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Association Of Mutation And Expression Of The Brother Of The Regulator Of Imprinted Sites (Boris) Gene With Breast Cancer Progression, Mohammad Salman Akhtar, Naseem Akhter, Arshi Talat, Raed A. Alharbi, Abdulmajeed A. A Sindi, Faisal Klufah, Hanan E. Alyahyawi, Abdulmohsen Alruwetei, Abrar Ahmad, Mazin A. Zamzami, Svs Deo, Syed Akhtar Husain, Osama A. Badi, Mohammad Jahir Khan

Neurology Articles

INTRODUCTION: The BORIS, 11 zinc-finger transcription factors, is a member of the cancer-testis antigen (CTA) family. It is mapped to chromosome number 20q13.2 and this region is genetically linked to the early onset of breast cancer. The current study analyzed the correlation between BORIS mutations and the expression of the protein in breast cancer cases.

MATERIALS AND METHODS: A population-based study including a total of 155 breast cancer tissue samples and an equal number of normal adjacent tissues from Indian female breast cancer patients was carried out. Mutations of the BORIS gene were detected by polymerase chain reaction-single standard confirmation …

Human Papillomavirus Vaccine Uptake Among Teens Before And During The Covid-19 Pandemic In The United States, Dina K. Abouelella, Julia E. Canick, Justin M. Barnes, Rebecca L. Rohde, Tammara L. Watts, Eric Adjei Boakye, Nosayaba Osazuwa-Peters

Public Health Sciences Articles

It is unclear how the COVID-19 pandemic impacted human papillomavirus (HPV) vaccine uptake and which sociodemographic groups may have been most impacted. We aimed to assess differences in HPV vaccine uptake (initiation and completion) before and during the pandemic in the United States. We conducted a cross-sectional study using data from the 2019 to 2020 National Immunization Surveys - Teen (NIS-Teen), comparing vaccine initiation and completion rates in 2019 vs. 2020, based on confirmed reports by a healthcare provider. Weighted logistic regression analysis estimated odds of vaccine initiation and completion for both adolescent and parental characteristics. There were 18,788 adolescents …

Association Between Sexual Activity And Human Papillomavirus (Hpv) Vaccine Initiation And Completion Among College Students, Eric Adjei Boakye, Stacey L. Mckinney, Kelli D. Whittington, Valerie E. Boyer, Maria C. Franca, Minjee Lee, Richard C. Mckinnies, Sandra K. Collins, Mary A. Gerend

Public Health Sciences Articles

HPV vaccination is most effective if received before initiation of sexual activity. Previous studies suggested that young adult women who were not sexually active were not interested in receiving the vaccine because they did not think it was necessary. Whether this misperception is still prevalent today-and also shared by men-is unknown. This study examined whether sexual activity was associated with HPV vaccine uptake (initiation and completion) among university students. A cross-sectional study was conducted between February and May 2021 among students (n = 951) at a public Midwestern University. Sexual activity was categorized as "never" or "ever" had oral and/or …

The Adoption Of The Hpv Vaccine School-Entry Requirement In Puerto Rico: How Practical Lessons Can Inform Future Vaccine Policies, C. Vázquez-Otero, Elizabeth Lockhart

Center for Health Policy and Health Services Research Articles

Vaccine requirements are policy-level strategies used to improve population health outcomes; however, discourse politicization of vaccines may hinder adoption and implementation. An example of the complexities related to adoption of vaccine policies in the United States (US) is the human papillomavirus (HPV) vaccine school-entry requirement. In 2018, Puerto Rico's (PR) Department of Health adopted this policy. This study assessed stakeholders' recommendations for adoption of the HPV vaccine school-entry requirement that could inform future vaccine policies. Stakeholders (e.g., researchers, members of medical and non-profit organizations) were interviewed from May to August 2018. Participants (n = 20) discussed recommendations for public health …

