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Missouri University of Science and Technology
Amino acid sequence<br />Amino acids -- Analysis<br />Peptides -- Analysis
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Amino Acid Sequence Of An Iodotyrosyl-Containing Peptide Produced By Tryptic Digestion Of Thyroglobulin, Pai-Chun Chiang
Amino Acid Sequence Of An Iodotyrosyl-Containing Peptide Produced By Tryptic Digestion Of Thyroglobulin, Pai-Chun Chiang
Masters Theses
"Thyroglobulin was digested with trypsin. An iodotyrosyl-containing peptide was isolated from tryptic digests by a combination of electrophoresis and paper chromatography. The amino acid sequence of this peptide was determined by applying the Edman degradation and by using the proteolytic enzyme, carboxypeptidase A. The sequence of this peptide is: NH₂-Ala-Ile(Leu)-Ala-Ser-Phe-Gly-Asp-Tyr-Glu-Phe-COOH The importance of the position of the tyrosyl residue which is iodinated to form monoiodotyrosine (MIT) , diiodotyrosine (DIT) , and thyroxine (T₄) is considered in connection with the structure-activity relationship of the protein"--Abstract, page ii.