Digital Commons Network^™

Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel 3 Promotes Hcc Development In A Female-Biased Manner, Yueqi Zhang, Xinhui Liu, Kairui Sun, Yue Luo, Jack Yang, Aimin Li, Matti Kiupel, Stefanie Fenske, Martin Biel, Qing-Sheng Mi, Hongbing Wang, Hua Xiao

Dermatology Articles

Sex differences in hepatocellular carcinoma (HCC) development are regulated by sex and non-sex chromosomes, sex hormones, and environmental factors. We previously reported that Ncoa5(+/-) mice develop HCC in a male-biased manner. Here we show that NCOA5 expression is reduced in male patient HCCs while the expression of an NCOA5-interacting tumor suppressor, TIP30, is lower in female HCCs. Tip30 heterozygous deletion does not change HCC incidence in Ncoa5(+/-) male mice but dramatically increases HCC incidence in Ncoa5(+/-) female mice, accompanied by hepatic hyperpolarization-activated cyclic nucleotide-gated cation channel 3 (HCN3) overexpression. HCN3 overexpression cooperates with MYC to promote mouse HCC development, whereas …

Macomb Care Experience Patient And Family Advisory Council - A Year Of Change, Maureen G. Bennett, Brooke Shankin, Kristi Theol, Austin Lasota

2023 Patient Advisor Retreat

Vision of the Committee: To create partnerships among health care practitioners, patients and families that will lead to the best outcomes and enhance the quality and safety of our health care. Objective/Purpose: Provide advice, consultation, evaluation and recommendations regarding programs, educational efforts, selected research activities and operational initiatives that affect patients and families. Provide feedback and suggestions to enhance the patient/family experience at Henry Ford Macomb Hospital. Promote respectful, effective partnerships between patients, families, healthcare providers and administration. Provide a vital link between Henry Ford Macomb Hospital and the community. Participate in educating hospital personnel about various issues from a …

Patient Involvement And Communication Council, Angela Murphy, Laura Gooseberry, Becca Austin, Rob Behrendt, Lara Miskevich

2023 Patient Advisor Retreat

Patient-Centered Care (nothing about me without me) is the best approach to improve outcomes and provide value to each patient. The Council is involved in the following: Act as champions of patient experience andbring ideas, thoughts, and opinions on various topics and processes. Review patient and family communications to ensure engagement in health care services. Provide feedback regarding communication gaps between patients and providers. Revise and improve materials to be understood by patients and their caregivers.

Steps Pfac: Seniors Using Technology To Engage In Pain Self-Management, Lisa D. Landvogt, Leslie Grijalva, Tracie Mason, Jessica Judson, Courtney Latimer, Jaye Clement, Kimberlydawn Widsom, Tashfia Jilu, Sara Nguyen, Rebecca Lindsay, Mary Javenic

2023 Patient Advisor Retreat

STEPS stands for Seniors using Technology to Engage in Pain Self-management. We are testing to see if a pain self-management program can help people live better with chronic pain and reduce pain’s impact on their lives. Participants will: Complete three 60-minute telephone surveys Baseline, 2-month follow-up, and 12-month follow-up. Be randomly placed into one of two groups (50/50 chance): Intervention Group: A 7-week program with web-based videos and weekly telephone sessions led by a Community Health Worker. Control Group: A control group that receives program materials & a half-day workshop after the final survey.

