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Environmentally Persistent Free Radicals Decrease Cardiac Function Before And After Ischemia/Reperfusion Injury In Vivo, Kevin Lord, David Moll, John K. Lindsey, Sarah Mahne, Girija Raman, Tammy Dugas, Stephania Cormier, Dana Troxlair, Slawo Lomnicki, Barry Dellinger, Kurt Varner
Environmentally Persistent Free Radicals Decrease Cardiac Function Before And After Ischemia/Reperfusion Injury In Vivo, Kevin Lord, David Moll, John K. Lindsey, Sarah Mahne, Girija Raman, Tammy Dugas, Stephania Cormier, Dana Troxlair, Slawo Lomnicki, Barry Dellinger, Kurt Varner
Faculty Publications
Exposure to airborne particles is associated with increased cardiovascular morbidity and mortality. During the combustion of chlorine-containing hazardous materials and fuels, chlorinated hydrocarbons chemisorb to the surface of transition metal-oxide-containing particles, reduce the metal, and form an organic free radical. These radical-particle systems can survive in the environment for days and are called environmentally persistent free radicals (EPFRs). This study determined whether EPFRs could decrease left ventricular function before and after ischemia and reperfusion (I/R) in vivo. Male Brown-Norway rats were dosed (8mg/kg, intratracheal) 24h prior to testing with particles containing the EPFR of 1, 2-dichlorobenzene (DCB230). DCB230 treatment decreased …
Inhibitory Effects Of Berry Anthocyanins On Palmitic Acid- Or Lipopolysaccharide- Induced Inflammation In Human Preadipocytes, Chenfei Gao
LSU Master's Theses
Obesity is an inflammatory disease associated with the development and progression of chronic degenerative diseases including insulin resistance, cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), and cancer. Circulating free fatty acid (FFA) are known risk factors promoting inflammation that can lead to CVD. Pre/adipocytes are known storage of low grade inflammatory biomarkers associated with obesity. However, the effects of dietary anthocyanins on inflammatory biomarkers in preadipocytes have not been reported. Berries are rich sources of naturally occurring antioxidant polyphenolics. There is increasing interest in the ability of berry anthocyanins to provide health benefits against obesity. Anthocyanins were isolated from …
Pharmacological And Non-Pharmacological Approaches To Prevent Hypertension-Induced Renal Disease In The Spontaneously Hypertensive Rate, Carrie Marie Elks
Pharmacological And Non-Pharmacological Approaches To Prevent Hypertension-Induced Renal Disease In The Spontaneously Hypertensive Rate, Carrie Marie Elks
LSU Doctoral Dissertations
Hypertension affects 50 million Americans and remains the second leading cause of renal failure in the United States. Current pharmacological and non-pharmacological approaches to treat hypertension have proven effective, but the complexities of the disease and its renal effects warrant the need for new treatments. The hypothesis of this dissertation was that pharmacological or non-pharmacological approaches to reducing inflammation and oxidative stress would prevent hypertension-induced renal injury in the spontaneously hypertensive rat (SHR). In the first study, we blocked the inflammatory transcription factor, nuclear factor-kappa B (NF-ĸB), with pyrrolidine dithiocarbamate in the SHR kidney. In treated SHR, blood pressure decreased, …
The Role Of Inflammatory Molecules In Hypertension, Jeffrey Paul Cardinale
The Role Of Inflammatory Molecules In Hypertension, Jeffrey Paul Cardinale
LSU Doctoral Dissertations
Hypertension is a serious condition with high morbidity and mortality rates, as well as a major predisposing factor for multiple cardiovascular and renal diseases. Angiotensin II (Ang II) of the renin-angiotensin system (RAS) plays a pivotal role in propagating the hypertensive response. Moreover, hypertension is considered a chronic low-grade inflammatory condition that intimately involves the actions of proinflammatory cytokines (PICs) such as tumor necrosis factor-alpha (TNF). Recent evidence highlights the role that inflammation, specifically TNF, plays in hypertension and in regulating the RAS, but the understanding as to how inflammation is regulated following Ang II or TNF activation, as well …