Medical Students' Knowledge Of Hpv, Hpv Vaccine, And Hpv-Associated Head And Neck Cancer, Eric Y. Du, Eric Adjei Boakye, Derian B. Taylor, Duaa Kuziez, Rebecca L. Rohde, Jaibir S. Pannu, Matthew C. Simpson, Rolvix H. Patterson, Mark A. Varvares, Nosayaba Osazuwa-Peters

Public Health Sciences Articles

On the basis of their training, medical students are considered "the best case scenario" among university students in knowledge of the human papillomavirus (HPV). We evaluated differences in knowledge of HPV, HPV vaccine, and head and neck cancer (HNC) among medical students. A previously validated questionnaire was completed by 247 medical students at a Midwestern university. Outcomes of interest were knowledge score for HPV and HPV vaccine, and HNC, derived from combining questionnaire items to form HPV knowledge and HNC scores, and analyzed using multivariate linear regression. Mean scores for HPV knowledge were 19.4 out of 26, and 7.2 out …

1428p Suicidal Outcomes Among Cancer Survivors: Examining Associations With Depression And Non-Medical Pain Prescriptions, Nosayaba Osazuwa-Peters, Oyomoare Osazuwa-Peters, Eric Adjei Boakye, D. Abouelella, Justin M. Barnes, Nicole Bates, Katherine Ramos

Public Health Sciences Meeting Abstracts

Background: A cancer diagnosis results in significant distress and adverse psychosocial sequelae, including suicide, the 10th leading cause of death in the United States. Primary risks for death by suicide include depression, and opioid abuse, which are prevalent amongst cancer survivors. Yet, it remains unclear whether they are also associated with other suicidal outcomes, such as ideation, planning, and suicidal attempt. This study examined associations between suicide-related outcomes, depression and non-medical use of pain prescriptions among cancer survivors in the United States.

Methods: We used cross-sectional data from the National Survey on Drug Use and Health (NSDUH; 2015-2019), a nationwide …

Post-Implementation Review Of The Himalaya Home Care Project For Home Isolated Covid-19 Patients In Nepal, Rakchya Amatya, Kritika Mishra, Kshitij Karki, Isha Puri, Archita Gautam, Sweta Thapa, Urmila Katwal, Siddhesh Veer, John Zervos, Linda M. Kaljee, Tyler Prentiss, Kate Zenlea, Gina Maki, Pawan Jung Rayamajhi, Narendra K. Khanal, Pomawati Thapa, Madan Kumar Upadhyaya, Deepak Bajracharya

Global Health Initiative Articles

Background: The emergence of coronavirus disease 2019 (COVID-19) has resulted in a pandemic that has significantly impacted healthcare systems at a global level. Health care facilities in Nepal, as in other low- and middle-income countries, have limited resources for the treatment and management of COVID-19 patients. Only critical cases are admitted to the hospital resulting in most patients in home isolation.

Methods: Himalaya Home Care (HHC) was initiated to monitor and provide counseling to home isolated COVID-19 patients for disease prevention, control, and treatment. Counselors included one physician and four nurses. Lists of patients were obtained from district and municipal …

Head And Neck Cancer Survivorship Consensus Statement From The American Head And Neck Society, Neerav Goyal, Andrew Day, Joel Epstein, Joseph Goodman, Evan Graboyes, Scharukh Jalisi, Ana P Kiess, Jamie A Ku, Matthew C Miller, Aru Panwar, Vijay A Patel, Assuntina Sacco, Vlad Sandulache, Amy M. Williams, Daniel Deschler, D. Gregory Farwell, Cherie-Ann Nathan, Carole Fakhry, Nishant Agrawal

Otolaryngology Articles

Objectives: To provide a consensus statement describing best practices and evidence regarding head and neck cancer survivorship.

Methods: Key topics regarding head and neck cancer survivorship were identified by the multidisciplinary membership of the American Head and Neck Society Survivorship, Supportive Care & Rehabilitation Service. Guidelines were generated by combining expert opinion and a review of the literature and categorized by level of evidence.