All Of Us Research Program Pfac, Janine Hussein, Tiffany S. Lee, Cathy Peltz, Christine C. Johnson, Brian Ahmedani

2023 Patient Advisor Retreat

The goal of the All of Us Research Program (AoURP) is to help improve the future of health by accelerating health research and medical breakthroughs. The AoURPis part of the National Institutes of Health (NIH) Precision Medicine Initiative and seeks to help researchers understand more about why people get sick or stay healthy. The All of Us Research Program has established nationwide partnerships to build a research cohort to advance precision medicine. One million or more people living in the U.S. are being asked to share various types of health data over 10 years or more to build the largest …

Shift Worker Patient & Family Advisor Council (Pfac), Grace Paniccia, Jonny Russell, Salma Habash, Philip Cheng

2023 Patient Advisor Retreat

The Shift Worker Patient and Family Advisory Council (SHIFT PFAC) is an active patient engagement program aimed at improving the lives of night shift workers through their involvement and influence in our studies. We are proud to work with night shift workers as they are a group often overlooked in healthcare initiatives. We aim to work with the SHIFT PFAC to improve not only the physical health, but also the job satisfaction and overall well-being of night shift workers. The purpose of the SHIFT PFAC meetings is to foster an open dialogue where study participants can share their valuable insights, …

Experienced Transformation Patient & Family Advisory Council, John Bollinger, Thomas Eisenmann, Missy Ewald, Julie Goldstein-Dunn, Ally Hunter, Jennifer Kindseth, Shivani Mehta, Vanessa Mona, Stephanie Ryan, Courtney Stevens, Rajitha Viswaraju

2023 Patient Advisor Retreat

Providing Patient-Centered Care (Nothing about me without me) is the best approach to improving outcomes and providing value to each patient. This council works on initiatives and process improvement around pre-visit, onsite visit, and post-visit communication and delivery. Additional Henry Ford Health priorities are to leverage existing or new digital solutions that facilitate patient access, strengthen existing referral channels and growing new ones with potential future partners, assist patients with understanding and paying their health expenses, and better manage total per member per month cost through patient/member engagement in their wellness and care.

Hfwh Pfac Of Influence, Julie Johns, John Chandler Ii

2023 Patient Advisor Retreat

Our team is engaged with leaders from multidisciplinary departments that are working on improvement projects, ranging from marketing and messaging materials, physical plant changes, hardwiring best practices in communication and patient engagement. Our goal is to assist department leaders by improving and enhancing communication between patients, families and staff and always keeping the patient voice present on behalf of our community.

Using Storytelling To Share Lived Experiences With Maternal Mental Health (Mama), Sara Santarossa, Amy Loree, Courtney Latimer, Wendy Corriveau, Sara Mertz, Hailey Maddox, Leah M. Copeland, Dana Murphy, Ashley B. Redding

2023 Patient Advisor Retreat

Mental health conditions are a top medical complication of pregnancy and childbirth and are associated with a range of adverse maternal and child outcomes. Approximately 1 in 7 to 1 in 4 birthing people experience symptoms of a mental health condition during pregnancy or postpartum, yet few are diagnosed or treated. There remain critical knowledge gaps and significant challenges to adequately addressing maternal mental health. Project aims to use storytelling to share diverse perspectives on MAternal MentAl health (MAMA), build capacity and engagement for patient centered research by sharing these stories in a Storytelling Symposium, and with the aid of …

West Bloomfield Care Experience Patient And Family Advisory Council: A Year Of Change, Maureen G. Bennett, Luke Sparkman, Ioana Harland, Colleen Berson

2023 Patient Advisor Retreat

Purpose: To enable Henry Ford Health System to provide the highest standard of safe, comprehensive and compassionate healthcare while integrating the voice of the patients and families in policy and program decision making. Scope: Providing Patient-Centered Care (Nothing about me, without me) is the best approach to improving outcomes and providing value to each patient. The Patient Advisory Council members are involved in some or all ofthe following functions as part of their advisory role: Acting as Champions of the ideal patient experience by bringing their ideas, thoughts and opinions about various topics and processes. Reviewing communications to patients and …

Bump: Burnout Mitigation In Physician Trainees, Jacqueline Pflaum-Carlson, Sara Santarossa, Lisa Mclean, Julie A. Hamilton, Dana Murphy, Ashley B. Redding

2023 Patient Advisor Retreat

Physician burnout affects healthcare organizations at every level and has been associated with higher self-reported errors, increased turnover, and has a negative impact on patient care; it is estimated that tens of thousands of Americans die each year as a result ofpreventable medical errors. This project seeks to reduce the symptoms of physician burnout by exploring Acceptance Commitment Therapy (ACT) compared to Body Mapping as effective interventions in preventing and mitigating burnout in physician trainees at Henry Ford Health (HFH) in Detroit, Michigan.

