genome-wide association studies (GWAS) have been instrumental in identifying genetic variants associated with PD, the reliance on large sample sizes and population-level analyses may overlook variants with lower minor allele frequencies or individual-specific relevance. Individualized Bayesian Inference (IBI) offers a promising method to complement GWAS by identifying and prioritizing candidate genetic markers at both the individual and patients-like-me subgroup levels. This study evaluates the application of IBI to PD genetics, using GWAS as a baseline for comparison. We analyzed genetic data from the Fox Insight online …
Automated Haulage Trucks: Impact On Workplace Safety And Efficiency In Surface Mining Systems, Samuel Frimpong, Mabel Obosu
Automated Haulage Trucks: Impact On Workplace Safety And Efficiency In Surface Mining Systems, Samuel Frimpong, Mabel Obosu
Mining Engineering Faculty Research & Creative Works
The mining industry continues to face significant safety challenges, particularly with powered haulage equipment (PHE). PHE incidents account for a substantial percentage of mining-related fatalities, often resulting from vehicle collisions, equipment rollovers, operator errors, and blind-spot hazards. Despite the industry's efforts to improve safety protocols, fatal accidents involving haulage trucks remain persistent. The mining industry has increasingly adopted automation to enhance operational efficiency and improve safety, particularly in surface mines where haulage truck accidents remain a critical concern. Automation has significantly reduced human exposure to hazardous tasks by removing operators from dangerous environments, thereby mitigating risks associated with human error …
Benchmarking Zero-Shot Open-Vocabulary And Fine-Tuned Object Detectors For Underground Mine Personnel Detection, Ellen Essien, Samuel Frimpong
Benchmarking Zero-Shot Open-Vocabulary And Fine-Tuned Object Detectors For Underground Mine Personnel Detection, Ellen Essien, Samuel Frimpong
Mining Engineering Faculty Research & Creative Works
Reliable personnel detection is critical for the safe deployment of autonomous haulage systems in underground mining, where challenging environmental conditions demand robust real-time perception. Existing research has focused primarily on fine-tuned convolutional detectors, while systematic comparisons with zero-shot vision-language models remain limited. This study presents a cross-paradigm benchmark comparing four zero-shot vision-language models (YOLO-World, Grounding DINO, OWL-ViT, and OWLv2) with four fine-tuned YOLO detectors (YOLOv8s, YOLOv9s, YOLO11s, and YOLO26s) using 31,396 real-world underground coal mine images. Detection performance was evaluated using precision, recall, F1-score, average precision, inference speed, and condition- and target scale-specific recall. The experimental results show that the …
Geometric And Operational Design Principles For Autonomous Haulage Systems In Open-Pit Mining: A Systematic Review, Justina Senam Lotsu, Samuel Frimpong, Muhammad Azeem Raza
Geometric And Operational Design Principles For Autonomous Haulage Systems In Open-Pit Mining: A Systematic Review, Justina Senam Lotsu, Samuel Frimpong, Muhammad Azeem Raza
Mining Engineering Faculty Research & Creative Works
The rapid deployment of autonomous haulage systems (AHSs) in open-pit mining has significantly altered haul road geometric design requirements, as autonomous trucks operate under strict kinematic constraints related to turning radius, gradient, and braking performance. Since haulage accounts for 50–60% of total mining costs, optimizing haul road geometry is critical for improving operational efficiency, energy consumption, and safety. This study presents a systematic review of 50 highly relevant studies selected from 81 candidate publications published between 2003 and 2025 through structured database searches and citation chaining. The review synthesizes current developments in haul road layout optimization, turning radius accommodation, gradient …
Biodesulfurization Of Crude Oil Using Locally Isolated Pseudomonas Aeruginosa From Oil-Contaminated Soil In Iraqi Kurdistan, Yousif Mohammed Sharif, Sherwan Mohammed Simo, Lokman Aziz Abdulkareem, Muthanna H. Al-Dahhan
Biodesulfurization Of Crude Oil Using Locally Isolated Pseudomonas Aeruginosa From Oil-Contaminated Soil In Iraqi Kurdistan, Yousif Mohammed Sharif, Sherwan Mohammed Simo, Lokman Aziz Abdulkareem, Muthanna H. Al-Dahhan
Chemical and Biochemical Engineering Faculty Research & Creative Works