Results: Several areas regarding survivorship including dysphonia, dysphagia, fatigue, chronic pain, intimacy, the ability to return to work, financial toxicity, lymphedema, psycho-oncology, physical activity, and substance abuse were identified and discussed. Additionally, the group identified and …

Predictive Processing During A Naturalistic Statistical Learning Task In Asd, Neelima Wagley, Renee Lajiness-O'Neill, Jessica Sf Hay, Margaret Ugolini, Susan M. Bowyer, Ioulia Kovelman, Jonathan R. Brennan

Neurology Articles

Children's sensitivity to regularities within the linguistic stream, such as the likelihood that syllables co-occur, is foundational to speech segmentation and language acquisition. Yet, little is known about the neurocognitive mechanisms underlying speech segmentation in typical development and in neurodevelopmental disorders that impact language acquisition such as autism spectrum disorder (ASD). Here, we investigate the neural signals of statistical learning in 15 human participants (children ages 8-12) with a clinical diagnosis of ASD and 14 age-matched and gender-matched typically developing peers. We tracked the evoked neural responses to syllable sequences in a naturalistic statistical learning corpus using magnetoencephalography (MEG) in …

Cancer Screening During Covid-19: A Perspective From Nci's Prospr Consortium, Douglas A. Corley, Mai Sedki, Debra P. Ritzwoller, Robert T. Greenlee, Christine Neslund-Dudas, Katharine A. Rendle, Stacey A. Honda, Joanne E. Schottinger, Natalia Udaltsova, Anil Vachani, Sarah Kobrin, Christopher I Li, Jennifer S. Haas

Public Health Sciences Articles

No abstract provided.

An Unusual Case Of Urban Actinomyces Pyogenes Infective Endocarditis, Maher Musleh, Anita Ukani, Zain Tariq, Erica Herc

Case Reports

Actinomyces pyogenes is a gram positive bacillus known to cause pyogenic infections in animals with rare reports in humans with farm animal exposure. A 52-year-old male who was an active injection drug user presented to the emergency department with right-sided weakness, expressive aphasia, and altered mental status. He was found to be tachycardic and febrile. The patient was admitted two weeks prior for bilateral pneumonia and blood cultures grew Actinomyces pyogenes. Infectious Diseases was not consulted during that admission. On this admission, CT head showed a large left MCA ischemic stroke. Further imaging was concerning for septic emboli to the …

Update And Review Of Bleeding Considerations In Dermatologic Surgery: Hemostatic Techniques And Treatment Strategies For Bleeding Complications, Sanjana Iyengar, Danielle Yeager, Joel L. Cohen, David M. Ozog

Dermatology Articles

BACKGROUND: There are many intraoperative and postoperative techniques to aid hemostasis in dermatologic procedures. An updated understanding is critical for the surgeon.

OBJECTIVE: To provide an updated review of methods for hemostasis and therapies for postprocedural purpura and ecchymosis applicable to dermatology.

MATERIALS AND METHODS: A review of Ovid MEDLINE was performed to review the English-language medical literature of hemostatic options and their use in cutaneous surgery. All available publication years were included from 1946 to present.

RESULTS: A comprehensive and current list of hemostatic options used in the intraoperative and postoperative period is provided along with traditional and emerging …

Comprehensive Proteomics And Microrna Analyses Of Adult Neural Stem Cell Derived Exosomes After Stroke, Xian-Shuang Liu, Michael Chopp, Chao Li, Wan-Long Pan, Baoyan Fan, Albert M. Levin, Ruilan Zhang, Zhenggang Zhang

Neurology Meeting Abstracts

Introduction: Neural stem cells (NSC) are known to facilitate healing of ischemic brain tissues. Recent studies show that NSC derived exosomes function as paracrine effectors to promote neurovascular remodelling including angiogenesis and axonal outgrowth after stroke; nevertheless, the contents of the non-stroke and post stroke NSC exosome proteome and miRNA cargo have not been determined.