Improving Research Is A Multipronged Collaborative Approach Reliant On "Expert" Humility And Respect, Philip Cheng, Andrew Bossick, Ashley B. Redding

2023 Patient Advisor Retreat

Our project goal is to bring together Henry Ford health sciences researchers and community members to promote the engagement of diverse patient perspectives. This poster highlights current initiatives pertaining to the integration of diverse perspectives into the research process to enhance our science at the group, system, and NIH level.

Our Contributions To The Hermelin Brain Tumor Center (Hbtc), Megan Sauer, Marc Betman, Ron Leach, Mike Coughlin, Jeni Barry, Dominik Mackowski, Lisa Scarpace, Nestelynn Gay

2023 Patient Advisor Retreat

The Hermelin Brain Tumor Center Patient and Family Advisory Council is comprised of patients and care partners who have generously agreed to come together to share their experiences and ideas. Mission Statement: Our goal is to drive patient and caregiver education, innovation, research, and success to continue to be a center of excellence. We aim to amplify the strengths of the Hermelin Brain Tumor Center by sharing our combined experience as patients, caregivers, and clinicians to its continual improvement and development.

Peir Ideas (Patients Engaged In Research - Inclusion, Diversity, Equity, Acceptance, And Safety), Sara Santarossa, Andrew Bossick, Karen Kippen, Christine L. M Joseph, Leah M. Copeland, Dana Murphy, Ashley Redding, Angela Murphy, Maureen G. Bennett

2023 Patient Advisor Retreat

This project involves long-, mid-, and short-term objectives to address gaps in the science of engagement in research focused on development and/or assessment of instruments that measure meaningful patient engagement in research (PEIR). PEIR involves patients undertaking roles beyond those of traditional study participants by including them throughout the entire research process. Long-term objective is to develop a national model for measuring meaningful PEIR that is adaptable for all settings and catchment areas. Mid-term objective is to create the sustained engagement of a diverse group of stakeholders in the design, implementation, evaluation, and dissemination of Science of Engagement research. How …

Pursuing Equity In Patient Care (Pepc), Linda Stechison, Jaquetta Hinton, Marla R. Gorosh, Kimberleydawn Wisdom

2023 Patient Advisor Retreat

Participating on the PEPC Committee is an opportunity to observe the exchange of information with leaders who are in positions to act on Quality Improvement (QI) projects/clinical research(CR) results to expand scope, encourage spread, and share resources. As Patient Advisors we use the lenses of our personal identities, work history, and life experiences to provide perspective for the patients’ voices. We see the barriers of the patient-clinician relationship that don’t address the power differential and make assumptions (unconscious bias) that affect adherence and outcomes of care.

The Patient Perspective On Covid-19 Restrictions Lifting: A Descriptive Study Of Resuming In-Person Meetings, Sara Santarossa, Ashley Rapp, Dana Murphy, Janine Hussein

2023 Patient Advisor Retreat

Henry Ford’s Patient Engaged Research Center (PERC): Our mission is to translate the patient voice into evidence-based care through community engagement and world-class research methods. PERC Patient Advisor Program: PERC relies on active participation of its Patient Advisors (PAs) in the Patient Advisor Program (the Program). PAs contribute their patient and/or caregiver experience and feedback to HFH projects and initiatives to ensure care is patient-centered. COVID-19: Due to the COVID-19 pandemic, the Program adapted virtual participation in order to continue to engage PAs. Purpose: When restrictions started lifting, PERC surveyed PAs to gather feedback on resuming in-person participation