Locally sourced crude oil from Iraqi Kurdistan contains recalcitrant organosulfur compounds that impair air quality, corrode refinery equipment, and hinder compliance with fuel sulfur regulations. This study isolated a Pseudomonas sp. closely related to the Pseudomonas aeruginosa from oil-contaminated soil near Kashy Refinery (Duhok Province, Kurdistan Region, Iraq) and evaluated its biodesulfurization potential as an environmentally friendly alternative to hydrodesulfurization. Batch experiments were conducted at 34 °C and atmospheric pressure using mineral salts medium supplemented with 1%, 3%, and 5% (v/v) Tawki crude oil. The highest sulfur removal efficiency of 83.33% was obtained at 1% (v/v) crude oil after 10 …
A Transfer-Learning And Continuous Optimization-Based Framework For Predicting Heat Treatment-Dependent Mechanical Properties Of Ded-Processed Low-Alloy Steels, Atiqur Rahman, Sung Heng Wu, Ranjit Joy, Frank Liou
A Transfer-Learning And Continuous Optimization-Based Framework For Predicting Heat Treatment-Dependent Mechanical Properties Of Ded-Processed Low-Alloy Steels, Atiqur Rahman, Sung Heng Wu, Ranjit Joy, Frank Liou
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Directed energy deposition (DED) of low-alloy steels involves strongly coupled effects among alloy composition, solidification behavior, and post-deposition heat treatment, making mechanical property prediction difficult when target-domain data are limited. This study develops a transfer-learning and continuous optimization framework for predicting heat treatment-dependent yield strength (YS), ultimate tensile strength (UTS), hardness (HV), and as-solidified phase fractions of martensite, ferrite, and austenite in DED-processed low-alloy steels. A CALPHAD-based dataset was generated for 125 low-alloy steel compositions. A multilayer perceptron (MLP) surrogate was first trained as a baseline model, then fine-tuned through transfer learning and progressively updated as staged continuous optimization; the …
Field Calibration Of Flow Over Tilting Weirs In Canals, Joseph E. Pugh, Timothy K. Gates, S. Karan Venayagamoorthy, Caner Kutlu
Field Calibration Of Flow Over Tilting Weirs In Canals, Joseph E. Pugh, Timothy K. Gates, S. Karan Venayagamoorthy, Caner Kutlu
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
Tilting weirs are widely used to regulate water levels in open channel irrigation systems and can also provide flow measurement capability that helps optimize irrigation efficiency and ensure equitable water distribution. This case study demonstrates adaptation of lab-based tilting weir ratings to field settings, where flow behavior is more complex. We compile and analyze an extensive data set derived from independent studies of five structures within three canal systems, featuring both lined and unlined channels with discharge ranging from 0.35 to 15 m3/s (12 to 530 ft3/s). Results indicate that lab-based rating equations can be calibrated to account for site-specific …
Laplace Factor Models In High-Dimensional Data, Siqi Liu, Xuerong Meggie Wen, Akim Adekpedjou, Guangbao Guo
Laplace Factor Models In High-Dimensional Data, Siqi Liu, Xuerong Meggie Wen, Akim Adekpedjou, Guangbao Guo
Mathematics and Statistics Faculty Research & Creative Works
Laplace factor models (LFMs) provide a heavy-tailed alternative to Gaussian factor models by representing high-dimensional observations through a low-rank common component and Laplace-distributed idiosyncratic errors. This paper develops an assumption-consistent finite-sample analysis of matrix concentration, covariance estimation, and Monte Carlo integration under this model. We first formulate the model with explicit dimensional, independence, covariance, and identifiability conditions. Standard matrix Laplace-transform and matrix Bernstein inequalities are then recalled with their precise applicability conditions. Because untruncated Laplace variables are neither almost surely bounded nor strongly log-concave, these standard results cannot be applied directly in the forms commonly used for bounded or Gaussian-like …
Where Do Ai Coding Agents Fail? An Empirical Study Of Failed Agentic Pull Requests In Github, Ramtin Ehsani, Sakshi Pathak, Shriya Rawal, Abdullah Al Mujahid, Mia Mohammad Imran, Preetha Chatterjee
Where Do Ai Coding Agents Fail? An Empirical Study Of Failed Agentic Pull Requests In Github, Ramtin Ehsani, Sakshi Pathak, Shriya Rawal, Abdullah Al Mujahid, Mia Mohammad Imran, Preetha Chatterjee
Computer Science Faculty Research & Creative Works
