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Investigating Combinatorial Approaches In Virtual Screening On Human Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (Pfkfb3): A Case Study For Small Molecule Kinases, Robert B. Crochet, Michael C. Cavalier, Minsuh Seo, Jeong Do Kim, Young Sun Yim, Seung Jong Park, Yong Hwan Lee
Investigating Combinatorial Approaches In Virtual Screening On Human Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (Pfkfb3): A Case Study For Small Molecule Kinases, Robert B. Crochet, Michael C. Cavalier, Minsuh Seo, Jeong Do Kim, Young Sun Yim, Seung Jong Park, Yong Hwan Lee
Faculty Publications
Efforts toward improving the predictiveness in tier-based approaches to virtual screening (VS) have mainly focused on protein kinases. Despite their significance as drug targets, small molecule kinases have been rarely tested with these approaches. In this paper, we investigate the efficacy of a pharmacophore screening-combined structure-based docking approach on the human inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, an emerging target for cancer chemotherapy. Six out of a total 1364 compounds from NCI's Diversity Set II were selected as true actives via throughput screening. Using a database constructed from these compounds, five programs were tested for structure-based docking (SBD) performance, the MOE of which showed …
Oncogenic Potential Of Yin Yang 1 Mediated Through Control Of Imprinted Genes, Michelle M. Thiaville, Joomyeong Kim
Oncogenic Potential Of Yin Yang 1 Mediated Through Control Of Imprinted Genes, Michelle M. Thiaville, Joomyeong Kim
Faculty Publications
The transcription factor Yin Yang (YY) 1 is one of the most evolutionarily well-conserved DNA binding proteins that is ubiquitously expressed among different tissue types. YY1 functions as a critical regulator for a diverse set of genes, making its role in the cancerous environment elusive. Recent studies have demonstrated that clusters of YY1 binding sites are overrepresented in imprinted gene loci. These clustered binding sites may function as a molecular rheostat with respect to YY1 protein levels. YY1 levels were documented to be altered in various tumor tissues in conjunction with the transcriptional levels of the imprinted genes it regulates. …
Are Local Chemical Releases Causing An Increase In Cancer Rates In East Baton Rouge Parish?, India T. Anderson
Are Local Chemical Releases Causing An Increase In Cancer Rates In East Baton Rouge Parish?, India T. Anderson
LSU Master's Theses
Environmental pollution has become a steadily growing problem in today’s society. East Baton Rouge alone has 13 chemical plants in the parish. The goal of this research is to find out if the chemical releases in the parish are having an effect on the cancer rates in East Baton Rouge Parish. I gathered data from all 64 parishes in Louisiana. The four chemicals I chose to study specifically, Benzene, Dioxin, Formaldehyde, and Xylene. Chemical release data was taken from the Toxic Release Inventory (TRI) website and software from the years1988 to 2009, which was the last reporting year. The cancers …