Neural Modulation Enhancement Using Connectivity-Based Eeg Neurofeedback With Simultaneous Fmri For Emotion Regulation, Amin Dehghani, Hamid Soltanian-Zadeh, Gholam-Ali Hossein-Zadeh

Research Administration Articles

Emotion regulation plays a key role in human behavior and overall well-being. Neurofeedback is a non-invasive self-brain training technique used for emotion regulation to enhance brain function and treatment of mental disorders through behavioral changes. Previous neurofeedback research often focused on using activity from a single brain region as measured by fMRI or power from one or two EEG electrodes. In a new study, we employed connectivity-based EEG neurofeedback through recalling positive autobiographical memories and simultaneous fMRI to upregulate positive emotion. In our novel approach, the feedback was determined by the coherence of EEG electrodes rather than the power of …

Tapinarof Cream 1% Once Daily For The Treatment Of Plaque Psoriasis: Case Photography Of Clinical Outcomes From Three Phase 3 Trials, Seemal R. Desai, Linda F. Stein Gold, Michael C. Cameron, Alexandra Golant, G. Michael Lewitt, Matthew J. Bruno, George Martin, Philip M. Brown, David S. Rubenstein, Victoria Butners, Anna M. Tallman

Dermatology Articles

Tapinarof cream 1% (VTAMA(®); Dermavant Sciences, Inc.) is a non-steroidal, topical, aryl hydrocarbon receptor agonist approved by the US Food and Drug Administration (FDA) to treat plaque psoriasis in adults and under investigation for the treatment of psoriasis in children down to 2 years of age, and for atopic dermatitis in adults and children down to 2 years of age. The PSOARING phase 3 clinical trial program evaluated tapinarof cream 1% once daily (QD) in adults with mild to severe plaque psoriasis for up to 52 weeks (NCT03956355, NCT03983980, NCT04053387).

Here we present case photography documenting outcomes in the PSOARING …

The Perceived Usability Of Virtual Visits Among Black Adults' Receiving Oncology Care: A Qualitative Analysis, Samantha Tam, Christine Neslund-Dudas, Amy M. Barrett, Lauren C. J Barrow, Ilona Fridman, Alan C. Kinlaw, Praveen Puviindran, Trevor J. Royce, Angela B. Smith, Jacob N. Stein, William A. Wood, Jennifer Elston Lafata

Otolaryngology Articles

BACKGROUND: With the COVID-19 pandemic came rapid uptake in virtual oncology care. During this, sociodemographic inequities in access to virtual visits (VVs) have become apparent. To better understand these issues, we conducted a qualitative study to describe the perceived usability and acceptability of VVs among Black adults diagnosed with cancer.

METHODS: Adults who self-identified as Black and had a diagnosis of prostate, multiple myeloma, or head and neck cancer were recruited from 2 academic medical centers, and their community affiliates to participate in a semi-structured interview, regardless of prior VV experience. A patient and family advisory board was formed to …

Recharge Rooms: An Innovative Concept To Support Staff Well-Being, Madelyn L. Torakis, Gwen Gnam

2023 Nursing Research Conference

Introduction: Henry Ford Hospital partnered with Studio Elsewhere, a minority and women-owned design and technology studio from New York, that uses evidence-based and data-driven practices in developing virtual and physical interventions to promote brain health. These spaces, known as Recharge Rooms, are developed based on the theory that natural environments support health and resilience by reducing stress and anxiety and provide for better overall mental health. As a result, these immersive spaces are intentionally created to support healing. Each experience which includes visual and auditory sensory stimulation lasts 10-15 minutes.