AI coding agents are now submitting pull requests (PRs) to software projects, acting not just as assistants but as autonomous contributors. As these agentic contributions are rapidly increasing across real repositories, little is known about how they behave in practice and why many of them fail to be merged. In this paper, we conduct a large-scale study of 33k agent-authored PRs made by five coding agents across GitHub. (RQ1) We first quantitatively characterize merged and not-merged PRs along four broad dimensions: 1) merge outcomes across task types, 2) code changes, 3) CI build results, and 4) review dynamics. We observe …
Entity Labels Are Not Entity Signals: A Framework For Observable Relevance In Document Re-Ranking, Utshab Kumar Ghosh, Shubham Chatterjee
Entity Labels Are Not Entity Signals: A Framework For Observable Relevance In Document Re-Ranking, Utshab Kumar Ghosh, Shubham Chatterjee
Computer Science Faculty Research & Creative Works
Entity-aware document retrieval uses query-associated entities as ranking signals, assuming that semantically relevant entities are also useful retrieval signals. We show this assumption is insufficient - and explain why. Unlike terms, which are ground-truth observations, entity links are hypotheses produced by an imperfect linker: an entity can be topically central yet provide no discriminative signal if the linker fires indiscriminately across relevant and non-relevant documents. We formalize this as a distinction between Conceptual Entity Relevance (CER) - whether an entity is topically related to a query - and Observable Entity Relevance (OER) - whether its observed presence in a collection …
Reproduction Beyond Benchmarks: Constbert And Colbert-V2 Across Backends And Query Distributions, Utshab Kumar Ghosh, Ashish David, Shubham Chatterjee
Reproduction Beyond Benchmarks: Constbert And Colbert-V2 Across Backends And Query Distributions, Utshab Kumar Ghosh, Ashish David, Shubham Chatterjee
Computer Science Faculty Research & Creative Works
Reproducibility must validate architectural robustness, not just numerical accuracy. We evaluate ColBERT-v2 and ConstBERT across five dimensions, finding that while ConstBERT reproduces within 0.05% MRR@10 on MS-MARCO, both models show a drop of 86-97% on long, narrative queries (TREC ToT 2025). Ablations prove this failure is architectural: performance plateaus at 20 words because the MaxSim operator's uniform token weighting cannot distinguish signal from filler noise. Furthermore, undocumented backend parameters create an 8-point gap due to ConstBERT's sparse centroid coverage, and fine-tuning with 3x more data actually degrades performance by up to 29%. We conclude that architectural constraints in multi-vector retrieval …
Depro: Understanding The Role Of Llms In Debugging Competitive Programming Code, Nabiha Parvez, Md Tanvin Sarkar Pallab, Mia Mohammad Imran, Tarannum Shaila Zaman
Depro: Understanding The Role Of Llms In Debugging Competitive Programming Code, Nabiha Parvez, Md Tanvin Sarkar Pallab, Mia Mohammad Imran, Tarannum Shaila Zaman
Computer Science Faculty Research & Creative Works
Debugging consumes a substantial portion of the software development lifecycle, yet researchers do not yet understand well the effectiveness of Large Language Models (LLMs) in this task. Competitive programming offers a rich benchmark for such evaluation, given its diverse problem domains and strict efficiency requirements. We present an empirical study of LLM-based debugging on competitive programming problems and introduce DePro, a test-case-driven approach that assists programmers by correcting existing code rather than generating new solutions. DePro combines brute-force reference generation, stress testing, and iterative LLM-guided refinement to efficiently identify and resolve errors. Experiments on 13 faulty user submissions from Codeforces …
Llm-Enabled Open-Source Systems In The Wild: An Empirical Study Of Vulnerabilities In Github Security Advisories, Fariha Tanjim Shifat, Hariswar Baburaj, Ce Zhou, Jaydeb Sarker, Mia Mohammad Imran
Llm-Enabled Open-Source Systems In The Wild: An Empirical Study Of Vulnerabilities In Github Security Advisories, Fariha Tanjim Shifat, Hariswar Baburaj, Ce Zhou, Jaydeb Sarker, Mia Mohammad Imran
Computer Science Faculty Research & Creative Works