Methods: NSC derived exosomes were purified from conditioned media of cultured NSCs harvested from the subventricular zone of non-ischemic and ischemic rats, respectively. Liquid chromatography mass spectrometry (LCMS) and miRNA array were employed to comprehensively characterize the protein and miRNA contents of NSCs and their …

Rna-Binding Protein Fxr1 Regulates P21 And Terc Rna To Bypass P53-Mediated Cellular Senescence In Oscc., Mrinmoyee Majumder, Reniqua House, Nallasivam Palanisamy, Shuo Qie, Terrence A. Day, David Neskey, J A. Diehl, Viswanathan Palanisamy

Urology Articles

RNA-binding proteins (RBP) regulate numerous aspects of co- and post-transcriptional gene expression in cancer cells. Here, we demonstrate that RBP, fragile X-related protein 1 (FXR1), plays an essential role in cellular senescence by utilizing mRNA turnover pathway. We report that overexpressed FXR1 in head and neck squamous cell carcinoma targets (G-quadruplex (G4) RNA structure within) both mRNA encoding p21 (Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A, Cip1) and the non-coding RNA Telomerase RNA Component (TERC), and regulates their turnover to avoid senescence. Silencing of FXR1 in cancer cells triggers the activation of Cyclin-Dependent Kinase Inhibitors, p53, increases DNA damage, and ultimately, cellular …

Association Of Early Imaging For Back Pain With Clinical Outcomes In Older Adults, Jeffrey G. Jarvik, Laura S. Gold, Bryan A. Comstock, Patrick J. Heagerty, Sean D. Rundell, Judith A. Turner, Andrew L. Avins, Zoya Bauer, Brian W. Bresnahan, Janna L. Friedly, Kathryn James, Larry Kessler, Srdjan S. Nedeljkovic, David R. Nerenz, Xu Shi, Sean D. Sullivan, Leighton Chan, Jason M. Schwalb, Richard A. Deyo

Center for Health Policy and Health Services Research Articles

IMPORTANCE: In contrast to the recommendations for younger adults, many guidelines allow for older adults with back pain to undergo imaging without waiting 4 to 6 weeks. However, early imaging may precipitate interventions that do not improve outcomes.

OBJECTIVE: To compare function and pain at the 12-month follow-up visit among older adults who received early imaging with those who did not receive early imaging after a new primary care visit for back pain without radiculopathy.

DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort of 5239 patients 65 years or older with a new primary care visit for back pain (2011-2013) in 3 …

Multiple Endocrine Neoplasia Type 2b: Eighteen-Year Follow-Up Of A Four-Generation Family, Glen W. Sizemore, J. Aiden Carney, Hossein Gharib, Charles C. Capen

Henry Ford Hospital Medical Journal

Seven members with multiple endocrine neoplasia type 2B from a 15-member family have been followed for 18 years. All affected had the neuroma phenotype in a distribution compatible with autosomal dominant inheritance. The phenotype features have allowed 100% initial and continuing prediction of affected versus nonaffected status in as early as 1.5 years. Among the affected: immunoreactive plasma calcitonin (iCT) concentration was high in 100%; thyroid palpation was false-negative in 71%; and thyroid scintiscan was false-negative in 83%. All had total thyroidectomy, plus lymphadenectomy in three, for bilateral medullary thyroid carcinoma (MTC) or C-cell hyperplasia (in the youngest). None has …

Health Care Linkage Project: Improving Access To Care, Martha G. Ferguson, Lon Berkeley, Louis Fourcher, Belinda Guyton, Linda Ross Reiner

Henry Ford Hospital Medical Journal

The primary objective of the Health Care Linkage Project, funded by a grant from the Chicago Community Trust, is to develop, implement, and evaluate a primary health care linkage network within the city of Chicago that creates formalized linkages between community health centers, the Chicago Department of Health clinics, and hospitals. Six linkage networks are currently operational, with an additional two sites phased in during 1991. The success of the pilot project has been demonstrated by hundreds of patients receiving primary care and ancillary services on a more timely basis, by greater coordination between the public and private sector, by …

Public Health Care Delivery In Five U.S. Municipalities: Lessons And Implications, David G. Whiteis, J. Warren Salmon

