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Identifying The Molecular Mechanisms Responsible For Persistent Effects Of Developmental Exposure To Chlorpyrifos On Behavior, Navatha Alugubelly
Identifying The Molecular Mechanisms Responsible For Persistent Effects Of Developmental Exposure To Chlorpyrifos On Behavior, Navatha Alugubelly
Theses and Dissertations
Chlorpyrifos (CPF) is one of the most widely used organophosphorus insecticides (OPs). The developmental exposure to low levels of CPF results in the inhibition of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (FAAH) and in altered emotional behavior (increased social play) without affecting the acetylcholinesterase, the canonical target of OPs. However, the molecular mechanisms responsible for this increased social play are not known. In this study, male rat pups were exposed orally to either corn oil, 0.75 mg/kg CPF, or 0.02 mg/kg PF-04457845 (PF; a specific inhibitor of FAAH) daily from postnatal day 10 (PND10) - PND16. This dosage …