Large language models (LLMs) are increasingly embedded in open-source software (OSS) ecosystems, creating complex interactions among natural language prompts, probabilistic model outputs, and execution-capable components. However, it remains unclear whether traditional vulnerability disclosure frameworks adequately capture these model-mediated risks. To investigate this, we analyze 295 GitHub Security Advisories published between January 2025 and January 2026 that reference LLM-related components, and we manually annotate a sample of 100 advisories using the OWASP Top 10 for LLM Applications 2025.We find no evidence of new implementation-level weakness classes specific to LLM systems. Most advisories map to established CWEs, particularly injection and deserialization weaknesses. …
“Innocent” Electrolytes Can Influence Organic Electrosynthetic Selectivity, Zachary A. Nguyen, Nhu H. Quach, Mayank Tanwar, Joshua A. Beeler, Kevin Mcfadden, Dylan G. Boucher, Matthew Neurock, Shelley D. Minteer
“Innocent” Electrolytes Can Influence Organic Electrosynthetic Selectivity, Zachary A. Nguyen, Nhu H. Quach, Mayank Tanwar, Joshua A. Beeler, Kevin Mcfadden, Dylan G. Boucher, Matthew Neurock, Shelley D. Minteer
Chemistry Faculty Research & Creative Works
Organic electrosynthesis has emerged as a powerful strategy for leveraging electricity in organic synthesis. Despite its growing popularity, the fundamental molecular interactions governing electrochemical systems remain poorly understood. Many electrosynthetic reactions show strong dependence on the identity of the allegedly inert supporting electrolyte, which can significantly impact yields and selectivity, yet the physical origins of these effects are largely unexplored. A mechanistic understanding of electrolyte effects would enable more rational reaction design for applications. Here, we use cyclic voltammetry to investigate cobalt-based metal–carbon bond homolysis and elucidate how common supporting electrolytes influence reaction rates. Bulk electrolysis experiments further reveal how …
"Todo: Fix The Mess Gemini Created": Towards Understanding Genai-Induced Self-Admitted Technical Debt, Abdullah Al Mujahid, Mia Mohammad Imran
"Todo: Fix The Mess Gemini Created": Towards Understanding Genai-Induced Self-Admitted Technical Debt, Abdullah Al Mujahid, Mia Mohammad Imran
Computer Science Faculty Research & Creative Works
As large language models (LLMs) such as ChatGPT, Copilot, Claude, and Gemini become integrated into software development workflows, developers increasingly leave traces of AI involvement in their code comments. Among these, some comments explicitly acknowledge both the use of generative AI and the presence of technical shortcomings. Analyzing 6,540 LLM-referencing code comments from public Python and JavaScript-based GitHub repositories (November 2022-July 2025), we identified 81 that also self-admit technical debt (SATD). Developers most often describe postponed testing, incomplete adaptation, and limited understanding of AI-generated code, suggesting that AI assistance affects both when and why technical debt emerges. We term GenAI-Induced …
Learning Programming In Informal Spaces: Using Emotion As A Lens To Understand Novice Struggles On R/Learnprogramming, Alif Al Hasan, Subarna Saha, Mia Mohammad Imran
Learning Programming In Informal Spaces: Using Emotion As A Lens To Understand Novice Struggles On R/Learnprogramming, Alif Al Hasan, Subarna Saha, Mia Mohammad Imran
Computer Science Faculty Research & Creative Works
Novice programmers experience emotional difficulties in informal online learning environments, where Confusion and Frustration can hinder motivation and learning outcomes. This study investigates novice programmers' emotional experiences in informal settings, identifies causes of emotional struggle, and explores design opportunities for affect-aware support systems. We manually annotated 1,500 posts from r/learnprogramming using the Learning-Centered Emotions framework, applying clustering, and axial coding. Confusion, Curiosity, and Frustration dominated emotional experiences, sometimes co-occurring and linked to early learning stages. Positive emotions were infrequent. The primary emotional triggers included ambiguous errors, unclear learning pathways, and misaligned resources. We identify five key areas where novice programmers …
Dynlp: Parallel Dynamic Batch Update For Label Propagation In Graph-Based Semi-Supervised Learning, S. M. Shovan, Arindam Khanda, S. M. Ferdous, Sajal K. Das, Mahantesh Halappanavar
Dynlp: Parallel Dynamic Batch Update For Label Propagation In Graph-Based Semi-Supervised Learning, S. M. Shovan, Arindam Khanda, S. M. Ferdous, Sajal K. Das, Mahantesh Halappanavar