Methodology: Recharge Rooms create an immersive experience for participants. This …

Research Staff Covid-19 Pandemic Survey-Results From The Prevention And Early Treatment Of Acute Lung Injury (Petal) Network, Jasreen Gill, Andrew Bissonette, Andrew Cook, Jacqueline Day, Sheri Renaud, Gordon Jacobsen, Kristine Nelson, Lori-Ann Kozikowski, Namita Jayaprakash, Jayna Gardner-Gray, Jennifer Swiderek, Cathryn F. Oldmixon, Nancy J. Ringwood, Robert L. Sherwin, Mark D. Williams, Arielle H. Gupta, Nicholas J. Johnson, Robert C. Hyzy, Pauline K. Park, Emanuel Rivers

Emergency Medicine Articles

Objectives: There is a lack of knowledge about the challenges of researchers who continued in-person research during the early phases of the COVID-19 pandemic.

Design: Electronic survey assessing work-related exposure to COVID-19, logistical challenges, and procedural changes during the first year of the COVID-19 pandemic on clinical research.

Setting: National Heart, Lung, and Blood Institute-sponsored Prevention and Early Treatment of Acute Lung Injury Clinical Trial Network Centers.

Subjects: Research staff at research Network Sites. Measurements and Main

Results: The 37-question survey was completed by 277 individuals from 24 states between 29 September 2020, and 12 December 2020, yielding a response …

A Bibliometric Analysis Of The Rise Of Chatgpt In Medical Research, Nikki M. Barrington, Nithin Gupta, Basel Musmar, David Doyle, Nicholas Panico, Nikhil Godbole, Taylor K. Reardon, Randy S. D'Amico

Neurology Articles

The rapid emergence of publicly accessible artificial intelligence platforms such as large language models (LLMs) has led to an equally rapid increase in articles exploring their potential benefits and risks. We performed a bibliometric analysis of ChatGPT literature in medicine and science to better understand publication trends and knowledge gaps. Following title, abstract, and keyword searches of PubMed, Embase, Scopus, and Web of Science databases for ChatGPT articles published in the medical field, articles were screened for inclusion and exclusion criteria. Data were extracted from included articles, with citation counts obtained from PubMed and journal metrics obtained from Clarivate Journal …

A Phase I Clinical Trial Of Oncolytic Adenovirus Mediated Suicide And Interleukin-12 Gene Therapy In Patients With Recurrent Localized Prostate Adenocarcinoma, Shyam Nyati, Hans Stricker, Kenneth N. Barton, Pin Li, Mohamed A. Elshaikh, Haythem Y. Ali, Stephen L. Brown, Clara Hwang, James O. Peabody, Svend O. Freytag, Benjamin Movsas, Farzan Siddiqui

Radiation Oncology Articles

In a phase I dose escalation and safety study (NCT02555397), a replication-competent oncolytic adenovirus expressing yCD, TK and hIL-12 (Ad5-yCD/mutTKSR39rep-hIL-12) was administered in 15 subjects with localized recurrent prostate cancer (T1c-T2) at increasing doses (1 × 1010, to 1 × 1012 viral particles) followed by 7-day treatment of 5-fluorocytosine (5-FC) and valganciclovir (vGCV). The primary endpoint was toxicity through day 30 while the secondary and exploratory endpoints were quantitation of IL-12, IFNγ, CXCL10 and peripheral blood mononuclear cells (PBMC). The study maximum tolerated dose (MTD) was not reached indicating 1012 viral particles was safe. Total 115 adverse events were observed, …

Map3k19 Regulatory Variation In Populations With African Ancestry May Increase Covid-19 Severity, Zhongshan Cheng, Yi Cai, Ke Zhang, Jingxuan Zhang, Hongsheng Gui, Yu-Si Luo, Jie Zhou, Brian Deveale

Behavioral Health Articles

To identify ancestry-linked genetic risk variants associated with COVID-19 hospitalization, we performed an integrative analysis of two genome-wide association studies and resolved four single nucleotide polymorphisms more frequent in COVID-19-hospitalized patients with non-European ancestry. Among them, the COVID-19 risk SNP rs16831827 shows the largest difference in minor allele frequency (MAF) between populations with African and European ancestry and also shows higher MAF in hospitalized COVID-19 patients among cohorts of mixed ancestry (odds ratio [OR] = 1.20, 95% CI: 1.10-1.30) and entirely African ancestry (OR = 1.30, 95% CI: 1.02-1.67). rs16831827 is an expression quantitative trait locus of MAP3K19. MAP3K19 expression …