Henry Ford Hospital Medical Journal

Increasing pressures on private and public hospitals have necessitated a reassessment of urban health care delivery. Patients left unserved by stressed private hospitals have placed a greater burden on public institutions, which themselves are often old, underfunded, and in danger of closure. As policy analysts consider remedies, primary care in community-based settings has reemerged as an important component of planning. We present results of a comparative analysis of five public health care delivery systems (Boston, Dallas, Denver, Milwaukee, and Seattle), reflecting their economic, political, and cultural dynamics. Although significant differences in the relative centralization of care and reliance on community-based …

Community Health Centers: A Resource For Service And Training, Joan Hedgecock, Maria Castro, William B. Cruikshank

Henry Ford Hospital Medical Journal

The American Medical Student Association (AMSA) Foundation is assisting the U.S. Public Health Service in increasing the number of primary care physicians trained and committed to practice in medically underserved areas. In collaboration with the American Academy of Family Physicians, the Ambulatory Pediatrics Association, and the Society of General Internal Medicine, AMSA conducted an assessment of federally-funded residency programs to identify and describe their affiliations with federally-funded community and migrant health centers (CIMHCs). Of the 260 programs assessed and the 147 responses, 125 offer community-based training. Of these, 73 offer training in primary care centers and 39 offer training in …

Countycare Summary, Edward H. Mcnamara, Vernice Davis-Anthony, Deborah L. Scott

Henry Ford Hospital Medical Journal

No abstract provided.

Adolescent Health Problems: A Model For Their Solution, Roberta B. Abrams

Henry Ford Hospital Medical Journal

No abstract provided.

Cervicofacial Actinomycosis In Children, Michael E. Friduss, Dennis R. Maceri

Henry Ford Hospital Medical Journal

Actinomycotic infections, once common in humans and cattle, are now rare causes of disease in man. This general group of organisms belongs taxonomically between the true bacteria and the fungi; however, the organisms behave clinically like true anaerobes. The organism, although phagocytized by the host cells, is not killed. Therefore, d is defined as a facultative intracellular parasite of the host. The protean manifestations of actinomycotic infections often mimic infectious processes, such as osteomyelitis or granulomatous disease, as well as neoplasia. It is therefore important for the surgeon to include actinomycosis in the differential diagnosis of cervicofacial masses in children …

Diagnostic And Therapeutic Potential Of New Radiopharmaceutical Agents In Medullary Thyroid Carcinoma, Luigi Troncone, Vittoria Rufini, Giovina De Rosa, Amerigo Testa

Henry Ford Hospital Medical Journal

Recently developed radiopharmaceuticals have been proposed for imaging medullary thyroid carcinoma (MTC) with some having therapeutic potential. This study compares the imaging results obtained with radioiodinated meta-iodo-benzylguanidine (MIBG), 99mTc (V) DMSA, and 131I F(ab')2 anti-carcinoembryonic antigen (anti-CEA) in a group of MTC patients. In 23 patients 131I MIBG imaging showed a high specificity (no false-positive results) but a less satisfactory sensitivity (50%). In 12 patients 99mTc (V) DMSA revealed a better sensitivity (77%) but a lower specificity (three false-positive results). Positive results were obtained in two of three patients studied with 131I F(ab')2 anti-CEA. These data suggest that the highly …

Myasthenia Gravis, Stanton B. Elias

Henry Ford Hospital Medical Journal

No abstract provided.

Staging Carcinoma Of The Prostate, Joseph C. Cerny

Henry Ford Hospital Medical Journal

No abstract provided.

The Development Of Pediatrics In The United States, Jay H. Mayefsky

Henry Ford Hospital Medical Journal

No abstract provided.

The Circumcision Decision: A Plea For Informed Consent, Theresa Spinelli

Henry Ford Hospital Medical Journal

No abstract provided.

Surgery For Morbid Obesity: A Continuing Challenge, Brack A. Bivins, Farouck N. Obeid, H. Mathilda Horst, Victor J. Sorensen

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Health Care Policy Issues Related To Aids: Lessons Learned From The Henry Ford Hospital Experience, David W. Benfer

Henry Ford Hospital Medical Journal

No abstract provided.