Computer Science Faculty Research & Creative Works
Semi-supervised learning aims to infer class labels using only a small fraction of labeled data. In graph-based semi-supervised learning, this is typically achieved through label propagation to predict labels of unlabeled nodes. However, in real-world applications, new data often arrives in batches, and stale data often becomes irrelevant. Each time a new batch appears, reapplying the traditional label propagation algorithm to recompute all labels is redundant, computationally intensive, and inefficient. To address the absence of an efficient label propagation update method, we propose DynLP, a novel GPU-centric Dynamic Batched Parallel Label Propagation algorithm that performs only the necessary updates, propagating …
Nascent Titanium-/Silicon-Containing Particle Formation In Corona-Discharge-Assisted Combustion, Chanakya Bagya Ramesh, Frank Daoru Han, Yang Wang
Nascent Titanium-/Silicon-Containing Particle Formation In Corona-Discharge-Assisted Combustion, Chanakya Bagya Ramesh, Frank Daoru Han, Yang Wang
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Adding plasmas to a flame has been shown to introduce high concentrations of charges, ions, and radicals to the said flame. This technique of adding plasma to a flame is called plasma-assisted combustion (PAC), and this addition has been shown to make a flame more stable and efficient. At the same time, PAC has also been shown to alter particle formation during combustion. Here, we investigate the effect of a high-frequency (∼21 kHz) alternating current (AC) corona discharge on particle formation and growth in a premixed flame, especially at the initial stages (with particle sizes below 10 nm). We first …
Managing Risks Under Nuclear Power Plant Projects: A Latent Similarity-Guided Contract Customization, Mariam Elazhary, Islam H. El-Adaway
Managing Risks Under Nuclear Power Plant Projects: A Latent Similarity-Guided Contract Customization, Mariam Elazhary, Islam H. El-Adaway
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
Global energy is transforming, with nuclear power emerging as a pivotal player in achieving sustainable and low-carbon energy goals. The nature of nuclear technology introduces unique challenges, such as stringent safety and environmental requirements. Existing studies focus on general risk identification, such as supply chain delays, cost overruns, and public perception issues. However, these studies fail to address integrating these risks into tailored contractual provisions, which are critical for navigating the unique challenges of nuclear projects. The goal of this paper is to examine how standard construction contracts can be tailored to better accommodate the risks inherent in nuclear power …
Distinct Regulatory Dna Methylation Signatures Across Multiple Sclerosis, Neuromyelitis Optica, And Neurological Post-Acute Sequelae Of Covid-19, Syed Ilyas Munzir, Daniel B. Hier, Michael D. Carrithers
Distinct Regulatory Dna Methylation Signatures Across Multiple Sclerosis, Neuromyelitis Optica, And Neurological Post-Acute Sequelae Of Covid-19, Syed Ilyas Munzir, Daniel B. Hier, Michael D. Carrithers
Electrical and Computer Engineering Faculty Research & Creative Works
Background/Objectives: Our prior epigenome-wide association study (EWAS) on multiple sclerosis (MS) identified myeloid-associated methylation signatures and an association with enhancer regions. Here we compared differential DNA methylation across three central nervous system inflammatory disorders: MS, neuromyelitis optica (NMO), and neurologic post-acute sequelae of COVID-19 (neuro-PASC). Methods: Whole-blood DNA was profiled on Infinium MethylationEPIC arrays. Analyses included EWAS at the CpG level, differentially methylation region (DMR) analysis, and gene regulatory-element enrichment using Locus Overlap Analysis (LOLA). Limma linear models were adjusted for race, EPIC array version, age, sex, disease-modifying treatment class, and blood cell composition. Results: All three diseases were associated …
Existence And Uniqueness Of Positive Solutions For Hilfer–Hadamard-Type Fractional Differential Equations With Γ-Concave And Sub-Homogeneous Operators, Hasan Rasouli, Hojjat Afshari, Martin Bohner
Existence And Uniqueness Of Positive Solutions For Hilfer–Hadamard-Type Fractional Differential Equations With Γ-Concave And Sub-Homogeneous Operators, Hasan Rasouli, Hojjat Afshari, Martin Bohner
Mathematics and Statistics Faculty Research & Creative Works