Detection Of Diagnostic And Prognostic Methylation-Based Signatures In Liquid Biopsy Specimens From Patients With Meningiomas, Grayson A. Herrgott, James M. Snyder, Ruicong She, Tathiane M. Malta, Thais S. Sabedot, Ian Y. Lee, Jacob Pawloski, Guilherme G. Podolsky-Gondim, Karam P. Asmaro, Jiaqi Zhang, Cara E. Cannella, Kevin K. Nelson, Bartow Thomas, Ana C. De Carvalho, Laura A. Hasselbach, Kelly M. Tundo, Rehnuma Newaz, Andrea D. Transou, Natalia S. Morosini, Victor Francisco, Laila M. Poisson, Dhananjay A. Chitale, Abir Mukherjee, Maritza S. Mosella, Adam M. Robin, Tobias Walbert, Mark Rosenblum, Tom Mikkelsen, Steven N. Kalkanis, Daniela P. C Tirapelli, Daniel J. Weisenberger, Carlos G. Carlotti, Jack Rock, Ana V. Castro, Houtan Noushmehr

Neurosurgery Articles

Recurrence of meningiomas is unpredictable by current invasive methods based on surgically removed specimens. Identification of patients likely to recur using noninvasive approaches could inform treatment strategy, whether intervention or monitoring. In this study, we analyze the DNA methylation levels in blood (serum and plasma) and tissue samples from 155 meningioma patients, compared to other central nervous system tumor and non-tumor entities. We discover DNA methylation markers unique to meningiomas and use artificial intelligence to create accurate and universal models for identifying and predicting meningioma recurrence, using either blood or tissue samples. Here we show that liquid biopsy is a …

Neighborhood Disadvantage And Neural Correlates Of Threat And Reward Processing In Survivors Of Recent Trauma, E. Kate Webb, Timothy D. Ely, Grace E. Rowland, Lauren A. M Lebois, Sanne J. H Van Rooij, Steven E. Bruce, Tanja Jovanovic, Stacey L. House, Francesca L. Beaudoin, Xinming An, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher A. Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Robert A. Swor, Jose L. Pascual, Mark J. Seamon, Elizabeth M. Datner, Claire Pearson, David A. Peak, Roland C. Merchant, Robert M. Domeier, Niels K. Rathlev, Paulina Sergot, Leon D. Sanchez, Ronald C. Kessler, Karestan C. Koenen, Samuel A. Mclean, Jennifer S. Stevens, Kerry J. Ressler, Nathaniel G. Harnett

Emergency Medicine Articles

IMPORTANCE: Differences in neighborhood socioeconomic characteristics are important considerations in understanding differences in risk vs resilience in mental health. Neighborhood disadvantage is associated with alterations in the function and structure of threat neurocircuitry.

OBJECTIVE: To investigate associations of neighborhood disadvantage with white and gray matter and neural reactivity to positive and negative stimuli in the context of trauma exposure.

DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, survivors of trauma who completed sociodemographic and posttraumatic symptom assessments and neuroimaging were recruited as part of the Advancing Understanding of Recovery After Trauma (AURORA) study between September 2017 and June 2021. Data …

Racial, Ethnic, And Sex Diversity In Academic Medical Leadership, Austin M. Meadows, Madelyn M. Skinner, Alaa A. Hazime, Russell G. Day, Jessi A. Fore, Charles S. Day

Orthopedics Articles

IMPORTANCE: For the past 50 years, significant gaps have existed in gender and racial diversity across various medical specialties, despite the many benefits of a diverse physician workforce. One proposed approach to increasing diversity is top-down diversification, in which diverse leadership results in increased minority and female workforce representation.

