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Up-Regulation Of P-Glycoprotein Reduces Intracellular Accumulation Of Beta Amyloid: Investigation Of P-Glycoprotein As A Novel Therapeutic Target For Alzheimer's Disease, Alaa H. Abuznait, Courtney Cain, Drury Ingram, David Burk, Amal Kaddoumi
Up-Regulation Of P-Glycoprotein Reduces Intracellular Accumulation Of Beta Amyloid: Investigation Of P-Glycoprotein As A Novel Therapeutic Target For Alzheimer's Disease, Alaa H. Abuznait, Courtney Cain, Drury Ingram, David Burk, Amal Kaddoumi
Faculty Publications
Objectives: Several studies have suggested the efflux transporter P-glycoprotein (P-gp) to play a role in the etiology of Alzheimer's disease through the clearance of amyloid beta (Aβ) from the brain. In this study, we aimed to investigate the possibility of P-gp as a potential therapeutic target for Alzheimer's disease by examining the impact of P-gp up-regulation on the clearance of Aβ, a neuropathological hallmark of Alzheimer's disease. Methods: Uptake studies for 125I-radiolabelled Aβ 1-40, and fluorescent immunostaining technique for P-gp and fluorescent imaging of Aβ 1-40 were carried out in LS-180 cells following treatment with drugs known to induce P-gp …
Time Of Day Effects On Language Discourse In Healthy Aging And Dementia, Amanda L. Stead
Time Of Day Effects On Language Discourse In Healthy Aging And Dementia, Amanda L. Stead
LSU Doctoral Dissertations
This study’s purpose was to investigate whether language discourse follows a diurnal pattern across one 10-hour day in normal healthy aging individuals (NHA) and individuals with mild to moderate Alzheimer’s disease. Ten healthy older adults; and ten older adults clinically labeled with probable Alzheimer’s disease were recruited for this study. Measurements of procedural language, narrative language, and cognition, the Benton Judgment of Line Orientation (BJLO), were collected across one day at 9:00am, 12:00pm, 3:00 pm, and 6:00pm. Language samples were evaluated for linguistic variables to evaluate the quantity and quality of the discourse samples. Results indicated that the two groups …
Psychometric Evaluation Of A Proposed, Alzheimer's Aggression Scale, Kristina Little
Psychometric Evaluation Of A Proposed, Alzheimer's Aggression Scale, Kristina Little
LSU Master's Theses
Aggressive behavior is a common symptom of mid- to late-stage Alzheimer’s disease, causing unique challenges for caregivers and healthcare professionals. In previous research, aggressive behavior related to dementia was linked to higher caregiver distress and burden. The purpose of this study was to examine the psychometric properties of an aggressive behavior subscale of the Revised Memory and Behavior Problem Checklist (RMBPC) among Alzheimer’s disease caregivers. The subscale measures the frequency of aggressive behavior and the caregiver’s reaction. The sample consisted of 419 caregivers reporting some frequency of aggressive behavior by the care recipient. Exploratory factor analysis was favorable. Convergent validity …