In this research, we present necessary and sufficient conditions for the existence and uniqueness of positive solutions for a class of Hilfer–Hadamard-type fractional differential equations with boundary value problems, including those with integral boundary conditions. The obtained results are conditional on a specific set of strong assumptions, which substantially narrow the class of admissible nonlinearities, coefficients, and boundary data. Thus, the present work extends the Hadamard-type framework to the Hilfer–Hadamard setting only within this restrictive regime, rather than providing a full extension to all Hilfer–Hadamard systems. We utilize the properties of (Formula presented.) -concave and sub-homogeneous operators along with two …
Hsv-1 Us3 Hijacks Conserved Actin Regulatory Complexes To Drive F-Actin Remodeling, Md Imran Hossain, Md Arifuzzaman, Md Mehedi Hasan, Seung Jong Park, Leila Rahimian, Ojasvi Dutta, Vladimir Chouljenko, Harikrishnan Mohan, Reza Ghavimi, Konstantin G. Kousoulas
Hsv-1 Us3 Hijacks Conserved Actin Regulatory Complexes To Drive F-Actin Remodeling, Md Imran Hossain, Md Arifuzzaman, Md Mehedi Hasan, Seung Jong Park, Leila Rahimian, Ojasvi Dutta, Vladimir Chouljenko, Harikrishnan Mohan, Reza Ghavimi, Konstantin G. Kousoulas
Computer Science Faculty Research & Creative Works
The herpes simplex virus 1 (HSV-1) US3 is a multifunctional serine/threonine kinase that promotes HSV-1 replication and spread. But its role and the mechanisms by which US3 regulates actin cytoskeletal remodeling remain poorly defined. We combined flow cytometry, confocal microscopy, immunoprecipitation-mass spectrometry (IP-MS), protein complex mapping, and machine learning to characterize US3-mediated F-actin dynamics. Flow cytometry and confocal microscopy showed that wild-type HSV-1 induces significant F-actin remodeling, while the ΔUS3 mutant displays F-actin levels comparable to uninfected cells, identifying US3 as a key regulator. IP-MS identified 47 high-confidence US3 interactors enriched in conserved actin regulatory complexes, including Arp2/3 nucleation machinery, …
Binding Energy Of Muonic Beryllium: Perturbative Versus All-Order Calculations, Shikha Rathi, Ulrich D. Jentschura, Paul Indelicato, Ben Ohayon
Binding Energy Of Muonic Beryllium: Perturbative Versus All-Order Calculations, Shikha Rathi, Ulrich D. Jentschura, Paul Indelicato, Ben Ohayon
Physics Faculty Research & Creative Works
We compute the ground-state binding energy of muonic (Formula presented) (Formula presented) Be in two ways: first, the fully perturbative treatment of the nuclear-size effect often employed in light systems, and second, an approach that accounts for the finite-nuclear-size to all orders (and is inspired by calculations otherwise employed for heavy muonic ions). The results are compared term by term and show that both approaches agree to better than one part-per-million of the total energy. The objective of this work is twofold. The first is practical: to provide a parameterization that allows the extraction of the (Formula presented) (Formula presented) …
Label-Flip Attack Detection Via Trust-Weighted Aggregation In Federated Learning For Underground Mine Security, Md Sazedur Rahman, Sanjay Madria, Samuel Frimpong
Label-Flip Attack Detection Via Trust-Weighted Aggregation In Federated Learning For Underground Mine Security, Md Sazedur Rahman, Sanjay Madria, Samuel Frimpong
Computer Science Faculty Research & Creative Works
Underground mining operations are increasingly dependent on autonomous vehicles, robotic drilling systems, and intelligent inspection platforms operating in confined, GPS-denied tunnel environments. These systems rely on distributed perception models to interpret navigation cues, hazard warnings, and environmental signals in real time. While centralized deep learning can enhance model performance, transferring raw operational data across mining sites introduces serious confidentiality and security risks. Federated Learning (FL) offers a privacy-preserving alternative by enabling collaborative model training without sharing local datasets. However, deploying FL in underground mining introduces several critical challenges: (i) Training labels may be modified either maliciously by compromised clients or …
High-Throughput Optical Analysis To Inform Design Of Electrochemical Biosensors, Nathan J. Ricks, Michael A. Pence, Monica Brachi, Shelley D. Minteer
High-Throughput Optical Analysis To Inform Design Of Electrochemical Biosensors, Nathan J. Ricks, Michael A. Pence, Monica Brachi, Shelley D. Minteer