OBJECTIVE: To investigate the changes in academic medical leadership diversity from 2007 to 2019 and to assess the recent leadership diversity of various specialties compared with the averages across all specialties.

DESIGN, SETTING, AND PARTICIPANTS: This was a cross-sectional analysis of physicians in varying academic roles in 2007, 2019, and 2020. …

Biomarker-Directed Therapy In Black And White Men With Metastatic Castration-Resistant Prostate Cancer, Clara Hwang, Nicholas C. Henderson, Shih-Chun Chu, Brandon Holland, Frank C. Cackowski, Amanda B. Pilling, Albert Jang, Shoshana Rothstein, Matthew Labriola, Joseph J. Park, Alyssa Ghose, Mehmet A. Bilen, Seema Mustafa, Deepak Kilari, Michael J. Pierro, Bicky Thapa, Abhishek Tripathi, Rohan Garje, Aditya Ravindra, Vadim S. Koshkin, Erik Hernandez, Michael T. Schweizer, Andrew J. Armstrong, Rana R. Mckay, Tanya B. Dorff, Ajjai S. Alva, Pedro C. Barata

Hematology/Oncology Articles

IMPORTANCE: Black men have higher incidence and mortality from prostate cancer. Whether precision oncology disparities affect Black men with metastatic castration-resistant prostate cancer (mCRPC) is unknown.

OBJECTIVE: To compare precision medicine data and outcomes between Black and White men with mCRPC.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used data collected by the Prostate Cancer Precision Medicine Multi-Institutional Collaborative Effort (PROMISE) consortium, a multi-institutional registry with linked clinicogenomic data, from April 2020 to December 2021. Participants included Black and White patients with mCRPC with molecular data. Data were analyzed from December 2021 to May 2023.

EXPOSURES: Database-reported race and …

Mesenchymal-Derived Extracellular Vesicles Enhance Microglia-Mediated Synapse Remodeling After Cortical Injury In Aging Rhesus Monkeys, Yuxin Zhou, Hrishti Bhatt, Chromewell A. Mojica, Hongqi Xin, Monica A. Pessina, Douglas L. Rosene, Tara L. Moore, Maria Medalla

Neurology Articles

Understanding the microglial neuro-immune interactions in the primate brain is vital to developing therapeutics for cortical injury, such as stroke or traumatic brain injury. Our previous work showed that mesenchymal-derived extracellular vesicles (MSC-EVs) enhanced motor recovery in aged rhesus monkeys following injury of primary motor cortex (M1), by promoting homeostatic ramified microglia, reducing injury-related neuronal hyperexcitability, and enhancing synaptic plasticity in perilesional cortices. A focal lesion was induced via surgical ablation of pial blood vessels over lying the cortical hand representation of M1 of aged female rhesus monkeys, that received intravenous infusions of either vehicle (veh) or EVs 24 h …

Weighing The Odds: Novel Β-Lactam/Β-Lactamase Inhibitor Use In Hospital-Acquired And Ventilator-Associated, Ashlan J. Kunz Coyne, Carolina Orzol, Michael P. Veve, Michael J. Rybak

Pharmacy Articles

BACKGROUND: Pseudomonas aeruginosa is a leading cause of hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP). Novel β-lactam/β-lactamase inhibitor (BL/BLI) combinations are often used for these infections; however, limited data exist to guide the dosing of BL/BLI in patients who are morbidly obese. Thus, we sought to evaluate the clinical and safety endpoints of patients who are morbidly obese (body mass index ≥35 kg/m(2)) and non-morbidly obese (<35 kg/m(2)) and receiving BL/BLI for P aeruginosa HABP/VABP.

METHODS: This retrospective study was based on a cohort of patients hospitalized at 2 urban academic medical centers in Detroit, Michigan, from August 2014 through February 2021 with P aeruginosa HABP/VABP who were receiving …