Chemistry Faculty Research & Creative Works
Electrochemical biosensors are central to wearable diagnostics, point-of-care testing, and continuous health monitoring due to their low power requirements, compatibility with miniaturized electronics, and proven clinical impact. Despite these advantages, the development of new electrochemical biosensors remains slow, constrained by limited throughput, complex electrode–biomolecule interfaces, and challenges associated with selectivity and performance in chemically complex environments. This perspective outlines how the next generation of electrochemical biosensors can be enabled by decoupling high-throughput front-end discovery and optimization from electrochemical readouts using nonelectrochemical surrogate assays. Optical, affinity, and cell-sorting platforms, including SELEX, fluorescence-activated cell sorting, and chemically coupled fluorescence assays, allow orders-of-magnitude …
Interseismic Creep Along The Enriquillo–Plantain Garden Fault, Haiti, Estimated From Insar, Rishabh Dutta, Jeremy L. Maurer, Yi Chieh Lee
Interseismic Creep Along The Enriquillo–Plantain Garden Fault, Haiti, Estimated From Insar, Rishabh Dutta, Jeremy L. Maurer, Yi Chieh Lee
Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works
The Enriquillo–Plantain Garden fault zone (EPGFZ) is a major left-lateral strike-slip fault in southern Haiti hosting several recent destructive earthquakes, including the 2021 MW 7.1 Nippes event with primary thrust-slip. To investigate how strain is accommodated in the vicinity of the 2021 event, we analyzed Sentinel-1 interferometric synthetic aperture radar (InSAR) data from 2017 to 2021 using a PS + DS (persistent + distributed scatterers) InSAR time-series approach to overcome decorrelation in this highly vegetated region. We reveal interseismic creep along the EPGF and adjacent Grand'Anse–Sud border faults, with pure strike-slip mechanism and rates up to 9 mm/yr. We suggest …
Employing Ac And Dc Electrolysis To Modulate Electroenzymatic Pathways For Efficient And Stereoselective H-D Exchange, Wassim El Housseini, Rokas Gerulskis, Nibedita Behera, Huaijun Guan, Rohit G. Jadhav, Zachary A. Nguyen, Egor Baiarashov, Michael A. Pence, Vamshi Krishna Kamaja, Trevor Larkin, Long Luo, Shelley D. Minteer
Employing Ac And Dc Electrolysis To Modulate Electroenzymatic Pathways For Efficient And Stereoselective H-D Exchange, Wassim El Housseini, Rokas Gerulskis, Nibedita Behera, Huaijun Guan, Rohit G. Jadhav, Zachary A. Nguyen, Egor Baiarashov, Michael A. Pence, Vamshi Krishna Kamaja, Trevor Larkin, Long Luo, Shelley D. Minteer
Chemistry Faculty Research & Creative Works
Stereoselective hydrogen isotope exchange (HIE) at chiral centers is an increasingly important strategy for preparing labeled molecules, yet its practical implementation depends on reliable control of nicotinamide cofactor regeneration. Here we introduce a redox-programmable electroenzymatic platform for stereoselective HIE based on electrode-controlled manipulation of the nicotinamide cofactor state. A wired ferredoxin–NADP+ reductase (FNR) electrode enables reversible electrochemical interconversion of NADP+ and its deuterated reduced form (NADPD) directly from D2O. Coupling this cofactor cycling with enantioselective alcohol dehydrogenases (ADHs) establishes a reversible alcohol–ketone redox manifold that drives efficient and stereoselective H-D exchange at chiral alcohols. Stereochemical outcomes are programmed …
Olaf: Towards Robust Llm-Based Annotation Framework In Empirical Software Engineering, Mia Mohammad Imran, Tarannum Shaila Zaman
Olaf: Towards Robust Llm-Based Annotation Framework In Empirical Software Engineering, Mia Mohammad Imran, Tarannum Shaila Zaman
Computer Science Faculty Research & Creative Works
Large Language Models (LLMs) are increasingly used in empirical software engineering (ESE) to automate or assist annotation tasks such as labeling commits, issues, and qualitative artifacts. Yet the reliability and reproducibility of such annotations remain underexplored. Existing studies often lack standardized measures for reliability, calibration, and drift, and frequently omit essential configuration details. We argue that LLM-based annotation should be treated as a measurement process rather than a purely automated activity. In this position paper, we outline the Operationalization for LLM-based Annotation Framework (OLAF), a conceptual framework that organizes key constructs: reliability, calibration, drift, consensus, aggregation, and transparency. The paper …